GREMLIN Database
Q97YZ6 - Acyl-CoA dehydrogenase (Acd-1)
UniProt: Q97YZ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (342)
Sequences: 33222 (18786)
Seq/√Len: 1015.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_Y218_K4.4951.00
154_N216_N3.6131.00
146_D221_K3.2391.00
116_R121_E3.1531.00
17_S46_K3.0271.00
196_R215_N2.9941.00
107_E111_R2.9251.00
67_D70_Y2.8781.00
116_R122_D2.8511.00
290_K311_R2.6511.00
156_Q213_Y2.5671.00
147_K218_K2.4841.00
283_R315_I2.3221.00
262_K266_E2.2791.00
11_R77_E2.2261.00
227_N230_D2.2211.00
230_D233_K2.2151.00
12_E16_N2.1601.00
184_T224_V2.1431.00
156_Q211_T2.0981.00
327_K332_L2.0811.00
107_E110_K2.0541.00
332_L336_A2.0531.00
273_E276_G2.0361.00
169_M190_M2.0241.00
58_P102_L1.9801.00
173_A186_F1.9271.00
46_K49_D1.9091.00
106_N109_Q1.8681.00
163_A210_N1.8611.00
45_R49_D1.8601.00
264_V319_N1.8521.00
125_C169_M1.8491.00
307_E347_S1.8291.00
147_K150_Y1.8181.00
196_R213_Y1.8151.00
80_R259_E1.8131.00
21_S25_R1.7891.00
77_E80_R1.7801.00
152_L218_K1.7771.00
198_S213_Y1.7701.00
279_A282_R1.7701.00
151_F186_F1.7601.00
272_D276_G1.7581.00
147_K152_L1.7481.00
145_E154_N1.7241.00
59_K65_G1.7221.00
152_L216_N1.7101.00
112_R222_N1.7001.00
189_N223_N1.6831.00
24_G36_D1.6671.00
112_R116_R1.6511.00
198_S211_T1.6401.00
255_K259_E1.6401.00
164_H210_N1.6391.00
268_E273_E1.6321.00
111_R115_P1.6261.00
192_Q217_V1.6231.00
310_Q341_T1.6191.00
41_R45_R1.5931.00
220_P223_N1.5881.00
311_R315_I1.5821.00
323_E329_K1.5821.00
149_D221_K1.5381.00
261_L265_K1.5381.00
257_A313_Y1.5201.00
104_H237_T1.5061.00
116_R119_R1.4991.00
151_F221_K1.4891.00
108_D112_R1.4881.00
221_K224_V1.4861.00
189_N192_Q1.4811.00
202_Q327_K1.4801.00
130_E157_K1.4781.00
224_V228_V1.4751.00
115_P119_R1.4631.00
82_G85_Y1.4591.00
80_R255_K1.4551.00
269_E277_L1.4541.00
146_D228_V1.4521.00
8_L12_E1.4521.00
146_D150_Y1.4521.00
314_E338_R1.4411.00
264_V280_F1.4321.00
154_N215_N1.4181.00
149_D218_K1.4161.00
260_S316_A1.3901.00
14_I81_A1.3881.00
132_Q141_T1.3661.00
72_V248_V1.3611.00
7_R77_E1.3601.00
61_Y110_K1.3551.00
190_M195_I1.3501.00
254_S312_I1.3501.00
66_L70_Y1.3451.00
127_G160_S1.3331.00
122_D167_D1.3281.00
55_I74_A1.3271.00
46_K50_A1.3241.00
45_R48_A1.3231.00
303_L347_S1.3091.00
309_L337_S1.2961.00
192_Q223_N1.2921.00
219_V223_N1.2881.00
258_L261_L1.2851.00
10_L52_Y1.2821.00
310_Q314_E1.2821.00
108_D222_N1.2811.00
240_N295_D1.2801.00
150_Y221_K1.2751.00
112_R223_N1.2731.00
117_I124_W1.2701.00
129_S159_W1.2641.00
146_D151_F1.2611.00
175_T184_T1.2601.00
113_Y168_Y1.2531.00
21_S24_G1.2531.00
172_L185_M1.2501.00
286_I290_K1.2431.00
256_I334_M1.2401.00
109_Q113_Y1.2371.00
144_A186_F1.2361.00
110_K114_L1.2231.00
153_V186_F1.2181.00
145_E152_L1.2131.00
7_R73_I1.2121.00
