GREMLIN Database
Q97YY3 - Sugar ABC transporter
UniProt: Q97YY3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (254)
Sequences: 68705 (45769)
Seq/√Len: 2871.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_G199_R3.9471.00
86_R90_I3.3031.00
187_M196_A3.1581.00
172_K176_D3.0471.00
83_L86_R2.6811.00
174_S208_V2.5361.00
94_S156_I2.5101.00
192_S195_G2.5091.00
112_R183_E2.4991.00
186_A196_A2.4881.00
84_W243_G2.4811.00
69_K73_T2.4741.00
43_S68_Y2.4371.00
183_E201_V2.4241.00
82_P86_R2.4241.00
98_I160_T2.4081.00
193_R196_A2.3631.00
66_T69_K2.3521.00
238_W246_Y2.3501.00
96_A213_A2.3271.00
66_T70_Y2.2151.00
171_A209_V2.1991.00
194_F198_L2.1841.00
258_A261_I2.1741.00
115_V118_K2.1141.00
195_G198_L2.0561.00
191_L195_G2.0551.00
167_A212_T2.0231.00
37_Y41_M1.9511.00
182_Y204_L1.9491.00
111_S176_D1.9481.00
104_L197_F1.9461.00
186_A191_L1.9191.00
122_A172_K1.9131.00
41_M45_S1.8941.00
104_L205_A1.8771.00
175_I205_A1.8621.00
83_L87_N1.7961.00
100_V213_A1.7761.00
187_M193_R1.7521.00
90_I94_S1.7031.00
90_I152_Y1.6981.00
95_T220_T1.6971.00
70_Y261_I1.6831.00
183_E196_A1.6771.00
92_A217_F1.6411.00
103_A167_A1.6331.00
183_E187_M1.6291.00
104_L171_A1.6141.00
243_G247_M1.5961.00
106_T168_A1.5901.00
22_Y26_I1.5471.00
180_P183_E1.5471.00
110_L168_A1.5211.00
70_Y73_T1.5091.00
224_F228_Y1.4781.00
65_F69_K1.4741.00
152_Y237_E1.4731.00
117_A120_I1.4641.00
80_S83_L1.4491.00
64_Y67_A1.4391.00
167_A216_G1.4341.00
75_N80_S1.4231.00
114_N118_K1.4051.00
40_F267_V1.3931.00
111_S172_K1.3851.00
34_F38_Y1.3771.00
202_M209_V1.3711.00
38_Y42_T1.3651.00
99_S216_G1.3631.00
211_L215_L1.3521.00
239_T242_I1.3351.00
175_I201_V1.3311.00
101_L105_I1.3191.00
107_G171_A1.3111.00
171_A212_T1.3031.00
180_P184_E1.2961.00
181_S184_E1.2811.00
91_L239_T1.2761.00
15_I19_A1.2731.00
108_Y175_I1.2621.00
112_R180_P1.2561.00
120_I123_T1.2441.00
26_I30_A1.2401.00
104_L209_V1.2341.00
245_Y249_G1.2271.00
70_Y74_T1.2261.00
238_W243_G1.2251.00
186_A200_I1.2211.00
282_R285_T1.2161.00
97_I101_L1.2081.00
87_N90_I1.2031.00
243_G246_Y1.1971.00
100_V209_V1.1941.00
17_R21_S1.1841.00
19_A23_L1.1801.00
94_S97_I1.1661.00
206_L210_A1.1651.00
178_I204_L1.1611.00
49_N62_H1.1601.00
16_L20_I1.1491.00
39_V267_V1.1441.00
273_L277_F1.1261.00
142_L146_K1.1231.00
192_S196_A1.1171.00
16_L19_A1.1151.00
46_N49_N1.1021.00
38_Y41_M1.0941.00
120_I124_F1.0931.00
144_F154_G1.0911.00
234_N237_E1.0861.00
19_A22_Y1.0861.00
171_A208_V1.0741.00
223_D226_L1.0621.00
14_K17_R1.0571.00
226_L230_F1.0521.00
105_I109_A1.0491.00
156_I160_T1.0481.00
164_S168_A1.0471.00
72_F82_P1.0461.00
74_T80_S1.0421.00
98_I156_I1.0381.00
94_S98_I1.0281.00
95_T99_S1.0241.00
278_I282_R1.0201.00
183_E193_R1.0181.00
111_S175_I1.0161.00
108_Y193_R1.0071.00
204_L207_P1.0061.00
