GREMLIN Database
Q97YY4 - Sugar ABC transporter
UniProt: Q97YY4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 368 (318)
Sequences: 21493 (15296)
Seq/√Len: 857.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_G225_E3.8731.00
64_H71_V3.6561.00
38_V206_A3.6561.00
35_E208_K3.4001.00
6_K30_E3.3211.00
298_G314_L3.2891.00
124_R129_D3.2701.00
9_N26_G3.2621.00
8_E64_H3.2421.00
22_Q25_R3.0961.00
116_K120_L2.7861.00
301_E315_K2.7821.00
218_Q232_S2.6191.00
25_R216_V2.5381.00
222_D225_E2.5331.00
111_S114_E2.4631.00
8_E66_Y2.4451.00
37_V210_A2.4401.00
13_E22_Q2.4221.00
6_K66_Y2.3991.00
11_W22_Q2.3941.00
131_L134_R2.3671.00
118_R156_G2.2971.00
32_E35_E2.2931.00
11_W62_K2.2911.00
98_Y102_A2.2911.00
98_Y133_E2.2591.00
7_L10_I2.2391.00
81_R158_D2.1681.00
98_Y120_L2.1531.00
12_K53_I2.1191.00
233_A280_L2.1061.00
98_Y116_K2.0851.00
183_Q187_D2.0661.00
9_N28_N2.0391.00
66_Y71_V2.0261.00
11_W26_G2.0091.00
210_A220_Y1.9631.00
123_A132_L1.9491.00
17_K23_V1.9251.00
127_R176_V1.9081.00
68_R158_D1.8951.00
213_H218_Q1.8921.00
210_A217_V1.8831.00
53_I60_Q1.8501.00
5_V159_I1.8481.00
24_L53_I1.8421.00
309_Y325_I1.8391.00
10_I60_Q1.8111.00
114_E117_K1.7791.00
117_K121_E1.7381.00
12_K61_D1.7211.00
102_A119_V1.7201.00
118_R121_E1.6501.00
98_Y119_V1.6461.00
263_I266_P1.6351.00
53_I65_V1.6281.00
315_K318_E1.6031.00
12_K58_L1.6011.00
316_I319_E1.6001.00
51_L195_V1.5901.00
70_E158_D1.5831.00
110_L114_E1.5601.00
256_I260_S1.5371.00
70_E75_L1.5331.00
27_L50_I1.5211.00
67_L72_V1.5141.00
122_V154_V1.5061.00
113_D117_K1.4951.00
256_I259_D1.4851.00
120_L132_L1.4831.00
299_K315_K1.4761.00
52_K58_L1.4711.00
71_V74_D1.4671.00
233_A246_I1.4641.00
250_E278_K1.4611.00
54_I193_I1.4551.00
13_E61_D1.4471.00
260_S263_I1.4431.00
102_A115_I1.4371.00
37_V220_Y1.4251.00
162_M192_I1.4221.00
120_L124_R1.4071.00
258_I261_Y1.3931.00
233_A237_S1.3851.00
203_L224_M1.3821.00
96_S135_K1.3701.00
261_Y264_G1.3591.00
110_L115_I1.3421.00
96_S99_D1.3391.00
121_E124_R1.3351.00
126_L150_A1.3331.00
4_Y33_K1.3291.00
4_Y30_E1.3111.00
7_L54_I1.3061.00
99_D106_K1.2971.00
246_I280_L1.2921.00
114_E118_R1.2921.00
72_V75_L1.2871.00
121_E156_G1.2831.00
314_L324_V1.2831.00
224_M228_K1.2691.00
225_E229_R1.2571.00
24_L50_I1.2541.00
7_L29_L1.2411.00
303_V312_I1.2411.00
11_W25_R1.2281.00
237_S246_I1.2041.00
104_P155_K1.2021.00
31_I37_V1.2001.00
8_E28_N1.2001.00
7_L50_I1.1941.00
274_K277_Q1.1921.00
29_L210_A1.1841.00
51_L161_L1.1781.00
37_V208_K1.1631.00
60_Q65_V1.1621.00
99_D102_A1.1551.00
311_I325_I1.1511.00
185_Q192_I1.1471.00
