GREMLIN Database
Q97Z12 - Heterodisulfide reductase subunit C (HdrC-2)
UniProt: Q97Z12 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 230 (182)
Sequences: 412 (263)
Seq/√Len: 19.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_I223_M5.0531.00
106_L132_I3.9231.00
95_D98_A3.7051.00
52_A59_T2.6700.98
163_G167_E2.4280.97
98_A101_E2.2690.95
36_I40_Q2.0810.92
99_L106_L2.0760.92
96_K101_E1.9610.89
89_D92_R1.9580.89
67_G107_W1.9520.89
113_Q126_E1.9290.89
212_W216_Q1.8870.87
103_Q140_G1.7680.84
44_D52_A1.7250.82
50_E53_N1.6710.80
97_Q216_Q1.6360.79
154_F164_R1.6350.78
64_W150_F1.5740.76
126_E130_H1.5630.75
35_M39_T1.5270.73
192_A196_K1.5250.73
213_D217_K1.4980.72
51_I125_V1.4910.72
38_R114_K1.4820.71
46_T49_D1.4480.69
98_A213_D1.4430.69
167_E172_A1.4400.69
46_T50_E1.4090.67
167_E198_G1.3980.67
129_V176_K1.3950.66
72_G126_E1.3780.65
66_C119_C1.3680.65
66_C115_C1.3680.65
66_C109_C1.3680.65
66_C73_C1.3680.65
66_C69_C1.3680.65
69_C73_C1.3680.65
63_C119_C1.3680.65
63_C115_C1.3680.65
63_C112_C1.3680.65
63_C109_C1.3680.65
63_C73_C1.3680.65
63_C69_C1.3680.65
115_C119_C1.3680.65
112_C119_C1.3680.65
69_C109_C1.3680.65
73_C119_C1.3680.65
73_C115_C1.3680.65
73_C112_C1.3680.65
109_C112_C1.3680.65
73_C109_C1.3680.65
66_C112_C1.3680.65
69_C119_C1.3680.65
109_C115_C1.3680.65
109_C119_C1.3680.65
69_C115_C1.3680.65
69_C112_C1.3680.65
112_C115_C1.3680.65
63_C66_C1.3680.65
62_A123_V1.3650.65
206_P209_V1.3600.64
106_L188_I1.3540.64
188_I191_G1.3400.63
128_V131_S1.3060.61
40_Q47_V1.2950.60
217_K221_E1.2730.59
133_H168_L1.2660.59
138_K213_D1.2630.58
58_V85_R1.2600.58
87_F106_L1.2580.58
65_Q74_T1.2560.58
59_T128_V1.2470.57
87_F103_Q1.2450.57
43_Y46_T1.2400.57
148_T154_F1.2300.56
45_P220_E1.2050.55
166_S169_T1.2040.55
68_T129_V1.1840.53
167_E199_L1.1810.53
220_E224_K1.1710.53
156_E224_K1.1640.52
171_G190_I1.1520.51
156_E169_T1.1410.51
35_M40_Q1.1410.51
88_I125_V1.1360.50
101_E216_Q1.1350.50
55_L138_K1.1350.50
60_I91_A1.1190.49
163_G176_K1.1050.48
185_K192_A1.1050.48
175_A180_V1.1000.48
161_N211_N1.0930.48
64_W89_D1.0830.47
193_A196_K1.0730.46
220_E223_M1.0690.46
114_K117_H1.0630.46
99_L221_E1.0570.45
132_I164_R1.0520.45
188_I196_K1.0490.45
49_D53_N1.0390.44
147_G166_S1.0290.44
71_S174_A1.0250.43
168_L171_G1.0200.43
130_H187_L1.0110.42
185_K188_I1.0050.42
209_V215_I1.0020.42
67_G120_P0.9750.40
60_I128_V0.9720.40
91_A193_A0.9700.40
163_G173_A0.9690.40
88_I123_V0.9690.40
101_E220_E0.9680.40
208_R212_W0.9680.40
36_I47_V0.9650.40
64_W68_T0.9630.39
134_H222_A0.9590.39
96_K103_Q0.9510.39
81_D194_I0.9410.38
154_F170_L0.9410.38
122_G178_G0.9340.38
81_D104_N0.9200.37
122_G127_E0.9060.36
171_G185_K0.9060.36
74_T128_V0.8960.35
125_V131_S0.8930.35
75_M148_T0.8920.35
70_T83_S0.8870.35
160_K165_I0.8840.35
191_G194_I0.8830.35
154_F167_E0.8740.34
68_T105_S0.8740.34
83_S88_I0.8670.34
196_K210_K0.8660.34
111_S133_H0.8650.34
62_A170_L0.8630.34
81_D204_L0.8580.33
71_S90_L0.8560.33
195_L224_K0.8560.33
141_L160_K0.8460.33
88_I128_V0.8380.32
141_L144_K0.8350.32
150_F174_A0.8350.32
80_P207_N0.8310.32
