GREMLIN Database
Q97Z04 - Uncharacterized protein
UniProt: Q97Z04 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (228)
Sequences: 22790 (16151)
Seq/√Len: 1069.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_A201_A5.3511.00
10_V14_K4.0961.00
9_I103_I3.4181.00
137_S198_V3.2621.00
8_L96_S3.1191.00
147_A229_L3.0861.00
12_Q97_I2.9741.00
89_P92_F2.7841.00
6_L10_V2.7441.00
110_P131_L2.7141.00
5_F99_L2.6041.00
9_I99_L2.5441.00
184_L188_Y2.4061.00
139_F223_G2.2161.00
228_I232_Y2.1401.00
140_M223_G2.1011.00
45_S48_P2.0851.00
187_R191_Y2.0761.00
14_K17_R2.0671.00
5_F9_I2.0021.00
218_G221_I1.8931.00
154_N157_A1.8551.00
215_W218_G1.8531.00
74_E97_I1.8391.00
184_L187_R1.8241.00
5_F92_F1.8221.00
185_P188_Y1.8191.00
190_T196_T1.8101.00
136_S220_I1.7751.00
140_M226_F1.7711.00
222_F226_F1.7691.00
114_V118_Y1.7541.00
218_G222_F1.7321.00
17_R21_P1.7161.00
147_A226_F1.6981.00
147_A233_V1.6771.00
191_Y197_Y1.6651.00
197_Y216_S1.6461.00
137_S141_A1.6301.00
129_F205_A1.6171.00
179_V190_T1.6061.00
223_G227_V1.5941.00
221_I225_I1.5701.00
106_L135_V1.5561.00
115_L119_L1.5431.00
128_P132_I1.5341.00
188_Y192_I1.5291.00
175_V199_S1.5001.00
11_M74_E1.4961.00
133_A205_A1.4951.00
152_I161_Y1.4861.00
200_Q216_S1.4751.00
143_M223_G1.4321.00
5_F95_I1.4321.00
143_M227_V1.4201.00
46_L49_F1.4091.00
148_L152_I1.4051.00
197_Y218_G1.3881.00
5_F96_S1.3751.00
9_I96_S1.3161.00
102_G135_V1.2941.00
136_S223_G1.2941.00
91_E95_I1.2821.00
105_T138_L1.2801.00
188_Y191_Y1.2801.00
14_K18_A1.2791.00
13_L17_R1.2651.00
136_S217_L1.2601.00
6_L9_I1.2561.00
133_A217_L1.2481.00
225_I229_L1.2391.00
129_F132_I1.2351.00
197_Y201_A1.2311.00
102_G139_F1.2221.00
223_G226_F1.2171.00
140_M219_I1.2061.00
200_Q204_Y1.2061.00
13_L100_S1.2041.00
191_Y196_T1.2001.00
36_L40_Y1.1971.00
217_L220_I1.1801.00
150_L233_V1.1681.00
96_S100_S1.1681.00
68_A158_V1.1571.00
185_P189_L1.1501.00
169_L193_E1.1481.00
134_L198_V1.1311.00
73_F76_N1.1261.00
220_I223_G1.1231.00
140_M222_F1.1211.00
226_F230_S1.1201.00
225_I228_I1.1151.00
82_L88_I1.1141.00
193_E196_T1.1101.00
182_I187_R1.1041.00
220_I224_F1.0991.00
74_E79_R1.0991.00
114_V117_S1.0971.00
78_G81_S1.0771.00
83_M87_G1.0731.00
20_L23_F1.0721.00
229_L233_V1.0651.00
7_N10_V1.0611.00
76_N155_I1.0581.00
72_A76_N1.0541.00
48_P51_V1.0531.00
197_Y200_Q1.0511.00
79_R82_L1.0441.00
82_L87_G1.0371.00
138_L142_S1.0371.00
179_V196_T1.0291.00
56_T195_T1.0201.00
143_M226_F1.0161.00
46_L50_I1.0121.00
