GREMLIN Database
Q97Z14 - Heterodisulfide reductase, subunit A (HdrA)
UniProt: Q97Z14 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 368 (299)
Sequences: 25483 (18019)
Seq/√Len: 1042.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_A267_Y4.0261.00
34_R81_I3.4071.00
242_M252_K3.3981.00
250_I264_T3.2351.00
161_R203_V3.2181.00
240_E252_K3.1981.00
242_M250_I3.0861.00
5_S28_N3.0551.00
30_V77_Y2.8901.00
252_K264_T2.7921.00
93_E105_V2.6651.00
203_V232_G2.6621.00
302_L310_Q2.6571.00
205_H234_I2.6501.00
5_S109_N2.5001.00
292_E300_K2.4601.00
18_A112_I2.4571.00
163_A251_I2.4271.00
92_F315_G2.4191.00
6_V22_L2.4011.00
161_R268_D2.3141.00
7_L94_I2.2481.00
112_I342_A2.2441.00
120_F277_E2.2411.00
95_S105_V2.2251.00
239_S254_E2.2111.00
28_N75_K2.1971.00
84_A95_S2.1761.00
317_F345_Y2.0921.00
302_L308_P2.0471.00
242_M264_T1.9831.00
112_I319_A1.9531.00
250_I266_P1.9381.00
129_G240_E1.9011.00
93_E107_K1.8891.00
294_E298_F1.8831.00
234_I263_L1.8801.00
161_R266_P1.8781.00
7_L32_V1.8731.00
252_K262_A1.8631.00
5_S30_V1.8411.00
239_S252_K1.7891.00
115_S322_I1.7891.00
292_E312_T1.7641.00
14_A319_A1.7421.00
237_R254_E1.7021.00
4_K30_V1.6981.00
161_R205_H1.6831.00
66_K69_Q1.6771.00
8_V19_T1.6531.00
127_E131_G1.6401.00
7_L106_E1.6401.00
50_L53_E1.6351.00
241_F248_T1.6251.00
133_I243_R1.5781.00
160_K268_D1.5731.00
254_E262_A1.5641.00
243_R249_V1.5621.00
86_K91_G1.5431.00
301_P323_T1.5421.00
96_I106_E1.5351.00
114_A319_A1.5211.00
110_A315_G1.5201.00
161_R202_A1.4981.00
284_Q288_I1.4871.00
205_H232_G1.4821.00
310_Q314_K1.4551.00
7_L108_A1.4471.00
248_T270_V1.4401.00
96_I99_K1.4361.00
56_P59_E1.4251.00
23_A74_V1.4201.00
214_Y217_M1.4011.00
302_L307_L1.3971.00
65_V69_Q1.3901.00
313_K316_I1.3831.00
294_E300_K1.3831.00
32_V106_E1.3781.00
62_D66_K1.3751.00
241_F270_V1.3741.00
139_I143_E1.3621.00
338_A342_A1.3611.00
25_M343_Y1.3561.00
253_G263_L1.3501.00
335_G339_A1.3341.00
253_G265_V1.3321.00
86_K93_E1.3281.00
110_A317_F1.3211.00
110_A345_Y1.3201.00
255_D261_R1.3151.00
110_A342_A1.3101.00
244_G249_V1.3071.00
239_S262_A1.2981.00
163_A207_Y1.2941.00
21_E340_M1.2851.00
339_A343_Y1.2831.00
145_M148_E1.2721.00
143_E146_L1.2621.00
323_T334_E1.2591.00
66_K70_E1.2581.00
7_L30_V1.2331.00
222_Y226_Q1.2231.00
118_E279_G1.2061.00
141_D144_G1.2041.00
144_G148_E1.2031.00
255_D263_L1.1941.00
108_A111_I1.1931.00
86_K95_S1.1891.00
118_E277_E1.1821.00
