GREMLIN Database
Q97YZ8 - Uncharacterized protein
UniProt: Q97YZ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 458 (410)
Sequences: 4501 (2967)
Seq/√Len: 146.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
300_K305_N4.3791.00
297_Y300_K4.0871.00
359_E389_K4.0471.00
361_V397_V3.8471.00
274_D295_P3.7601.00
263_R267_D3.6611.00
358_K390_N3.4821.00
389_K394_G3.2241.00
357_V388_I3.2071.00
349_T352_E3.1771.00
259_L262_N3.1231.00
210_K395_D3.0371.00
115_N192_N3.0331.00
105_S108_E2.9851.00
387_E395_D2.9511.00
389_K395_D2.8501.00
359_E387_E2.7191.00
111_S115_N2.4891.00
165_N168_N2.4491.00
151_G285_T2.4251.00
125_S166_E2.4141.00
22_I139_E2.3931.00
387_E394_G2.3521.00
348_M352_E2.2901.00
83_L89_K2.2771.00
270_T297_Y2.2761.00
83_L87_E2.2221.00
57_Y73_E2.1431.00
349_T418_N2.1281.00
272_I344_K2.1141.00
197_D200_R2.1111.00
354_L388_I2.1091.00
272_I295_P2.1051.00
196_V200_R2.0961.00
263_R411_K2.0821.00
268_V301_D2.0781.00
118_E122_D2.0251.00
68_L71_N2.0061.00
268_V416_V1.9981.00
294_R320_K1.9831.00
355_E392_K1.9411.00
141_E148_R1.9281.00
83_L88_P1.9111.00
82_G85_N1.9061.00
190_N193_E1.9021.00
267_D301_D1.8791.00
270_T301_D1.8731.00
82_G89_K1.8531.00
284_Y293_A1.8441.00
265_G410_L1.8411.00
85_N89_K1.8351.00
220_V357_V1.8301.00
164_L202_V1.8251.00
123_F196_V1.8041.00
353_L415_A1.7741.00
263_R303_K1.7591.00
82_G87_E1.7231.00
200_R204_E1.7071.00
83_L86_T1.7041.00
309_Q319_V1.7021.00
166_E169_R1.6941.00
377_G405_K1.6831.00
16_V144_V1.6701.00
126_V164_L1.6641.00
109_K133_Y1.6581.00
296_K324_S1.6401.00
111_S114_K1.6341.00
314_S320_K1.6331.00
356_D415_A1.6291.00
123_F199_V1.6271.00
388_I394_G1.6211.00
362_Y388_I1.6161.00
220_V353_L1.6141.00
119_A192_N1.6111.00
8_Y16_V1.6051.00
7_L10_K1.6021.00
175_Y197_D1.6021.00
348_M415_A1.6001.00
149_I286_T1.5991.00
126_V203_T1.5931.00
238_F298_L1.5911.00
46_Y61_S1.5841.00
71_N75_K1.5831.00
408_E412_A1.5801.00
166_E208_K1.5781.00
164_L203_T1.5781.00
164_L206_L1.5751.00
295_P342_F1.5701.00
50_Y73_E1.5631.00
252_G257_A1.5571.00
119_A195_V1.5491.00
309_Q313_S1.5381.00
350_F354_L1.5371.00
345_P420_L1.5241.00
296_K306_E1.5181.00
265_G269_V1.4971.00
284_Y339_S1.4971.00
22_I44_D1.4781.00
117_Y121_K1.4761.00
7_L68_L1.4631.00
405_K408_E1.4561.00
360_G388_I1.4521.00
348_M356_D1.4451.00
30_F35_L1.4411.00
350_F353_L1.4311.00
7_L11_F1.4291.00
386_Y393_I1.4161.00
108_E111_S1.4151.00
143_I148_R1.4121.00
309_Q317_F1.3941.00
222_S362_Y1.3861.00
32_N128_S1.3831.00
139_E150_V1.3791.00
298_L308_L1.3691.00
82_G86_T1.3591.00
220_V388_I1.3551.00
114_K118_E1.3521.00
109_K135_E1.3511.00
272_I297_Y1.3501.00