179_V187_R1.0091.00
34_F38_F1.0071.00
52_A57_F1.0031.00
51_V55_I0.9971.00
151_G233_V0.9881.00
25_F29_L0.9871.00
209_N213_L0.9851.00
152_I157_A0.9841.00
164_I168_V0.9781.00
30_F34_F0.9641.00
13_L103_I0.9631.00
144_L165_I0.9611.00
52_A55_I0.9531.00
9_I100_S0.9521.00
121_H124_I0.9501.00
196_T200_Q0.9451.00
12_Q15_M0.9421.00
132_I136_S0.9371.00
12_Q100_S0.9351.00
147_A230_S0.9341.00
153_R157_A0.9321.00
183_P187_R0.9121.00
73_F77_A0.9111.00
36_L39_G0.9101.00
94_A231_R0.9091.00
94_A230_S0.9081.00
199_S203_Y0.9071.00
144_L226_F0.8991.00
53_G66_S0.8901.00
113_L130_L0.8841.00
128_P131_L0.8831.00
47_T51_V0.8821.00
51_V54_T0.8811.00
92_F96_S0.8791.00
83_M88_I0.8761.00
134_L202_L0.8741.00
82_L86_T0.8701.00
9_I13_L0.8631.00
216_S219_I0.8621.00
98_A143_M0.8561.00
91_E231_R0.8541.00
219_I223_G0.8541.00
127_I131_L0.8501.00
204_Y210_P0.8491.00
79_R83_M0.8481.00
12_Q101_N0.8471.00
212_S215_W0.8461.00
229_L232_Y0.8431.00
130_L202_L0.8381.00
198_V201_A0.8341.00
208_G211_L0.8331.00
163_T167_F0.8331.00
32_I36_L0.8281.00
37_V40_Y0.8281.00
143_M230_S0.8271.00
207_I210_P0.8231.00
218_G226_F0.8201.00
179_V191_Y0.8171.00
39_G120_L0.8171.00
97_I101_N0.8161.00
166_S170_S0.8121.00
35_M38_F0.8091.00
145_G149_G0.8091.00
16_I27_S0.8051.00
129_F213_L0.8021.00
72_A75_R0.7991.00
115_L118_Y0.7951.00
37_V41_I0.7891.00
11_M15_M0.7791.00
109_I134_L0.7771.00
35_M39_G0.7741.00
62_G66_S0.7731.00
218_G225_I0.7671.00
31_P34_F0.7641.00
88_I93_Y0.7621.00
200_Q212_S0.7621.00
106_L110_P0.7611.00
55_I58_Y0.7601.00
146_M150_L0.7531.00
227_V231_R0.7461.00
132_I217_L0.7431.00
156_Y160_Q0.7371.00
44_R48_P0.7361.00
83_M86_T0.7331.00
103_I107_I0.7241.00
11_M82_L0.7231.00
146_M149_G0.7231.00
75_R82_L0.7221.00
159_N163_T0.7201.00
177_F181_F0.7191.00
224_F227_V0.7191.00
54_T57_F0.7181.00
42_S45_S0.7081.00
221_I224_F0.7051.00
45_S49_F0.6991.00
69_Q72_A0.6931.00
40_Y119_L0.6921.00
197_Y222_F0.6911.00
32_I115_L0.6881.00
29_L32_I0.6881.00
198_V219_I0.6881.00
49_F55_I0.6861.00
111_I114_V0.6861.00
99_L103_I0.6841.00
26_F30_F0.6841.00
204_Y208_G0.6821.00
48_P52_A0.6771.00
98_A142_S0.6731.00
35_M112_I0.6731.00
113_L134_L0.6721.00
224_F228_I0.6721.00
101_N105_T0.6711.00
75_R153_R0.6691.00
170_S173_A0.6671.00
213_L217_L0.6651.00
74_E78_G0.6621.00
187_R190_T0.6611.00
209_N214_L0.6611.00
207_I211_L0.6611.00
157_A160_Q0.6591.00
109_I135_V0.6591.00
31_P35_M0.6551.00
98_A227_V0.6551.00
43_I46_L0.6541.00
68_A74_E0.6531.00
75_R80_F0.6511.00
174_P196_T0.6501.00
