GREMLIN Database
Q97YY1 - Maltose ABC transporter
UniProt: Q97YY1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 523 (412)
Sequences: 20304 (16522)
Seq/√Len: 814.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_T121_Q4.0381.00
467_N470_Q3.6811.00
284_Y288_Y3.5221.00
208_K334_N3.4091.00
163_L374_I3.3211.00
277_V469_T3.2561.00
89_T119_H3.0571.00
164_N190_S2.9121.00
207_K211_P2.8431.00
281_N285_N2.8281.00
221_V285_N2.8201.00
91_T121_Q2.7601.00
207_K336_G2.7071.00
105_N109_A2.7031.00
285_N289_N2.6851.00
225_E289_N2.6131.00
115_F379_L2.5971.00
216_T219_Q2.5831.00
110_Q113_Q2.5691.00
473_Q477_Q2.4991.00
469_T473_Q2.3761.00
111_F379_L2.3671.00
128_V131_S2.3301.00
112_E119_H2.3131.00
205_Y336_G2.2701.00
477_Q481_Q2.2681.00
87_P119_H2.2391.00
225_E229_K2.2351.00
373_Q376_A2.2231.00
186_E191_L2.2221.00
166_S190_S2.2081.00
379_L382_L2.2051.00
222_Q226_S2.2041.00
179_P183_K2.1981.00
118_I376_A2.1911.00
274_T278_N2.1821.00
106_E109_A2.1331.00
219_Q222_Q2.1131.00
210_V316_I2.1011.00
91_T123_T2.0821.00
429_E433_E2.0171.00
466_V474_G2.0111.00
476_E480_I2.0041.00
272_N473_Q1.9901.00
212_Y215_N1.9821.00
110_Q114_A1.9681.00
109_A113_Q1.9461.00
386_N389_A1.9381.00
226_S230_T1.9341.00
183_K186_E1.9291.00
93_W136_A1.9231.00
278_N281_N1.9001.00
460_E466_V1.8841.00
281_N468_A1.8801.00
474_G478_A1.8631.00
470_Q474_G1.8601.00
222_Q225_E1.8441.00
281_N469_T1.8181.00
176_L405_Q1.7791.00
144_I373_Q1.7781.00
110_Q383_Y1.7651.00
391_L395_E1.7441.00
162_V360_L1.7151.00
301_A304_A1.7131.00
88_V376_A1.6981.00
460_E465_K1.6761.00
365_Q373_Q1.6761.00
375_K379_L1.6751.00
193_G358_G1.6651.00
125_G128_V1.6611.00
218_E221_V1.6491.00
168_Y378_L1.6341.00
277_V281_N1.6221.00
237_A314_T1.6191.00
221_V225_E1.6171.00
146_Y362_S1.6101.00
452_N456_Q1.6061.00
108_L112_E1.5971.00
109_A112_E1.5891.00
164_N167_Q1.5881.00
461_F471_A1.5841.00
470_Q473_Q1.5751.00
453_S478_A1.5641.00
163_L363_S1.5551.00
474_G477_Q1.5521.00
477_Q480_I1.5501.00
108_L380_F1.5421.00
221_V286_L1.5401.00
261_T268_V1.5301.00
101_N105_N1.5301.00
277_V468_A1.5241.00
214_P219_Q1.5241.00
221_V289_N1.5071.00
215_N219_Q1.5041.00
88_V373_Q1.4891.00
361_V381_V1.4861.00
205_Y338_A1.4831.00
185_W358_G1.4821.00
137_A142_A1.4821.00
111_F115_F1.4691.00
218_E222_Q1.4661.00
466_V471_A1.4631.00
272_N476_E1.4491.00
209_F315_A1.4471.00
203_M338_A1.4461.00
112_E115_F1.4351.00
365_Q377_A1.4351.00
365_Q374_I1.4331.00
132_Q136_A1.4291.00
227_V315_A1.4241.00
