GREMLIN Database
Q97Z15 - Heterodisulfite reductase, subunit B (HdrB-1)
UniProt: Q97Z15 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 437 (332)
Sequences: 239 (110)
Seq/√Len: 6.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_N71_E3.9770.93
28_V32_I3.4500.87
375_D378_G3.2940.84
13_V17_F3.1540.82
267_V351_D3.1390.81
119_D130_N3.1300.81
228_D272_A2.9530.77
93_C125_S2.7340.71
209_S351_D2.7330.71
28_V31_R2.7190.71
236_T264_S2.7100.70
87_L113_L2.6610.69
222_Q267_V2.5750.66
144_G157_G2.3030.57
70_V73_Q2.2800.56
87_L131_Y2.2410.55
27_E32_I2.2130.54
233_A276_D2.1520.52
73_Q77_G2.1460.51
273_K370_H2.1380.51
90_H149_N1.9980.46
248_T252_P1.9770.45
166_T169_G1.9750.45
232_A267_V1.9180.43
315_N318_I1.9100.43
294_E348_V1.9030.43
61_H99_I1.9020.43
32_I35_R1.8390.41
225_Y361_A1.8100.40
74_T77_G1.8060.39
34_Y251_D1.8030.39
238_C283_C1.7910.39
125_S167_S1.7870.39
378_G382_K1.7860.39
85_T158_Y1.7700.38
223_K226_N1.7700.38
82_I85_T1.7690.38
209_S266_T1.7610.38
265_G269_N1.7580.38
94_G356_A1.7550.38
86_K116_D1.7270.37
163_H169_G1.7080.36
219_A226_N1.7030.36
164_C169_G1.6760.35
219_A224_K1.6760.35
85_T285_G1.6740.35
70_V76_N1.6720.35
85_T308_I1.6680.35
320_V351_D1.6650.35
26_N231_K1.6630.35
374_T377_E1.6210.33
17_F235_H1.6100.33
321_T348_V1.6010.33
375_D381_R1.5990.33
96_C149_N1.5950.33
207_H307_V1.5950.33
33_I36_Y1.5910.32
164_C168_F1.5760.32
93_C126_C1.5690.32
284_C326_C1.5640.32
117_Y329_T1.5640.32
372_H378_G1.5520.31
52_L59_I1.5420.31
374_T378_G1.5410.31
376_V383_I1.5330.31
93_C167_S1.5200.30
219_A222_Q1.5100.30
248_T253_E1.4960.30
282_D298_S1.4890.29
167_S170_H1.4790.29
49_M266_T1.4600.28
238_C285_G1.4410.28
51_K334_Q1.4400.28
377_E382_K1.4320.28
271_G274_L1.4310.28
306_K310_A1.4290.28
53_E62_H1.4260.28
378_G383_I1.4220.27
282_D305_K1.4200.27
319_F348_V1.4110.27
53_E144_G1.3980.27
39_P223_K1.3910.27
219_A223_K1.3910.27
17_F323_D1.3890.26
107_F162_I1.3810.26
246_E354_F1.3760.26
80_K286_F1.3720.26
69_P73_Q1.3650.26
67_N81_K1.3640.26
377_E381_R1.3620.26
209_S352_A1.3610.26
295_R300_S1.3540.26
242_K323_D1.3390.25
286_F294_E1.3360.25
51_K276_D1.3330.25
141_A176_N1.3210.25
38_T41_G1.3210.25
238_C284_C1.3160.24
222_Q225_Y1.3150.24
119_D217_K1.3050.24
171_Y175_R1.3020.24
236_T277_Y1.2980.24
13_V235_H1.2870.24
207_H350_A1.2870.24
213_Y217_K1.2830.24
379_F383_I1.2700.23
330_L377_E1.2660.23
236_T253_E1.2600.23
65_P77_G1.2560.23
374_T383_I1.2460.23
11_R210_E1.2440.23
246_E274_L1.2430.23
102_Y223_K1.2370.22
166_T177_M1.2360.22
282_D306_K1.2340.22
233_A277_Y1.2290.22
131_Y294_E1.2270.22
143_A178_I1.2260.22
89_H164_C1.2240.22
175_R205_V1.2220.22
73_Q76_N1.2190.22
267_V354_F1.2110.22