194_I198_G0.8290.32
37_E47_V0.8240.31
150_F199_L0.8210.31
57_G129_V0.8190.31
96_K139_H0.8160.31
48_W51_I0.8130.31
173_A205_R0.8120.31
104_N173_A0.8090.31
87_F110_V0.8070.30
131_S207_N0.8020.30
207_N212_W0.7990.30
45_P48_W0.7900.29
205_R223_M0.7790.29
41_T47_V0.7770.29
85_R121_K0.7740.29
55_L58_V0.7730.29
221_E224_K0.7720.29
180_V185_K0.7660.28
72_G114_K0.7660.28
188_I192_A0.7650.28
101_E139_H0.7620.28
78_Y158_V0.7580.28
208_R213_D0.7520.27
108_R117_H0.7520.27
190_I193_A0.7520.27
39_T42_G0.7490.27
154_F200_I0.7440.27
150_F154_F0.7430.27
52_A190_I0.7380.27
139_H224_K0.7240.26
72_G150_F0.7240.26
93_K173_A0.7190.26
82_Y103_Q0.7100.25
150_F167_E0.7100.25
136_L141_L0.7050.25
142_V148_T0.7040.25
89_D184_L0.7040.25
65_Q90_L0.6900.24
123_V208_R0.6860.24
151_D170_L0.6850.24
175_A184_L0.6850.24
86_R129_V0.6810.24
106_L136_L0.6810.24
78_Y218_V0.6740.24
172_A195_L0.6720.24
93_K170_L0.6690.23
135_Y218_V0.6690.23
188_I213_D0.6690.23
164_R170_L0.6670.23
100_I136_L0.6660.23
173_A195_L0.6660.23
115_C120_P0.6620.23
73_C120_P0.6620.23
112_C120_P0.6620.23
69_C120_P0.6620.23
66_C120_P0.6620.23
109_C120_P0.6620.23
63_C120_P0.6620.23
146_P208_R0.6610.23
53_N161_N0.6600.23
121_K175_A0.6560.23
85_R123_V0.6550.23
94_G150_F0.6540.23
80_P114_K0.6470.22
37_E219_L0.6460.22
61_S110_V0.6450.22
50_E219_L0.6450.22
116_T166_S0.6390.22
175_A185_K0.6360.22
171_G200_I0.6330.22
82_Y193_A0.6330.22
90_L129_V0.6320.22
139_H194_I0.6320.22
165_I168_L0.6290.22
35_M114_K0.6280.22
178_G185_K0.6250.22
67_G71_S0.6210.21
158_V165_I0.6200.21
82_Y200_I0.6170.21
97_Q101_E0.6170.21
154_F163_G0.6160.21
49_D52_A0.6060.21
185_K221_E0.5960.20
68_T77_E0.5940.20
81_D114_K0.5930.20
163_G191_G0.5920.20
72_G92_R0.5920.20
158_V169_T0.5910.20
110_V126_E0.5910.20
44_D139_H0.5900.20
70_T116_T0.5830.20
110_V127_E0.5820.20
67_G121_K0.5770.19
96_K108_R0.5760.19
163_G199_L0.5760.19
138_K142_V0.5710.19
114_K151_D0.5700.19
62_A113_Q0.5690.19
100_I177_A0.5620.19
145_D170_L0.5620.19
116_T126_E0.5610.19
150_F176_K0.5580.19
84_P92_R0.5570.19
149_V178_G0.5560.19
144_K198_G0.5550.19
45_P223_M0.5540.19
71_S184_L0.5530.19
36_I39_T0.5510.18
161_N200_I0.5490.18
53_N148_T0.5490.18
51_I54_T0.5460.18
38_R126_E0.5450.18
205_R212_W0.5420.18
83_S110_V0.5420.18
194_I203_V0.5400.18
169_T224_K0.5380.18
90_L219_L0.5380.18
197_G205_R0.5360.18
75_M110_V0.5320.18
58_V104_N0.5260.18
60_I65_Q0.5260.18
118_R140_G0.5250.17
47_V51_I0.5240.17
124_L127_E0.5160.17
142_V212_W0.5160.17
150_F163_G0.5110.17
53_N205_R0.5050.17
53_N218_V0.5020.17
169_T178_G0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kf6B 1 0.6391 99.9 0.695 Contact Map
3kwlA 1 0.8174 99.9 0.697 Contact Map
2h88B 1 0.6043 99.9 0.698 Contact Map
2wdqB 1 0.613 99.9 0.704 Contact Map
2bs2B 1 0.6043 99.8 0.72 Contact Map
4ysxB 1 0.6609 99.8 0.726 Contact Map
4p6vA 1 0.4609 99.1 0.821 Contact Map
3i9v9 1 0.6609 99.1 0.822 Contact Map
3cf4A 2 0.9478 98.9 0.84 Contact Map
3c8yA 1 0.9522 98 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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