Q97YZ6 - SULSO - GREMLIN Contacts

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Q97YZ6 - Acyl-CoA dehydrogenase (Acd-1)

UniProt:	Q97YZ6	Sequences: MNEEEYRLKLREWIRNSAPESLKGRKILFETVEFDDYNELRSWQRKLADAGYLGITWPKEYGGQGLDPIYEVIAYEEFIRAGLPYGRSLGSIGLMVVAPAILKHGNEDQKRRYLPRILRAEDIWCQGFSEPQAGSDLASVTTRAEDKGDYFLVNGQKIWSSYAHIADYMILLARTGEDKYKGLTMFILNMKQEGIRVSPINQLTGKSDFNTVYFNNVKVPKNNVIGNVGDGWKVAMTVLNHERFMLGVTMLFTSKIALESLKGVKEKEELEDEVEGLEAFYRRILIKLRKGEDIDVEGSMLKLLASELLQRIYEIAVMNYDLETIMKEKWYLGMLASRGRTIAGGTSEILRNVVGERALKLPK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	363 (342)
Sequences:	33222 (18786)
Seq/√Len:	1015.8

ECOLI - CAIA YDIO AIDB FADE
BACSU - FADE ACDC ACDA ACDB YDBM
HALSA - Q9HS75 Q9HRI6 Q9HPT2 Q9HRB3 Q9HQF0 Q9HMK7
SULSO - Q97YZ6 Q97UW6 Q97VU6 Q97U78 Q97V73 Q97WQ8 Q97XW3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
150_Y	218_K	4.495	1.00
154_N	216_N	3.613	1.00
146_D	221_K	3.239	1.00
116_R	121_E	3.153	1.00
17_S	46_K	3.027	1.00
196_R	215_N	2.994	1.00
107_E	111_R	2.925	1.00
67_D	70_Y	2.878	1.00
116_R	122_D	2.851	1.00
290_K	311_R	2.651	1.00
156_Q	213_Y	2.567	1.00
147_K	218_K	2.484	1.00
283_R	315_I	2.322	1.00
262_K	266_E	2.279	1.00
11_R	77_E	2.226	1.00
227_N	230_D	2.221	1.00
230_D	233_K	2.215	1.00
12_E	16_N	2.160	1.00
184_T	224_V	2.143	1.00
156_Q	211_T	2.098	1.00
327_K	332_L	2.081	1.00
107_E	110_K	2.054	1.00
332_L	336_A	2.053	1.00
273_E	276_G	2.036	1.00
169_M	190_M	2.024	1.00
58_P	102_L	1.980	1.00
173_A	186_F	1.927	1.00
46_K	49_D	1.909	1.00
106_N	109_Q	1.868	1.00
163_A	210_N	1.861	1.00
45_R	49_D	1.860	1.00
264_V	319_N	1.852	1.00
125_C	169_M	1.849	1.00
307_E	347_S	1.829	1.00
147_K	150_Y	1.818	1.00
196_R	213_Y	1.815	1.00
80_R	259_E	1.813	1.00
21_S	25_R	1.789	1.00
77_E	80_R	1.780	1.00
152_L	218_K	1.777	1.00
198_S	213_Y	1.770	1.00
279_A	282_R	1.770	1.00
151_F	186_F	1.760	1.00
272_D	276_G	1.758	1.00
147_K	152_L	1.748	1.00
145_E	154_N	1.724	1.00
59_K	65_G	1.722	1.00
152_L	216_N	1.710	1.00
112_R	222_N	1.700	1.00
189_N	223_N	1.683	1.00
24_G	36_D	1.667	1.00
112_R	116_R	1.651	1.00
198_S	211_T	1.640	1.00
255_K	259_E	1.640	1.00
164_H	210_N	1.639	1.00
268_E	273_E	1.632	1.00
111_R	115_P	1.626	1.00
192_Q	217_V	1.623	1.00
310_Q	341_T	1.619	1.00
41_R	45_R	1.593	1.00
220_P	223_N	1.588	1.00
311_R	315_I	1.582	1.00
323_E	329_K	1.582	1.00
149_D	221_K	1.538	1.00
261_L	265_K	1.538	1.00
257_A	313_Y	1.520	1.00
104_H	237_T	1.506	1.00
116_R	119_R	1.499	1.00
151_F	221_K	1.489	1.00
108_D	112_R	1.488	1.00
221_K	224_V	1.486	1.00
189_N	192_Q	1.481	1.00
202_Q	327_K	1.480	1.00
130_E	157_K	1.478	1.00
224_V	228_V	1.475	1.00
115_P	119_R	1.463	1.00
82_G	85_Y	1.459	1.00
