GREMLIN Database
Q97YZ7 - Uncharacterized protein
UniProt: Q97YZ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 409 (392)
Sequences: 4543 (2988)
Seq/√Len: 150.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_E273_T4.2181.00
265_A268_E4.0001.00
319_N351_R3.7801.00
243_T263_N3.7081.00
321_V359_I3.5831.00
232_K236_D3.5001.00
376_V402_K3.4141.00
376_V400_L3.3921.00
194_K403_D3.3861.00
311_S314_S2.9981.00
228_K231_E2.9861.00
351_R356_V2.9671.00
188_Y357_G2.8131.00
349_V357_G2.7871.00
351_R357_G2.6121.00
319_N349_V2.5981.00
139_E253_G2.4551.00
104_S108_S2.3821.00
23_K126_E2.3581.00
349_V356_V2.2551.00
315_L398_Y2.1901.00
239_T265_A2.1681.00
103_L107_L2.1671.00
310_T314_S2.1621.00
311_S380_R2.1321.00
381_E398_Y2.1221.00
112_S154_E2.1001.00
241_L263_N2.0651.00
241_L306_K2.0441.00
316_L350_Y1.9951.00
232_K373_K1.9931.00
317_S354_N1.9611.00
128_S136_N1.9521.00
237_K269_N1.9341.00
177_K180_E1.9241.00
176_K180_E1.9071.00
234_G372_L1.8741.00
239_T269_N1.8561.00
237_K378_L1.8431.00
236_D269_N1.8321.00
8_Y11_E1.7621.00
371_I401_V1.7611.00
100_F103_L1.7591.00
338_D367_N1.7581.00
113_E152_N1.7491.00
107_L110_I1.7061.00
152_N182_A1.7051.00
252_W261_T1.7041.00
350_Y356_V1.6981.00
277_L287_L1.6851.00
9_V17_V1.6851.00
312_F398_Y1.6671.00
155_H159_W1.6651.00
91_K94_T1.6641.00
232_K271_V1.6591.00
315_L377_E1.6381.00
66_N69_P1.6371.00
320_V350_Y1.6351.00
17_V132_S1.6281.00
318_G400_L1.6261.00
264_K292_N1.6171.00
282_S288_P1.6131.00
318_G377_E1.6121.00
99_L103_L1.6091.00
137_G254_F1.6071.00
97_L101_D1.6041.00
262_Y288_P1.5991.00
103_L108_S1.5891.00
152_N185_T1.5661.00
180_E183_S1.5591.00
195_Y406_L1.5581.00
374_N402_K1.5501.00
322_F350_Y1.5361.00
312_F316_L1.5311.00
103_L110_I1.5261.00
102_D172_K1.5131.00
215_A266_I1.5021.00
374_N403_D1.5011.00
370_R374_N1.5001.00
310_T377_E1.4981.00
156_S160_A1.4921.00
263_N304_E1.4741.00
64_N69_P1.4651.00
73_P77_F1.4601.00
154_E186_G1.4591.00
23_K45_S1.4581.00
277_L281_L1.4561.00
264_K274_T1.4541.00
196_D400_L1.4501.00
126_E138_T1.4491.00
170_Q173_D1.4381.00
31_L36_V1.4341.00
212_A303_L1.4331.00
47_Y62_I1.4331.00
367_N370_R1.4271.00
348_V355_P1.4041.00
198_I315_L1.4001.00
130_V136_N1.3831.00
196_D402_K1.3821.00
94_T97_L1.3721.00
8_Y12_V1.3701.00
234_G238_F1.3621.00
114_Y153_K1.3601.00
252_W301_W1.3551.00
198_I400_L1.3451.00
241_L265_A1.3441.00
220_I275_P1.3361.00
101_D104_S1.3351.00
277_L285_F1.3351.00
101_D105_P1.3341.00
155_H158_Q1.3301.00
266_I276_L1.3291.00
310_T318_G1.3231.00
