GREMLIN Database
Q97YZ1 - Haloacetate dehalogenase
UniProt: Q97YZ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 198 (187)
Sequences: 27165 (21517)
Seq/√Len: 1573.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_K144_E4.1641.00
107_K112_S3.0241.00
136_Y140_A2.7971.00
126_E130_S2.7591.00
158_A165_G2.5941.00
99_T103_E2.4051.00
83_K114_Y2.4021.00
149_S154_D2.3141.00
80_I83_K2.3131.00
90_D116_K2.2681.00
5_K164_K2.2661.00
136_Y139_E2.2141.00
99_T123_R2.2111.00
92_Y117_G2.1851.00
94_L133_V2.0631.00
95_S102_I2.0601.00
126_E132_K2.0291.00
138_L145_A2.0071.00
159_K183_D1.9921.00
187_R191_E1.9471.00
117_G140_A1.9411.00
10_F91_I1.8971.00
155_V165_G1.8761.00
156_I160_N1.8061.00
63_I67_L1.8041.00
8_L89_A1.7921.00
86_S114_Y1.7211.00
138_L163_M1.7131.00
86_S116_K1.6971.00
164_K183_D1.6511.00
146_Y166_I1.6451.00
79_A189_F1.6281.00
147_L158_A1.6251.00
103_E112_S1.6161.00
91_I115_F1.5961.00
84_D88_I1.5651.00
9_A147_L1.5641.00
138_L142_K1.5621.00
9_A94_L1.5311.00
9_A137_F1.5171.00
169_N187_R1.5031.00
7_I141_V1.4841.00
62_K66_E1.4691.00
5_K146_Y1.4631.00
8_L148_V1.4621.00
169_N185_V1.3361.00
76_H170_R1.3321.00
8_L85_I1.3321.00
166_I186_V1.3141.00
81_Y189_F1.3031.00
61_D65_E1.2901.00
92_Y141_V1.2881.00
65_E69_K1.2781.00
62_K65_E1.2651.00
84_D87_T1.2551.00
16_I79_A1.2391.00
15_T148_V1.2321.00
29_K33_Y1.2291.00
7_I145_A1.2281.00
166_I184_V1.2261.00
12_L17_L1.2251.00
152_P156_I1.2201.00
103_E107_K1.2181.00
75_T111_L1.2151.00
12_L93_I1.2141.00
66_E70_W1.2041.00
12_L102_I1.2011.00
119_F140_A1.2001.00
49_I53_A1.1921.00
153_F156_I1.1871.00
188_D191_E1.1831.00
134_Y147_L1.1761.00
134_Y157_G1.1681.00
30_Q34_T1.1531.00
102_I120_S1.1451.00
131_P135_R1.1341.00
64_E68_N1.1061.00
65_E68_N1.1011.00
9_A145_A1.0841.00
119_F137_F1.0801.00
48_E52_I1.0591.00
13_Y19_L1.0401.00
145_A163_M1.0401.00
86_S91_I1.0291.00
94_L137_F1.0151.00
7_I90_D1.0041.00
99_T120_S0.9971.00
45_D48_E0.9961.00
23_S27_R0.9901.00
82_L115_F0.9901.00
137_F141_V0.9811.00
63_I66_E0.9801.00
12_L97_G0.9791.00
25_E29_K0.9761.00
134_Y163_M0.9751.00
83_K87_T0.9731.00
63_I70_W0.9721.00
117_G141_V0.9701.00
132_K136_Y0.9681.00
135_R139_E0.9661.00
159_K165_G0.9611.00
80_I114_Y0.9541.00
66_E69_K0.9511.00
110_G113_S0.9491.00
33_Y65_E0.9461.00
26_M30_Q0.9431.00
147_L163_M0.9411.00
93_I115_F0.9401.00
52_I55_S0.9371.00
52_I56_Y0.9331.00
78_D188_D0.9251.00
134_Y149_S0.9231.00
104_E108_L0.9131.00
135_R161_S0.9041.00
7_I92_Y0.9041.00
25_E28_R0.9001.00
25_E72_S0.8951.00
29_K69_K0.8951.00
155_V182_P0.8941.00
124_V136_Y0.8931.00
83_K113_S0.8921.00
29_K32_E0.8911.00
75_T80_I0.8831.00
28_R32_E0.8741.00
99_T122_E0.8631.00
50_T54_I0.8591.00
125_K132_K0.8571.00
43_Y47_D0.8561.00
56_Y60_E0.8551.00
9_A141_V0.8521.00
56_Y59_G0.8511.00
165_G183_D0.8481.00
55_S59_G0.8481.00
142_K163_M0.8481.00
135_R142_K0.8461.00
104_E107_K0.8441.00
85_I89_A0.8391.00
132_K135_R0.8381.00
47_D53_A0.8371.00
119_F136_Y0.8351.00
47_D51_K0.8351.00
159_K181_E0.8311.00
49_I57_T0.8301.00
13_Y97_G0.8271.00
102_I105_L0.8211.00
164_K184_V0.8211.00
82_L114_Y0.8201.00