83_D97_K1.1821.00
145_M149_N1.1741.00
337_A341_K1.1731.00
192_A195_I1.1731.00
9_I115_S1.1691.00
8_V15_G1.1651.00
315_G345_Y1.1641.00
32_V77_Y1.1601.00
5_S107_K1.1541.00
9_I113_A1.1481.00
143_E147_H1.1341.00
299_V322_I1.1281.00
214_Y218_E1.1231.00
301_P318_L1.1231.00
30_V75_K1.1201.00
11_A33_E1.1181.00
211_I214_Y1.1161.00
142_I145_M1.1111.00
6_V112_I1.1021.00
140_S144_G1.1021.00
138_Q141_D1.1001.00
166_L173_A1.0941.00
243_R248_T1.0881.00
343_Y347_T1.0751.00
38_L78_T1.0741.00
209_M237_R1.0701.00
219_D223_W1.0571.00
6_V27_V1.0521.00
30_V106_E1.0401.00
11_A38_L1.0361.00
32_V96_I1.0291.00
6_V110_A1.0231.00
284_Q287_K1.0221.00
137_Y142_I1.0221.00
193_M196_K1.0201.00
237_R256_T1.0191.00
144_G147_H1.0161.00
19_T31_V1.0071.00
310_Q345_Y1.0051.00
140_S143_E1.0001.00
165_L238_I0.9971.00
142_I146_L0.9961.00
139_I144_G0.9841.00
82_V94_I0.9821.00
27_V343_Y0.9791.00
160_K202_A0.9751.00
218_E221_L0.9751.00
163_A265_V0.9731.00
18_A338_A0.9711.00
318_L322_I0.9701.00
22_L342_A0.9681.00
14_A331_S0.9661.00
257_M261_R0.9601.00
89_S316_I0.9601.00
32_V108_A0.9581.00
299_V318_L0.9521.00
89_S313_K0.9431.00
318_L323_T0.9391.00
137_Y140_S0.9331.00
309_V337_A0.9331.00
138_Q142_I0.9311.00
311_S318_L0.9301.00
59_E62_D0.9241.00
77_Y80_S0.9141.00
4_K110_A0.9101.00
141_D145_M0.9091.00
64_L67_T0.9081.00
146_L149_N0.9071.00
81_I97_K0.9041.00
317_F341_K0.9031.00
31_V74_V0.9001.00
84_A288_I0.9001.00
30_V108_A0.8991.00
139_I145_M0.8981.00
267_Y270_V0.8941.00
194_E197_Q0.8911.00
218_E225_S0.8901.00
137_Y143_E0.8891.00
4_K75_K0.8861.00
112_I338_A0.8851.00
18_A335_G0.8851.00
4_K7_L0.8801.00
195_I198_R0.8761.00
139_I142_I0.8761.00
319_A338_A0.8721.00
212_R226_Q0.8611.00
138_Q144_G0.8611.00
113_A322_I0.8611.00
137_Y145_M0.8581.00
221_L225_S0.8581.00
25_M340_M0.8551.00
19_T74_V0.8511.00
36_P79_E0.8491.00
110_A346_I0.8451.00
310_Q315_G0.8431.00
137_Y269_M0.8371.00
204_V207_Y0.8291.00
333_T337_A0.8291.00
291_L299_V0.8281.00
6_V342_A0.8281.00
196_K199_I0.8271.00
38_L65_V0.8251.00
220_K224_K0.8251.00
222_Y225_S0.8231.00
309_V323_T0.8141.00
301_P309_V0.8131.00
22_L27_V0.8101.00
331_S335_G0.8071.00
165_L270_V0.8051.00
141_D146_L0.8051.00
201_D205_H0.8031.00
215_G218_E0.8031.00
253_G256_T0.8021.00
77_Y106_E0.7991.00
155_K158_P0.7991.00
206_I209_M0.7961.00
205_H208_Y0.7961.00
121_D131_G0.7951.00
192_A196_K0.7891.00
143_E148_E0.7871.00
167_C208_Y0.7871.00
223_W226_Q0.7831.00