204_M399_A1.3171.00
307_E382_R1.3171.00
200_S322_F1.3131.00
159_W177_K1.3131.00
259_T289_S1.3101.00
105_P109_L1.2981.00
126_E140_S1.2951.00
230_G273_T1.2941.00
159_W162_S1.2911.00
74_V77_F1.2861.00
79_I83_N1.2851.00
198_I350_Y1.2851.00
155_H160_A1.2741.00
217_G277_L1.2691.00
221_M285_F1.2621.00
304_E395_V1.2571.00
104_S107_L1.2541.00
33_E115_P1.2411.00
175_I179_N1.2401.00
312_F315_L1.2331.00
228_K369_K1.2311.00
165_S168_S1.2291.00
7_K11_E1.2221.00
100_F104_S1.2221.00
313_E317_S1.2191.00
9_V13_K1.2181.00
211_V372_L1.2171.00
92_N95_N1.2141.00
269_N273_T1.2091.00
245_K261_T1.2041.00
113_E179_N1.1931.00
101_D172_K1.1791.00
6_V17_V1.1781.00
18_G50_A1.1781.00
238_F378_L1.1751.00
157_G178_A1.1731.00
152_N179_N1.1681.00
265_A269_N1.1681.00
259_T291_G1.1641.00
322_F355_P1.1601.00
343_A347_T1.1591.00
102_D108_S1.1561.00
239_T306_K1.1511.00
18_G131_T1.1461.00
87_Y91_K1.1431.00
173_D177_K1.1391.00
6_V10_Q1.1381.00
384_S395_V1.1361.00
313_E354_N1.1301.00
80_M83_N1.1271.00
321_V362_V1.1261.00
379_S398_Y1.1230.99
178_A182_A1.1220.99
75_D79_I1.1210.99
76_F79_I1.1160.99
102_D106_L1.1150.99
263_N306_K1.1140.99
72_T75_D1.1120.99
304_E382_R1.1060.99
100_F107_L1.1050.99
165_S247_D1.1040.99
259_T279_N1.1040.99
333_N338_D1.1040.99
155_H360_G1.1020.99
106_L109_L1.1010.99
239_T268_E1.0960.99
6_V132_S1.0960.99
124_D140_S1.0950.99
106_L110_I1.0910.99
29_I36_V1.0890.99
265_A273_T1.0850.99
282_S289_S1.0700.99
172_K176_K1.0680.99
229_P287_L1.0670.99
99_L102_D1.0650.99
81_S84_E1.0640.99
95_N120_I1.0590.99
110_I176_K1.0580.99
274_T290_T1.0520.99
95_N122_I1.0510.99
316_L322_F1.0450.99
73_P76_F1.0440.99
23_K43_T1.0330.99
72_T77_F1.0330.99
196_D403_D1.0280.99
238_F305_V1.0200.99
190_I195_Y1.0190.99
150_A179_N1.0190.99
188_Y349_V1.0160.99
93_N97_L1.0140.99
102_D110_I1.0110.99
99_L107_L1.0100.99
371_I404_V1.0060.99
333_N336_E1.0040.99
312_F380_R0.9960.99
27_I122_I0.9930.99
106_L176_K0.9920.99
359_I362_V0.9910.99
315_L379_S0.9890.99
155_H162_S0.9860.99
198_I312_F0.9850.99
194_K405_R0.9820.99
370_R373_K0.9790.99
131_T135_F0.9770.99
208_M305_V0.9760.99
105_P172_K0.9750.99
71_L77_F0.9730.99
100_F108_S0.9660.98
240_L267_I0.9660.98
378_L399_A0.9620.98
85_R88_K0.9600.98
204_M396_Y0.9560.98
277_L289_S0.9440.98
16_E133_K0.9390.98
251_S302_N0.9380.98
237_K310_T0.9370.98
220_I225_S0.9320.98
102_D107_L0.9280.98
168_S247_D0.9280.98
71_L75_D0.9270.98
71_L74_V0.9260.98
158_Q162_S0.9250.98
156_S161_F0.9240.98
330_R341_T0.9230.98
