GREMLIN Database
Q97Z11 - Heterodisulfide reductase, subunit B (HdrB-2)
UniProt: Q97Z11 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (242)
Sequences: 6241 (3872)
Seq/√Len: 248.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_K198_E4.0611.00
271_A279_F3.7821.00
31_L278_A3.6681.00
9_K39_P3.4841.00
28_S275_Q3.4541.00
155_K200_V3.4221.00
130_A274_S3.3891.00
74_R108_K2.8161.00
58_N61_A2.7471.00
48_C88_C2.5461.00
83_S89_H2.4841.00
128_V136_N2.4551.00
18_L26_D2.4201.00
24_S275_Q2.3681.00
203_E234_R2.3461.00
10_V133_Y2.2431.00
204_A231_E2.1911.00
225_E254_N2.1821.00
160_Y186_F2.1791.00
202_F232_A2.1591.00
9_K41_E2.1441.00
29_L84_A2.1421.00
239_I271_A2.1321.00
135_Y187_F2.0441.00
16_C48_C1.9741.00
29_L130_A1.9531.00
154_L239_I1.9251.00
154_L238_E1.9201.00
157_A202_F1.8991.00
25_Y275_Q1.8551.00
241_V276_L1.8371.00
231_E234_R1.8271.00
156_V197_A1.8141.00
186_F201_P1.8041.00
93_S132_E1.8021.00
38_I133_Y1.7941.00
110_N114_E1.7911.00
71_A108_K1.7661.00
8_G38_I1.7651.00
54_V91_S1.7091.00
12_F84_A1.6751.00
49_C88_C1.6361.00
16_C88_C1.6321.00
131_V273_F1.6041.00
47_N68_R1.5621.00
32_V277_V1.5341.00
230_K264_E1.5311.00
107_E110_N1.5311.00
230_K234_R1.5241.00
32_V281_F1.5161.00
30_K40_L1.4981.00
107_E111_M1.4881.00
156_V241_V1.4741.00
157_A235_N1.4671.00
9_K79_D1.4581.00
225_E250_A1.4581.00
36_L281_F1.4541.00
128_V132_E1.4351.00
204_A227_R1.4331.00
67_A71_A1.4291.00
82_V133_Y1.4271.00
11_A78_A1.4191.00
165_V182_P1.3741.00
111_M115_K1.3571.00
51_A87_G1.3551.00
192_L195_L1.3531.00
68_R72_L1.3421.00
225_E229_L1.3421.00
71_A74_R1.3411.00
63_V67_A1.3351.00
226_A230_K1.3331.00
155_K238_E1.3161.00
132_E136_N1.3011.00
112_Y127_L1.2971.00
194_A197_A1.2921.00
66_P96_Q1.2761.00
111_M114_E1.2721.00
16_C49_C1.2431.00
150_P195_L1.2301.00
271_A276_L1.2251.00
156_V276_L1.2191.00
222_L254_N1.2171.00
128_V133_Y1.2051.00
271_A275_Q1.1851.00
136_N140_I1.1841.00
11_A76_M1.1751.00
153_G198_E1.1641.00
233_K266_L1.1621.00
10_V38_I1.1601.00
28_S278_A1.1551.00
32_V274_S1.1471.00
83_S92_L1.1441.00
209_C247_G1.1411.00
232_A240_L1.1351.00
243_D273_F1.1351.00
31_L282_G1.1331.00
32_V278_A1.1061.00
232_A268_T1.1041.00
27_V31_L1.0971.00
43_I46_Y1.0901.00
10_V82_V1.0891.00
252_E256_E1.0721.00
96_Q113_L1.0671.00
218_V222_L1.0671.00
109_T113_L1.0601.00
229_L255_M1.0601.00
85_C244_C1.0491.00
136_N184_R1.0421.00
89_H168_K1.0411.00
139_G187_F1.0341.00
204_A207_M1.0311.00
132_E184_R1.0291.00
15_G85_C1.0261.00
226_A264_E1.0231.00
51_A55_K1.0181.00
81_V112_Y1.0081.00
188_M192_L1.0051.00
80_A128_V1.0001.00
269_P279_F1.0001.00
14_P46_Y0.9921.00
34_Q40_L0.9891.00