216_S223_K1.2050.22
72_A75_L1.2000.22
164_C348_V1.1950.21
206_V346_L1.1940.21
100_P210_E1.1860.21
250_Y292_L1.1850.21
69_P74_T1.1810.21
272_A275_V1.1790.21
41_G360_G1.1720.21
320_V354_F1.1720.21
13_V323_D1.1640.21
85_T334_Q1.1570.21
166_T295_R1.1560.21
70_V74_T1.1550.21
163_H167_S1.1540.20
379_F382_K1.1540.20
54_D114_E1.1530.20
71_E335_W1.1520.20
73_Q78_S1.1480.20
167_S175_R1.1450.20
52_L280_W1.1440.20
264_S277_Y1.1430.20
315_N320_V1.1380.20
103_P286_F1.1190.20
242_K287_G1.1160.20
369_I381_R1.1120.20
28_V87_L1.1100.19
339_A343_N1.1070.19
221_Q233_A1.1070.19
72_A78_S1.1040.19
169_G177_M1.0980.19
43_E46_K1.0950.19
246_E253_E1.0940.19
90_H96_C1.0920.19
105_S110_M1.0850.19
47_E151_W1.0840.19
271_G361_A1.0760.19
46_K317_D1.0750.19
10_Q17_F1.0700.19
151_W345_N1.0680.19
82_I360_G1.0680.19
370_H374_T1.0670.19
371_W374_T1.0570.18
76_N110_M1.0560.18
10_Q323_D1.0550.18
108_W117_Y1.0550.18
70_V219_A1.0550.18
380_L383_I1.0530.18
56_G287_G1.0500.18
115_I220_A1.0440.18
137_S146_Y1.0350.18
248_T251_D1.0310.18
153_A358_A1.0310.18
56_G59_I1.0280.18
169_G175_R1.0270.18
345_N367_A1.0260.18
138_N164_C1.0250.18
42_L151_W1.0230.18
162_I230_I1.0180.18
222_Q230_I1.0080.17
252_P280_W1.0010.17
65_P68_N0.9930.17
378_G381_R0.9930.17
10_Q13_V0.9850.17
92_S324_T0.9790.17
285_G288_F0.9650.16
273_K381_R0.9640.16
372_H375_D0.9610.16
240_V249_V0.9560.16
93_C289_R0.9550.16
93_C149_N0.9510.16
216_S266_T0.9480.16
218_K223_K0.9440.16
151_W171_Y0.9420.16
17_F57_E0.9410.16
279_T382_K0.9390.16
68_N361_A0.9380.16
218_K227_L0.9330.16
14_R26_N0.9320.16
111_N305_K0.9310.16
311_V319_F0.9300.16
159_F206_V0.9240.16
61_H158_Y0.9220.16
222_Q226_N0.9210.16
51_K109_V0.9170.16
166_T307_V0.9150.15
375_D380_L0.9140.15
53_E149_N0.9140.15
106_V161_L0.9130.15
231_K273_K0.9130.15
20_S100_P0.9080.15
216_S219_A0.9040.15
84_T118_L0.9030.15
44_H50_Y0.9020.15
133_A149_N0.9010.15
94_G288_F0.8950.15
76_N151_W0.8950.15
232_A265_G0.8950.15
369_I374_T0.8940.15
225_Y267_V0.8910.15
345_N371_W0.8910.15
74_T78_S0.8880.15
368_Q371_W0.8840.15
268_Q312_E0.8840.15
82_I311_V0.8790.15
116_D248_T0.8780.15
327_V330_L0.8770.15
122_H155_E0.8750.15
50_Y55_K0.8730.15
102_Y347_P0.8700.15
326_C333_S0.8680.15
376_V379_F0.8680.15
224_K266_T0.8670.15
73_Q347_P0.8670.15
236_T242_K0.8650.15
137_S288_F0.8650.15
207_H287_G0.8650.15
307_V310_A0.8650.15
287_G323_D0.8630.15
160_P206_V0.8610.15
367_A374_T0.8540.14
24_D335_W0.8510.14
283_C326_C0.8510.14
238_C326_C0.8510.14
149_N322_S0.8500.14
207_H242_K0.8480.14
12_E93_C0.8480.14
151_W231_K0.8470.14
309_P312_E0.8460.14
278_S351_D0.8460.14
28_V294_E0.8400.14
10_Q235_H0.8400.14
151_W178_I0.8310.14
