GREMLIN Database
Q97Z02 - Uncharacterized protein
UniProt: Q97Z02 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 171 (160)
Sequences: 24508 (16017)
Seq/√Len: 1266.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_Y11_I3.4371.00
71_V75_Y3.2341.00
40_F43_F2.6821.00
23_E91_V2.5561.00
108_L112_R2.4541.00
89_L93_D2.4191.00
36_S44_I2.4041.00
161_L164_N2.3201.00
114_D117_N2.2781.00
106_P109_E2.1621.00
123_G127_S2.0791.00
37_E40_F2.0211.00
160_Q163_L1.9901.00
32_I45_T1.9651.00
61_L65_V1.9521.00
116_K120_K1.9151.00
6_V10_I1.9031.00
30_I35_Y1.8791.00
105_Q109_E1.8731.00
160_Q164_N1.8721.00
115_W119_L1.8231.00
159_F163_L1.7241.00
141_T144_S1.7231.00
151_L155_I1.7151.00
11_I15_L1.7111.00
117_N120_K1.6931.00
153_V156_S1.6491.00
8_P12_S1.5991.00
109_E112_R1.5991.00
154_L157_I1.5961.00
66_I75_Y1.5601.00
156_S163_L1.5551.00
161_L166_I1.5531.00
153_V157_I1.5481.00
75_Y79_S1.5261.00
155_I158_S1.5141.00
88_L92_K1.4971.00
119_L123_G1.4751.00
152_I156_S1.4631.00
43_F47_L1.4561.00
109_E113_H1.4501.00
156_S164_N1.4481.00
71_V78_L1.4391.00
30_I94_I1.4371.00
120_K124_I1.4251.00
132_F136_T1.4101.00
157_I160_Q1.4081.00
125_K128_E1.3841.00
70_S74_P1.3531.00
155_I160_Q1.3441.00
31_V48_L1.3261.00
153_V159_F1.3161.00
163_L166_I1.2771.00
162_F166_I1.2701.00
110_A118_I1.2461.00
37_E44_I1.2441.00
155_I159_F1.2431.00
75_Y78_L1.2211.00
156_S159_F1.2101.00
40_F44_I1.2011.00
161_L165_P1.1981.00
104_T108_L1.1781.00
61_L64_L1.1611.00
108_L111_K1.1571.00
141_T145_S1.1451.00
85_L89_L1.1361.00
156_S161_L1.1231.00
112_R115_W1.1031.00
162_F165_P1.0801.00
7_Y10_I1.0791.00
118_I122_I1.0771.00
98_K101_R1.0731.00
153_V163_L1.0571.00
156_S160_Q1.0451.00
34_A97_Q1.0421.00
91_V94_I1.0311.00
99_V102_S1.0261.00
125_K129_S1.0231.00
24_W49_Q1.0221.00
105_Q108_L1.0211.00
9_L77_F0.9951.00
8_P11_I0.9941.00
122_I125_K0.9931.00
133_Y137_S0.9911.00
153_V161_L0.9821.00
104_T109_E0.9821.00
139_I143_S0.9711.00
62_T66_I0.9631.00
65_V68_N0.9631.00
63_I76_S0.9631.00
51_S55_G0.9621.00
121_S125_K0.9571.00
143_S147_S0.9531.00
81_T85_L0.9461.00
159_F162_F0.9421.00
153_V160_Q0.9381.00
153_V164_N0.9381.00
100_T103_E0.9341.00
62_T79_S0.9331.00
152_I155_I0.9321.00
63_I66_I0.9161.00
151_L154_L0.9051.00
111_K115_W0.9031.00
87_S91_V0.9031.00
57_I61_L0.9021.00
154_L160_Q0.9001.00
158_S161_L0.8971.00
157_I161_L0.8941.00
157_I163_L0.8931.00
52_V56_I0.8921.00
35_Y95_T0.8761.00
152_I157_I0.8761.00
129_S132_F0.8761.00
158_S162_F0.8751.00
132_F139_I0.8731.00
30_I97_Q0.8691.00
52_V132_F0.8671.00
157_I166_I0.8631.00
154_L158_S0.8481.00
156_S166_I0.8451.00
143_S153_V0.8351.00
25_G29_T0.8341.00
49_Q52_V0.8271.00
160_Q165_P0.8201.00
43_F46_S0.8171.00
23_E27_A0.8141.00
157_I164_N0.8141.00
