GREMLIN Database
Q97Z16 - Heterodisulfide reductase, subunit C (HdrC-1)
UniProt: Q97Z16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 280 (214)
Sequences: 265 (178)
Seq/√Len: 12.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_R236_N5.7661.00
194_V197_K4.5991.00
83_D86_P3.8140.99
86_P94_M2.9550.95
197_K231_L2.7670.93
83_D94_M2.5630.90
86_P89_M2.5480.90
109_V139_A2.3820.87
91_Q94_M2.2900.84
84_F89_M2.2430.83
259_I263_W2.2360.83
121_R126_N2.2220.83
257_E261_E2.2060.82
176_D183_P2.1770.81
86_P93_M2.1000.79
136_R229_G2.0490.77
83_D87_R2.0360.76
46_A49_F1.9810.74
83_D88_E1.9460.73
255_Q258_E1.9390.73
187_E191_N1.9120.72
85_G88_E1.8910.71
190_K193_D1.8490.69
86_P92_Y1.8350.68
116_Y127_E1.7820.66
176_D250_E1.7600.65
222_M232_D1.7430.64
241_L263_W1.7420.64
176_D180_D1.7040.62
88_E94_M1.7020.62
83_D89_M1.6630.60
71_V160_T1.6430.59
197_K200_P1.6430.59
258_E262_K1.5890.57
85_G89_M1.5740.56
194_V250_E1.5500.55
80_K124_F1.5500.55
260_K263_W1.5090.53
86_P95_R1.5090.53
101_I105_V1.5000.52
84_F87_R1.4770.51
88_E92_Y1.4660.51
202_D230_V1.4290.49
87_R110_W1.4270.49
64_R196_R1.4220.48
86_P132_I1.4020.47
46_A52_A1.4000.47
160_T241_L1.3840.46
63_L90_I1.3760.46
86_P136_R1.3590.45
91_Q95_R1.3570.45
193_D197_K1.3200.43
50_W53_V1.3170.43
183_P192_M1.3150.43
50_W56_D1.2880.42
107_K139_A1.2860.42
234_L246_M1.2790.41
117_T233_S1.2790.41
51_E54_K1.2720.41
77_P109_V1.2520.40
64_R252_R1.2460.40
156_R171_D1.2430.39
185_A190_K1.2310.39
184_Q193_D1.2270.39
102_W105_V1.2230.39
83_D93_M1.2180.38
69_C122_C1.2130.38
118_C122_C1.2130.38
69_C118_C1.2130.38
115_C122_C1.2130.38
72_C76_C1.2130.38
72_C112_C1.2130.38
72_C115_C1.2130.38
72_C118_C1.2130.38
112_C115_C1.2130.38
72_C122_C1.2130.38
112_C118_C1.2130.38
115_C118_C1.2130.38
76_C122_C1.2130.38
76_C118_C1.2130.38
76_C115_C1.2130.38
76_C112_C1.2130.38
112_C122_C1.2130.38
69_C115_C1.2130.38
69_C112_C1.2130.38
69_C76_C1.2130.38
66_C76_C1.2130.38
66_C112_C1.2130.38
66_C72_C1.2130.38
66_C69_C1.2130.38
66_C122_C1.2130.38
66_C118_C1.2130.38
66_C115_C1.2130.38
69_C72_C1.2130.38
52_A56_D1.2100.38
84_F94_M1.1950.37
50_W54_K1.1910.37
208_D212_H1.1900.37
92_Y95_R1.1830.37
55_S131_L1.1820.37
200_P233_S1.1590.36
181_W188_E1.1570.35
103_E107_K1.1390.35
84_F93_M1.1350.34
101_I187_E1.1310.34
206_R211_W1.1180.34
106_N218_A1.1090.33
78_A113_V1.1090.33
240_D244_M1.1070.33
103_E241_L1.0980.33
89_M94_M1.0880.32
87_R93_M1.0670.31
225_F249_Y1.0580.31
184_Q189_S1.0560.31
180_D183_P1.0400.30
195_Y202_D1.0380.30
128_I131_L1.0280.30
113_V127_E1.0260.30
101_I104_F1.0250.30
203_L235_K1.0130.29
184_Q190_K1.0070.29
177_A180_D1.0070.29
83_D91_Q1.0060.29
105_V109_V0.9990.29
194_V232_D0.9960.28
88_E95_R0.9950.28
133_M246_M0.9940.28
161_V168_V0.9940.28
106_N109_V0.9900.28
201_V231_L0.9850.28
87_R95_R0.9840.28
96_D99_D0.9790.28
168_V212_H0.9770.28
205_Q260_K0.9680.27
140_V250_E0.9670.27
71_V189_S0.9580.27
209_I213_A0.9470.26
93_M179_P0.9410.26
77_P113_V0.9330.26
143_G201_V0.9190.25
83_D92_Y0.9160.25
210_G239_K0.9010.25
55_S60_N0.8860.24
125_N258_E0.8520.23
97_E100_K0.8520.23
116_Y119_S0.8430.23
179_P186_V0.8310.22
84_F88_E0.8260.22
172_M196_R0.8240.22
207_T244_M0.8100.21
188_E191_N0.8060.21
122_C136_R0.8040.21
76_C136_R0.8040.21
118_C136_R0.8040.21
66_C136_R0.8040.21
72_C136_R0.8040.21
69_C136_R0.8040.21
112_C136_R0.8040.21
115_C136_R0.8040.21
99_D103_E0.8020.21
77_P110_W0.8000.21
170_P236_N0.7990.21
46_A50_W0.7910.21
43_R47_V0.7890.21
198_A258_E0.7820.20
138_Y178_F0.7800.20
100_K105_V0.7800.20
68_N101_I0.7770.20
