GREMLIN Database
Q97YZ3 - Acyl-CoA dehydrogenase related protein (Acd-like1)
UniProt: Q97YZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 266 (252)
Sequences: 29908 (17978)
Seq/√Len: 1132.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_R230_K3.6741.00
90_D144_R3.5161.00
25_E47_K3.2711.00
94_S142_E2.9731.00
195_R234_N2.8741.00
61_G64_N2.8451.00
33_K37_S2.6401.00
88_G147_D2.6061.00
19_N71_I2.5691.00
174_E178_N2.4371.00
89_V144_R2.3111.00
20_E24_R2.2891.00
191_A194_H2.1721.00
176_S238_S2.1711.00
166_T207_R2.1441.00
246_A251_H2.1061.00
96_G139_I2.0141.00
8_N11_L2.0081.00
11_L64_N1.9581.00
242_I248_L1.9401.00
134_R141_G1.9391.00
171_E249_D1.9251.00
47_K50_D1.9171.00
184_K188_S1.8811.00
169_L203_I1.8511.00
109_I128_S1.8351.00
212_V216_S1.8221.00
180_I185_P1.8071.00
89_V92_L1.8001.00
185_P188_S1.7841.00
46_G50_D1.7541.00
181_A189_Y1.7251.00
251_H255_K1.7151.00
206_V224_A1.6911.00
166_T170_K1.6501.00
71_I74_E1.6401.00
230_K234_N1.6191.00
13_L17_S1.6151.00
199_D231_A1.6061.00
13_L16_N1.5991.00
11_L61_G1.5941.00
96_G137_K1.5831.00
74_E170_K1.5731.00
12_E15_K1.5601.00
113_K124_E1.5551.00
128_S133_V1.5531.00
167_A171_E1.5481.00
87_L94_S1.5351.00
16_N20_E1.5141.00
176_S192_I1.5121.00
192_I238_S1.5061.00
173_V177_K1.4921.00
171_E239_H1.4901.00
122_D150_F1.4901.00
171_E174_E1.4771.00
22_L75_N1.4601.00
70_E207_R1.4441.00
91_Y124_E1.4371.00
184_K189_Y1.4251.00
88_G91_Y1.4071.00
15_K71_I1.4011.00
104_D136_Y1.4001.00
49_K54_F1.3981.00
199_D234_N1.3981.00
148_F151_N1.3901.00
147_D150_F1.3861.00
233_L258_I1.3811.00
103_V136_Y1.3691.00
204_E212_V1.3621.00
11_L67_L1.3581.00
165_A203_I1.3371.00
9_E13_L1.3351.00
42_M46_G1.3351.00
130_D133_V1.3251.00
228_A257_V1.3251.00
127_E130_D1.3201.00
212_V215_T1.3181.00
229_F233_L1.3131.00
112_P123_V1.3091.00
91_Y147_D1.3091.00
235_S250_L1.3091.00
169_L173_V1.3041.00
17_S51_L1.2911.00
18_F53_I1.2851.00
60_T64_N1.2691.00
145_K148_F1.2651.00
74_E166_T1.2631.00
229_F254_L1.2531.00
15_K67_L1.2391.00
56_F68_L1.2311.00
140_E143_W1.2301.00
12_E16_N1.2221.00
145_K149_D1.2191.00
159_A210_Y1.2151.00
165_A231_A1.2131.00
46_G49_K1.2111.00
47_K51_L1.2051.00
172_T235_S1.2041.00
200_A204_E1.2041.00
146_S149_D1.1981.00
202_R227_K1.1941.00
129_P133_V1.1921.00
76_L79_G1.1911.00
66_L214_P1.1851.00
92_L144_R1.1791.00
168_V232_I1.1691.00
162_I203_I1.1681.00
206_V227_K1.1621.00
70_E166_T1.1451.00
29_Y34_H1.1401.00
128_S135_V1.1391.00
176_S187_G1.1381.00
19_N23_S1.1221.00
93_V124_E1.1201.00
130_D143_W1.0981.00
9_E12_E1.0961.00
203_I231_A1.0941.00
21_F47_K1.0931.00
208_S212_V1.0881.00
85_S94_S1.0851.00
21_F51_L1.0771.00
226_K230_K1.0751.00
144_R147_D1.0641.00
227_K230_K1.0571.00
63_T215_T1.0491.00
17_S53_I1.0481.00
66_L159_A1.0451.00
