GREMLIN Database
Q97YZ2 - Uncharacterized protein
UniProt: Q97YZ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (175)
Sequences: 18144 (13307)
Seq/√Len: 1005.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_T151_S4.5951.00
22_G52_K3.9461.00
56_F67_A3.6031.00
53_S80_G3.0601.00
138_E155_P2.6941.00
137_V154_L2.6371.00
55_I152_I2.5311.00
24_I53_S2.4311.00
133_L136_G2.3631.00
38_I73_F2.3261.00
139_I150_I2.3091.00
83_N129_E2.2411.00
85_G148_D2.1511.00
133_L138_E2.0971.00
78_K126_F2.0851.00
80_G126_F2.0711.00
17_E23_L2.0601.00
181_D184_G2.0171.00
130_E191_N2.0131.00
53_S78_K2.0071.00
154_L157_L2.0061.00
139_I152_I1.9941.00
14_F201_Y1.9931.00
159_A201_Y1.9751.00
26_I57_T1.8981.00
22_G50_K1.8971.00
158_N198_S1.8251.00
23_L46_K1.8061.00
82_D150_I1.7921.00
82_D141_K1.7811.00
138_E153_Y1.6951.00
40_G44_L1.6761.00
51_I77_A1.5871.00
40_G43_R1.5871.00
129_E132_E1.5731.00
14_F161_I1.5431.00
26_I161_I1.5371.00
17_E46_K1.5221.00
86_V90_K1.5151.00
38_I42_T1.5151.00
71_K125_D1.4861.00
22_G53_S1.4531.00
80_G128_L1.4501.00
68_Y72_R1.4281.00
153_Y160_I1.3871.00
140_I153_Y1.3811.00
186_R190_E1.3751.00
24_I55_I1.3741.00
151_S160_I1.3691.00
23_L51_I1.2921.00
67_A79_F1.2921.00
153_Y158_N1.2881.00
144_G188_S1.2801.00
149_S163_G1.2671.00
69_E73_F1.2361.00
184_G187_K1.2141.00
42_T73_F1.2131.00
83_N127_V1.2121.00
191_N194_S1.2071.00
25_L51_I1.2031.00
142_T188_S1.1931.00
86_V127_V1.1921.00
165_T192_I1.1781.00
151_S192_I1.1771.00
35_R39_E1.1661.00
39_E43_R1.1621.00
39_E42_T1.1291.00
128_L150_I1.1271.00
130_E141_K1.0971.00
71_K79_F1.0931.00
140_I191_N1.0851.00
199_M207_S1.0831.00
146_T149_S1.0811.00
57_T163_G1.0631.00
84_N141_K1.0631.00
28_S54_V1.0621.00
26_I152_I1.0461.00
68_Y71_K1.0381.00
41_I51_I1.0361.00
23_L52_K1.0261.00
126_F132_E1.0241.00
81_I85_G1.0221.00
85_G146_T1.0081.00
18_T21_N0.9971.00
183_D187_K0.9651.00
34_G69_E0.9561.00
151_S165_T0.9451.00
190_E193_K0.9361.00
182_F186_R0.9351.00
84_N87_N0.9331.00
28_S67_A0.9191.00
162_V200_V0.9151.00
131_G138_E0.9131.00
182_F185_L0.9131.00
61_V65_G0.9071.00
19_N22_G0.9031.00
34_G66_G0.9021.00
159_A199_M0.9001.00
165_T185_L0.8981.00
16_I26_I0.8921.00
200_V208_S0.8901.00
142_T149_S0.8901.00
57_T152_I0.8871.00
12_K205_G0.8841.00
25_L28_S0.8791.00
15_L40_G0.8791.00
189_V193_K0.8761.00
15_L23_L0.8741.00
153_Y195_F0.8721.00
18_T22_G0.8611.00
36_R40_G0.8561.00
59_S85_G0.8531.00
59_S81_I0.8501.00
26_I55_I0.8501.00
147_N184_G0.8501.00
56_F79_F0.8481.00
54_V79_F0.8471.00
36_R39_E0.8471.00
155_P158_N0.8431.00
153_Y197_P0.8291.00
168_G206_V0.8271.00
140_I151_S0.8261.00
91_N94_I0.8251.00
55_I137_V0.8251.00
24_I137_V0.8231.00
54_V77_A0.8221.00
11_V29_G0.8221.00
83_N86_V0.8191.00
54_V67_A0.8161.00
46_K50_K0.8111.00
136_G156_E0.8101.00
190_E194_S0.8091.00
142_T165_T0.8071.00
13_V37_I0.8031.00
33_S36_R0.7881.00
160_I200_V0.7861.00
85_G88_Y0.7811.00
92_G95_R0.7801.00
23_L50_K0.7791.00