120_V195_V1.3501.00
84_D87_E1.3351.00
139_E152_R1.3321.00
259_L407_T1.3311.00
52_K78_G1.3151.00
127_K165_N1.3151.00
249_A307_Y1.3131.00
107_D111_S1.3111.00
113_F131_F1.3081.00
301_D305_N1.3081.00
291_V321_S1.3001.00
8_Y12_R1.2951.00
110_I114_K1.2931.00
86_T89_K1.2931.00
182_G185_V1.2871.00
126_V199_V1.2811.00
361_V400_P1.2761.00
261_D305_N1.2671.00
164_L199_V1.2641.00
269_V416_V1.2621.00
5_Q144_V1.2571.00
240_A309_Q1.2551.00
33_G117_Y1.2551.00
195_V199_V1.2511.00
297_Y301_D1.2311.00
119_A196_V1.2181.00
351_D392_K1.2171.00
177_L194_V1.2031.00
11_F71_N1.2011.00
137_I152_R1.1881.00
276_T293_A1.1821.00
270_T344_K1.1801.00
351_D355_E1.1731.00
353_L417_D1.1701.00
250_Q317_F1.1701.00
362_Y393_I1.1701.00
297_Y305_N1.1671.00
291_V323_G1.1661.00
84_D89_K1.1641.00
342_F420_L1.1621.00
295_P344_K1.1611.00
372_D377_G1.1591.00
291_V311_R1.1591.00
175_Y194_V1.1591.00
270_T300_K1.1571.00
17_E49_R1.1501.00
171_A398_L1.1481.00
220_V350_F1.1461.00
165_N170_T1.1431.00
230_A343_F1.1370.99
59_A70_S1.1340.99
192_N196_V1.1330.99
85_N88_P1.1290.99
193_E197_D1.1260.99
260_K319_V1.1240.99
314_S321_S1.1180.99
120_V162_L1.1150.99
26_F109_K1.1070.99
212_F217_T1.1050.99
162_L199_V1.1030.99
5_Q8_Y1.1000.99
52_K77_E1.0990.99
52_K74_Y1.0980.99
19_R327_A1.0940.99
6_S10_K1.0940.99
28_M35_L1.0900.99
357_V414_D1.0890.99
354_L357_V1.0860.99
382_G385_A1.0720.99
354_L362_Y1.0720.99
408_E411_K1.0710.99
326_R337_R1.0650.99
22_I42_T1.0640.99
271_V299_I1.0590.99
269_V343_F1.0570.99
283_Y340_N1.0540.99
397_V400_P1.0450.99
135_E183_L1.0430.99
210_K387_E1.0420.99
198_K202_V1.0380.99
217_T387_E1.0280.99
7_L71_N1.0270.99
234_V410_L1.0260.99
199_V203_T1.0170.99
26_F135_E1.0170.99
173_A198_K1.0100.99
275_P284_Y1.0090.99
133_Y158_V1.0090.99
306_E322_N1.0030.99
59_A73_E1.0010.99
159_G174_F1.0010.99
350_F362_Y0.9980.99
252_G258_E0.9930.99
271_V341_T0.9920.99
357_V360_G0.9910.99
269_V413_V0.9840.98
162_L202_V0.9770.98
266_S416_V0.9770.98
309_Q321_S0.9740.98
94_E98_G0.9720.98
24_S42_T0.9720.98
372_D375_R0.9680.98
30_F114_K0.9670.98
182_G279_N0.9640.98
61_S70_S0.9610.98
352_E355_E0.9590.98
378_Q409_L0.9480.98
255_Y407_T0.9460.98
45_G58_F0.9370.98
15_Y145_N0.9360.98
268_V348_M0.9310.98
51_Y56_L0.9310.98
84_D88_P0.9290.98
277_I280_S0.9290.98
350_F418_N0.9250.98
8_Y50_Y0.9240.98
115_N118_E0.9230.98
15_Y142_I0.9200.98
348_M353_L0.9160.98
71_N74_Y0.9150.98
324_S339_S0.9150.98
296_K322_N0.9140.98
179_G185_V0.9100.97
58_F333_E0.9070.97
191_L195_V0.9070.97
120_V198_K0.9050.97
115_N119_A0.9040.97
275_P339_S0.8980.97
221_L363_I0.8980.97
275_P293_A0.8970.97
57_Y77_E0.8950.97