92_F313_K0.7821.00
21_E336_Y0.7811.00
214_Y219_D0.7791.00
142_I148_E0.7781.00
83_D95_S0.7741.00
221_L226_Q0.7731.00
54_L57_A0.7701.00
18_A319_A0.7701.00
140_S146_L0.7691.00
142_I147_H0.7691.00
43_K62_D0.7621.00
128_Y131_G0.7621.00
234_I257_M0.7621.00
22_L339_A0.7621.00
130_Y240_E0.7571.00
140_S145_M0.7561.00
217_M226_Q0.7561.00
139_I146_L0.7501.00
14_A112_I0.7471.00
224_K228_D0.7461.00
162_V269_M0.7451.00
329_S332_I0.7451.00
89_S92_F0.7421.00
22_L29_V0.7421.00
111_I316_I0.7411.00
192_A199_I0.7371.00
207_Y253_G0.7361.00
195_I199_I0.7341.00
79_E98_D0.7301.00
244_G247_D0.7291.00
236_G256_T0.7281.00
23_A73_N0.7261.00
68_V74_V0.7261.00
59_E63_P0.7211.00
211_I215_G0.7171.00
194_E198_R0.7151.00
15_G114_A0.7111.00
341_K344_E0.7081.00
17_S335_G0.7061.00
308_P311_S0.7061.00
105_V315_G0.7061.00
238_I251_I0.7051.00
82_V96_I0.7041.00
67_T70_E0.7041.00
307_L310_Q0.7021.00
79_E96_I0.7001.00
319_A342_A0.6971.00
321_A331_S0.6961.00
150_K155_K0.6961.00
33_E78_T0.6941.00
80_S96_I0.6941.00
128_Y241_F0.6921.00
217_M220_K0.6911.00
143_E149_N0.6871.00
208_Y235_R0.6851.00
165_L274_N0.6841.00
136_I241_F0.6781.00
192_A197_Q0.6771.00
17_S21_E0.6751.00
54_L60_V0.6741.00
213_T216_L0.6741.00
310_Q341_K0.6691.00
54_L58_S0.6691.00
169_G173_A0.6681.00
121_D138_Q0.6651.00
193_M197_Q0.6651.00
219_D222_Y0.6621.00
21_E25_M0.6611.00
203_V207_Y0.6601.00
286_A299_V0.6581.00
9_I111_I0.6581.00
220_K223_W0.6561.00
139_I148_E0.6561.00
201_D209_M0.6551.00
156_G159_P0.6531.00
340_M344_E0.6531.00
4_K109_N0.6521.00
86_K89_S0.6521.00
144_G149_N0.6521.00
52_P55_R0.6481.00
119_H138_Q0.6481.00
136_I139_I0.6471.00
113_A316_I0.6451.00
244_G250_I0.6441.00
201_D204_V0.6441.00
137_Y141_D0.6431.00
216_L220_K0.6411.00
131_G272_L0.6391.00
40_G43_K0.6391.00
16_L68_V0.6341.00
139_I147_H0.6331.00
248_T266_P0.6321.00
8_V29_V0.6301.00
309_V338_A0.6291.00
217_M221_L0.6281.00
293_F299_V0.6281.00
214_Y226_Q0.6271.00
205_H209_M0.6251.00
169_G218_E0.6241.00
142_I149_N0.6201.00
344_E349_G0.6201.00
58_S62_D0.6201.00
40_G46_K0.6171.00
308_P341_K0.6161.00
336_Y340_M0.6131.00
85_A111_I0.6101.00
327_T330_D0.6081.00
42_P45_L0.6071.00
79_E97_K0.6041.00
166_L172_D0.6041.00
41_T44_R0.6021.00
309_V341_K0.6011.00
236_G257_M0.6001.00
207_Y265_V0.5981.00
254_E257_M0.5971.00
211_I236_G0.5961.00
330_D334_E0.5931.00
172_D225_S0.5931.00
215_G222_Y0.5931.00
166_L169_G0.5931.00
86_K90_D0.5931.00
