GREMLIN Database
Q97Z08 - Na(+)/H(+) antiporter
UniProt: Q97Z08 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (365)
Sequences: 15143 (10387)
Seq/√Len: 543.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
214_K218_R3.6771.00
318_F328_A3.6251.00
112_A312_F3.6161.00
206_V210_I3.3841.00
192_L196_A3.3451.00
306_T372_F3.3291.00
210_I214_K3.2961.00
336_L380_L3.2731.00
122_G125_S2.9061.00
214_K217_D2.8561.00
327_N330_A2.8031.00
114_Y130_G2.6151.00
208_S235_L2.4141.00
235_L253_A2.4111.00
196_A200_I2.3891.00
303_L307_A2.3821.00
200_I244_Y2.3651.00
116_F308_I2.3651.00
92_K95_G2.3491.00
193_K196_A2.3391.00
302_S368_F2.3311.00
114_Y123_L2.2501.00
188_T192_L2.1701.00
114_Y117_Y2.1201.00
111_F115_Y2.0811.00
115_Y123_L2.0231.00
299_V303_L2.0141.00
345_G366_I1.9941.00
195_I199_V1.9861.00
98_G160_S1.9431.00
350_S353_L1.9361.00
300_I304_E1.9271.00
318_F335_A1.9091.00
350_S354_S1.9031.00
65_S68_E1.8831.00
322_L331_A1.8741.00
191_S195_I1.8541.00
207_V210_I1.8391.00
128_I352_G1.8311.00
353_L363_F1.8131.00
80_F232_L1.8051.00
21_L39_A1.7781.00
87_G90_P1.7731.00
124_D176_V1.7571.00
45_P49_G1.7531.00
236_T246_P1.7421.00
305_L369_M1.7301.00
319_P323_A1.7301.00
321_A331_A1.7201.00
187_V190_I1.7181.00
231_V253_A1.7141.00
314_W335_A1.7101.00
42_I47_A1.6961.00
154_G334_V1.6941.00
117_Y123_L1.6921.00
322_L328_A1.6841.00
234_G238_L1.6791.00
316_G320_F1.6751.00
89_A92_K1.6681.00
295_N299_V1.6631.00
76_I236_T1.6541.00
372_F376_I1.6471.00
25_V35_G1.6411.00
349_A366_I1.6401.00
205_L209_I1.6391.00
170_L348_I1.5971.00
359_N362_E1.5731.00
199_V202_V1.5621.00
126_A130_G1.5551.00
38_L42_I1.5391.00
66_Y69_F1.5331.00
158_M337_G1.5261.00
114_Y127_L1.5251.00
199_V203_V1.5201.00
189_S192_L1.5161.00
239_M249_S1.5111.00
212_I231_V1.4991.00
112_A115_Y1.4851.00
68_E72_E1.4851.00
21_L25_V1.4831.00
327_N331_A1.4621.00
308_I312_F1.4591.00
123_L127_L1.4461.00
110_F134_G1.4401.00
152_G155_I1.4341.00
290_N293_T1.4331.00
218_R221_D1.4171.00
318_F331_A1.4101.00
154_G330_A1.4021.00
158_M334_V1.3961.00
117_Y126_A1.3911.00
100_L324_Y1.3881.00
103_T107_L1.3841.00
200_I204_I1.3801.00
42_I45_P1.3771.00
318_F322_L1.3641.00
12_S16_L1.3581.00
95_G99_F1.3521.00
379_A383_I1.3421.00
193_K197_L1.3411.00
192_L195_I1.3271.00
145_I155_I1.3261.00
309_A369_M1.3161.00
111_F114_Y1.3151.00
14_F283_V1.3131.00
318_F332_N1.3091.00
89_A93_S1.3041.00
209_I213_P1.3031.00
46_Y49_G1.3021.00
240_V246_P1.2991.00
135_A169_D1.2981.00
45_P48_L1.2981.00
187_V191_S1.2961.00
44_G47_A1.2911.00
153_K330_A1.2881.00
23_S27_K1.2861.00
107_L111_F1.2851.00
353_L360_Q1.2771.00
346_L370_S1.2721.00
17_L39_A1.2701.00
211_L214_K1.2691.00
132_A349_A1.2681.00
154_G333_T1.2671.00
149_K154_G1.2641.00
208_S212_I1.2611.00
105_G109_P1.2551.00
12_S230_A1.2541.00
351_L354_S1.2531.00
103_T106_A1.2441.00
133_M369_M1.2431.00
237_L241_S1.2401.00
80_F254_G1.2391.00
312_F316_G1.2371.00
97_L157_F1.2251.00
23_S26_Q1.2211.00