89_L92_K0.8131.00
50_L54_I0.8081.00
124_I127_S0.8051.00
102_S106_P0.8031.00
159_F164_N0.7981.00
140_F144_S0.7861.00
82_F85_L0.7851.00
118_I121_S0.7851.00
153_V165_P0.7821.00
31_V44_I0.7741.00
48_L52_V0.7731.00
152_I163_L0.7651.00
53_P57_I0.7641.00
21_G36_S0.7591.00
62_T76_S0.7491.00
99_V103_E0.7451.00
156_S165_P0.7331.00
158_S163_L0.7251.00
66_I71_V0.7231.00
69_Y72_Y0.7221.00
151_L156_S0.7221.00
72_Y75_Y0.7181.00
47_L50_L0.7121.00
113_H116_K0.7101.00
78_L81_T0.7031.00
64_L68_N0.7031.00
80_I84_S0.7011.00
50_L53_P0.7011.00
128_E131_N0.6971.00
130_A134_I0.6931.00
145_S148_F0.6881.00
116_K119_L0.6871.00
53_P164_N0.6841.00
154_L163_L0.6821.00
155_I162_F0.6811.00
143_S146_I0.6801.00
146_I149_L0.6801.00
152_I159_F0.6771.00
49_Q53_P0.6751.00
107_L110_A0.6751.00
66_I76_S0.6701.00
56_I136_T0.6691.00
109_E114_D0.6621.00
100_T104_T0.6621.00
28_S48_L0.6621.00
18_L21_G0.6611.00
115_W118_I0.6601.00
152_I160_Q0.6601.00
160_Q166_I0.6561.00
64_L155_I0.6541.00
98_K103_E0.6541.00
14_L18_L0.6521.00
154_L159_F0.6501.00
87_S90_L0.6481.00
154_L165_P0.6471.00
86_L89_L0.6471.00
159_F166_I0.6411.00
123_G126_V0.6361.00
134_I137_S0.6351.00
38_H41_R0.6271.00
156_S162_F0.6191.00
152_I161_L0.6191.00
34_A96_T0.6121.00
126_V129_S0.6091.00
157_I162_F0.5991.00
24_W28_S0.5901.00
76_S79_S0.5901.00
18_L22_G0.5901.00
16_Q77_F0.5881.00
121_S124_I0.5851.00
24_W48_L0.5841.00
76_S80_I0.5841.00
135_F143_S0.5821.00
153_V166_I0.5771.00
158_S166_I0.5751.00
151_L164_N0.5731.00
155_I163_L0.5731.00
78_L82_F0.5681.00
39_K43_F0.5681.00
138_Y141_T0.5671.00
104_T107_L0.5661.00
58_L62_T0.5631.00
56_I59_S0.5611.00
49_Q56_I0.5551.00
102_S105_Q0.5551.00
70_S73_W0.5521.00
140_F143_S0.5511.00
63_I67_Y0.5461.00
12_S15_L0.5441.00
64_L154_L0.5431.00
152_I164_N0.5421.00
132_F137_S0.5391.00
111_K118_I0.5381.00
151_L160_Q0.5351.00
139_I144_S0.5321.00
103_E109_E0.5261.00
10_I14_L0.5241.00
49_Q128_E0.5191.00
32_I41_R0.5181.00
12_S16_Q0.5161.00
59_S63_I0.5151.00
61_L157_I0.5151.00
129_S133_Y0.5131.00
60_S64_L0.5131.00
53_P136_T0.5121.00
79_S82_F0.5121.00
20_L52_V0.5111.00
106_P110_A0.5101.00
144_S150_S0.5091.00
57_I161_L0.5081.00
64_L67_Y0.5071.00
117_N125_K0.5061.00
137_S142_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gc0A 1 0.9942 99.7 0.463 Contact Map
4j05A 3 0.924 99.7 0.473 Contact Map
1pw4A 1 0.9649 99.7 0.476 Contact Map
4pypA 1 0.9883 99.7 0.484 Contact Map
4zw9A 1 0.9883 99.7 0.484 Contact Map
2gfpA 2 0.9766 99.7 0.497 Contact Map
4ldsA 2 0.9883 99.6 0.506 Contact Map
3wdoA 1 0.9649 99.6 0.51 Contact Map
3o7qA 1 0.9825 99.5 0.547 Contact Map
4u4vA 1 0.924 99.4 0.577 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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