GREMLIN Database
Q97YZ4 - Uncharacterized protein
UniProt: Q97YZ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 432 (372)
Sequences: 4987 (4116)
Seq/√Len: 213.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_A133_V3.5551.00
286_K293_F3.4681.00
79_F116_L3.3971.00
265_R269_R3.3211.00
58_Q61_K3.2331.00
47_V50_S3.1251.00
258_V336_N3.1171.00
338_I377_V3.1071.00
56_I143_S3.1031.00
129_V142_I3.0241.00
342_L363_F2.7771.00
55_I167_V2.7421.00
92_D95_S2.7281.00
44_V56_I2.6181.00
28_Y55_I2.6061.00
56_I141_V2.5471.00
33_L62_K2.4911.00
339_F363_F2.3971.00
401_K421_K2.3951.00
30_D34_D2.3151.00
60_V115_F2.2711.00
171_S344_R2.2291.00
57_N76_I2.1881.00
40_L211_L2.1801.00
41_A129_V2.0801.00
363_F377_V2.0401.00
130_R134_D2.0161.00
56_I115_F1.9541.00
394_F398_R1.9521.00
264_F279_Q1.9281.00
283_E287_N1.9001.00
350_N366_K1.8611.00
255_I313_C1.8411.00
227_Y230_I1.8251.00
283_E286_K1.8251.00
254_Y291_I1.8071.00
292_F343_L1.8051.00
65_E111_K1.7971.00
286_K291_I1.7771.00
179_K202_E1.7731.00
273_I278_V1.7711.00
29_S58_Q1.7691.00
43_S162_H1.7461.00
23_G58_Q1.7071.00
293_F309_K1.6971.00
374_I402_A1.6961.00
30_D33_L1.6781.00
297_L364_V1.6761.00
27_E177_E1.6691.00
204_L337_L1.6661.00
312_Y336_N1.6531.00
81_D135_R1.6501.00
390_G394_F1.6271.00
373_E403_Y1.6261.00
224_L321_V1.6141.00
47_V314_I1.6121.00
215_N218_D1.6081.00
405_I423_V1.6081.00
172_F203_Y1.6081.00
364_V374_I1.5791.00
403_Y423_V1.5771.00
375_Y405_I1.5751.00
54_T58_Q1.5561.00
176_L199_L1.5551.00
47_V209_F1.5541.00
292_F314_I1.5441.00
367_V370_E1.5431.00
384_V388_L1.5291.00
50_S167_V1.5241.00
175_F213_V1.5151.00
39_G133_V1.5111.00
352_F366_K1.5031.00
341_E345_R1.5011.00
170_L178_F1.4961.00
294_V312_Y1.4911.00
339_F351_V1.4831.00
228_E232_F1.4791.00
28_Y167_V1.4761.00
282_T311_V1.4711.00
294_V339_F1.4671.00
271_L278_V1.4661.00
224_L227_Y1.4611.00
223_L317_G1.4401.00
27_E173_K1.4341.00
267_I271_L1.4291.00
35_L163_L1.4261.00
45_I289_Y1.4181.00
395_L418_D1.4171.00
172_F196_I1.4161.00
266_K269_R1.4151.00
60_V113_Y1.3961.00
122_I125_W1.3921.00
386_R389_K1.3811.00
36_L59_V1.3671.00
391_I395_L1.3611.00
31_Q34_D1.3601.00
388_L392_E1.3551.00
118_E145_S1.3541.00
250_L281_Y1.3521.00
404_I422_V1.3511.00
245_E249_N1.3471.00
32_L165_L1.3391.00
134_D161_R1.3351.00
341_E344_R1.3291.00
57_N135_R1.3191.00
163_L225_Q1.3141.00
121_K127_G1.3131.00
336_N340_L1.3081.00
93_L96_L1.3081.00
231_I234_D1.2991.00
293_F311_V1.2941.00
58_Q62_K1.2911.00
243_N246_E1.2901.00
204_L333_L1.2821.00
110_S137_E1.2741.00
251_A285_M1.2701.00
25_E62_K1.2621.00
390_G393_E1.2601.00
319_S333_L1.2581.00
225_Q229_D1.2501.00
77_V84_F1.2481.00
166_E289_Y1.2461.00
224_L228_E1.2431.00
275_F279_Q1.2431.00
387_E391_I1.2391.00
200_F337_L1.2371.00
334_F377_V1.2271.00
340_L344_R1.2231.00
29_S33_L1.2061.00
63_L113_Y1.2001.00
380_Q383_D1.1891.00
303_E306_K1.1861.00
246_E273_I1.1801.00
144_G161_R1.1751.00
28_Y165_L1.1721.00
253_F257_N1.1721.00
234_D237_S1.1671.00
330_I379_Y1.1671.00