9_K50_A1.2101.00
171_L188_L1.2091.00
272_D277_L1.2071.00
124_W168_Y1.2041.00
190_M197_V1.2031.00
314_E341_T1.2001.00
57_W118_L1.1991.00
286_I289_R1.1961.00
127_G169_M1.1851.00
103_K237_T1.1831.00
338_R341_T1.1801.00
299_S350_L1.1791.00
146_D149_D1.1741.00
280_F319_N1.1741.00
287_K312_I1.1681.00
172_L183_L1.1641.00
76_E255_K1.1571.00
195_I217_V1.1551.00
316_A331_Y1.1501.00
48_A53_L1.1481.00
308_L311_R1.1391.00
45_R121_E1.1381.00
108_D111_R1.1181.00
242_E344_G1.1131.00
144_A173_A1.1131.00
303_L351_R1.1101.00
277_L281_Y1.1071.00
35_D202_Q1.1071.00
151_F175_T1.0981.00
127_G214_F1.0871.00
283_R348_E1.0751.00
42_S45_R1.0691.00
232_W236_M1.0661.00
286_I351_R1.0641.00
97_V124_W1.0631.00
313_Y337_S1.0621.00
310_Q335_L1.0611.00
194_G217_V1.0611.00
60_E111_R1.0591.00
158_I211_T1.0531.00
105_G109_Q1.0521.00
9_K52_Y1.0461.00
250_M340_R1.0431.00
171_L214_F1.0411.00
42_S46_K1.0371.00
307_E311_R1.0351.00
142_T153_V1.0341.00
168_Y189_N1.0321.00
341_T347_S1.0261.00
143_R154_N1.0251.00
11_R15_R1.0241.00
287_K315_I1.0221.00
136_D139_S1.0211.00
69_I73_I1.0201.00
104_H234_V1.0191.00
317_V335_L1.0131.00
294_I297_E1.0091.00
169_M195_I1.0071.00
151_F228_V1.0061.00
57_W98_A1.0021.00
79_I86_G1.0001.00
186_F224_V0.9961.00
145_E216_N0.9941.00
253_T309_L0.9911.00
109_Q223_N0.9911.00
13_W46_K0.9871.00
278_E282_R0.9841.00
290_K308_L0.9701.00
265_K275_E0.9631.00
56_T71_E0.9601.00
277_L280_F0.9561.00
145_E176_G0.9551.00
112_R189_N0.9541.00
122_D168_Y0.9491.00
257_A334_M0.9461.00
184_T228_V0.9461.00
218_K221_K0.9461.00
253_T334_M0.9421.00
153_V171_L0.9411.00
150_Y220_P0.9411.00
306_S347_S0.9401.00
60_E107_E0.9391.00
153_V219_V0.9331.00
254_S308_L0.9331.00
39_E42_S0.9321.00
197_V212_V0.9311.00
10_L14_I0.9221.00
193_E218_K0.9221.00
58_P61_Y0.9211.00
7_R11_R0.9201.00
167_D191_K0.9191.00
304_L308_L0.9171.00
174_R183_L0.9161.00
169_M212_V0.9121.00
204_T335_L0.9121.00
109_Q187_I0.9121.00
170_I185_M0.9101.00
280_F284_I0.9081.00
340_R343_A0.9081.00
14_I18_A0.9021.00
335_L338_R0.9001.00
347_S351_R0.9001.00
10_L74_A0.8991.00
195_I212_V0.8981.00
264_V275_E0.8961.00
307_E351_R0.8941.00
259_E262_K0.8921.00
314_E335_L0.8821.00
159_W323_E0.8781.00
15_R80_R0.8771.00
206_K339_G0.8761.00
274_V277_L0.8751.00
281_Y352_N0.8751.00
313_Y334_M0.8731.00
339_G343_A0.8731.00
125_C166_A0.8721.00
176_G182_G0.8701.00
311_R314_E0.8681.00
163_A197_V0.8681.00
13_W50_A0.8651.00
159_W326_M0.8641.00
310_Q338_R0.8611.00
153_V173_A0.8581.00
264_V284_I0.8561.00
73_I77_E0.8551.00
278_E281_Y0.8541.00
296_V357_R0.8521.00
224_V227_N0.8481.00
151_F224_V0.8461.00
214_F217_V0.8441.00
97_V170_I0.8421.00
307_E341_T0.8361.00
43_W46_K0.8351.00
140_V172_L0.8341.00
257_A316_A0.8341.00
144_A151_F0.8321.00
247_G301_L0.8311.00