306_K321_T0.8310.14
65_P162_I0.8280.14
109_V114_E0.8240.14
167_S172_K0.8230.14
71_E122_H0.8230.14
74_T111_N0.8190.14
39_P57_E0.8170.14
164_C177_M0.8120.14
47_E286_F0.8100.14
45_V266_T0.8100.14
376_V381_R0.8100.14
233_A236_T0.8100.14
60_I253_E0.8090.14
328_T356_A0.8080.14
75_L251_D0.8080.14
68_N72_A0.8080.14
24_D281_W0.8080.14
81_K220_A0.8080.14
231_K274_L0.8040.14
76_N223_K0.8000.13
17_F242_K0.8000.13
140_V158_Y0.7920.13
65_P320_V0.7890.13
147_V171_Y0.7870.13
82_I285_G0.7870.13
61_H280_W0.7860.13
286_F308_I0.7840.13
151_W179_I0.7790.13
86_K267_V0.7790.13
71_E363_P0.7760.13
79_P311_V0.7730.13
21_D25_W0.7690.13
54_D377_E0.7680.13
41_G44_H0.7660.13
144_G343_N0.7650.13
211_W357_L0.7640.13
210_E311_V0.7640.13
113_L119_D0.7590.13
13_V242_K0.7580.13
374_T380_L0.7570.13
281_W310_A0.7570.13
175_R179_I0.7550.13
28_V33_I0.7510.13
57_E242_K0.7510.13
217_K265_G0.7470.13
370_H377_E0.7460.13
47_E293_T0.7460.13
374_T381_R0.7460.13
116_D317_D0.7450.13
50_Y54_D0.7430.13
288_F326_C0.7430.13
59_I66_Y0.7430.13
117_Y361_A0.7420.13
73_Q202_P0.7420.13
162_I221_Q0.7400.12
65_P85_T0.7400.12
163_H170_H0.7380.12
280_W308_I0.7360.12
144_G154_Y0.7340.12
52_L58_I0.7330.12
119_D219_A0.7330.12
167_S177_M0.7310.12
213_Y218_K0.7310.12
64_K358_A0.7310.12
46_K318_I0.7310.12
13_V57_E0.7310.12
166_T170_H0.7300.12
124_T142_L0.7260.12
73_Q232_A0.7230.12
217_K231_K0.7220.12
248_T353_Q0.7210.12
77_G232_A0.7210.12
15_E28_V0.7200.12
231_K341_G0.7200.12
242_K264_S0.7200.12
330_L380_L0.7170.12
376_V382_K0.7150.12
251_D275_V0.7150.12
68_N359_M0.7150.12
362_D369_I0.7140.12
55_K59_I0.7130.12
166_T207_H0.7060.12
94_G167_S0.7050.12
267_V317_D0.7040.12
317_D367_A0.7030.12
63_I67_N0.7000.12
97_G277_Y0.6980.12
279_T365_I0.6940.12
60_I234_V0.6940.12
93_C237_P0.6910.12
73_Q104_T0.6900.12
360_G366_I0.6870.12
318_I349_L0.6860.12
154_Y158_Y0.6840.12
201_I204_E0.6820.12
146_Y288_F0.6820.12
63_I267_V0.6810.12
271_G341_G0.6810.12
117_Y206_V0.6810.12
219_A273_K0.6810.12
212_L240_V0.6810.12
168_F177_M0.6790.12
26_N30_Q0.6780.12
146_Y233_A0.6730.11
242_K277_Y0.6720.11
267_V278_S0.6720.11
327_V348_V0.6710.11
102_Y234_V0.6690.11
206_V315_N0.6660.11
217_K266_T0.6650.11
124_T293_T0.6610.11
70_V104_T0.6600.11
131_Y329_T0.6590.11
163_H166_T0.6570.11
219_A225_Y0.6530.11
267_V367_A0.6490.11
367_A370_H0.6490.11
19_M25_W0.6470.11
233_A253_E0.6460.11
60_I323_D0.6430.11
299_R361_A0.6430.11
54_D72_A0.6410.11
79_P117_Y0.6380.11
84_T156_T0.6370.11
113_L211_W0.6350.11
48_E219_A0.6330.11
65_P305_K0.6310.11
178_I269_N0.6310.11
72_A76_N0.6300.11
166_T174_V0.6300.11
106_V110_M0.6290.11
125_S289_R0.6280.11
60_I84_T0.6280.11
229_N320_V0.6270.11