356_N360_Q1.2041.00
310_T339_V1.2021.00
96_I100_L1.2001.00
189_S193_K1.1991.00
16_L230_A1.1971.00
201_W205_L1.1941.00
90_P93_S1.1881.00
188_T191_S1.1871.00
109_P113_A1.1791.00
302_S306_T1.1781.00
25_V28_Y1.1771.00
110_F131_T1.1741.00
94_S97_L1.1691.00
218_R222_K1.1621.00
104_F107_L1.1571.00
143_S147_E1.1491.00
235_L249_S1.1481.00
309_A341_R1.1471.00
300_I303_L1.1451.00
328_A332_N1.1441.00
157_F326_R1.1341.00
90_P156_N1.1331.00
129_L133_M1.1311.00
95_G98_G1.1301.00
239_M244_Y1.1301.00
202_V206_V1.1301.00
130_G134_G1.1241.00
198_V202_V1.1231.00
203_V206_V1.1221.00
301_L365_G1.1191.00
20_I23_S1.1171.00
315_L319_P1.1131.00
326_R330_A1.1091.00
352_G355_Y1.1041.00
238_L241_S1.0961.00
358_L361_E1.0891.00
194_I198_V1.0831.00
203_V207_V1.0721.00
12_S234_G1.0701.00
230_A234_G1.0701.00
124_D180_L1.0631.00
197_L201_W1.0551.00
106_A168_V1.0511.00
194_I197_L1.0501.00
12_S237_L1.0491.00
222_K225_E1.0391.00
145_I158_M1.0351.00
305_L365_G1.0341.00
129_L366_I1.0331.00
337_G381_F1.0321.00
81_A85_E1.0291.00
94_S98_G1.0271.00
296_L300_I1.0261.00
163_A251_F1.0251.00
136_T141_V1.0231.00
132_A366_I1.0231.00
269_I273_L1.0221.00
46_Y290_N1.0181.00
108_L111_F1.0171.00
351_L355_Y1.0111.00
361_E365_G1.0091.00
340_P377_G1.0071.00
366_I370_S1.0001.00
307_A311_I0.9981.00
206_V256_A0.9981.00
22_S32_K0.9961.00
260_S263_N0.9951.00
100_L104_F0.9891.00
9_F12_S0.9821.00
100_L323_A0.9821.00
314_W332_N0.9801.00
67_I284_Y0.9661.00
222_K226_E0.9621.00
329_K333_T0.9591.00
121_F129_L0.9591.00
196_A199_V0.9581.00
332_N335_A0.9571.00
228_P232_L0.9571.00
234_G237_L0.9561.00
341_R345_G0.9561.00
133_M309_A0.9511.00
145_I150_L0.9511.00
19_E22_S0.9451.00
88_I92_K0.9431.00
110_F172_L0.9401.00
365_G369_M0.9301.00
310_T314_W0.9291.00
79_I247_I0.9251.00
306_T310_T0.9221.00
135_A345_G0.9181.00
19_E230_A0.9151.00
136_T162_A0.9111.00
63_I66_Y0.9111.00
326_R331_A0.9101.00
127_L176_V0.9101.00
21_L24_L0.9101.00
302_S365_G0.9091.00
96_I99_F0.9081.00
122_G126_A0.9051.00
116_F304_E0.9031.00
41_M291_F0.9001.00
26_Q29_G0.9001.00
110_F114_Y0.8981.00
320_F324_Y0.8961.00
195_I198_V0.8941.00
309_A373_T0.8911.00
24_L27_K0.8901.00
131_T172_L0.8871.00
322_L325_L0.8811.00
104_F320_F0.8801.00
108_L316_G0.8801.00
299_V302_S0.8781.00
301_L304_E0.8741.00
204_I244_Y0.8731.00
87_G259_N0.8711.00
329_K332_N0.8711.00
17_L21_L0.8681.00
352_G356_N0.8681.00
18_A283_V0.8661.00
112_A116_F0.8641.00
270_S273_L0.8551.00
112_A316_G0.8541.00
97_L100_L0.8511.00
177_I355_Y0.8481.00
128_I180_L0.8471.00
311_I315_L0.8451.00
303_L306_T0.8441.00
35_G39_A0.8391.00
250_A254_G0.8381.00
228_P231_V0.8371.00
321_A326_R0.8341.00
41_M47_A0.8331.00
204_I235_L0.8331.00
285_I367_V0.8311.00
131_T348_I0.8301.00
22_S35_G0.8291.00
125_S359_N0.8291.00
293_T364_E0.8271.00
319_P322_L0.8231.00
84_L257_F0.8211.00
36_E279_P0.8211.00
357_A361_E0.8211.00
229_L232_L0.8191.00
331_A335_A0.8191.00
380_L383_I0.8171.00
80_F228_P0.8171.00
