GREMLIN Database
Q97YZ5 - Monoamine oxidase regulatory protein
UniProt: Q97YZ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 163 (135)
Sequences: 6897 (4527)
Seq/√Len: 389.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_K121_I2.8841.00
70_G113_K2.7251.00
22_F127_K2.6851.00
30_K123_E2.5711.00
37_T117_T2.5651.00
125_T139_T2.3811.00
105_E154_K2.3001.00
126_D137_Y2.2711.00
26_Q29_Q2.2301.00
110_K148_E2.1191.00
123_E139_T1.9691.00
43_V114_I1.9261.00
36_R42_D1.8941.00
60_E64_K1.8611.00
27_V126_D1.7731.00
123_E141_R1.7651.00
143_L149_E1.7421.00
78_T112_V1.7411.00
121_I143_L1.7321.00
121_I141_R1.7021.00
141_R149_E1.6551.00
112_V150_V1.6391.00
39_T42_D1.6331.00
139_T154_K1.6011.00
40_D60_E1.5781.00
61_E64_K1.5741.00
128_K135_R1.5741.00
48_G53_L1.5471.00
40_D71_R1.5111.00
32_E121_I1.5091.00
60_E70_G1.5071.00
144_N148_E1.4991.00
60_E71_R1.4941.00
79_A106_M1.4491.00
38_I81_I1.4341.00
82_A142_T1.4201.00
26_Q127_K1.3851.00
77_L81_I1.3801.00
116_D145_Q1.3281.00
125_T154_K1.3251.00
44_V48_G1.3161.00
27_V127_K1.3081.00
33_S121_I1.3061.00
107_D152_T1.2911.00
35_G117_T1.2671.00
139_T152_T1.2601.00
128_K137_Y1.2361.00
104_L137_Y1.2281.00
47_T74_P1.2161.00
35_G119_R1.2141.00
62_Y65_K1.1981.00
137_Y154_K1.1841.00
113_K116_D1.1811.00
85_L120_A1.1811.00
109_K152_T1.1771.00
40_D44_V1.1641.00
127_K136_V1.1531.00
84_G88_Q1.1521.00
102_T156_E1.1391.00
120_A140_I1.1361.00
104_L154_K1.1151.00
78_T151_M1.1011.00
30_K33_S1.0981.00
112_V118_L1.0971.00
41_A45_I1.0811.00
82_A120_A1.0801.00
55_P62_Y1.0721.00
38_I77_L1.0681.00
45_I48_G1.0621.00
41_A44_V1.0591.00
125_T137_Y1.0561.00
116_D144_N1.0541.00
119_R143_L1.0411.00
57_F75_G1.0201.00
142_T151_M1.0171.00
122_V138_L1.0001.00
42_D45_I0.9891.00
120_A142_T0.9761.00
59_D62_Y0.9691.00
137_Y156_E0.9621.00
53_L58_L0.9491.00
34_K88_Q0.9371.00
103_K106_M0.9231.00
25_F136_V0.9171.00
100_A103_K0.8991.00
47_T58_L0.8961.00
124_V138_L0.8881.00
135_R156_E0.8871.00
61_E65_K0.8851.00
43_V73_I0.8821.00
74_P77_L0.8821.00
22_F129_E0.8761.00
50_T74_P0.8661.00
138_L157_I0.8611.00
41_A48_G0.8591.00
144_N150_V0.8441.00
124_V136_V0.8421.00
28_G123_E0.8241.00
119_R147_G0.8231.00
76_L103_K0.8181.00
76_L83_I0.8171.00
106_M153_L0.8161.00
52_A74_P0.8071.00
113_K146_L0.8051.00
56_L66_T0.8031.00
78_T142_T0.7981.00
32_E119_R0.7951.00
116_D146_L0.7941.00
87_Y90_P0.7921.00
149_E152_T0.7831.00
89_L122_V0.7761.00
102_T105_E0.7751.00
101_L158_L0.7741.00
37_T115_G0.7711.00
76_L79_A0.7671.00
109_K149_E0.7641.00
73_I77_L0.7611.00
110_K144_N0.7611.00
133_D158_L0.7581.00
62_Y66_T0.7551.00
122_V140_I0.7541.00
55_P59_D0.7531.00
127_K134_G0.7501.00
36_R81_I0.7441.00
44_V58_L0.7431.00
117_T145_Q0.7421.00
55_P66_T0.7421.00
104_L107_D0.7401.00
117_T144_N0.7311.00
109_K151_M0.7201.00
54_N62_Y0.7181.00
141_R152_T0.7171.00
129_E132_K0.7161.00
100_A155_M0.7141.00
83_I103_K0.7121.00
29_Q127_K0.7111.00
70_G114_I0.6910.99
71_R114_I0.6880.99
72_I113_K0.6790.99
82_A153_L0.6660.99
144_N147_G0.6640.99
103_K155_M0.6610.99
64_K69_K0.6540.99
68_F111_P0.6520.99
130_R135_R0.6430.99
57_F74_P0.6420.99
76_L80_S0.6420.99
42_D51_G0.6420.99
145_Q148_E0.6400.99
25_F127_K0.6360.99
83_I87_Y0.6350.99
56_L62_Y0.6320.99
25_F29_Q0.6320.99
118_L150_V0.6300.99
52_A57_F0.6270.99
104_L156_E0.6240.99
79_A108_A0.6220.99
82_A140_I0.6190.99
76_L108_A0.6160.99
69_K113_K0.6150.99
64_K67_R0.6140.99
36_R84_G0.6120.99
47_T52_A0.6110.99
45_I50_T0.6110.99
66_T69_K0.6070.99
37_T42_D0.6040.99
64_K70_G0.6000.99
130_R158_L0.5920.98
51_G77_L0.5920.98
143_L147_G0.5900.98
95_G98_F0.5890.98
25_F124_V0.5880.98
82_A151_M0.5870.98
118_L142_T0.5790.98
72_I111_P0.5730.98
98_F133_D0.5710.98
87_Y91_V0.5700.98
45_I49_I0.5700.98
44_V60_E0.5690.98
110_K150_V0.5690.98
39_T44_V0.5660.98
67_R72_I0.5630.98
31_W122_V0.5590.98
36_R77_L0.5550.98
49_I53_L0.5520.98
86_T155_M0.5500.97
140_I153_L0.5480.97
132_K158_L0.5450.97
79_A151_M0.5440.97
101_L135_R0.5400.97
86_T138_L0.5280.97
54_N57_F0.5270.97
75_G78_T0.5250.97
128_K131_E0.5240.97
98_F103_K0.5200.96
50_T77_L0.5190.96
44_V71_R0.5140.96
102_T107_D0.5130.96
50_T57_F0.5100.96
130_R133_D0.5070.96
82_A155_M0.5040.96
57_F63_G0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q6wA 6 0.9018 100 0.275 Contact Map
3exzA 2 0.8589 100 0.276 Contact Map
2bi0A 3 0.8896 100 0.279 Contact Map
4e3eA 3 0.908 100 0.291 Contact Map
4ffuA 6 0.9387 100 0.302 Contact Map
4rv2B 2 0.8344 99.9 0.323 Contact Map
3ir3A 2 0.773 99.9 0.324 Contact Map
4w78B 2 0.7791 99.9 0.328 Contact Map
2c2iA 2 0.8834 99.9 0.331 Contact Map
3k67A 2 0.908 99.9 0.342 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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