125_S203_T0.8940.97
116_L191_L0.8940.97
116_L158_V0.8920.97
18_V46_Y0.8920.97
265_G299_I0.8880.97
363_I402_F0.8880.97
385_A397_V0.8860.97
47_S327_A0.8820.97
20_R46_Y0.8820.97
171_A205_V0.8790.97
5_Q16_V0.8780.97
232_E236_H0.8770.97
354_L359_E0.8750.97
21_H138_E0.8730.97
5_Q9_D0.8650.97
48_V70_S0.8600.96
69_S72_K0.8560.96
289_E311_R0.8510.96
386_Y396_P0.8510.96
215_R359_E0.8480.96
220_V362_Y0.8430.96
31_L36_M0.8390.96
218_D359_E0.8390.96
29_S37_G0.8380.96
310_N336_I0.8340.96
366_Y370_N0.8330.96
240_A317_F0.8330.96
141_E150_V0.8280.96
351_D354_L0.8260.96
250_Q309_Q0.8230.95
111_S118_E0.8220.95
235_G341_T0.8210.95
145_N311_R0.8190.95
277_I342_F0.8150.95
6_S9_D0.8150.95
378_Q404_G0.8120.95
213_G359_E0.8110.95
350_F419_T0.8100.95
119_A122_D0.8080.95
353_L357_V0.8040.95
44_D64_P0.8040.95
238_F304_V0.8040.95
123_F203_T0.8020.95
217_T361_V0.8020.95
392_K395_D0.8000.95
203_T206_L0.8000.95
104_M108_E0.7950.95
338_M341_T0.7950.95
98_G101_F0.7910.94
29_S132_F0.7910.94
370_N380_Y0.7910.94
232_E235_G0.7870.94
230_A271_V0.7860.94
24_S137_I0.7860.94
273_D296_K0.7840.94
77_E80_E0.7830.94
82_G88_P0.7800.94
120_V199_V0.7770.94
97_E100_P0.7760.94
217_T397_V0.7740.94
325_A336_I0.7730.94
15_Y144_V0.7730.94
371_I380_Y0.7720.94
256_L304_V0.7710.94
125_S206_L0.7710.94
225_L228_I0.7650.93
275_P296_K0.7650.93
310_N369_W0.7630.93
309_Q314_S0.7630.93
310_N313_S0.7620.93
226_T343_F0.7610.93
361_V387_E0.7610.93
162_L198_K0.7600.93
20_R44_D0.7600.93
313_S336_I0.7590.93
274_D342_F0.7590.93
388_I393_I0.7570.93
235_G337_R0.7550.93
99_K137_I0.7530.93
104_M109_K0.7510.93
35_L110_I0.7500.93
212_F361_V0.7490.93
112_F115_N0.7470.93
5_Q18_V0.7460.92
211_S399_F0.7440.92
364_K386_Y0.7420.92
258_E262_N0.7420.92
236_H239_E0.7410.92
74_Y78_G0.7400.92
354_L358_K0.7380.92
275_P283_Y0.7340.92
265_G413_V0.7330.92
25_T134_D0.7320.92
225_L366_Y0.7280.92
210_K389_K0.7220.91
9_D144_V0.7210.91
140_K151_G0.7200.91
356_D414_D0.7190.91
19_R140_K0.7190.91
371_I406_T0.7180.91
142_I149_I0.7150.91
135_E156_L0.7120.91
354_L393_I0.7110.91
72_K76_I0.7100.91
230_A269_V0.7080.90
250_Q313_S0.7080.90
238_F256_L0.7080.90
368_E404_G0.7080.90
119_A123_F0.7070.90
175_Y201_S0.7060.90
193_E196_V0.7050.90
209_G398_L0.7050.90
115_N191_L0.7040.90
49_R289_E0.7020.90
355_E359_E0.7020.90
366_Y369_W0.7020.90
360_G393_I0.6980.90
196_V199_V0.6970.90
293_A339_S0.6960.90
90_E93_Y0.6960.90
310_N335_L0.6920.89
390_N394_G0.6910.89
266_S269_V0.6900.89
93_Y285_T0.6890.89
13_Y52_K0.6870.89
277_I283_Y0.6870.89
23_V138_E0.6850.89
27_G132_F0.6850.89
294_R306_E0.6810.89
27_G39_F0.6810.89