195_Y349_V0.9230.98
377_E400_L0.9230.98
235_S378_L0.9220.98
278_N298_P0.9210.98
314_S317_S0.9190.98
110_I179_N0.9180.98
46_Y59_L0.9180.98
25_R43_T0.9120.98
300_A303_L0.9110.98
350_Y355_P0.9110.98
19_L47_Y0.9090.98
226_M369_K0.9080.98
79_I82_K0.9070.98
244_P252_W0.9040.98
264_K290_T0.9030.98
106_L175_I0.9010.98
103_L109_L0.8990.98
375_I399_A0.8990.98
293_A298_P0.8990.98
257_E279_N0.8990.98
77_F80_M0.8980.98
310_T315_L0.8980.98
150_A182_A0.8960.97
312_F322_F0.8930.97
199_L323_I0.8910.97
316_L319_N0.8810.97
99_L110_I0.8800.97
339_F371_I0.8800.97
105_P108_S0.8770.97
312_F381_E0.8770.97
171_V175_I0.8770.97
292_N301_W0.8760.97
86_E91_K0.8730.97
382_R395_V0.8720.97
238_F375_I0.8720.97
71_L79_I0.8710.97
32_V37_A0.8690.97
161_F174_S0.8650.97
22_V125_V0.8640.97
120_I146_G0.8630.97
193_G319_N0.8570.97
16_E129_L0.8560.97
99_L104_S0.8560.97
348_V358_V0.8540.97
240_L303_L0.8510.97
71_L76_F0.8470.96
157_G162_S0.8460.96
244_P301_W0.8430.96
244_P261_T0.8430.96
62_I69_P0.8430.96
210_S341_T0.8410.96
157_G160_A0.8390.96
209_E213_R0.8370.96
347_T359_I0.8350.96
34_S104_S0.8300.96
5_M12_V0.8290.96
21_R47_Y0.8270.96
310_T380_R0.8270.96
322_F398_Y0.8260.96
234_G267_I0.8200.96
52_K57_G0.8190.96
109_L176_K0.8160.96
217_G285_F0.8160.96
74_V79_I0.8140.96
30_K38_T0.8130.96
59_L295_W0.8080.95
72_T78_P0.8040.95
339_F366_D0.8020.95
191_T319_N0.8010.95
128_S138_T0.7990.95
156_S159_W0.7980.95
80_M84_E0.7950.95
75_D82_K0.7950.95
75_D78_P0.7910.95
323_I364_I0.7880.95
215_A272_F0.7850.95
198_I322_F0.7840.95
45_S65_L0.7830.95
10_Q132_S0.7820.95
25_R124_D0.7810.94
276_L300_A0.7730.94
208_M399_A0.7730.94
72_T76_F0.7720.94
86_E89_M0.7700.94
316_L355_P0.7690.94
326_V330_R0.7690.94
210_S332_Q0.7640.94
221_M277_L0.7640.94
86_E90_V0.7580.94
73_P82_K0.7580.94
187_K360_G0.7580.94
47_Y69_P0.7560.93
211_V233_A0.7540.93
158_Q161_F0.7540.93
354_N357_G0.7520.93
196_D319_N0.7520.93
332_Q341_T0.7500.93
281_L298_P0.7500.93
278_N281_L0.7490.93
21_R45_S0.7480.93
324_N348_V0.7480.93
73_P79_I0.7480.93
155_H184_I0.7480.93
203_V206_N0.7470.93
9_V51_L0.7450.93
14_G53_K0.7450.93
246_E304_E0.7410.93
67_E70_K0.7400.93
127_R139_E0.7390.93
76_F81_S0.7390.93
244_P264_K0.7380.93
77_F82_K0.7380.93
102_D105_P0.7370.93
157_G182_A0.7360.93
76_F80_M0.7310.92
199_L326_V0.7310.92
350_Y400_L0.7290.92
73_P80_M0.7290.92
30_K119_I0.7270.92
112_S185_T0.7260.92
320_V355_P0.7260.92
250_N393_Q0.7250.92
74_V78_P0.7240.92
173_D176_K0.7220.92
129_L137_G0.7210.92
242_D264_K0.7200.92