80_R	255_K	1.455	1.00
269_E	277_L	1.454	1.00
146_D	228_V	1.452	1.00
8_L	12_E	1.452	1.00
146_D	150_Y	1.452	1.00
314_E	338_R	1.441	1.00
264_V	280_F	1.432	1.00
154_N	215_N	1.418	1.00
149_D	218_K	1.416	1.00
260_S	316_A	1.390	1.00
14_I	81_A	1.388	1.00
132_Q	141_T	1.366	1.00
72_V	248_V	1.361	1.00
7_R	77_E	1.360	1.00
61_Y	110_K	1.355	1.00
190_M	195_I	1.350	1.00
254_S	312_I	1.350	1.00
66_L	70_Y	1.345	1.00
127_G	160_S	1.333	1.00
122_D	167_D	1.328	1.00
55_I	74_A	1.327	1.00
46_K	50_A	1.324	1.00
45_R	48_A	1.323	1.00
303_L	347_S	1.309	1.00
309_L	337_S	1.296	1.00
192_Q	223_N	1.292	1.00
219_V	223_N	1.288	1.00
258_L	261_L	1.285	1.00
10_L	52_Y	1.282	1.00
310_Q	314_E	1.282	1.00
108_D	222_N	1.281	1.00
240_N	295_D	1.280	1.00
150_Y	221_K	1.275	1.00
112_R	223_N	1.273	1.00
117_I	124_W	1.270	1.00
129_S	159_W	1.264	1.00
146_D	151_F	1.261	1.00
175_T	184_T	1.260	1.00
113_Y	168_Y	1.253	1.00
21_S	24_G	1.253	1.00
172_L	185_M	1.250	1.00
286_I	290_K	1.243	1.00
256_I	334_M	1.240	1.00
109_Q	113_Y	1.237	1.00
144_A	186_F	1.236	1.00
110_K	114_L	1.223	1.00
153_V	186_F	1.218	1.00
145_E	152_L	1.213	1.00
7_R	73_I	1.212	1.00
9_K	50_A	1.210	1.00
171_L	188_L	1.209	1.00
272_D	277_L	1.207	1.00
124_W	168_Y	1.204	1.00
190_M	197_V	1.203	1.00
314_E	341_T	1.200	1.00
57_W	118_L	1.199	1.00
286_I	289_R	1.196	1.00
127_G	169_M	1.185	1.00
103_K	237_T	1.183	1.00
338_R	341_T	1.180	1.00
299_S	350_L	1.179	1.00
146_D	149_D	1.174	1.00
280_F	319_N	1.174	1.00
287_K	312_I	1.168	1.00
172_L	183_L	1.164	1.00
76_E	255_K	1.157	1.00
195_I	217_V	1.155	1.00
316_A	331_Y	1.150	1.00
48_A	53_L	1.148	1.00
308_L	311_R	1.139	1.00
45_R	121_E	1.138	1.00
108_D	111_R	1.118	1.00
242_E	344_G	1.113	1.00
144_A	173_A	1.113	1.00
303_L	351_R	1.110	1.00
277_L	281_Y	1.107	1.00
35_D	202_Q	1.107	1.00
151_F	175_T	1.098	1.00
127_G	214_F	1.087	1.00
283_R	348_E	1.075	1.00
42_S	45_R	1.069	1.00
232_W	236_M	1.066	1.00
286_I	351_R	1.064	1.00
97_V	124_W	1.063	1.00
313_Y	337_S	1.062	1.00
310_Q	335_L	1.061	1.00
194_G	217_V	1.061	1.00
60_E	111_R	1.059	1.00
158_I	211_T	1.053	1.00
105_G	109_Q	1.052	1.00
9_K	52_Y	1.046	1.00
250_M	340_R	1.043	1.00
171_L	214_F	1.041	1.00
42_S	46_K	1.037	1.00
307_E	311_R	1.035	1.00
142_T	153_V	1.034	1.00
168_Y	189_N	1.032	1.00
341_T	347_S	1.026	1.00
143_R	154_N	1.025	1.00
11_R	15_R	1.024	1.00
287_K	315_I	1.022	1.00
136_D	139_S	1.021	1.00
69_I	73_I	1.020	1.00
104_H	234_V	1.019	1.00
317_V	335_L	1.013	1.00
294_I	297_E	1.009	1.00
169_M	195_I	1.007	1.00
151_F	228_V	1.006	1.00
57_W	98_A	1.002	1.00
79_I	86_G	1.000	1.00
186_F	224_V	0.996	1.00
145_E	216_N	0.994	1.00
253_T	309_L	0.991	1.00
109_Q	223_N	0.991	1.00