14_F203_S0.7761.00
160_I195_F0.7751.00
78_K125_D0.7671.00
69_E72_R0.7651.00
17_E40_G0.7621.00
15_L25_L0.7611.00
81_I89_L0.7581.00
143_P188_S0.7581.00
128_L152_I0.7541.00
66_G69_E0.7541.00
185_L189_V0.7521.00
67_A71_K0.7421.00
34_G38_I0.7391.00
17_E44_L0.7371.00
55_I150_I0.7351.00
87_N91_N0.7341.00
149_S165_T0.7311.00
114_F117_R0.7301.00
12_K203_S0.7271.00
128_L139_I0.7261.00
179_Y185_L0.7211.00
13_V29_G0.7171.00
118_K122_V0.7091.00
23_L41_I0.7051.00
124_V127_V0.7031.00
17_E21_N0.6991.00
133_L155_P0.6991.00
138_E195_F0.6971.00
113_P116_F0.6961.00
25_L41_I0.6911.00
158_N196_N0.6861.00
9_S61_V0.6851.00
81_I124_V0.6841.00
16_I154_L0.6831.00
115_F119_F0.6811.00
140_I160_I0.6761.00
165_T188_S0.6691.00
117_R121_G0.6681.00
136_G155_P0.6671.00
187_K191_N0.6671.00
122_V125_D0.6591.00
154_L159_A0.6581.00
56_F64_I0.6551.00
35_R69_E0.6511.00
154_L158_N0.6501.00
82_D85_G0.6441.00
71_K76_D0.6371.00
52_K78_K0.6341.00
123_N127_V0.6331.00
171_R174_K0.6331.00
83_N87_N0.6311.00
115_F118_K0.6291.00
16_I24_I0.6291.00
25_L37_I0.6261.00
137_V152_I0.6221.00
173_L176_P0.6211.00
35_R38_I0.6201.00
202_V205_G0.6161.00
174_K177_N0.6151.00
187_K190_E0.6151.00
128_L134_V0.6141.00
197_P200_V0.6111.00
201_Y207_S0.5961.00
128_L132_E0.5951.00
181_D185_L0.5941.00
186_R193_K0.5921.00
88_Y147_N0.5921.00
131_G191_N0.5881.00
81_I86_V0.5871.00
28_S66_G0.5851.00
162_V166_L0.5851.00
15_L41_I0.5821.00
93_K96_E0.5801.00
87_N90_K0.5781.00
141_K150_I0.5751.00
147_N177_N0.5751.00
129_E141_K0.5731.00
161_I201_Y0.5711.00
42_T45_G0.5701.00
174_K185_L0.5691.00
64_I67_A0.5681.00
37_I66_G0.5661.00
59_S64_I0.5611.00
166_L200_V0.5601.00
84_N148_D0.5561.00
25_L70_V0.5551.00
130_E134_V0.5511.00
151_S188_S0.5501.00
118_K121_G0.5501.00
90_K123_N0.5501.00
167_Q185_L0.5501.00
114_F121_G0.5471.00
15_L51_I0.5471.00
191_N195_F0.5471.00
162_V202_V0.5461.00
173_L177_N0.5461.00
18_T24_I0.5431.00
80_G132_E0.5411.00
53_S56_F0.5401.00
132_E139_I0.5391.00
41_I46_K0.5371.00
114_F119_F0.5371.00
91_N95_R0.5371.00
153_Y196_N0.5301.00
60_H63_H0.5291.00
51_I70_V0.5291.00
153_Y157_L0.5291.00
59_S148_D0.5271.00
21_N45_G0.5261.00
72_R120_N0.5241.00
151_S162_V0.5211.00
15_L46_K0.5161.00
115_F120_N0.5151.00
193_K197_P0.5151.00
53_S126_F0.5141.00
59_S88_Y0.5131.00
162_V165_T0.5091.00
131_G141_K0.5091.00
29_G56_F0.5081.00
168_G208_S0.5071.00
18_T23_L0.5061.00
119_F122_V0.5001.00
140_I195_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.9812 100 0.307 Contact Map
2vw8A 2 0.9812 100 0.311 Contact Map
2zwrA 1 0.8873 100 0.337 Contact Map
4efzA 2 0.9014 100 0.342 Contact Map
1qh5A 1 0.7934 100 0.342 Contact Map
4yslA 2 0.9014 100 0.345 Contact Map
2p18A 1 0.8028 100 0.345 Contact Map
1k07A 1 0.9343 100 0.346 Contact Map
2yheA 3 0.9906 100 0.346 Contact Map
1xm8A 1 0.8028 100 0.347 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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