208_K220_Y1.1451.00
24_L27_L1.1351.00
112_K116_K1.1321.00
64_H73_D1.1281.00
97_V139_L1.1211.00
248_R280_L1.1131.00
32_E208_K1.1121.00
75_L79_D1.1041.00
95_M103_F1.1041.00
312_I326_E1.1021.00
182_K205_L1.0951.00
313_H323_R1.0941.00
98_Y132_L1.0921.00
115_I119_V1.0901.00
13_E62_K1.0891.00
244_M282_G1.0891.00
4_Y68_R1.0881.00
213_H234_W1.0801.00
257_I260_S1.0791.00
211_I235_V1.0671.00
125_M187_D1.0651.00
17_K22_Q1.0601.00
166_L181_L1.0561.00
259_D262_R1.0531.00
121_E125_M1.0411.00
106_K112_K1.0391.00
257_I261_Y1.0381.00
120_L129_D1.0351.00
4_Y32_E1.0331.00
33_K68_R1.0241.00
256_I261_Y1.0201.00
60_Q73_D1.0191.00
45_E212_L1.0181.00
259_D263_I1.0161.00
185_Q190_P1.0151.00
33_K158_D1.0111.00
66_Y69_G1.0101.00
13_E23_V1.0091.00
108_M155_K1.0011.00
291_R295_E0.9981.00
248_R278_K0.9951.00
252_E257_I0.9941.00
283_V288_M0.9891.00
257_I262_R0.9871.00
211_I226_I0.9801.00
36_F185_Q0.9801.00
6_K69_G0.9781.00
10_I53_I0.9751.00
36_F192_I0.9751.00
223_P227_Y0.9631.00
182_K186_R0.9621.00
228_K305_D0.9581.00
13_E16_E0.9541.00
244_M247_I0.9501.00
9_N62_K0.9471.00
83_A152_A0.9461.00
50_I212_L0.9451.00
94_F137_S0.9451.00
166_L194_Y0.9421.00
101_I150_A0.9331.00
262_R265_L0.9291.00
101_I123_A0.9231.00
89_Y168_N0.9211.00
221_G226_I0.9151.00
224_M305_D0.9131.00
121_E187_D0.9111.00
217_V220_Y0.9111.00
300_V312_I0.9011.00
102_A106_K0.9001.00
273_V277_Q0.8991.00
122_V153_L0.8981.00
76_P79_D0.8961.00
35_E207_T0.8901.00
305_D310_S0.8891.00
291_R294_G0.8791.00
39_I50_I0.8771.00
180_E183_Q0.8711.00
92_Y95_M0.8711.00
101_I154_V0.8701.00
34_G191_T0.8691.00
196_T202_A0.8661.00
156_G187_D0.8631.00
92_Y104_P0.8621.00
91_I136_P0.8621.00
315_K320_T0.8591.00
311_I323_R0.8591.00
13_E17_K0.8581.00
55_A161_L0.8571.00
14_Y23_V0.8561.00
298_G316_I0.8551.00
135_K138_Q0.8491.00
67_L82_V0.8491.00
36_F205_L0.8481.00
160_I190_P0.8471.00
175_V179_E0.8461.00
266_P269_Y0.8421.00
8_E30_E0.8421.00
100_N151_R0.8331.00
134_R138_Q0.8301.00
112_K115_I0.8281.00
34_G189_K0.8271.00
103_F107_V0.8201.00
123_A128_I0.8141.00
156_G190_P0.8131.00
110_L118_R0.8121.00
227_Y286_E0.8111.00
65_V72_V0.8101.00
249_G256_I0.8101.00
245_N249_G0.8091.00
83_A157_A0.8091.00
29_L220_Y0.7981.00
96_S133_E0.7971.00
177_A180_E0.7961.00
52_K57_L0.7911.00
273_V276_G0.7861.00
264_G267_E0.7841.00
258_I263_I0.7831.00
83_A155_K0.7831.00
172_Q237_S0.7801.00
53_I58_L0.7751.00
306_L311_I0.7751.00
38_V202_A0.7711.00
31_I191_T0.7701.00
10_I65_V0.7691.00
116_K119_V0.7651.00
39_I210_A0.7651.00
75_L78_K0.7611.00
95_M99_D0.7601.00
182_K204_S0.7601.00