386_R390_G1.1651.00
129_V140_I1.1641.00
260_N332_S1.1631.00
33_L63_L1.1601.00
339_F343_L1.1601.00
375_Y403_Y1.1521.00
118_E161_R1.1501.00
206_Y212_V1.1471.00
258_V319_S1.1451.00
32_L59_V1.1431.00
172_F175_F1.1431.00
261_K308_D1.1411.00
120_Q144_G1.1381.00
292_F340_L1.1371.00
76_I115_F1.1371.00
33_L37_E1.1281.00
168_F292_F1.1201.00
249_N252_I1.1201.00
395_L402_A1.1141.00
29_S55_I1.1111.00
171_S174_E1.1091.00
160_G360_E1.1051.00
199_L202_E1.0991.00
25_E177_E1.0991.00
219_K222_I1.0941.00
201_S205_S1.0941.00
114_I138_A1.0901.00
264_F282_T1.0841.00
254_Y282_T1.0771.00
384_V387_E1.0761.00
99_L103_L1.0751.00
221_K225_Q1.0731.00
228_E248_K1.0731.00
391_I394_F1.0731.00
387_E390_G1.0731.00
175_F199_L1.0721.00
277_N281_Y1.0711.00
378_T381_L1.0701.00
406_T410_E1.0701.00
201_S330_I1.0701.00
265_R275_F1.0691.00
25_E30_D1.0651.00
203_Y337_L1.0621.00
169_P208_G1.0611.00
175_F202_E1.0591.00
416_G419_L1.0511.00
168_F344_R1.0491.00
41_A142_I1.0481.00
144_G331_G1.0451.00
250_L278_V1.0421.00
231_I237_S1.0331.00
119_V126_E1.0321.00
203_Y208_G1.0311.00
27_E171_S1.0281.00
361_V374_I1.0281.00
25_E29_S1.0271.00
23_G54_T1.0201.00
49_R160_G1.0181.00
223_L227_Y1.0161.00
197_K201_S1.0161.00
50_S209_F1.0151.00
360_E378_T1.0141.00
181_I199_L1.0111.00
342_L351_V1.0111.00
366_K372_R1.0111.00
319_S329_N1.0101.00
28_Y31_Q1.0091.00
198_V202_E1.0091.00
276_R279_Q1.0051.00
114_I140_I1.0051.00
115_F141_V1.0041.00
93_L100_Y1.0001.00
247_A285_M0.9991.00
215_N219_K0.9971.00
294_V351_V0.9951.00
144_G160_G0.9941.00
268_S275_F0.9911.00
44_V167_V0.9881.00
27_E30_D0.9861.00
80_E130_R0.9751.00
294_V353_Y0.9751.00
261_K353_Y0.9751.00
204_L330_I0.9721.00
254_Y311_V0.9701.00
45_I164_I0.9701.00
250_L267_I0.9691.00
272_N275_F0.9651.00
32_L42_I0.9641.00
248_K252_I0.9621.00
172_F199_L0.9611.00
394_F397_I0.9561.00
310_K335_E0.9431.00
75_L78_N0.9380.99
172_F176_L0.9290.99
393_E396_K0.9250.99
34_D218_D0.9220.99
23_G29_S0.9210.99
253_F270_S0.9210.99
320_N333_L0.9190.99
360_E376_Q0.9170.99
124_G127_G0.9170.99
170_L175_F0.9160.99
335_E360_E0.9160.99
331_G378_T0.9160.99
161_R362_D0.9140.99
339_F377_V0.9110.99
179_K199_L0.9100.99
42_I141_V0.9080.99
93_L97_Y0.9070.99
227_Y251_A0.9050.99
406_T409_D0.9040.99
60_V74_T0.9030.99
36_L139_N0.9000.99
237_S240_N0.8980.99
282_T293_F0.8950.99
211_L214_S0.8930.99
331_G335_E0.8930.99
118_E331_G0.8910.99
36_L63_L0.8910.99
389_K393_E0.8890.99
132_I136_K0.8870.99
416_G422_V0.8870.99
392_E395_L0.8850.99
127_G130_R0.8840.99
31_Q221_K0.8790.99
29_S62_K0.8780.99
239_C284_C0.8780.99
80_E131_S0.8770.99
268_S278_V0.8770.99
373_E401_K0.8770.99
60_V65_E0.8770.99
33_L59_V0.8770.99
43_S142_I0.8750.99
173_K177_E0.8730.99
266_K270_S0.8720.99
45_I166_E0.8670.99
136_K139_N0.8630.99
395_L398_R0.8560.99
257_N260_N0.8510.99
212_V226_L0.8500.99
403_Y421_K0.8490.99
214_S218_D0.8460.99
169_P314_I0.8460.99
97_Y101_K0.8450.99
118_E144_G0.8430.99
115_F143_S0.8400.99
365_V373_E0.8390.99
29_S59_V0.8390.99
316_N336_N0.8380.99
