GREMLIN Database
Q97YY7 - Uncharacterized protein
UniProt: Q97YY7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (210)
Sequences: 2207 (1444)
Seq/√Len: 99.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_K61_N3.4971.00
69_S73_N3.1431.00
183_K186_E3.1271.00
14_H17_P3.0431.00
175_A231_T2.8711.00
191_M232_A2.8161.00
8_I44_V2.7821.00
172_F194_A2.7651.00
106_V132_L2.7351.00
75_W128_S2.6881.00
176_L231_T2.6701.00
35_A70_I2.5941.00
31_F74_F2.5341.00
45_A63_E2.4121.00
169_I227_M2.2811.00
113_P126_S2.2641.00
12_N62_Y2.2481.00
8_I41_L2.1631.00
20_L27_D2.1031.00
134_N186_E2.0751.00
10_E14_H2.0371.00
35_A113_P2.0281.00
29_Y34_E1.9291.00
11_S41_L1.9231.00
69_S84_L1.8871.00
83_A103_P1.8361.00
67_N71_L1.8001.00
12_N59_V1.7971.00
142_G197_H1.7771.00
25_D30_H1.7651.00
134_N178_L1.7401.00
41_L62_Y1.7301.00
62_Y65_E1.7101.00
79_Y128_S1.7081.00
76_N79_Y1.6991.00
208_D211_Y1.6851.00
64_K68_Q1.6551.00
68_Q72_K1.6441.00
75_W125_Y1.6191.00
28_A83_A1.6171.00
76_N104_P1.6161.00
131_K135_R1.5901.00
138_F143_L1.5741.00
71_L119_L1.5531.00
108_S170_T1.5431.00
202_L219_S1.5381.00
127_I181_L1.5261.00
203_L224_S1.5201.00
130_F181_L1.4931.00
176_L230_I1.4821.00
176_L234_N1.4701.00
198_S203_L1.4661.00
136_T147_P1.4651.00
83_A102_E1.4591.00
153_Y159_D1.4511.00
47_I51_L1.4181.00
62_Y66_L1.4071.00
32_W109_A1.3991.00
15_L66_L1.3971.00
16_L65_E1.3870.99
56_Y59_V1.3860.99
74_F84_L1.3830.99
53_F56_Y1.3740.99
45_A57_T1.3730.99
12_N41_L1.3700.99
133_V143_L1.3630.99
76_N81_A1.3500.99
130_F174_E1.3460.99
78_D104_P1.3430.99
110_T133_V1.3420.99
34_E74_F1.3420.99
134_N174_E1.2970.99
57_T60_L1.2920.99
204_P214_P1.2800.99
37_N66_L1.2720.99
131_K134_N1.2320.99
71_L80_F1.2320.99
134_N138_F1.2310.99
48_Y57_T1.2210.99
171_T194_A1.2100.99
131_K183_K1.1980.98
159_D162_A1.1890.98
168_M207_I1.1680.98
119_L126_S1.1630.98
79_Y110_T1.1610.98
39_L43_S1.1610.98
20_L25_D1.1530.98
177_Y181_L1.1410.98
169_I223_W1.1390.98
80_F119_L1.1180.98
150_M153_Y1.1150.98
121_P180_E1.1060.97
168_M224_S1.0940.97
188_L192_Y1.0920.97
25_D146_F1.0870.97
174_E190_L1.0760.97
169_I224_S1.0750.97
31_F110_T1.0710.97
41_L66_L1.0650.97
9_T13_Y1.0590.97
208_D213_Y1.0590.97
59_V62_Y1.0550.97
179_E234_N1.0490.96
174_E178_L1.0480.96
179_E184_S1.0470.96
184_S238_P1.0310.96
209_P215_L1.0140.96
165_P215_L1.0090.96
8_I12_N1.0060.96
140_T193_W1.0040.96
191_M235_Y1.0020.95
114_I126_S1.0010.95
192_Y195_Y1.0000.95
175_A190_L0.9990.95
73_N102_E0.9920.95
124_N127_I0.9770.95
9_T12_N0.9670.94
25_D152_H0.9650.94
143_L174_E0.9600.94
44_V60_L0.9590.94
188_L239_S0.9580.94
195_Y198_S0.9420.94
115_D177_Y0.9390.94
179_E235_Y0.9210.93
34_E37_N0.9160.93
132_L136_T0.9070.92
49_K57_T0.9030.92
56_Y60_L0.9020.92
127_I130_F0.9000.92
207_I212_A0.8830.91
220_P225_S0.8690.91
134_N190_L0.8680.91
191_M195_Y0.8600.90
226_A230_I0.8570.90
126_S177_Y0.8460.89
126_S130_F0.8440.89
214_P219_S0.8430.89
231_T234_N0.8340.89
71_L125_Y0.8340.89
11_S44_V0.8280.88
106_V136_T0.8260.88
227_M230_I0.8250.88
19_D33_T0.8180.88
232_A236_K0.8100.87
25_D151_Y0.8040.87
148_N151_Y0.8010.87
164_E206_A0.8000.87
110_T129_N0.7990.87
80_F84_L0.7990.87
192_Y196_N0.7980.87
167_W221_L0.7950.86
124_N128_S0.7920.86
198_S224_S0.7890.86
28_A102_E0.7840.86
50_A53_F0.7810.85
202_L220_P0.7780.85
35_A116_F0.7670.84
106_V133_V0.7660.84
75_W79_Y0.7560.83
122_T127_I0.7540.83
179_E231_T0.7480.83
185_N189_N0.7460.83
9_T56_Y0.7450.83
165_P206_A0.7450.83
144_A147_P0.7430.82