13_W	46_K	0.987	1.00
278_E	282_R	0.984	1.00
290_K	308_L	0.970	1.00
265_K	275_E	0.963	1.00
56_T	71_E	0.960	1.00
277_L	280_F	0.956	1.00
145_E	176_G	0.955	1.00
112_R	189_N	0.954	1.00
122_D	168_Y	0.949	1.00
257_A	334_M	0.946	1.00
184_T	228_V	0.946	1.00
218_K	221_K	0.946	1.00
253_T	334_M	0.942	1.00
153_V	171_L	0.941	1.00
150_Y	220_P	0.941	1.00
306_S	347_S	0.940	1.00
60_E	107_E	0.939	1.00
153_V	219_V	0.933	1.00
254_S	308_L	0.933	1.00
39_E	42_S	0.932	1.00
197_V	212_V	0.931	1.00
10_L	14_I	0.922	1.00
193_E	218_K	0.922	1.00
58_P	61_Y	0.921	1.00
7_R	11_R	0.920	1.00
167_D	191_K	0.919	1.00
304_L	308_L	0.917	1.00
174_R	183_L	0.916	1.00
169_M	212_V	0.912	1.00
204_T	335_L	0.912	1.00
109_Q	187_I	0.912	1.00
170_I	185_M	0.910	1.00
280_F	284_I	0.908	1.00
340_R	343_A	0.908	1.00
14_I	18_A	0.902	1.00
335_L	338_R	0.900	1.00
347_S	351_R	0.900	1.00
10_L	74_A	0.899	1.00
195_I	212_V	0.898	1.00
264_V	275_E	0.896	1.00
307_E	351_R	0.894	1.00
259_E	262_K	0.892	1.00
314_E	335_L	0.882	1.00
159_W	323_E	0.878	1.00
15_R	80_R	0.877	1.00
206_K	339_G	0.876	1.00
274_V	277_L	0.875	1.00
281_Y	352_N	0.875	1.00
313_Y	334_M	0.873	1.00
339_G	343_A	0.873	1.00
125_C	166_A	0.872	1.00
176_G	182_G	0.870	1.00
311_R	314_E	0.868	1.00
163_A	197_V	0.868	1.00
13_W	50_A	0.865	1.00
159_W	326_M	0.864	1.00
310_Q	338_R	0.861	1.00
153_V	173_A	0.858	1.00
264_V	284_I	0.856	1.00
73_I	77_E	0.855	1.00
278_E	281_Y	0.854	1.00
296_V	357_R	0.852	1.00
224_V	227_N	0.848	1.00
151_F	224_V	0.846	1.00
214_F	217_V	0.844	1.00
97_V	170_I	0.842	1.00
307_E	341_T	0.836	1.00
43_W	46_K	0.835	1.00
140_V	172_L	0.834	1.00
257_A	316_A	0.834	1.00
144_A	151_F	0.832	1.00
247_G	301_L	0.831	1.00
22_L	25_R	0.829	1.00
14_I	78_F	0.829	1.00
13_W	17_S	0.824	1.00
125_C	190_M	0.823	1.00
289_R	300_M	0.823	1.00
263_G	323_E	0.823	1.00
43_W	85_Y	0.823	1.00
280_F	283_R	0.820	1.00
260_S	319_N	0.820	1.00
192_Q	195_I	0.819	1.00
9_K	12_E	0.818	1.00
186_F	219_V	0.818	1.00
106_N	110_K	0.816	1.00
262_K	265_K	0.813	1.00
290_K	304_L	0.809	1.00
168_Y	187_I	0.807	1.00
41_R	167_D	0.806	1.00
256_I	259_E	0.802	1.00
128_F	239_L	0.801	1.00
61_Y	107_E	0.800	1.00
41_R	165_I	0.797	1.00
127_G	212_V	0.797	1.00
15_R	19_P	0.797	1.00
230_D	234_V	0.793	1.00
167_D	190_M	0.792	1.00
285_L	289_R	0.784	1.00
270_L	277_L	0.783	1.00
174_R	177_E	0.780	1.00
317_V	331_Y	0.779	1.00
260_S	320_Y	0.779	1.00
282_R	352_N	0.774	1.00
176_G	229_G	0.774	1.00
246_L	344_G	0.774	1.00
308_L	312_I	0.773	1.00
38_N	41_R	0.773	1.00
22_L	26_K	0.772	1.00
144_A	175_T	0.770	1.00
127_G	171_L	0.770	1.00
204_T	332_L	0.769	1.00
275_E	278_E	0.768	1.00
177_E	181_K	0.765	1.00
98_A	117_I	0.764	1.00
143_R	177_E	0.764	1.00