157_A232_A0.9811.00
14_P42_K0.9721.00
211_G214_V0.9691.00
151_L154_L0.9681.00
158_P185_P0.9671.00
35_D281_F0.9541.00
89_H127_L0.9541.00
41_E78_A0.9541.00
156_V239_I0.9501.00
161_G242_T0.9491.00
38_I137_T0.9411.00
66_P99_L0.9381.00
14_P26_D0.9371.00
142_A145_T0.9361.00
41_E76_M0.9351.00
12_F26_D0.9301.00
7_Y39_P0.9271.00
137_T140_I0.9191.00
170_Y184_R0.9191.00
130_A134_I0.9171.00
96_Q100_T0.9161.00
153_G196_G0.9141.00
30_K34_Q0.9141.00
150_P153_G0.9091.00
212_P216_S0.9091.00
137_T142_A0.9061.00
192_L199_V0.9061.00
255_M266_L0.9041.00
134_I277_V0.9031.00
248_H270_L0.9021.00
211_G215_Y0.8961.00
32_V130_A0.8911.00
68_R71_A0.8881.00
195_L277_V0.8781.00
241_V273_F0.8771.00
31_L35_D0.8751.00
165_V206_T0.8741.00
29_L33_A0.8721.00
24_S27_V0.8660.99
255_M270_L0.8620.99
55_K87_G0.8610.99
67_A102_Y0.8560.99
69_N72_L0.8530.99
192_L197_A0.8510.99
133_Y137_T0.8390.99
27_V30_K0.8240.99
110_N113_L0.8200.99
10_V40_L0.8110.99
218_V253_T0.8090.99
74_R111_M0.8050.99
97_Y100_T0.8040.99
155_K236_G0.8010.99
205_K231_E0.8000.99
26_D30_K0.7990.99
192_L196_G0.7950.99
70_L109_T0.7950.99
203_E231_E0.7940.99
81_V92_L0.7900.99
69_N92_L0.7860.99
87_G246_L0.7850.99
80_A133_Y0.7840.99
229_L254_N0.7840.99
242_T248_H0.7780.99
83_S127_L0.7760.99
72_L75_E0.7720.99
186_F192_L0.7670.99
154_L197_A0.7660.99
239_I269_P0.7650.99
240_L251_I0.7640.99
22_G25_Y0.7630.99
240_L268_T0.7610.99
108_K111_M0.7600.99
90_Y167_P0.7560.99
183_E186_F0.7550.99
22_G245_P0.7550.99
230_K233_K0.7540.99
96_Q99_L0.7500.98
11_A79_D0.7500.98
53_E61_A0.7490.98
150_P196_G0.7480.98
90_Y94_R0.7470.98
151_L239_I0.7470.98
233_K264_E0.7450.98
154_L279_F0.7440.98
182_P206_T0.7430.98
60_M63_V0.7430.98
6_P39_P0.7410.98
233_K237_A0.7400.98
114_E127_L0.7400.98
222_L226_A0.7360.98
46_Y73_A0.7340.98
275_Q278_A0.7330.98
53_E65_L0.7270.98
33_A38_I0.7250.98
12_F29_L0.7250.98
164_Y170_Y0.7230.98
213_H221_A0.7220.98
162_C208_C0.7210.98
132_E170_Y0.7130.98
92_L112_Y0.7120.98
97_Y101_K0.7120.98
25_Y245_P0.7050.98
9_K78_A0.7030.98
29_L274_S0.7020.98
228_I232_A0.6990.98
103_P107_E0.6970.98
70_L74_R0.6970.98
145_T194_A0.6960.98
169_S182_P0.6950.98
188_M191_I0.6920.97
34_Q39_P0.6920.97
8_G137_T0.6880.97
183_E187_F0.6860.97
187_F192_L0.6850.97
33_A130_A0.6850.97
229_L233_K0.6830.97
107_E114_E0.6810.97
87_G163_L0.6790.97
151_L197_A0.6780.97
54_V62_G0.6760.97
22_G249_V0.6740.97
223_H226_A0.6720.97
278_A282_G0.6720.97
35_D278_A0.6710.97
238_E267_R0.6710.97
159_Y228_I0.6700.97
13_Y92_L0.6690.97
202_F231_E0.6690.97
25_Y28_S0.6610.97
276_L280_A0.6610.97
93_S168_K0.6590.97
128_V137_T0.6570.97
157_A199_V0.6570.97
11_A43_I0.6450.96