170_I212_T1.0061.00
149_L153_I0.9991.00
246_Y249_G0.9961.00
108_Y197_F0.9901.00
240_A244_L0.9801.00
191_L196_A0.9791.00
97_I213_A0.9791.00
89_L93_G0.9781.00
196_A199_R0.9631.00
224_F245_Y0.9571.00
18_L22_Y0.9421.00
155_L227_A0.9381.00
29_A33_I0.9381.00
95_T159_Y0.9371.00
90_I93_G0.9321.00
68_Y267_V0.9321.00
59_L62_H0.9271.00
21_S25_L0.9131.00
223_D227_A0.9041.00
269_M273_L0.9041.00
118_K176_D0.9031.00
237_E240_A0.8961.00
14_K18_L0.8921.00
99_S103_A0.8901.00
119_K122_A0.8891.00
107_G111_S0.8871.00
93_G97_I0.8831.00
42_T263_A0.8721.00
152_Y156_I0.8711.00
174_S205_A0.8701.00
279_V283_M0.8691.00
205_A208_V0.8671.00
98_I101_L0.8661.00
235_V238_W0.8591.00
238_W242_I0.8581.00
95_T156_I0.8581.00
141_Y145_A0.8571.00
206_L209_V0.8561.00
196_A201_V0.8541.00
85_I89_L0.8521.00
71_L268_I0.8491.00
87_N152_Y0.8481.00
126_Y169_F0.8471.00
159_Y220_T0.8471.00
140_L158_A0.8451.00
90_I153_I0.8431.00
103_A168_A0.8411.00
91_L152_Y0.8401.00
67_A70_Y0.8361.00
227_A239_T0.8341.00
91_L159_Y0.8311.00
110_L122_A0.8291.00
246_Y250_L0.8251.00
275_A279_V0.8251.00
116_P119_K0.8241.00
241_T244_L0.8231.00
171_A205_A0.8231.00
86_R89_L0.8211.00
191_L199_R0.8211.00
216_G220_T0.8191.00
109_A115_V0.8181.00
42_T45_S0.8141.00
198_L202_M0.8121.00
167_A171_A0.8101.00
153_I157_L0.8101.00
158_A226_L0.8081.00
107_G168_A0.8001.00
48_P51_I0.7991.00
197_F202_M0.7971.00
99_S163_T0.7951.00
261_I265_G0.7931.00
81_F265_G0.7901.00
44_F63_I0.7871.00
99_S167_A0.7871.00
206_L283_M0.7841.00
67_A260_N0.7831.00
133_Y162_G0.7741.00
193_R197_F0.7691.00
240_A248_A0.7661.00
72_F75_N0.7651.00
137_A225_A0.7601.00
63_I66_T0.7581.00
39_V263_A0.7511.00
49_N61_K0.7501.00
182_Y200_I0.7461.00
45_S49_N0.7451.00
46_N61_K0.7421.00
247_M258_A0.7411.00
44_F64_Y0.7381.00
45_S60_P0.7381.00
263_A267_V0.7341.00
99_S220_T0.7331.00
107_G175_I0.7261.00
133_Y225_A0.7251.00
140_L230_F0.7231.00
69_K72_F0.7221.00
20_I23_L0.7201.00
96_A217_F0.7201.00
28_M32_S0.7201.00
249_G256_A0.7201.00
209_V212_T0.7111.00
185_I189_D0.7111.00
92_A96_A0.7101.00
100_V171_A0.7081.00
260_N263_A0.7081.00
126_Y129_T0.7071.00
84_W87_N0.7071.00
242_I246_Y0.7051.00
153_I156_I0.7041.00
46_N62_H0.7041.00
64_Y68_Y0.6991.00
94_S160_T0.6981.00
23_L26_I0.6971.00
178_I205_A0.6951.00
185_I188_I0.6931.00
197_F201_V0.6931.00
82_P85_I0.6931.00
136_S161_P0.6891.00
25_L29_A0.6891.00
110_L172_K0.6871.00
34_F37_Y0.6821.00
62_H66_T0.6781.00
259_Y263_A0.6741.00
280_S283_M0.6721.00
20_I24_V0.6661.00
109_A113_L0.6651.00
110_L121_L0.6651.00
116_P120_I0.6641.00
85_I240_A0.6621.00
201_V204_L0.6591.00
171_A175_I0.6581.00
106_T164_S0.6581.00
180_P187_M0.6571.00
103_A171_A0.6551.00
39_V266_A0.6551.00
274_M278_I0.6521.00
259_Y262_F0.6511.00
96_A100_V0.6501.00
106_T125_I0.6491.00