22_L25_R0.8291.00
14_I78_F0.8291.00
13_W17_S0.8241.00
125_C190_M0.8231.00
289_R300_M0.8231.00
263_G323_E0.8231.00
43_W85_Y0.8231.00
280_F283_R0.8201.00
260_S319_N0.8201.00
192_Q195_I0.8191.00
9_K12_E0.8181.00
186_F219_V0.8181.00
106_N110_K0.8161.00
262_K265_K0.8131.00
290_K304_L0.8091.00
168_Y187_I0.8071.00
41_R167_D0.8061.00
256_I259_E0.8021.00
128_F239_L0.8011.00
61_Y107_E0.8001.00
41_R165_I0.7971.00
127_G212_V0.7971.00
15_R19_P0.7971.00
230_D234_V0.7931.00
167_D190_M0.7921.00
285_L289_R0.7841.00
270_L277_L0.7831.00
174_R177_E0.7801.00
317_V331_Y0.7791.00
260_S320_Y0.7791.00
282_R352_N0.7741.00
176_G229_G0.7741.00
246_L344_G0.7741.00
308_L312_I0.7731.00
38_N41_R0.7731.00
22_L26_K0.7721.00
144_A175_T0.7701.00
127_G171_L0.7701.00
204_T332_L0.7691.00
275_E278_E0.7681.00
177_E181_K0.7651.00
98_A117_I0.7641.00
143_R177_E0.7641.00
317_V324_T0.7621.00
135_S349_I0.7611.00
290_K315_I0.7591.00
80_R256_I0.7561.00
289_R303_L0.7531.00
12_E15_R0.7521.00
164_H208_D0.7521.00
184_T229_G0.7501.00
282_R286_I0.7481.00
275_E281_Y0.7471.00
330_W334_M0.7461.00
288_L300_M0.7401.00
191_K195_I0.7381.00
247_G305_A0.7371.00
174_R182_G0.7371.00
60_E110_K0.7351.00
320_Y331_Y0.7351.00
352_N356_E0.7301.00
156_Q198_S0.7301.00
60_E63_G0.7291.00
55_I66_L0.7291.00
113_Y223_N0.7271.00
47_L52_Y0.7251.00
165_I208_D0.7241.00
140_V183_L0.7221.00
253_T337_S0.7201.00
19_P22_L0.7191.00
13_W47_L0.7171.00
313_Y335_L0.7171.00
289_R304_L0.7161.00
15_R81_A0.7141.00
113_Y187_I0.7111.00
142_T157_K0.7081.00
172_L235_A0.7081.00
175_T182_G0.7071.00
283_R286_I0.7001.00
150_Y222_N0.6951.00
143_R176_G0.6931.00
142_T155_G0.6911.00
350_L353_V0.6901.00
250_M306_S0.6871.00
21_S26_K0.6861.00
273_E277_L0.6851.00
160_S212_V0.6841.00
277_L284_I0.6821.00
100_A238_V0.6821.00
113_Y122_D0.6741.00
291_G294_I0.6721.00
175_T228_V0.6721.00
38_N42_S0.6711.00
41_R123_I0.6691.00
57_W61_Y0.6671.00
260_S264_V0.6641.00
293_D297_E0.6621.00
102_L110_K0.6611.00
313_Y331_Y0.6601.00
309_L313_Y0.6581.00
142_T171_L0.6581.00
283_R319_N0.6571.00
256_I330_W0.6561.00
281_Y284_I0.6551.00
131_P156_Q0.6551.00
126_Q235_A0.6541.00
18_A21_S0.6511.00
146_D152_L0.6501.00
54_G118_L0.6501.00
99_P103_K0.6481.00
179_K182_G0.6471.00
100_A104_H0.6461.00
248_V252_F0.6451.00
330_W333_G0.6451.00
130_E142_T0.6441.00
264_V274_V0.6431.00
7_R76_E0.6431.00
188_L214_F0.6411.00
318_M338_R0.6381.00
228_V231_G0.6361.00
221_K228_V0.6351.00
310_Q337_S0.6321.00
206_K343_A0.6311.00
281_Y355_G0.6291.00
168_Y223_N0.6291.00
109_Q112_R0.6291.00
233_K237_T0.6271.00
170_I225_I0.6271.00
105_G110_K0.6261.00
17_S21_S0.6231.00
60_E65_G0.6221.00
261_L284_I0.6221.00
268_E272_D0.6201.00
47_L85_Y0.6191.00
73_I76_E0.6171.00
273_E281_Y0.6161.00
197_V210_N0.6161.00
346_T349_I0.6161.00