249_G279_V0.7571.00
200_V306_L0.7551.00
308_P325_I0.7551.00
183_Q302_M0.7531.00
261_Y266_P0.7451.00
179_E302_M0.7441.00
82_V159_I0.7391.00
317_N320_T0.7381.00
106_K115_I0.7311.00
12_K49_T0.7311.00
45_E50_I0.7311.00
175_V200_V0.7301.00
40_L211_I0.7301.00
164_E197_H0.7251.00
265_L268_E0.7211.00
256_I266_P0.7201.00
179_E313_H0.7151.00
302_M305_D0.7141.00
7_L65_V0.7131.00
128_I131_L0.7111.00
118_R122_V0.7081.00
184_L190_P0.7041.00
260_S264_G0.7031.00
48_T52_K0.7011.00
122_V125_M0.7011.00
157_A160_I0.7011.00
101_I104_P0.7001.00
248_R319_E0.6951.00
27_L217_V0.6941.00
26_G62_K0.6921.00
302_M313_H0.6901.00
174_R198_D0.6901.00
127_R130_N0.6891.00
171_A178_R0.6891.00
256_I262_R0.6871.00
259_D266_P0.6861.00
224_M310_S0.6861.00
256_I263_I0.6861.00
122_V126_L0.6851.00
263_I268_E0.6841.00
213_H216_V0.6841.00
313_H320_T0.6841.00
247_I322_I0.6841.00
14_Y58_L0.6781.00
262_R267_E0.6781.00
53_I61_D0.6781.00
298_G301_E0.6771.00
223_P226_I0.6761.00
111_S115_I0.6761.00
130_N143_Q0.6741.00
81_R108_M0.6741.00
194_Y206_A0.6741.00
256_I264_G0.6701.00
98_Y115_I0.6701.00
235_V239_L0.6681.00
272_L276_G0.6681.00
200_V204_S0.6661.00
267_E270_K0.6661.00
252_E255_S0.6651.00
288_M324_V0.6651.00
300_V314_L0.6641.00
276_G279_V0.6611.00
284_R288_M0.6591.00
301_E313_H0.6581.00
136_P147_V0.6571.00
16_E22_Q0.6561.00
97_V147_V0.6551.00
171_A175_V0.6551.00
158_D190_P0.6521.00
212_L217_V0.6491.00
39_I212_L0.6481.00
25_R214_D0.6481.00
127_R180_E0.6461.00
129_D132_L0.6461.00
113_D116_K0.6461.00
160_I192_I0.6441.00
199_Q238_F0.6431.00
73_D77_P0.6421.00
22_Q26_G0.6411.00
245_N248_R0.6411.00
283_V286_E0.6401.00
42_P45_E0.6401.00
243_P246_I0.6401.00
234_W237_S0.6371.00
269_Y273_V0.6311.00
83_A192_I0.6311.00
59_R74_D0.6301.00
162_M194_Y0.6271.00
255_S262_R0.6261.00
263_I267_E0.6221.00
4_Y69_G0.6211.00
179_E183_Q0.6191.00
258_I262_R0.6191.00
227_Y230_P0.6181.00
178_R204_S0.6181.00
36_F194_Y0.6141.00
81_R155_K0.6131.00
290_I294_G0.6131.00
260_S267_E0.6131.00
281_V284_R0.6121.00
176_V180_E0.6121.00
161_L193_I0.6101.00
184_L188_L0.6101.00
300_V303_V0.6101.00
262_R266_P0.6091.00
286_E325_I0.6081.00
310_S313_H0.6061.00
276_G280_L0.6061.00
254_D264_G0.6051.00
123_A129_D0.6051.00
182_K185_Q0.6051.00
95_M100_N0.6041.00
261_Y265_L0.6021.00
290_I324_V0.5991.00
13_E25_R0.5971.00
12_K23_V0.5971.00
119_V122_V0.5961.00
259_D264_G0.5961.00
87_Q168_N0.5951.00
246_I249_G0.5941.00
149_I162_M0.5941.00
7_L27_L0.5921.00
283_V287_D0.5911.00
175_V241_N0.5911.00
167_S171_A0.5911.00
15_E22_Q0.5901.00
100_N136_P0.5901.00