164_H228_A1.0431.00
213_N221_F1.0381.00
201_L220_I1.0321.00
162_I210_Y1.0321.00
84_S93_V1.0251.00
43_E46_G1.0211.00
87_L92_L1.0021.00
177_K187_G0.9941.00
168_V235_S0.9861.00
94_S141_G0.9861.00
198_D202_R0.9811.00
90_D147_D0.9791.00
93_V111_T0.9781.00
209_R220_I0.9771.00
176_S196_I0.9741.00
145_K151_N0.9721.00
21_F25_E0.9721.00
161_I260_L0.9711.00
112_P121_V0.9711.00
202_R234_N0.9701.00
22_L72_I0.9681.00
201_L223_H0.9671.00
86_M124_E0.9641.00
167_A253_H0.9561.00
18_F22_L0.9501.00
70_E211_L0.9451.00
73_G80_I0.9391.00
236_I254_L0.9351.00
233_L254_L0.9331.00
111_T126_I0.9291.00
57_I65_A0.9251.00
168_V253_H0.9211.00
99_Y242_I0.9191.00
116_S119_N0.9111.00
99_Y245_T0.9071.00
18_F68_L0.9071.00
165_A227_K0.8991.00
115_I118_K0.8861.00
194_H198_D0.8851.00
200_A220_I0.8821.00
63_T211_L0.8741.00
236_I250_L0.8721.00
43_E47_K0.8701.00
17_S20_E0.8671.00
190_Q194_H0.8661.00
204_E208_S0.8661.00
127_E149_D0.8591.00
82_A112_P0.8571.00
86_M91_Y0.8551.00
29_Y33_K0.8521.00
204_E207_R0.8431.00
129_P132_S0.8421.00
20_E23_S0.8411.00
84_S97_V0.8391.00
15_K19_N0.8381.00
195_R238_S0.8371.00
42_M105_K0.8351.00
173_V196_I0.8331.00
132_S135_V0.8321.00
109_I133_V0.8311.00
164_H253_H0.8281.00
172_T238_S0.8241.00
130_D149_D0.8221.00
91_Y150_F0.8221.00
162_I206_V0.8191.00
125_E129_P0.8181.00
23_S27_N0.8151.00
232_I253_H0.8151.00
134_R139_I0.8101.00
161_I225_Y0.8061.00
139_I142_E0.8041.00
176_S186_I0.8031.00
195_R198_D0.8011.00
172_T239_H0.8001.00
230_K233_L0.7991.00
98_N137_K0.7971.00
11_L63_T0.7951.00
232_I257_V0.7931.00
232_I254_L0.7891.00
170_K174_E0.7851.00
164_H257_V0.7771.00
93_V113_K0.7721.00
198_D234_N0.7701.00
158_S210_Y0.7691.00
22_L26_W0.7671.00
179_R182_F0.7621.00
115_I119_N0.7611.00
23_S75_N0.7601.00
249_D252_L0.7601.00
254_L258_I0.7591.00
48_V53_I0.7591.00
23_S74_E0.7591.00
205_L209_R0.7581.00
131_P135_V0.7561.00
169_L200_A0.7521.00
166_T200_A0.7501.00
174_E177_K0.7501.00
92_L142_E0.7481.00
31_S252_L0.7471.00
108_A127_E0.7471.00
154_I165_A0.7421.00
74_E167_A0.7421.00
236_I243_G0.7411.00
129_P135_V0.7381.00
133_V138_I0.7331.00
202_R205_L0.7301.00
172_T176_S0.7281.00
227_K231_A0.7281.00
42_M107_E0.7271.00
107_E128_S0.7251.00
152_K155_L0.7201.00
199_D235_S0.7151.00
144_R148_F0.7151.00
158_S224_A0.7141.00
198_D230_K0.7121.00
137_K145_K0.7111.00
19_N74_E0.7101.00
204_E209_R0.7091.00
223_H226_K0.7091.00
136_Y139_I0.7081.00
19_N75_N0.7071.00
86_M113_K0.7071.00
56_F60_T0.7061.00
212_V217_P0.7031.00
158_S221_F0.7001.00
210_Y224_A0.7001.00
175_Y242_I0.7001.00
167_A170_K0.6981.00
133_V143_W0.6971.00
192_I195_R0.6941.00
239_H250_L0.6931.00
114_G121_V0.6911.00
186_I189_Y0.6901.00
21_F48_V0.6831.00
146_S151_N0.6831.00
162_I165_A0.6831.00
63_T67_L0.6821.00
192_I196_I0.6811.00