251_I255_M0.6420.96
151_L280_A0.6420.96
30_K42_K0.6400.96
213_H216_S0.6400.96
214_V217_D0.6380.96
212_P215_Y0.6380.96
142_A146_K0.6320.96
166_R244_C0.6300.96
85_C245_P0.6260.95
11_A41_E0.6250.95
13_Y49_C0.6240.95
45_D75_E0.6210.95
154_L276_L0.6200.95
18_L84_A0.6190.95
191_I194_A0.6180.95
163_L250_A0.6160.95
226_A254_N0.6140.95
22_G248_H0.6140.95
151_L276_L0.6130.95
143_I281_F0.6120.95
206_T228_I0.6120.95
33_A40_L0.6100.95
34_Q38_I0.6090.95
211_G216_S0.6090.95
48_C52_L0.6090.95
62_G91_S0.6080.95
64_L67_A0.6060.95
71_A75_E0.5990.94
137_T141_E0.5980.94
160_Y185_P0.5980.94
207_M227_R0.5980.94
45_D76_M0.5970.94
70_L108_K0.5960.94
146_K151_L0.5960.94
64_L68_R0.5950.94
11_A73_A0.5940.94
188_M194_A0.5920.94
52_L159_Y0.5910.94
23_K27_V0.5910.94
154_L269_P0.5870.94
97_Y110_N0.5850.94
62_G66_P0.5850.94
214_V221_A0.5810.93
187_F193_K0.5800.93
135_Y139_G0.5780.93
85_C88_C0.5760.93
200_V235_N0.5750.93
160_Y201_P0.5750.93
164_Y243_D0.5740.93
8_G39_P0.5700.93
158_P199_V0.5680.93
202_F235_N0.5670.92
255_M268_T0.5660.92
129_H164_Y0.5630.92
98_Y101_K0.5630.92
99_L109_T0.5630.92
160_Y184_R0.5620.92
194_A280_A0.5600.92
131_V243_D0.5590.92
219_E222_L0.5570.92
31_L34_Q0.5560.92
231_E235_N0.5550.92
18_L25_Y0.5550.92
141_E144_K0.5540.92
80_A136_N0.5490.91
151_L271_A0.5490.91
65_L68_R0.5470.91
42_K46_Y0.5470.91
25_Y248_H0.5440.91
170_Y185_P0.5390.90
8_G79_D0.5390.90
89_H129_H0.5320.90
11_A14_P0.5320.90
278_A281_F0.5310.90
12_F18_L0.5300.90
90_Y163_L0.5290.90
240_L255_M0.5280.90
191_I197_A0.5270.89
77_G115_K0.5260.89
16_C85_C0.5260.89
54_V59_T0.5260.89
81_V127_L0.5250.89
161_G244_C0.5240.89
199_V202_F0.5240.89
184_R187_F0.5240.89
112_Y115_K0.5230.89
233_K267_R0.5220.89
219_E223_H0.5210.89
35_D144_K0.5200.89
95_T100_T0.5160.88
14_P19_D0.5150.88
86_P161_G0.5120.88
55_K224_L0.5120.88
87_G244_C0.5120.88
143_I146_K0.5110.88
201_P235_N0.5100.88
62_G99_L0.5100.88
52_L55_K0.5080.88
162_C247_G0.5080.88
113_L127_L0.5060.88
229_L232_A0.5050.87
162_C209_C0.5050.87
229_L251_I0.5040.87
59_T63_V0.5020.87
21_L249_V0.5020.87
15_G18_L0.5020.87
160_Y165_V0.5010.87
108_K115_K0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.8721 100 0.322 Contact Map
3cf4A 2 0.7148 100 0.587 Contact Map
3c8yA 1 0.8459 98.5 0.862 Contact Map
2jfzA 2 0.4033 89.8 0.929 Contact Map
3outA 5 0.4098 89.7 0.929 Contact Map
2gzmA 3 0.4131 89.5 0.93 Contact Map
1b73A 2 0.4033 88.1 0.932 Contact Map
3s81A 2 0.7311 88 0.932 Contact Map
3istA 2 0.4197 84.5 0.935 Contact Map
2eq5A 2 0.4164 84 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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