46_Y291_F0.8161.00
81_A274_L0.8151.00
213_P256_A0.8101.00
296_L299_V0.8101.00
356_N359_N0.8071.00
317_I334_V0.8071.00
99_F103_T0.8071.00
210_I213_P0.8061.00
341_R370_S0.8051.00
186_S189_S0.8041.00
17_L43_I0.8031.00
237_L240_V0.8031.00
40_G44_G0.8021.00
44_G49_G0.8001.00
103_T168_V0.8001.00
357_A360_Q0.7991.00
137_S165_D0.7981.00
145_I149_K0.7931.00
37_L371_I0.7911.00
232_L236_T0.7911.00
304_E307_A0.7841.00
43_I287_A0.7771.00
22_S26_Q0.7771.00
141_V337_G0.7751.00
137_S140_A0.7721.00
361_E364_E0.7711.00
76_I246_P0.7671.00
310_T376_I0.7661.00
176_V180_L0.7661.00
349_A363_F0.7661.00
94_S153_K0.7651.00
333_T337_G0.7651.00
235_L239_M0.7641.00
136_T165_D0.7641.00
77_L277_F0.7621.00
138_L162_A0.7601.00
152_G156_N0.7591.00
108_L112_A0.7541.00
83_G255_V0.7541.00
148_G151_K0.7531.00
22_S25_V0.7521.00
374_T378_S0.7461.00
185_T188_T0.7441.00
292_L296_L0.7441.00
14_F18_A0.7441.00
314_W318_F0.7431.00
363_F366_I0.7381.00
18_A22_S0.7381.00
271_S275_S0.7361.00
102_A105_G0.7331.00
160_S163_A0.7311.00
41_M44_G0.7301.00
113_A133_M0.7291.00
370_S374_T0.7271.00
333_T381_F0.7261.00
101_G317_I0.7241.00
262_K265_K0.7201.00
325_L331_A0.7201.00
217_D221_D0.7191.00
77_L273_L0.7141.00
45_P290_N0.7131.00
213_P260_S0.7121.00
328_A331_A0.7111.00
289_V367_V0.7111.00
175_V190_I0.7091.00
301_L305_L0.7071.00
68_E288_E0.7061.00
105_G313_K0.7061.00
97_L101_G0.7051.00
183_E186_S0.7031.00
100_L320_F0.6991.00
76_I232_L0.6981.00
236_T250_A0.6981.00
311_I314_W0.6971.00
74_S281_F0.6951.00
229_L233_F0.6951.00
207_V211_L0.6941.00
123_L126_A0.6941.00
170_L245_S0.6941.00
255_V258_A0.6911.00
336_L384_Y0.6901.00
12_S19_E0.6901.00
281_F343_E0.6901.00
97_L324_Y0.6861.00
213_P217_D0.6851.00
165_D339_V0.6841.00
32_K36_E0.6841.00
292_L295_N0.6821.00
360_Q364_E0.6821.00
20_I24_L0.6811.00
212_I216_T0.6811.00
182_G186_S0.6731.00
41_M46_Y0.6701.00
306_T373_T0.6691.00
314_W336_L0.6691.00
88_I91_I0.6661.00
213_P216_T0.6661.00
162_A165_D0.6651.00
281_F347_V0.6641.00
77_L232_L0.6641.00
102_A107_L0.6621.00
99_F102_A0.6611.00
293_T296_L0.6611.00
309_A313_K0.6611.00
228_P266_I0.6591.00
196_A244_Y0.6551.00
330_A333_T0.6531.00
236_T240_V0.6521.00
349_A362_E0.6511.00
107_L110_F0.6491.00
185_T190_I0.6471.00
13_I17_L0.6461.00
124_D179_I0.6451.00
232_L235_L0.6421.00
212_I253_A0.6411.00
228_P270_S0.6411.00
85_E146_E0.6401.00
375_L379_A0.6391.00
216_T226_E0.6391.00
9_F13_I0.6341.00
121_F125_S0.6321.00
186_S190_I0.6311.00
129_L365_G0.6291.00
228_P257_F0.6291.00
376_I380_L0.6271.00
97_L326_R0.6271.00
49_G60_L0.6271.00
102_A161_S0.6271.00
198_V201_W0.6261.00
285_I343_E0.6261.00
117_Y121_F0.6261.00
21_L35_G0.6251.00
279_P283_V0.6231.00
10_D13_I0.6231.00
174_S178_A0.6151.00
304_E308_I0.6131.00
106_A110_F0.6121.00
204_I207_V0.6121.00
86_H251_F0.6121.00
21_L27_K0.6111.00
79_I135_A0.6111.00
161_S334_V0.6101.00
22_S36_E0.6081.00
44_G287_A0.6071.00
119_S122_G0.6051.00
173_L348_I0.6041.00
77_L229_L0.6021.00