317_V	324_T	0.762	1.00
135_S	349_I	0.761	1.00
290_K	315_I	0.759	1.00
80_R	256_I	0.756	1.00
289_R	303_L	0.753	1.00
12_E	15_R	0.752	1.00
164_H	208_D	0.752	1.00
184_T	229_G	0.750	1.00
282_R	286_I	0.748	1.00
275_E	281_Y	0.747	1.00
330_W	334_M	0.746	1.00
288_L	300_M	0.740	1.00
191_K	195_I	0.738	1.00
247_G	305_A	0.737	1.00
174_R	182_G	0.737	1.00
60_E	110_K	0.735	1.00
320_Y	331_Y	0.735	1.00
352_N	356_E	0.730	1.00
156_Q	198_S	0.730	1.00
60_E	63_G	0.729	1.00
55_I	66_L	0.729	1.00
113_Y	223_N	0.727	1.00
47_L	52_Y	0.725	1.00
165_I	208_D	0.724	1.00
140_V	183_L	0.722	1.00
253_T	337_S	0.720	1.00
19_P	22_L	0.719	1.00
13_W	47_L	0.717	1.00
313_Y	335_L	0.717	1.00
289_R	304_L	0.716	1.00
15_R	81_A	0.714	1.00
113_Y	187_I	0.711	1.00
142_T	157_K	0.708	1.00
172_L	235_A	0.708	1.00
175_T	182_G	0.707	1.00
283_R	286_I	0.700	1.00
150_Y	222_N	0.695	1.00
143_R	176_G	0.693	1.00
142_T	155_G	0.691	1.00
350_L	353_V	0.690	1.00
250_M	306_S	0.687	1.00
21_S	26_K	0.686	1.00
273_E	277_L	0.685	1.00
160_S	212_V	0.684	1.00
277_L	284_I	0.682	1.00
100_A	238_V	0.682	1.00
113_Y	122_D	0.674	1.00
291_G	294_I	0.672	1.00
175_T	228_V	0.672	1.00
38_N	42_S	0.671	1.00
41_R	123_I	0.669	1.00
57_W	61_Y	0.667	1.00
260_S	264_V	0.664	1.00
293_D	297_E	0.662	1.00
102_L	110_K	0.661	1.00
313_Y	331_Y	0.660	1.00
309_L	313_Y	0.658	1.00
142_T	171_L	0.658	1.00
283_R	319_N	0.657	1.00
256_I	330_W	0.656	1.00
281_Y	284_I	0.655	1.00
131_P	156_Q	0.655	1.00
126_Q	235_A	0.654	1.00
18_A	21_S	0.651	1.00
146_D	152_L	0.650	1.00
54_G	118_L	0.650	1.00
99_P	103_K	0.648	1.00
179_K	182_G	0.647	1.00
100_A	104_H	0.646	1.00
248_V	252_F	0.645	1.00
330_W	333_G	0.645	1.00
130_E	142_T	0.644	1.00
264_V	274_V	0.643	1.00
7_R	76_E	0.643	1.00
188_L	214_F	0.641	1.00
318_M	338_R	0.638	1.00
228_V	231_G	0.636	1.00
221_K	228_V	0.635	1.00
310_Q	337_S	0.632	1.00
206_K	343_A	0.631	1.00
281_Y	355_G	0.629	1.00
168_Y	223_N	0.629	1.00
109_Q	112_R	0.629	1.00
233_K	237_T	0.627	1.00
170_I	225_I	0.627	1.00
105_G	110_K	0.626	1.00
17_S	21_S	0.623	1.00
60_E	65_G	0.622	1.00
261_L	284_I	0.622	1.00
268_E	272_D	0.620	1.00
47_L	85_Y	0.619	1.00
73_I	76_E	0.617	1.00
273_E	281_Y	0.616	1.00
197_V	210_N	0.616	1.00
346_T	349_I	0.616	1.00
117_I	168_Y	0.615	1.00
148_G	218_K	0.615	1.00
87_R	206_K	0.614	1.00
240_N	298_G	0.614	1.00
276_G	281_Y	0.614	1.00
54_G	64_Q	0.612	1.00
11_R	80_R	0.609	1.00
14_I	17_S	0.604	1.00
21_S	42_S	0.602	1.00
300_M	354_V	0.600	1.00
255_K	288_L	0.600	1.00
99_P	102_L	0.600	1.00
286_I	315_I	0.599	1.00
140_V	174_R	0.597	1.00
112_R	115_P	0.595	1.00
200_I	211_T	0.595	1.00
142_T	173_A	0.595	1.00
204_T	336_A	0.594	1.00
148_G	152_L	0.589	1.00
128_F	137_L	0.588	1.00