84_F95_R0.7770.20
177_A182_G0.7680.20
89_M93_M0.7670.20
119_S138_Y0.7670.20
165_G245_I0.7610.20
180_D186_V0.7590.20
168_V236_N0.7550.20
71_V162_I0.7460.19
120_M225_F0.7450.19
51_E103_E0.7450.19
181_W184_Q0.7350.19
74_S145_Q0.7350.19
48_K55_S0.7320.19
43_R46_A0.7280.19
157_V207_T0.7250.19
102_W109_V0.7230.19
177_A193_D0.7220.19
152_A156_R0.7210.19
141_K145_Q0.7180.18
84_F92_Y0.7170.18
177_A183_P0.7160.18
47_V99_D0.7160.18
63_L131_L0.7080.18
141_K144_L0.7070.18
183_P190_K0.7040.18
44_E47_V0.7030.18
255_Q259_I0.7030.18
177_A184_Q0.6990.18
256_L259_I0.6950.18
50_W64_R0.6940.18
117_T247_D0.6930.18
49_F58_R0.6900.18
204_L221_M0.6800.17
45_V65_G0.6800.17
209_I242_Y0.6790.17
234_L250_E0.6770.17
101_I137_E0.6760.17
115_C123_P0.6740.17
118_C123_P0.6740.17
72_C123_P0.6740.17
76_C123_P0.6740.17
66_C123_P0.6740.17
112_C123_P0.6740.17
69_C123_P0.6740.17
67_L124_F0.6740.17
208_D215_L0.6730.17
171_D236_N0.6730.17
257_E262_K0.6700.17
171_D197_K0.6680.17
44_E48_K0.6680.17
43_R51_E0.6650.17
208_D240_D0.6610.17
165_G169_T0.6570.17
91_Q208_D0.6560.17
201_V232_D0.6490.16
87_R94_M0.6490.16
119_S137_E0.6480.16
44_E187_E0.6480.16
159_L226_V0.6480.16
70_G76_C0.6470.16
66_C70_G0.6470.16
70_G112_C0.6470.16
70_G118_C0.6470.16
70_G122_C0.6470.16
70_G115_C0.6470.16
51_E125_N0.6470.16
48_K98_V0.6460.16
104_F107_K0.6450.16
152_A251_E0.6390.16
211_W246_M0.6370.16
179_P184_Q0.6360.16
89_M92_Y0.6330.16
231_L236_N0.6300.16
236_N260_K0.6300.16
88_E93_M0.6260.16
97_E127_E0.6250.16
198_A216_Q0.6230.16
186_V237_V0.6220.16
113_V241_L0.6210.16
57_F132_I0.6200.16
138_Y160_T0.6200.16
163_T203_L0.6190.16
111_A240_D0.6160.16
83_D95_R0.6150.16
210_G250_E0.6060.15
49_F53_V0.6040.15
73_T113_V0.6040.15
87_R92_Y0.6000.15
64_R71_V0.5960.15
180_D184_Q0.5950.15
233_S236_N0.5940.15
114_Q136_R0.5920.15
208_D244_M0.5880.15
104_F203_L0.5870.15
181_W191_N0.5870.15
153_P158_L0.5850.15
49_F94_M0.5830.15
184_Q191_N0.5830.15
217_T220_E0.5770.15
203_L245_I0.5730.14
74_S80_K0.5700.14
54_K59_Y0.5700.14
48_K59_Y0.5690.14
208_D213_A0.5680.14
232_D250_E0.5680.14
208_D218_A0.5640.14
86_P229_G0.5640.14
117_T127_E0.5590.14
252_R258_E0.5580.14
127_E233_S0.5550.14
129_A143_G0.5540.14
109_V142_F0.5530.14
198_A235_K0.5530.14
90_I144_L0.5530.14
47_V50_W0.5450.14
194_V199_V0.5440.14
255_Q260_K0.5420.14
48_K83_D0.5420.14
61_E79_A0.5420.14
67_L103_E0.5410.14
102_W143_G0.5410.14
159_L168_V0.5410.14
125_N130_G0.5400.14
181_W186_V0.5390.14
222_M238_D0.5380.14
135_L179_P0.5350.14
70_G126_N0.5320.13
60_N63_L0.5310.13
46_A60_N0.5290.13
186_V189_S0.5280.13
188_E255_Q0.5230.13
89_M95_R0.5220.13
98_V141_K0.5210.13
205_Q240_D0.5210.13
164_T170_P0.5200.13
216_Q263_W0.5190.13
107_K124_F0.5160.13
125_N201_V0.5150.13
167_Q244_M0.5150.13
135_L156_R0.5150.13
259_I262_K0.5140.13
169_T235_K0.5120.13
65_G71_V0.5090.13
257_E260_K0.5070.13
64_R74_S0.5050.13
90_I131_L0.5050.13
44_E51_E0.5050.13
99_D224_I0.5040.13
128_I225_F0.5020.13
46_A51_E0.5020.13
116_Y120_M0.5020.13
210_G238_D0.5020.13
176_D179_P0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.8179 99.7 0.816 Contact Map
1kf6B 1 0.5321 99.3 0.855 Contact Map
2h88B 1 0.5036 99.2 0.857 Contact Map
2bs2B 1 0.4893 99.2 0.86 Contact Map
3cf4A 2 0.9321 99.2 0.861 Contact Map
4ysxB 1 0.5464 99.1 0.863 Contact Map
2wdqB 1 0.5071 99.1 0.863 Contact Map
4p6vA 1 0.3893 99 0.87 Contact Map
3c8yA 1 0.7571 98.1 0.903 Contact Map
3i9v9 1 0.5357 97.8 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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