117_I168_Y0.6151.00
148_G218_K0.6151.00
87_R206_K0.6141.00
240_N298_G0.6141.00
276_G281_Y0.6141.00
54_G64_Q0.6121.00
11_R80_R0.6091.00
14_I17_S0.6041.00
21_S42_S0.6021.00
300_M354_V0.6001.00
255_K288_L0.6001.00
99_P102_L0.6001.00
286_I315_I0.5991.00
140_V174_R0.5971.00
112_R115_P0.5951.00
200_I211_T0.5951.00
142_T173_A0.5951.00
204_T336_A0.5941.00
148_G152_L0.5891.00
128_F137_L0.5881.00
279_A283_R0.5881.00
258_L288_L0.5871.00
128_F172_L0.5871.00
92_I96_V0.5861.00
251_L255_K0.5821.00
71_E245_M0.5801.00
187_I225_I0.5801.00
173_A184_T0.5801.00
287_K290_K0.5801.00
195_I214_F0.5771.00
142_T214_F0.5761.00
71_E95_M0.5761.00
285_L288_L0.5751.00
9_K64_Q0.5731.00
133_A141_T0.5721.00
184_T226_G0.5711.00
267_K270_L0.5701.00
323_E326_M0.5681.00
17_S50_A0.5681.00
123_I165_I0.5671.00
35_D38_N0.5651.00
163_A212_V0.5641.00
269_E274_V0.5641.00
174_R180_Y0.5631.00
254_S309_L0.5631.00
227_N234_V0.5621.00
171_L217_V0.5611.00
18_A43_W0.5611.00
303_L307_E0.5581.00
37_Y202_Q0.5561.00
37_Y40_L0.5551.00
72_V244_F0.5551.00
35_D327_K0.5541.00
188_L217_V0.5541.00
239_L243_R0.5541.00
93_G97_V0.5541.00
257_A260_S0.5531.00
191_K197_V0.5521.00
202_Q328_E0.5521.00
153_V188_L0.5461.00
147_K221_K0.5461.00
303_L350_L0.5431.00
83_L253_T0.5431.00
322_L325_I0.5381.00
329_K332_L0.5371.00
125_C160_S0.5361.00
57_W102_L0.5361.00
94_L98_A0.5361.00
199_P210_N0.5361.00
160_S163_A0.5351.00
263_G329_K0.5351.00
93_G117_I0.5341.00
175_T186_F0.5331.00
98_A114_L0.5321.00
59_K64_Q0.5301.00
237_T241_H0.5291.00
287_K316_A0.5291.00
299_S353_V0.5281.00
286_I311_R0.5281.00
19_P81_A0.5261.00
274_V281_Y0.5261.00
101_I105_G0.5261.00
326_M329_K0.5261.00
239_L242_E0.5251.00
300_M304_L0.5251.00
338_R342_I0.5241.00
103_K241_H0.5231.00
164_H197_V0.5221.00
75_Y79_I0.5201.00
268_E276_G0.5191.00
41_R44_Q0.5181.00
263_G266_E0.5181.00
161_S209_F0.5161.00
8_L15_R0.5161.00
204_T325_I0.5141.00
177_E182_G0.5141.00
349_I352_N0.5131.00
306_S340_R0.5131.00
113_Y116_R0.5111.00
14_I19_P0.5111.00
100_A234_V0.5101.00
278_E289_R0.5101.00
333_G336_A0.5091.00
254_S257_A0.5091.00
268_E271_E0.5071.00
58_P63_G0.5071.00
75_Y245_M0.5051.00
23_K330_W0.5041.00
97_V117_I0.5031.00
186_F221_K0.5011.00
320_Y329_K0.5011.00
303_L354_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l1fA 4 0.9697 100 0.146 Contact Map
2z1qA 2 0.9642 100 0.153 Contact Map
3p4tA 4 0.9725 100 0.155 Contact Map
2jifA 4 0.9697 100 0.155 Contact Map
1rx0A 4 0.9669 100 0.156 Contact Map
1ivhA 4 0.9697 100 0.157 Contact Map
3ii9A 4 0.9697 100 0.157 Contact Map
2d29A 4 0.9697 100 0.158 Contact Map
4p13A 4 0.9725 100 0.158 Contact Map
3owaA 3 0.9669 100 0.158 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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