279_A	283_R	0.588	1.00
258_L	288_L	0.587	1.00
128_F	172_L	0.587	1.00
92_I	96_V	0.586	1.00
251_L	255_K	0.582	1.00
71_E	245_M	0.580	1.00
187_I	225_I	0.580	1.00
173_A	184_T	0.580	1.00
287_K	290_K	0.580	1.00
195_I	214_F	0.577	1.00
142_T	214_F	0.576	1.00
71_E	95_M	0.576	1.00
285_L	288_L	0.575	1.00
9_K	64_Q	0.573	1.00
133_A	141_T	0.572	1.00
184_T	226_G	0.571	1.00
267_K	270_L	0.570	1.00
323_E	326_M	0.568	1.00
17_S	50_A	0.568	1.00
123_I	165_I	0.567	1.00
35_D	38_N	0.565	1.00
163_A	212_V	0.564	1.00
269_E	274_V	0.564	1.00
174_R	180_Y	0.563	1.00
254_S	309_L	0.563	1.00
227_N	234_V	0.562	1.00
171_L	217_V	0.561	1.00
18_A	43_W	0.561	1.00
303_L	307_E	0.558	1.00
37_Y	202_Q	0.556	1.00
37_Y	40_L	0.555	1.00
72_V	244_F	0.555	1.00
35_D	327_K	0.554	1.00
188_L	217_V	0.554	1.00
239_L	243_R	0.554	1.00
93_G	97_V	0.554	1.00
257_A	260_S	0.553	1.00
191_K	197_V	0.552	1.00
202_Q	328_E	0.552	1.00
153_V	188_L	0.546	1.00
147_K	221_K	0.546	1.00
303_L	350_L	0.543	1.00
83_L	253_T	0.543	1.00
322_L	325_I	0.538	1.00
329_K	332_L	0.537	1.00
125_C	160_S	0.536	1.00
57_W	102_L	0.536	1.00
94_L	98_A	0.536	1.00
199_P	210_N	0.536	1.00
160_S	163_A	0.535	1.00
263_G	329_K	0.535	1.00
93_G	117_I	0.534	1.00
175_T	186_F	0.533	1.00
98_A	114_L	0.532	1.00
59_K	64_Q	0.530	1.00
237_T	241_H	0.529	1.00
287_K	316_A	0.529	1.00
299_S	353_V	0.528	1.00
286_I	311_R	0.528	1.00
19_P	81_A	0.526	1.00
274_V	281_Y	0.526	1.00
101_I	105_G	0.526	1.00
326_M	329_K	0.526	1.00
239_L	242_E	0.525	1.00
300_M	304_L	0.525	1.00
338_R	342_I	0.524	1.00
103_K	241_H	0.523	1.00
164_H	197_V	0.522	1.00
75_Y	79_I	0.520	1.00
268_E	276_G	0.519	1.00
41_R	44_Q	0.518	1.00
263_G	266_E	0.518	1.00
161_S	209_F	0.516	1.00
8_L	15_R	0.516	1.00
204_T	325_I	0.514	1.00
177_E	182_G	0.514	1.00
349_I	352_N	0.513	1.00
306_S	340_R	0.513	1.00
113_Y	116_R	0.511	1.00
14_I	19_P	0.511	1.00
100_A	234_V	0.510	1.00
278_E	289_R	0.510	1.00
333_G	336_A	0.509	1.00
254_S	257_A	0.509	1.00
268_E	271_E	0.507	1.00
58_P	63_G	0.507	1.00
75_Y	245_M	0.505	1.00
23_K	330_W	0.504	1.00
97_V	117_I	0.503	1.00
186_F	221_K	0.501	1.00
320_Y	329_K	0.501	1.00
303_L	354_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4l1fA	4	0.9697	100	0.146	Contact Map
2z1qA	2	0.9642	100	0.153	Contact Map
3p4tA	4	0.9725	100	0.155	Contact Map
2jifA	4	0.9697	100	0.155	Contact Map
1rx0A	4	0.9669	100	0.156	Contact Map
1ivhA	4	0.9697	100	0.157	Contact Map
3ii9A	4	0.9697	100	0.157	Contact Map
2d29A	4	0.9697	100	0.158	Contact Map
4p13A	4	0.9725	100	0.158	Contact Map
3owaA	3	0.9669	100	0.158	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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