161_S317_I0.6021.00
115_Y118_I0.6021.00
88_I255_V0.6021.00
72_E240_V0.6011.00
344_T347_V0.5971.00
185_T189_S0.5961.00
135_A138_L0.5891.00
204_I239_M0.5881.00
97_L153_K0.5871.00
67_I71_A0.5850.99
332_N384_Y0.5830.99
362_E366_I0.5820.99
70_L336_L0.5820.99
238_L242_L0.5810.99
83_G250_A0.5810.99
137_S370_S0.5800.99
265_K268_E0.5800.99
161_S165_D0.5780.99
245_S248_I0.5780.99
101_G161_S0.5780.99
318_F321_A0.5770.99
18_A279_P0.5760.99
364_E367_V0.5740.99
15_I18_A0.5730.99
39_A283_V0.5700.99
36_E283_V0.5690.99
128_I132_A0.5690.99
306_T376_I0.5680.99
79_I251_F0.5670.99
80_F253_A0.5670.99
101_G334_V0.5650.99
43_I46_Y0.5650.99
200_I242_L0.5650.99
290_N360_Q0.5640.99
85_E267_K0.5630.99
169_D344_T0.5620.99
131_T135_A0.5610.99
169_D348_I0.5610.99
18_A25_V0.5610.99
345_G348_I0.5590.99
320_F323_A0.5590.99
98_G161_S0.5580.99
101_G157_F0.5560.99
208_S238_L0.5550.99
114_Y126_A0.5540.99
140_A374_T0.5530.99
359_N363_F0.5530.99
136_T342_G0.5530.99
44_G48_L0.5530.99
34_I375_L0.5510.99
89_A259_N0.5500.99
321_A334_V0.5500.99
256_A259_N0.5490.99
62_G65_S0.5490.99
113_A130_G0.5470.99
24_L28_Y0.5470.99
173_L351_L0.5450.99
171_L174_S0.5450.99
128_I176_V0.5420.99
235_L238_L0.5420.99
244_Y249_S0.5420.99
252_V256_A0.5410.99
210_I256_A0.5400.99
263_N267_K0.5390.99
19_E227_F0.5380.99
261_V264_S0.5370.99
375_L378_S0.5360.99
219_I225_E0.5350.99
314_W317_I0.5340.99
141_V144_I0.5340.99
190_I194_I0.5330.99
377_G380_L0.5320.99
336_L377_G0.5320.99
133_M341_R0.5320.99
204_I252_V0.5310.99
137_S345_G0.5310.99
135_A165_D0.5310.99
221_D224_I0.5300.99
229_L273_L0.5300.99
191_S194_I0.5300.99
220_S225_E0.5290.99
360_Q363_F0.5280.99
369_M372_F0.5280.99
10_D63_I0.5260.99
197_L243_G0.5260.99
42_I48_L0.5250.99
231_V235_L0.5250.99
90_P94_S0.5240.99
241_S244_Y0.5240.99
170_L344_T0.5230.99
131_T134_G0.5230.99
177_I180_L0.5220.99
105_G165_D0.5210.99
268_E271_S0.5200.99
125_S129_L0.5200.99
197_L200_I0.5190.99
217_D261_V0.5190.99
101_G105_G0.5170.99
211_L215_I0.5160.99
142_A159_V0.5160.99
189_S196_A0.5150.99
110_F113_A0.5140.99
221_D226_E0.5140.99
201_W209_I0.5130.99
202_V248_I0.5120.99
230_A237_L0.5120.99
144_I147_E0.5120.99
22_S279_P0.5120.99
374_T377_G0.5110.99
15_I22_S0.5110.99
71_A75_V0.5100.99
315_L318_F0.5080.99
369_M373_T0.5080.99
178_A182_G0.5060.99
306_T309_A0.5060.99
334_V337_G0.5050.99
118_I122_G0.5050.99
79_I169_D0.5040.99
101_G321_A0.5030.98
289_V371_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bwzA 2 0.9591 100 0.219 Contact Map
4cz8A 2 0.9693 100 0.235 Contact Map
4czbA 2 0.9693 100 0.245 Contact Map
1zcdA 1 0.8491 99.9 0.598 Contact Map
2mdfA 1 0.1458 98.1 0.854 Contact Map
3zuxA 1 0.7647 97.7 0.869 Contact Map
4n7wA 2 0.7596 97.4 0.875 Contact Map
2k3cA 1 0.0793 88.9 0.919 Contact Map
2l0eA 1 0.0793 85.9 0.923 Contact Map
2m7xA 1 0.0767 71.2 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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