55_N60_L0.7370.82
18_Q29_Y0.7320.81
236_K239_S0.7280.81
178_L183_K0.7270.81
130_F177_Y0.7240.81
120_P126_S0.7210.80
81_A104_P0.7190.80
164_E167_W0.7160.80
168_M194_A0.7140.80
113_P119_L0.7140.80
137_L220_P0.7140.80
70_I118_Y0.7120.80
55_N58_I0.7110.80
8_I11_S0.7100.79
31_F84_L0.7100.79
164_E223_W0.7090.79
105_S148_N0.7080.79
11_S15_L0.7070.79
22_V223_W0.7060.79
175_A194_A0.7060.79
17_P27_D0.6990.78
11_S144_A0.6970.78
146_F162_A0.6970.78
187_A235_Y0.6940.78
22_V109_A0.6940.78
194_A197_H0.6920.78
80_F118_Y0.6910.78
49_K63_E0.6880.77
46_E50_A0.6860.77
47_I50_A0.6850.77
111_L133_V0.6850.77
42_Q61_N0.6830.77
57_T61_N0.6820.77
80_F123_S0.6810.77
66_L70_I0.6800.76
194_A203_L0.6790.76
11_S37_N0.6770.76
223_W227_M0.6760.76
44_V48_Y0.6740.76
34_E70_I0.6650.75
71_L84_L0.6630.75
127_I131_K0.6570.74
38_V42_Q0.6470.73
81_A103_P0.6440.73
58_I61_N0.6410.72
39_L106_V0.6400.72
206_A223_W0.6400.72
168_M214_P0.6390.72
169_I173_F0.6360.72
188_L235_Y0.6330.71
145_R205_E0.6310.71
111_L130_F0.6300.71
183_K187_A0.6290.71
48_Y52_N0.6260.70
232_A235_Y0.6250.70
141_G193_W0.6230.70
131_K181_L0.6200.70
9_T60_L0.6180.69
195_Y228_F0.6180.69
79_Y82_S0.6170.69
160_A163_P0.6160.69
125_Y128_S0.6160.69
76_N102_E0.6110.69
25_D166_P0.6100.68
44_V121_P0.6030.68
17_P65_E0.6020.67
48_Y55_N0.6010.67
115_D176_L0.6010.67
228_F232_A0.5980.67
40_G43_S0.5970.67
117_G137_L0.5960.67
67_N80_F0.5940.66
16_L73_N0.5930.66
128_S132_L0.5930.66
218_T221_L0.5920.66
78_D185_N0.5910.66
179_E238_P0.5880.66
79_Y132_L0.5880.66
67_N119_L0.5880.66
152_H217_T0.5870.65
80_F235_Y0.5840.65
149_D152_H0.5840.65
54_S58_I0.5840.65
204_P209_P0.5830.65
11_S40_G0.5820.65
30_H83_A0.5820.65
80_F83_A0.5810.65
80_F125_Y0.5810.65
167_W223_W0.5810.65
71_L120_P0.5770.64
146_F159_D0.5770.64
135_R186_E0.5750.64
147_P152_H0.5730.64
77_N125_Y0.5730.64
171_T228_F0.5720.64
186_E189_N0.5690.63
142_G207_I0.5670.63
21_S25_D0.5660.63
167_W218_T0.5630.62
141_G189_N0.5630.62
9_T62_Y0.5620.62
224_S227_M0.5610.62
234_N238_P0.5590.62
135_R185_N0.5580.62
176_L227_M0.5560.61
32_W112_L0.5530.61
149_D212_A0.5520.61
138_F178_L0.5520.61
131_K178_L0.5510.61
8_I47_I0.5510.61
21_S164_E0.5480.60
38_V118_Y0.5470.60
128_S131_K0.5470.60
208_D215_L0.5470.60
197_H212_A0.5460.60
66_L229_V0.5460.60
18_Q28_A0.5450.60
172_F191_M0.5440.60
42_Q46_E0.5420.59
111_L202_L0.5410.59
127_I183_K0.5410.59
175_A199_Q0.5390.59
171_T197_H0.5390.59
123_S129_N0.5370.59
169_I207_I0.5360.59
168_M203_L0.5350.58
13_Y17_P0.5330.58
230_I234_N0.5320.58
117_G234_N0.5310.58
114_I177_Y0.5290.58
112_L115_D0.5260.57
164_E218_T0.5250.57
198_S225_S0.5250.57
199_Q219_S0.5230.57
178_L190_L0.5210.56
148_N152_H0.5200.56
25_D32_W0.5200.56
222_T232_A0.5170.56
172_F228_F0.5150.56
180_E234_N0.5130.55
173_F220_P0.5110.55
21_S40_G0.5110.55
207_I211_Y0.5090.55
29_Y73_N0.5080.55
53_F58_I0.5060.54
39_L116_F0.5040.54
178_L186_E0.5040.54
123_S126_S0.5040.54
79_Y83_A0.5010.54
108_S133_V0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fbaA 1 0.8333 100 0.324 Contact Map
2vn4A 1 0.9037 100 0.375 Contact Map
1gaiA 1 0.8963 100 0.383 Contact Map
1ulvA 1 0.9889 100 0.464 Contact Map
1lf6A 1 0.9185 100 0.474 Contact Map
3qt9A 1 0.8 100 0.528 Contact Map
3qryB 1 0.8148 100 0.54 Contact Map
3p2cA 2 0.8296 100 0.544 Contact Map
2p0vA 2 0.8222 100 0.544 Contact Map
3w7tA 1 0.8074 99.9 0.719 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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