195_Y321_V0.7200.92
244_P251_S0.7190.92
77_F83_N0.7190.92
213_R216_S0.7170.92
85_R90_V0.7150.91
92_N96_I0.7150.91
73_P78_P0.7140.91
327_W330_R0.7140.91
5_M70_K0.7100.91
313_E316_L0.7090.91
103_L106_L0.7050.91
27_I95_N0.7040.91
77_F81_S0.7010.91
225_S275_P0.7000.91
261_T301_W0.6990.91
47_Y70_K0.6960.90
87_Y90_V0.6920.90
212_A300_A0.6910.90
176_K179_N0.6900.90
14_G51_L0.6900.90
321_V349_V0.6900.90
277_L282_S0.6900.90
304_E384_S0.6900.90
243_T304_E0.6890.90
9_V14_G0.6890.90
189_E361_R0.6880.90
221_M281_L0.6880.90
33_E116_L0.6850.90
246_E251_S0.6840.90
72_T79_I0.6830.89
188_Y351_R0.6810.89
30_K117_Y0.6810.89
181_L200_S0.6790.89
211_V227_L0.6780.89
102_D109_L0.6780.89
133_K279_N0.6750.89
24_T123_D0.6750.89
26_R121_S0.6750.89
326_V331_F0.6730.89
208_M240_L0.6710.89
197_V404_V0.6690.89
269_N288_P0.6680.88
28_I40_Q0.6670.88
100_F110_I0.6660.88
280_E284_V0.6660.88
352_N356_V0.6650.88
105_P110_I0.6630.88
16_E132_S0.6620.88
20_L127_R0.6610.88
190_I193_G0.6590.88
308_G397_P0.6580.88
150_A178_A0.6570.88
50_A257_E0.6550.87
342_V361_R0.6540.87
75_D80_M0.6540.87
163_S166_F0.6530.87
245_K263_N0.6520.87
229_P275_P0.6520.87
18_G48_F0.6520.87
217_G221_M0.6520.87
343_A362_V0.6510.87
93_N96_I0.6510.87
234_G375_I0.6500.87
122_I144_I0.6490.87
248_R251_S0.6460.87
72_T81_S0.6430.86
195_Y359_I0.6410.86
125_V141_N0.6400.86
119_I147_Y0.6400.86
28_I119_I0.6390.86
326_V341_T0.6370.86
268_E271_V0.6350.86
221_M284_V0.6330.86
72_T80_M0.6300.85
75_D83_N0.6290.85
109_L179_N0.6280.85
102_D171_V0.6280.85
211_V215_A0.6280.85
331_F341_T0.6280.85
262_Y274_T0.6280.85
78_P82_K0.6250.85
278_N293_A0.6240.85
51_L58_F0.6230.85
7_K10_Q0.6220.85
231_E271_V0.6200.84
331_F340_S0.6200.84
325_N346_A0.6190.84
314_S318_G0.6170.84
177_K181_L0.6170.84
210_S330_R0.6160.84
318_G350_Y0.6130.84
201_P398_Y0.6110.84
159_W174_S0.6110.84
24_T125_V0.6110.84
278_N297_Y0.6110.84
281_L285_F0.6080.83
71_L80_M0.6070.83
107_L150_A0.6060.83
197_V406_L0.6060.83
198_I316_L0.6060.83
220_I272_F0.6050.83
218_Y222_S0.6050.83
208_M238_F0.6040.83
309_D380_R0.6030.83
26_R123_D0.6010.83
97_L102_D0.6010.83
97_L100_F0.6010.83
15_E54_D0.5990.82
71_L78_P0.5950.82
279_N283_N0.5940.82
203_V326_V0.5930.82
315_L400_L0.5920.82
203_V342_V0.5900.81
25_R126_E0.5890.81
216_S299_T0.5890.81
330_R339_F0.5890.81
219_A334_Y0.5880.81
106_L172_K0.5880.81
186_G358_V0.5880.81
233_A373_K0.5870.81
210_S339_F0.5870.81
15_E53_K0.5860.81
75_D81_S0.5820.81
188_Y356_V0.5800.80
216_S300_A0.5790.80
227_L272_F0.5790.80