212_S216_S0.6491.00
173_A196_T0.6491.00
39_G119_L0.6451.00
72_A158_V0.6451.00
59_V66_S0.6441.00
110_P114_V0.6421.00
53_G203_Y0.6411.00
75_R78_G0.6411.00
160_Q163_T0.6371.00
181_F184_L0.6371.00
56_T63_V0.6281.00
227_V230_S0.6271.00
95_I99_L0.6271.00
84_I90_R0.6261.00
104_A108_M0.6241.00
16_I104_A0.6231.00
47_T52_A0.6211.00
60_S66_S0.6171.00
52_A56_T0.6171.00
81_S84_I0.6171.00
183_P186_F0.6171.00
102_G142_S0.6171.00
48_P53_G0.6161.00
36_L115_L0.6051.00
169_L195_T0.6021.00
34_F41_I0.6001.00
182_I190_T0.6001.00
221_I228_I0.6001.00
34_F37_V0.5991.00
178_P182_I0.5991.00
48_P55_I0.5981.00
56_T198_V0.5981.00
63_V66_S0.5911.00
51_V116_G0.5901.00
79_R87_G0.5901.00
43_I48_P0.5891.00
38_F41_I0.5891.00
53_G57_F0.5891.00
211_L214_L0.5891.00
56_T137_S0.5881.00
222_F225_I0.5861.00
76_N80_F0.5861.00
102_G106_L0.5831.00
110_P113_L0.5771.00
228_I231_R0.5771.00
7_N14_K0.5761.00
35_M116_G0.5731.00
68_A162_S0.5701.00
218_G223_G0.5701.00
182_I186_F0.5661.00
133_A198_V0.5661.00
123_E126_S0.5661.00
68_A71_L0.5661.00
49_F203_Y0.5651.00
210_P213_L0.5641.00
146_M230_S0.5621.00
219_I222_F0.5611.00
131_L135_V0.5611.00
31_P37_V0.5611.00
8_L92_F0.5601.00
163_T168_V0.5591.00
46_L177_F0.5581.00
50_I54_T0.5531.00
29_L33_G0.5531.00
11_M79_R0.5521.00
189_L193_E0.5511.00
53_G58_Y0.5501.00
31_P38_F0.5481.00
192_I197_Y0.5461.00
113_L117_S0.5461.00
56_T59_V0.5451.00
134_L138_L0.5421.00
61_I66_S0.5381.00
80_F94_A0.5371.00
53_G62_G0.5351.00
136_S219_I0.5341.00
82_L85_A0.5311.00
148_L162_S0.5301.00
47_T50_I0.5301.00
80_F93_Y0.5291.00
223_G230_S0.5281.00
48_P56_T0.5281.00
5_F91_E0.5271.00
71_L75_R0.5271.00
220_I227_V0.5261.00
76_N79_R0.5251.00
113_L131_L0.5231.00
200_Q203_Y0.5221.00
72_A155_I0.5211.00
70_S73_F0.5191.00
88_I92_F0.5191.00
94_A146_M0.5171.00
10_V13_L0.5161.00
179_V182_I0.5131.00
194_P198_V0.5111.00
57_F61_I0.5091.00
215_W221_I0.5031.00
66_S101_N0.5021.00
54_T66_S0.5011.00
148_L165_I0.5001.00
52_A203_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zxeA 1 0.384 6.4 0.933 Contact Map
3ixzA 1 0.384 5.8 0.935 Contact Map
2mfrA 1 0.1772 4.2 0.939 Contact Map
2a65A 2 0.6371 3.5 0.941 Contact Map
2l9uA 2 0.1308 3.3 0.942 Contact Map
2m20A 2 0.1224 2.5 0.945 Contact Map
1iijA 1 0.1435 2.4 0.946 Contact Map
2rddB 1 0.1139 2 0.948 Contact Map
4xk8K 1 0.0886 1.7 0.95 Contact Map
2kncA 1 0.1519 1.6 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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