10_D13_L0.6801.00
195_R237_Q0.6801.00
108_A125_E0.6791.00
182_F189_Y0.6791.00
136_Y141_G0.6781.00
189_Y193_K0.6741.00
15_K70_E0.6731.00
27_N30_G0.6721.00
35_E255_K0.6651.00
143_W151_N0.6631.00
252_L256_R0.6591.00
29_Y43_E0.6591.00
36_V246_A0.6571.00
34_H39_D0.6551.00
111_T140_E0.6521.00
109_I138_I0.6521.00
209_R221_F0.6511.00
82_A114_G0.6511.00
159_A163_G0.6461.00
155_L165_A0.6451.00
172_T199_D0.6451.00
229_F258_I0.6431.00
31_S36_V0.6431.00
14_I64_N0.6431.00
146_S150_F0.6421.00
171_E253_H0.6411.00
93_V145_K0.6411.00
114_G120_D0.6381.00
124_E129_P0.6381.00
139_I151_N0.6361.00
124_E150_F0.6311.00
191_A195_R0.6281.00
209_R213_N0.6261.00
87_L142_E0.6261.00
143_W148_F0.6251.00
117_N120_D0.6251.00
116_S120_D0.6241.00
44_V79_G0.6241.00
143_W146_S0.6221.00
8_N64_N0.6221.00
131_P134_R0.6191.00
165_A206_V0.6181.00
228_A232_I0.6171.00
65_A156_L0.6111.00
78_P81_V0.6101.00
33_K36_V0.6091.00
145_K150_F0.6061.00
68_L72_I0.6051.00
88_G92_L0.6031.00
202_R226_K0.6021.00
39_D42_M0.5961.00
249_D253_H0.5931.00
180_I188_S0.5931.00
155_L214_P0.5921.00
198_D201_L0.5911.00
110_V123_V0.5881.00
207_R211_L0.5841.00
222_K225_Y0.5811.00
140_E145_K0.5721.00
26_W29_Y0.5721.00
90_D148_F0.5711.00
155_L159_A0.5711.00
77_L81_V0.5671.00
175_Y178_N0.5671.00
82_A121_V0.5661.00
197_V201_L0.5631.00
67_L70_E0.5601.00
201_L205_L0.5581.00
237_Q258_I0.5581.00
108_A149_D0.5561.00
155_L218_E0.5561.00
166_T203_I0.5561.00
44_V47_K0.5541.00
167_A249_D0.5531.00
199_D238_S0.5521.00
84_S95_V0.5521.00
139_I145_K0.5501.00
90_D146_S0.5471.00
139_I148_F0.5441.00
14_I68_L0.5431.00
71_I75_N0.5421.00
142_E145_K0.5421.00
202_R231_A0.5411.00
16_N23_S0.5391.00
139_I146_S0.5391.00
84_S111_T0.5391.00
69_N73_G0.5391.00
67_L71_I0.5371.00
204_E220_I0.5371.00
10_D64_N0.5351.00
66_L210_Y0.5351.00
103_V135_V0.5311.00
141_G145_K0.5301.00
22_L25_E0.5301.00
189_Y192_I0.5291.00
181_A186_I0.5281.00
26_W44_V0.5261.00
202_R206_V0.5211.00
232_I250_L0.5211.00
77_L80_I0.5191.00
14_I18_F0.5181.00
137_K141_G0.5181.00
136_Y151_N0.5151.00
130_D135_V0.5131.00
165_A168_V0.5111.00
153_V156_L0.5091.00
124_E133_V0.5081.00
97_V222_K0.5081.00
126_I130_D0.5051.00
242_I245_T0.5041.00
241_G244_F0.5031.00
233_L236_I0.5011.00
246_A255_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d29A 4 0.9925 100 0.248 Contact Map
2ix5A 4 0.9962 100 0.258 Contact Map
1bucA 4 0.9887 100 0.26 Contact Map
2jifA 4 0.9925 100 0.264 Contact Map
4p13A 4 0.9962 100 0.265 Contact Map
1ukwA 4 0.9887 100 0.266 Contact Map
4irnA 4 0.9774 100 0.267 Contact Map
4ktoA 4 0.9962 100 0.267 Contact Map
3nf4A 4 0.9925 100 0.268 Contact Map
3pfdA 4 0.9624 100 0.268 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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