184_E187_E0.6800.89
225_L363_I0.6800.89
32_N129_V0.6790.89
218_D357_V0.6790.89
221_L366_Y0.6790.89
313_S317_F0.6780.88
32_N121_K0.6780.88
119_A191_L0.6780.88
301_D320_K0.6760.88
11_F74_Y0.6710.88
249_A254_S0.6700.88
5_Q143_I0.6690.88
355_E358_K0.6690.88
212_F215_R0.6680.88
271_V343_F0.6670.88
138_E153_V0.6670.88
237_P255_Y0.6660.88
231_H236_H0.6660.88
175_Y198_K0.6650.87
173_A202_V0.6650.87
239_E338_M0.6630.87
229_M366_Y0.6600.87
353_L393_I0.6600.87
312_F316_K0.6560.87
119_A199_V0.6550.87
233_S236_H0.6550.87
231_H337_R0.6540.87
215_R361_V0.6500.86
203_T208_K0.6490.86
57_Y76_I0.6490.86
222_S364_K0.6490.86
260_K305_N0.6480.86
157_Y178_G0.6460.86
265_G271_V0.6460.86
108_E112_F0.6460.86
61_S64_P0.6440.86
41_F262_N0.6420.86
348_M418_N0.6410.85
328_A332_R0.6400.85
122_D196_V0.6390.85
13_Y50_Y0.6390.85
300_K303_K0.6390.85
11_F68_L0.6360.85
38_S114_K0.6360.85
368_E379_R0.6350.85
116_L160_M0.6350.85
201_S222_S0.6330.85
208_K396_P0.6330.85
264_I411_K0.6300.85
252_G259_L0.6300.85
260_K307_Y0.6300.85
263_R301_D0.6290.84
101_F156_L0.6280.84
185_V279_N0.6270.84
23_V136_S0.6270.84
342_F422_F0.6260.84
60_S327_A0.6250.84
24_S139_E0.6250.84
50_Y77_E0.6230.84
383_L401_V0.6220.84
25_T136_S0.6220.84
210_K394_G0.6210.84
113_F133_Y0.6210.84
367_M401_V0.6210.84
240_A250_Q0.6190.83
118_E412_A0.6180.83
100_P103_L0.6170.83
132_F159_G0.6170.83
220_V354_L0.6160.83
383_L400_P0.6160.83
365_S384_E0.6140.83
97_E279_N0.6130.83
238_F308_L0.6130.83
346_G418_N0.6110.83
367_M383_L0.6100.83
46_Y64_P0.6090.82
109_K113_F0.6090.82
231_H338_M0.6090.82
220_V417_D0.6070.82
233_S371_I0.6070.82
310_N325_A0.6070.82
239_E337_R0.6070.82
379_R403_Q0.6070.82
197_D201_S0.6060.82
370_N379_R0.6030.82
241_D251_A0.6010.82
250_Q316_K0.5990.81
218_D358_K0.5980.81
122_D192_N0.5960.81
262_N303_K0.5950.81
72_K77_E0.5950.81
311_R315_S0.5940.81
359_E390_N0.5930.81
120_V160_M0.5930.81
283_Y339_S0.5910.81
120_V129_V0.5900.80
210_K396_P0.5900.80
180_S283_Y0.5880.80
55_V82_G0.5870.80
17_E47_S0.5860.80
25_T43_D0.5850.80
280_S283_Y0.5850.80
352_E356_D0.5840.80
169_R208_K0.5840.80
297_Y324_S0.5820.80
298_L341_T0.5820.80
368_E401_V0.5810.79
367_M382_G0.5810.79
298_L306_E0.5810.79
260_K306_E0.5800.79
357_V362_Y0.5790.79
120_V126_V0.5790.79
218_D414_D0.5790.79
369_W380_Y0.5790.79
50_Y57_Y0.5780.79
70_S76_I0.5750.79
17_E58_F0.5740.79
19_R138_E0.5740.79
254_S307_Y0.5740.79
28_M106_V0.5740.79
232_E378_Q0.5740.79
236_H337_R0.5730.79
161_N172_T0.5720.78
204_E386_Y0.5720.78
210_K392_K0.5710.78
356_D388_I0.5710.78
308_L341_T0.5690.78
228_I232_E0.5690.78
129_V162_L0.5680.78
46_Y67_L0.5680.78