393_E397_I0.8380.99
313_C336_N0.8360.99
99_L102_E0.8340.99
95_S99_L0.8320.99
265_R268_S0.8280.99
176_L196_I0.8250.99
212_V223_L0.8220.99
166_E343_L0.8210.99
314_I340_L0.8180.99
64_I74_T0.8160.99
93_L128_F0.8140.99
362_D376_Q0.8140.99
152_K287_N0.8120.98
32_L55_I0.8090.98
134_D157_V0.8080.98
337_L341_E0.8070.98
236_I244_E0.8070.98
159_A229_D0.8060.98
41_A140_I0.8000.98
47_V168_F0.7980.98
79_F122_I0.7950.98
362_D378_T0.7950.98
94_F98_E0.7940.98
107_K110_S0.7930.98
200_F204_L0.7910.98
159_A162_H0.7910.98
116_L140_I0.7880.98
77_V81_D0.7860.98
56_I60_V0.7840.98
312_Y363_F0.7820.98
333_L337_L0.7820.98
33_L36_L0.7810.98
280_R284_C0.7790.98
144_G362_D0.7790.98
44_V55_I0.7790.98
118_E376_Q0.7720.98
417_D420_V0.7720.98
97_Y100_Y0.7720.98
221_K224_L0.7710.98
255_I322_L0.7680.98
85_G127_G0.7680.98
416_G421_K0.7680.98
49_R144_G0.7680.98
296_A307_Y0.7670.98
247_A284_C0.7650.98
95_S98_E0.7640.98
297_L366_K0.7610.98
361_V397_I0.7580.98
39_G225_Q0.7580.98
48_K118_E0.7580.98
247_A250_L0.7580.98
252_I322_L0.7570.98
370_E401_K0.7570.98
246_E271_L0.7560.98
241_I284_C0.7540.98
49_R360_E0.7490.97
292_F339_F0.7490.97
387_E394_F0.7460.97
50_S169_P0.7400.97
31_Q165_L0.7400.97
49_R158_L0.7350.97
38_K163_L0.7320.97
131_S135_R0.7310.97
251_A313_C0.7300.97
391_I404_I0.7300.97
316_N340_L0.7290.97
316_N333_L0.7280.97
348_I365_V0.7280.97
196_I199_L0.7250.97
81_D134_D0.7210.97
316_N320_N0.7200.97
241_I247_A0.7190.97
392_E402_A0.7190.97
116_L129_V0.7150.97
356_G359_G0.7150.97
316_N337_L0.7140.97
175_F178_F0.7140.97
48_K144_G0.7130.97
274_P277_N0.7100.97
232_F252_I0.7090.96
247_A281_Y0.7050.96
159_A237_S0.7020.96
169_P315_D0.7020.96
406_T422_V0.7010.96
366_K369_D0.7000.96
180_N183_L0.6950.96
257_N270_S0.6930.96
113_Y141_V0.6910.96
259_G312_Y0.6890.96
32_L36_L0.6840.96
209_F314_I0.6820.96
395_L419_L0.6820.96
36_L141_V0.6780.95
225_Q228_E0.6770.95
28_Y44_V0.6770.95
249_N279_Q0.6770.95
39_G163_L0.6750.95
253_F267_I0.6740.95
262_I267_I0.6740.95
234_D238_E0.6730.95
268_S271_L0.6700.95
253_F271_L0.6680.95
402_A419_L0.6660.95
160_G378_T0.6650.95
244_E248_K0.6650.95
75_L79_F0.6630.95
81_D131_S0.6620.95
335_E376_Q0.6620.95
318_I322_L0.6610.95
162_H229_D0.6610.95
331_G362_D0.6590.95
79_F125_W0.6580.95
267_I270_S0.6560.95
206_Y213_V0.6560.95
82_S131_S0.6560.95
258_V313_C0.6530.94
211_L215_N0.6530.94
411_G422_V0.6480.94
34_D217_R0.6480.94
383_D408_D0.6480.94
29_S36_L0.6460.94
202_E206_Y0.6450.94
88_R125_W0.6440.94
35_L40_L0.6430.94
127_G156_E0.6420.94
342_L375_Y0.6400.94
42_I163_L0.6400.94
385_E389_K0.6390.94
385_E388_L0.6390.94
174_E177_E0.6390.94
417_D421_K0.6350.94
83_R94_F0.6350.94
156_E238_E0.6320.93
351_V365_V0.6300.93
365_V375_Y0.6300.93
132_I139_N0.6280.93
403_Y408_D0.6280.93
310_K353_Y0.6270.93
297_L352_F0.6270.93
250_L282_T0.6250.93
264_F275_F0.6240.93
254_Y313_C0.6230.93
257_N266_K0.6200.93
116_L119_V0.6200.93
111_K137_E0.6180.93
74_T113_Y0.6180.93
388_L394_F0.6170.93
267_I278_V0.6160.93