292_N295_E0.5901.00
33_K189_K0.5891.00
117_K124_R0.5891.00
253_G256_I0.5841.00
258_I264_G0.5831.00
242_P282_G0.5831.00
104_P151_R0.5821.00
88_N144_M0.5821.00
285_P288_M0.5821.00
168_N178_R0.5811.00
265_L269_Y0.5791.00
219_A235_V0.5791.00
11_W24_L0.5781.00
271_N274_K0.5781.00
257_I264_G0.5771.00
185_Q207_T0.5751.00
237_S241_N0.5751.00
306_L309_Y0.5741.00
103_F106_K0.5741.00
202_A206_A0.5721.00
31_I193_I0.5721.00
251_I279_V0.5711.00
226_I230_P0.5711.00
288_M322_I0.5711.00
72_V82_V0.5711.00
117_K120_L0.5681.00
256_I265_L0.5681.00
294_G297_E0.5671.00
64_H74_D0.5661.00
283_V290_I0.5661.00
174_R201_E0.5651.00
251_I254_D0.5651.00
244_M248_R0.5641.00
260_S265_L0.5641.00
181_L192_I0.5641.00
224_M227_Y0.5631.00
225_E228_K0.5631.00
301_E320_T0.5621.00
183_Q301_E0.5611.00
258_I265_L0.5591.00
98_Y101_I0.5571.00
266_P270_K0.5561.00
91_I100_N0.5511.00
286_E290_I0.5501.00
209_V223_P0.5501.00
55_A84_M0.5471.00
85_V152_A0.5471.00
281_V285_P0.5471.00
314_L322_I0.5461.00
257_I263_I0.5451.00
36_F181_L0.5441.00
221_G231_N0.5411.00
37_V193_I0.5401.00
105_L154_V0.5391.00
85_V149_I0.5371.00
261_Y267_E0.5371.00
123_A126_L0.5361.00
185_Q188_L0.5351.00
247_I251_I0.5341.00
243_P247_I0.5331.00
92_Y100_N0.5321.00
276_G283_V0.5311.00
114_E156_G0.5301.00
149_I205_L0.5291.00
272_L275_N0.5281.00
296_I299_K0.5271.00
264_G268_E0.5271.00
35_E220_Y0.5251.00
104_P108_M0.5251.00
101_I122_V0.5241.00
282_G286_E0.5241.00
284_R287_D0.5231.00
320_T323_R0.5231.00
195_V199_Q0.5221.00
122_V150_A0.5181.00
250_E257_I0.5171.00
254_D257_I0.5171.00
182_K207_T0.5171.00
179_E204_S0.5161.00
179_E304_E0.5161.00
249_G281_V0.5161.00
125_M183_Q0.5161.00
93_P137_S0.5151.00
258_I266_P0.5151.00
32_E37_V0.5141.00
71_V75_L0.5141.00
299_K302_M0.5141.00
276_G284_R0.5131.00
280_L284_R0.5131.00
259_D265_L0.5131.00
39_I193_I0.5121.00
5_V31_I0.5111.00
300_V307_G0.5111.00
251_I255_S0.5101.00
43_S197_H0.5091.00
264_G269_Y0.5081.00
235_V238_F0.5051.00
290_I293_S0.5041.00
234_W238_F0.5031.00
38_V194_Y0.5021.00
284_R290_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v43A 2 0.9293 100 0.193 Contact Map
2it1A 1 0.9701 100 0.202 Contact Map
2yyzA 1 0.9538 100 0.205 Contact Map
1g291 4 0.9592 100 0.206 Contact Map
1oxxK 1 0.9212 100 0.212 Contact Map
3rlfA 2 0.981 100 0.218 Contact Map
3fvqA 2 0.9266 100 0.236 Contact Map
4tquS 2 0.962 100 0.237 Contact Map
1z47A 2 0.9239 100 0.238 Contact Map
3d31A 2 0.9076 100 0.25 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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