309_Q336_I0.5680.78
272_I342_F0.5670.78
381_V401_V0.5660.78
192_N195_V0.5660.78
72_K81_S0.5660.78
158_V191_L0.5650.78
288_D326_R0.5640.77
287_D323_G0.5640.77
97_E101_F0.5640.77
24_S40_R0.5620.77
93_Y96_K0.5610.77
266_S301_D0.5610.77
234_V341_T0.5610.77
289_E325_A0.5600.77
76_I80_E0.5600.77
241_D335_L0.5600.77
229_M406_T0.5600.77
108_E187_E0.5590.77
13_Y16_V0.5580.77
72_K75_K0.5580.77
379_R401_V0.5570.77
67_L70_S0.5570.77
71_N76_I0.5560.76
249_A317_F0.5550.76
273_D298_L0.5540.76
8_Y13_Y0.5540.76
73_E77_E0.5530.76
276_T295_P0.5520.76
407_T411_K0.5520.76
368_E382_G0.5520.76
368_E378_Q0.5510.76
213_G217_T0.5500.76
71_N78_G0.5500.76
236_H338_M0.5500.76
360_G391_G0.5490.76
221_L226_T0.5470.75
14_P52_K0.5470.75
29_S130_S0.5460.75
222_S226_T0.5460.75
382_G401_V0.5450.75
126_V202_V0.5440.75
78_G81_S0.5430.75
258_E307_Y0.5430.75
251_A375_R0.5430.75
134_D157_Y0.5410.74
231_H235_G0.5400.74
241_D248_F0.5400.74
75_K79_W0.5390.74
28_M109_K0.5380.74
231_H239_E0.5380.74
376_L405_K0.5380.74
342_F345_P0.5380.74
296_K308_L0.5370.74
234_V238_F0.5370.74
9_D12_R0.5360.74
296_K339_S0.5330.73
366_Y380_Y0.5330.73
112_F183_L0.5330.73
19_R45_G0.5290.73
314_S319_V0.5290.73
269_V301_D0.5280.73
209_G396_P0.5280.73
30_F113_F0.5280.73
136_S191_L0.5270.73
228_I369_W0.5260.72
232_E338_M0.5260.72
124_R168_N0.5240.72
101_F154_P0.5230.72
356_D390_N0.5230.72
386_Y400_P0.5230.72
234_V264_I0.5220.72
147_S311_R0.5220.72
355_E390_N0.5210.72
306_E319_V0.5190.71
255_Y410_L0.5190.71
116_L120_V0.5180.71
251_A399_F0.5170.71
200_R203_T0.5170.71
297_Y344_K0.5160.71
410_L413_V0.5160.71
19_R58_F0.5150.71
99_K187_E0.5140.71
69_S75_K0.5140.71
266_S270_T0.5130.71
240_A313_S0.5100.70
301_D344_K0.5100.70
358_K394_G0.5100.70
228_I368_E0.5100.70
417_D420_L0.5090.70
14_P53_D0.5070.70
190_N196_V0.5070.70
71_N196_V0.5060.70
140_K286_T0.5060.70
17_E51_Y0.5060.70
234_V299_I0.5060.70
99_K103_L0.5060.70
365_S382_G0.5050.69
249_A304_V0.5040.69
209_G282_G0.5030.69
413_V417_D0.5030.69
232_E337_R0.5020.69
130_S161_N0.5010.69
135_E186_L0.5000.69
237_P407_T0.5000.69
35_L38_S0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vl4A 2 0.9017 100 0.216 Contact Map
3qtdA 2 0.9148 100 0.223 Contact Map
3tv9A 2 0.9017 100 0.234 Contact Map
1vpbA 2 0.9039 100 0.239 Contact Map
1lfpA 1 0.2162 16.4 0.973 Contact Map
4f3qA 1 0.2118 15.3 0.973 Contact Map
1mw7A 1 0.1965 9.6 0.975 Contact Map
3gmgA 2 0.2227 8.8 0.976 Contact Map
2lg7A 1 0.1528 7 0.977 Contact Map
2zp1A 2 0.2817 6.3 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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