70_V75_L0.6270.11
66_Y96_C0.6270.11
253_E264_S0.6240.11
120_E307_V0.6230.11
75_L78_S0.6200.11
102_Y105_S0.6190.11
221_Q236_T0.6190.11
55_K61_H0.6180.11
150_M252_P0.6150.11
273_K367_A0.6140.11
154_Y285_G0.6140.11
178_I267_V0.6130.11
39_P219_A0.6090.11
15_E87_L0.6080.11
370_H376_V0.6070.11
57_E287_G0.6060.11
139_P345_N0.6050.11
370_H380_L0.6040.11
31_R300_S0.6030.11
273_K365_I0.6020.10
268_Q306_K0.6000.10
109_V209_S0.5990.10
221_Q264_S0.5930.10
163_H168_F0.5930.10
149_N303_L0.5890.10
155_E233_A0.5880.10
117_Y121_P0.5830.10
164_C287_G0.5820.10
80_K154_Y0.5820.10
316_A326_C0.5810.10
158_Y334_Q0.5810.10
90_H126_C0.5790.10
89_H109_V0.5790.10
225_Y270_F0.5790.10
41_G56_G0.5780.10
370_H381_R0.5770.10
296_E303_L0.5750.10
218_K224_K0.5700.10
146_Y215_M0.5650.10
161_L305_K0.5650.10
369_I373_A0.5640.10
113_L146_Y0.5640.10
86_K242_K0.5630.10
80_K285_G0.5620.10
121_P165_G0.5620.10
79_P111_N0.5610.10
57_E61_H0.5610.10
45_V133_A0.5610.10
312_E365_I0.5560.10
278_S327_V0.5530.10
171_Y347_P0.5530.10
356_A359_M0.5510.10
64_K363_P0.5490.10
140_V362_D0.5480.10
228_D271_G0.5480.10
41_G57_E0.5460.10
88_W277_Y0.5460.10
65_P147_V0.5460.10
232_A349_L0.5450.10
207_H235_H0.5440.10
220_A232_A0.5430.10
112_K359_M0.5430.10
45_V61_H0.5400.10
44_H59_I0.5400.10
45_V49_M0.5360.10
146_Y326_C0.5360.10
154_Y345_N0.5360.10
83_P251_D0.5350.10
366_I370_H0.5340.10
345_N363_P0.5330.10
104_T306_K0.5330.10
84_T279_T0.5330.10
280_W334_Q0.5310.10
322_S352_A0.5310.10
86_K317_D0.5290.10
39_P56_G0.5290.10
60_I161_L0.5290.10
43_E53_E0.5270.10
42_L269_N0.5250.10
131_Y142_L0.5230.09
33_I153_A0.5230.09
36_Y57_E0.5220.09
228_D275_V0.5220.09
272_A278_S0.5210.09
373_A376_V0.5210.09
46_K365_I0.5190.09
230_I251_D0.5180.09
326_C332_K0.5180.09
286_F332_K0.5170.09
231_K366_I0.5170.09
31_R35_R0.5170.09
17_F284_C0.5160.09
47_E62_H0.5150.09
363_P367_A0.5140.09
30_Q273_K0.5130.09
374_T379_F0.5110.09
169_G174_V0.5100.09
18_P284_C0.5090.09
30_Q365_I0.5090.09
27_E33_I0.5080.09
88_W242_K0.5080.09
137_S264_S0.5060.09
39_P47_E0.5060.09
157_G297_F0.5050.09
113_L288_F0.5040.09
83_P270_F0.5030.09
64_K271_G0.5030.09
47_E54_D0.5010.09
319_F333_S0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.73 100 0.65 Contact Map
3cf4A 2 0.746 100 0.801 Contact Map
3c8yA 1 0.7254 99.4 0.899 Contact Map
4uquA 2 0.1602 90.8 0.963 Contact Map
7fd1A 1 0.1693 88 0.965 Contact Map
1hfeL 2 0.7254 81.4 0.968 Contact Map
1jb0C 1 0.0915 42.9 0.975 Contact Map
3or1B 2 0.2357 40.1 0.976 Contact Map
1iqzA 1 0.0824 37.7 0.976 Contact Map
5c4iB 1 0.1373 37.4 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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