222_S336_E0.5780.80
332_Q368_L0.5780.80
190_I321_V0.5770.80
234_G240_L0.5770.80
89_M168_S0.5760.80
214_M226_M0.5750.80
277_L298_P0.5750.80
327_W363_R0.5740.80
173_D180_E0.5740.80
84_E87_Y0.5730.80
167_S170_Q0.5720.79
235_S238_F0.5710.79
299_T392_M0.5710.79
144_I166_F0.5700.79
36_V96_I0.5670.79
380_R398_Y0.5660.79
50_A296_I0.5650.79
200_S324_N0.5640.78
329_T341_T0.5630.78
340_S365_A0.5630.78
99_L108_S0.5620.78
188_Y358_V0.5600.78
10_Q14_G0.5600.78
303_L396_Y0.5580.78
308_G380_R0.5580.78
206_N329_T0.5570.78
379_S397_P0.5560.78
107_L175_I0.5560.78
113_E182_A0.5550.77
209_E212_A0.5510.77
170_Q177_K0.5510.77
240_L305_V0.5510.77
229_P273_T0.5510.77
104_S110_I0.5500.77
369_K373_K0.5480.76
396_Y399_A0.5480.76
20_L125_V0.5480.76
42_M231_E0.5470.76
349_V359_I0.5460.76
183_S348_V0.5450.76
163_S169_S0.5450.76
215_A276_L0.5440.76
315_L355_P0.5440.76
209_E299_T0.5430.76
78_P81_S0.5420.76
187_K358_V0.5390.75
330_R362_V0.5390.75
342_V363_R0.5380.75
74_V83_N0.5370.75
26_R42_M0.5360.75
215_A227_L0.5360.75
216_S278_N0.5350.75
212_A299_T0.5340.75
14_G17_V0.5340.75
337_G367_N0.5330.75
343_A364_I0.5330.75
251_S301_W0.5330.75
5_M8_Y0.5310.74
95_N99_L0.5310.74
147_Y158_Q0.5300.74
213_R334_Y0.5300.74
319_N352_N0.5290.74
121_S145_S0.5290.74
18_G52_K0.5290.74
278_N289_S0.5280.74
232_K269_N0.5280.74
265_A292_N0.5240.73
340_S363_R0.5240.73
83_N86_E0.5240.73
317_S352_N0.5230.73
223_G228_K0.5230.73
50_A57_G0.5220.73
85_R89_M0.5220.73
256_D293_A0.5210.73
5_M67_E0.5210.73
59_L296_I0.5200.73
26_R44_N0.5200.73
100_F109_L0.5200.73
229_P274_T0.5190.73
59_L294_G0.5190.73
205_G392_M0.5170.72
374_N404_V0.5140.72
255_D291_G0.5120.72
18_G59_L0.5110.71
203_V323_I0.5110.71
218_Y297_Y0.5110.71
264_K276_L0.5100.71
311_S379_S0.5100.71
74_V82_K0.5080.71
204_M305_V0.5080.71
146_G171_V0.5070.71
214_M369_K0.5070.71
242_D266_I0.5050.71
20_L59_L0.5050.71
213_R299_T0.5040.70
172_K175_I0.5030.70
6_V19_L0.5020.70
276_L303_L0.5000.70
366_D404_V0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vl4A 2 0.9633 100 0.135 Contact Map
3qtdA 2 0.9682 100 0.158 Contact Map
3tv9A 2 0.9535 100 0.162 Contact Map
1vpbA 2 0.9584 100 0.163 Contact Map
4bmhA 1 0.1345 10.3 0.971 Contact Map
3i9sA 4 0.1467 8.9 0.972 Contact Map
2kd0A 1 0.2078 6.4 0.974 Contact Map
4xybA 2 0.3276 5.5 0.975 Contact Map
3mgdA 2 0.1222 4.6 0.976 Contact Map
2w91A 1 0.1785 4.5 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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