145_A150_L0.6471.00
208_V212_T0.6461.00
70_Y258_A0.6441.00
62_H65_F0.6431.00
75_N83_L0.6431.00
209_V213_A0.6431.00
225_A228_Y0.6421.00
65_F68_Y0.6411.00
142_L145_A0.6391.00
125_I165_I0.6371.00
29_A32_S0.6351.00
122_A169_F0.6331.00
163_T219_G0.6321.00
75_N82_P0.6271.00
117_A121_L0.6251.00
158_A230_F0.6211.00
102_L160_T0.6181.00
47_A51_I0.6171.00
33_I37_Y0.6171.00
91_L156_I0.6151.00
266_A269_M0.6141.00
115_V121_L0.6091.00
18_L21_S0.6091.00
92_A221_Y0.6071.00
240_A246_Y0.6061.00
123_T127_I0.6051.00
228_Y242_I0.6031.00
91_L95_T0.6031.00
71_L265_G0.6011.00
240_A269_M0.6011.00
198_L201_V0.6001.00
99_S160_T0.6001.00
92_A220_T0.5991.00
119_K123_T0.5981.00
15_I18_L0.5981.00
140_L143_L0.5961.00
107_G172_K0.5941.00
243_G248_A0.5941.00
154_G158_A0.5931.00
137_A141_Y0.5921.00
237_E246_Y0.5911.00
263_A266_A0.5901.00
100_V104_L0.5891.00
196_A200_I0.5891.00
219_G222_L0.5881.00
108_Y201_V0.5881.00
88_S241_T0.5871.00
231_L234_N0.5861.00
272_P275_A0.5831.00
43_S264_A0.5821.00
61_K64_Y0.5811.00
237_E248_A0.5801.00
24_V28_M0.5791.00
45_S62_H0.5771.00
277_F281_Q0.5771.00
220_T223_D0.5741.00
213_A216_G0.5741.00
257_P261_I0.5731.00
237_E241_T0.5711.00
163_T216_G0.5711.00
247_M265_G0.5691.00
210_A213_A0.5681.00
170_I208_V0.5661.00
129_T166_F0.5661.00
275_A278_I0.5651.00
261_I264_A0.5631.00
113_L193_R0.5621.00
243_G265_G0.5621.00
88_S221_Y0.5611.00
87_N237_E0.5571.00
248_A262_F0.5531.00
245_Y248_A0.5531.00
71_L261_I0.5521.00
129_T165_I0.5521.00
68_Y264_A0.5511.00
60_P63_I0.5511.00
151_N234_N0.5481.00
106_T109_A0.5481.00
242_I245_Y0.5441.00
102_L164_S0.5431.00
47_A60_P0.5431.00
218_S222_L0.5401.00
178_I183_E0.5401.00
114_N119_K0.5391.00
124_F128_V0.5361.00
95_T160_T0.5341.00
30_A34_F0.5331.00
45_S61_K0.5311.00
96_A101_L0.5281.00
184_E187_M0.5261.00
69_K74_T0.5261.00
155_L159_Y0.5211.00
128_V165_I0.5211.00
247_M261_I0.5211.00
192_S198_L0.5201.00
122_A176_D0.5191.00
159_Y223_D0.5141.00
61_K65_F0.5141.00
122_A168_A0.5121.00
83_L90_I0.5091.00
114_N180_P0.5071.00
88_S242_I0.5071.00
74_T82_P0.5071.00
133_Y137_A0.5061.00
22_Y25_L0.5061.00
121_L125_I0.5051.00
152_Y155_L0.5041.00
114_N117_A0.5031.00
41_M44_F0.5021.00
115_V119_K0.5021.00
64_Y69_K0.5011.00
17_R20_I0.5001.00
27_I31_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquN 1 0.9189 100 0.313 Contact Map
3rlfG 1 0.9122 100 0.316 Contact Map
2onkC 2 0.8142 100 0.337 Contact Map
3d31C 2 0.7973 100 0.356 Contact Map
4tquM 1 0.8716 100 0.363 Contact Map
3rlfF 1 0.9155 100 0.406 Contact Map
4ymuD 2 0.7196 99.9 0.518 Contact Map
3tuiA 2 0.6993 99.9 0.552 Contact Map
2m8rA 1 0.1284 23.4 0.942 Contact Map
3tx3A 2 0.2128 15.9 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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