319_A335_G0.5921.00
216_L219_D0.5901.00
208_Y211_I0.5891.00
43_K46_K0.5891.00
58_S61_I0.5881.00
60_V63_P0.5871.00
286_A289_L0.5831.00
326_K329_S0.5831.00
207_Y210_D0.5821.00
32_V82_V0.5811.00
221_L224_K0.5801.00
208_Y212_R0.5801.00
39_G42_P0.5801.00
20_K24_N0.5801.00
81_I92_F0.5751.00
62_D65_V0.5741.00
137_Y144_G0.5741.00
205_H267_Y0.5741.00
168_V173_A0.5731.00
17_S332_I0.5711.00
33_E76_I0.5711.00
8_V18_A0.5701.00
11_A31_V0.5691.00
280_L322_I0.5691.00
290_G293_F0.5691.00
162_V165_L0.5681.00
20_K72_G0.5671.00
142_I271_I0.5671.00
197_Q200_P0.5661.00
57_A60_V0.5651.00
21_E24_N0.5651.00
201_D208_Y0.5641.00
15_G19_T0.5621.00
135_N139_I0.5601.00
57_A61_I0.5601.00
85_A94_I0.5591.00
121_D132_I0.5591.00
135_N138_Q0.5571.00
140_S148_E0.5571.00
164_I174_T0.5541.00
243_R247_D0.5511.00
60_V64_L0.5501.00
223_W228_D0.5501.00
4_K28_N0.5491.00
310_Q313_K0.5491.00
130_Y133_I0.5481.00
205_H265_V0.5451.00
138_Q143_E0.5431.00
136_I140_S0.5411.00
225_S228_D0.5411.00
172_D206_I0.5401.00
5_S108_A0.5391.00
138_Q145_M0.5391.00
170_S273_A0.5361.00
51_F54_L0.5361.00
222_Y235_R0.5351.00
9_I82_V0.5321.00
137_Y146_L0.5311.00
279_G284_Q0.5311.00
159_P202_A0.5311.00
92_F316_I0.5301.00
244_G248_T0.5291.00
204_V208_Y0.5281.00
202_A205_H0.5271.00
169_G174_T0.5261.00
342_A346_I0.5231.00
141_D148_E0.5221.00
164_I171_R0.5211.00
166_L174_T0.5211.00
253_G257_M0.5201.00
166_L171_R0.5191.00
298_F326_K0.5191.00
95_S98_D0.5171.00
56_P60_V0.5171.00
63_P67_T0.5171.00
122_S131_G0.5171.00
219_D226_Q0.5161.00
27_V342_A0.5161.00
193_M198_R0.5151.00
55_R61_I0.5141.00
168_V171_R0.5141.00
195_I200_P0.5131.00
163_A270_V0.5121.00
206_I210_D0.5101.00
55_R59_E0.5091.00
201_D210_D0.5081.00
161_R265_V0.5071.00
80_S98_D0.5071.00
31_V76_I0.5071.00
338_A341_K0.5061.00
91_G107_K0.5051.00
329_S333_T0.5041.00
38_L76_I0.5031.00
170_S174_T0.5021.00
137_Y148_E0.5011.00
171_R273_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ojtA 2 0.8723 100 0.375 Contact Map
2vdcG 1 0.8424 100 0.376 Contact Map
1mo9A 2 0.8614 100 0.377 Contact Map
3urhA 2 0.8587 100 0.378 Contact Map
3l8kA 3 0.8668 100 0.379 Contact Map
2q0lA 2 0.8071 100 0.38 Contact Map
1dxlA 2 0.8723 100 0.381 Contact Map
1gteA 4 0.875 100 0.382 Contact Map
3f8dA 2 0.8071 100 0.383 Contact Map
1vdcA 2 0.8342 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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