31_L36_L0.8201.00
186_V192_L0.8181.00
92_Y137_F0.8131.00
148_V166_I0.8111.00
146_Y164_K0.8071.00
95_S120_S0.8061.00
62_K69_K0.8041.00
167_Y185_V0.8031.00
12_L105_L0.8021.00
24_Q28_R0.7981.00
54_I58_L0.7931.00
50_T53_A0.7881.00
5_K89_A0.7841.00
9_A163_M0.7821.00
62_K67_L0.7801.00
157_G161_S0.7791.00
37_L40_M0.7771.00
53_A56_Y0.7761.00
13_Y95_S0.7751.00
85_I91_I0.7731.00
80_I110_G0.7711.00
47_D50_T0.7681.00
51_K55_S0.7661.00
91_I114_Y0.7601.00
120_S123_R0.7451.00
142_K145_A0.7451.00
155_V167_Y0.7391.00
64_E67_L0.7341.00
45_D49_I0.7341.00
32_E38_T0.7331.00
48_E53_A0.7321.00
97_G102_I0.7291.00
17_L105_L0.7261.00
148_V192_L0.7251.00
8_L146_Y0.7241.00
5_K144_E0.7211.00
166_I192_L0.7211.00
96_N127_Y0.7201.00
76_H79_A0.7191.00
117_G137_F0.7151.00
134_Y154_D0.7151.00
106_L112_S0.7131.00
67_L70_W0.7031.00
54_I57_T0.7031.00
6_K89_A0.7031.00
17_L109_N0.7011.00
170_R189_F0.6961.00
53_A57_T0.6921.00
76_H168_V0.6911.00
123_R140_A0.6901.00
22_I73_L0.6881.00
50_T58_L0.6881.00
168_V189_F0.6881.00
133_V137_F0.6871.00
21_A74_R0.6841.00
14_G20_S0.6831.00
33_Y62_K0.6801.00
78_D190_K0.6761.00
6_K90_D0.6751.00
23_S26_M0.6731.00
175_V187_R0.6721.00
80_I113_S0.6711.00
13_Y150_S0.6681.00
78_D170_R0.6601.00
61_D64_E0.6581.00
119_F133_V0.6561.00
45_D53_A0.6551.00
43_Y49_I0.6461.00
42_R45_D0.6451.00
103_E118_I0.6381.00
38_T41_G0.6371.00
46_F49_I0.6371.00
42_R47_D0.6361.00
18_D21_A0.6351.00
9_A92_Y0.6331.00
79_A82_L0.6331.00
13_Y105_L0.6281.00
32_E37_L0.6221.00
43_Y46_F0.6201.00
48_E55_S0.6181.00
133_V157_G0.6141.00
91_I116_K0.6141.00
156_I159_K0.6131.00
131_P160_N0.6131.00
78_D81_Y0.6091.00
81_Y148_V0.6061.00
135_R138_L0.6061.00
28_R39_I0.6061.00
186_V189_F0.6041.00
49_I54_I0.6031.00
44_V47_D0.6021.00
75_T109_N0.6001.00
33_Y69_K0.6001.00
62_K70_W0.5981.00
18_D74_R0.5961.00
102_I118_I0.5921.00
53_A58_L0.5921.00
147_L157_G0.5901.00
124_V133_V0.5881.00
96_N129_P0.5841.00
86_S113_S0.5761.00
10_F81_Y0.5751.00
176_D179_G0.5741.00
17_L73_L0.5701.00
134_Y158_A0.5601.00
48_E56_Y0.5591.00
46_F50_T0.5591.00
173_M176_D0.5571.00
147_L154_D0.5551.00
83_K86_S0.5431.00
115_F118_I0.5411.00
121_A133_V0.5401.00
15_T168_V0.5401.00
107_K113_S0.5391.00
97_G149_S0.5371.00
81_Y186_V0.5321.00
47_D52_I0.5301.00
42_R50_T0.5281.00
138_L161_S0.5271.00
19_L97_G0.5251.00
94_L119_F0.5251.00
77_Q190_K0.5251.00
94_L147_L0.5241.00
30_Q33_Y0.5231.00
42_R53_A0.5211.00
169_N174_P0.5181.00
15_T154_D0.5141.00
119_F141_V0.5111.00
53_A59_G0.5091.00
81_Y84_D0.5081.00
23_S97_G0.5071.00
97_G101_T0.5031.00
47_D54_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w43A 2 0.9747 100 0.33 Contact Map
3umbA 2 0.9848 100 0.344 Contact Map
3ed5A 1 0.9899 100 0.351 Contact Map
4uw9A 1 0.9141 100 0.351 Contact Map
3umgA 2 0.9899 100 0.352 Contact Map
3iruA 4 1 100 0.354 Contact Map
1swvA 2 0.9848 100 0.356 Contact Map
3sd7A 1 0.9899 100 0.357 Contact Map
4eekA 2 0.9899 100 0.357 Contact Map
2ymmA 2 0.9949 100 0.357 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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