334_F407_F0.6150.93
96_L100_Y0.6120.92
261_K264_F0.6110.92
145_S160_G0.6100.92
206_Y216_E0.6100.92
379_Y407_F0.6100.92
295_K309_K0.6080.92
403_Y409_D0.6070.92
285_M291_I0.6040.92
417_D422_V0.6030.92
255_I318_I0.6010.92
227_Y322_L0.6010.92
118_E378_T0.6000.92
75_L100_Y0.6000.92
248_K322_L0.6000.92
94_F128_F0.5970.91
410_E422_V0.5960.91
291_I311_V0.5960.91
259_G262_I0.5950.91
81_D84_F0.5940.91
118_E360_E0.5940.91
92_D96_L0.5930.91
42_I139_N0.5930.91
130_R148_S0.5920.91
323_G326_L0.5910.91
163_L229_D0.5890.91
386_R394_F0.5880.91
212_V222_I0.5870.91
230_I317_G0.5860.91
82_S85_G0.5860.91
383_D387_E0.5840.90
171_S175_F0.5840.90
363_F375_Y0.5800.90
78_N134_D0.5800.90
98_E102_E0.5800.90
209_F212_V0.5780.90
411_G416_G0.5780.90
76_I79_F0.5770.90
217_R220_E0.5770.90
250_L271_L0.5760.90
152_K155_R0.5740.90
170_L210_P0.5720.90
46_G51_G0.5710.89
226_L230_I0.5700.89
119_V125_W0.5680.89
312_Y339_F0.5680.89
90_A124_G0.5670.89
215_N222_I0.5670.89
338_I405_I0.5660.89
216_E220_E0.5650.89
60_V76_I0.5650.89
231_I235_V0.5650.89
98_E101_K0.5640.89
232_F236_I0.5640.89
126_E156_E0.5610.89
390_G395_L0.5590.88
388_L395_L0.5590.88
406_T411_G0.5590.88
88_R93_L0.5580.88
43_S164_I0.5570.88
42_I165_L0.5560.88
235_V239_C0.5550.88
60_V63_L0.5520.88
82_S86_D0.5510.88
178_F213_V0.5500.88
78_N81_D0.5500.88
153_S156_E0.5490.88
63_L74_T0.5480.88
96_L122_I0.5470.87
147_A151_N0.5470.87
168_F343_L0.5450.87
176_L203_Y0.5420.87
354_Y398_R0.5420.87
335_E378_T0.5380.87
153_S238_E0.5360.86
302_S305_A0.5360.86
40_L133_V0.5330.86
391_I398_R0.5330.86
218_D221_K0.5320.86
118_E335_E0.5310.86
269_R275_F0.5310.86
49_R178_F0.5300.86
47_V53_S0.5300.86
54_T57_N0.5290.86
34_D37_E0.5280.86
170_L174_E0.5280.86
408_D411_G0.5260.85
121_K157_V0.5260.85
374_I395_L0.5260.85
146_T150_N0.5250.85
266_K302_S0.5240.85
166_E314_I0.5220.85
49_R161_R0.5210.85
300_K303_E0.5200.85
356_G393_E0.5190.85
169_P209_F0.5180.84
395_L400_T0.5180.84
343_L351_V0.5180.84
132_I140_I0.5170.84
262_I265_R0.5140.84
59_V165_L0.5130.84
160_G376_Q0.5120.84
294_V363_F0.5120.84
277_N280_R0.5120.84
200_F330_I0.5110.84
128_F132_I0.5110.84
290_L313_C0.5110.84
28_Y174_E0.5080.83
35_L42_I0.5080.83
234_D240_N0.5070.83
302_S306_K0.5060.83
74_T115_F0.5050.83
296_A308_D0.5050.83
304_M352_F0.5050.83
245_E248_K0.5030.83
172_F337_L0.5030.83
298_S303_E0.5030.83
126_E162_H0.5010.82
327_N331_G0.5010.82
264_F278_V0.5010.82
209_F316_N0.5010.82
216_E219_K0.5000.82
418_D422_V0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fnaA 1 0.6458 100 0.694 Contact Map
2qenA 1 0.6528 100 0.703 Contact Map
3pfiA 3 0.6088 99.8 0.795 Contact Map
1hqcA 1 0.6296 99.6 0.82 Contact Map
1w5sA 1 0.7292 99.6 0.825 Contact Map
1fnnA 1 0.7176 99.5 0.83 Contact Map
1in4A 1 0.625 99.4 0.843 Contact Map
1l8qA 1 0.6528 99.3 0.849 Contact Map
4xgcA 1 0.5972 99.3 0.85 Contact Map
2v1uA 1 0.7407 99.2 0.856 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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