282_F286_L1.4221.00
207_K334_N1.4071.00
209_F227_V1.4001.00
473_Q476_E1.3811.00
457_Y474_G1.3771.00
387_Y391_L1.3711.00
461_F468_A1.3671.00
284_Y461_F1.3631.00
110_Q392_R1.3621.00
478_A481_Q1.3611.00
111_F118_I1.3601.00
144_I365_Q1.3531.00
87_P117_W1.3531.00
430_G433_E1.3421.00
389_A392_R1.3311.00
466_V470_Q1.3291.00
185_W191_L1.3271.00
228_N235_G1.3051.00
457_Y460_E1.3051.00
102_Q105_N1.3031.00
94_N122_V1.2931.00
308_L313_Q1.2901.00
433_E436_Q1.2771.00
275_A278_N1.2771.00
282_F285_N1.2531.00
157_F192_Y1.2531.00
145_V381_V1.2491.00
148_D360_L1.2481.00
224_A316_I1.2451.00
221_V282_F1.2391.00
111_F383_Y1.2311.00
457_Y466_V1.2291.00
112_E116_P1.2281.00
29_A32_G1.2281.00
309_F335_L1.2261.00
23_V27_V1.2221.00
102_Q106_E1.2221.00
111_F380_F1.2111.00
392_R396_V1.2101.00
362_S365_Q1.2051.00
210_V223_I1.2051.00
223_I226_S1.2041.00
261_T267_I1.2031.00
233_V313_Q1.1981.00
203_M316_I1.1941.00
225_E291_K1.1851.00
218_E344_S1.1841.00
363_S374_I1.1831.00
376_A379_L1.1801.00
383_Y389_A1.1791.00
106_E110_Q1.1741.00
108_L122_V1.1721.00
118_I379_L1.1611.00
228_N291_K1.1591.00
380_F384_F1.1521.00
344_S347_G1.1521.00
172_S382_L1.1521.00
220_L316_I1.1521.00
220_L224_A1.1501.00
405_Q408_N1.1461.00
361_V378_L1.1351.00
163_L365_Q1.1341.00
456_Q478_A1.1251.00
160_G363_S1.1251.00
145_V377_A1.1241.00
209_F233_V1.1161.00
202_V337_A1.1121.00
14_S17_L1.1071.00
167_Q170_P1.1061.00
14_S18_V1.1051.00
88_V117_W1.0951.00
157_F187_L1.0831.00
304_A307_Q1.0801.00
285_N288_Y1.0791.00
224_A291_K1.0781.00
380_F383_Y1.0761.00
133_F146_Y1.0731.00
457_Y475_M1.0641.00
307_Q311_A1.0571.00
284_Y468_A1.0551.00
450_Y479_F1.0541.00
425_N429_E1.0531.00
258_Q262_T1.0491.00
92_V359_F1.0481.00
170_P174_T1.0471.00
456_Q460_E1.0411.00
361_V377_A1.0381.00
449_Y452_N1.0341.00
261_T264_N1.0301.00
182_I186_E1.0291.00
460_E474_G1.0271.00
392_R395_E1.0181.00
137_A161_L1.0161.00
206_N209_F1.0151.00
120_V380_F1.0141.00
90_I373_Q1.0131.00
140_G364_P1.0081.00
24_V28_I1.0071.00
277_V472_S1.0071.00
226_S229_K1.0071.00
212_Y219_Q0.9941.00
174_T182_I0.9941.00
378_L382_L0.9921.00
220_L236_I0.9911.00
252_F257_G0.9911.00
388_Q391_L0.9881.00
211_P334_N0.9861.00
112_E117_W0.9831.00
90_I380_F0.9771.00
374_I378_L0.9771.00
111_F376_A0.9761.00
166_S170_P0.9631.00
387_Y405_Q0.9581.00
146_Y360_L0.9551.00
453_S456_Q0.9551.00
426_Q429_E0.9501.00
145_V380_F0.9491.00
179_P404_L0.9431.00
193_G360_L0.9411.00
326_A329_Q0.9391.00
234_W294_Y0.9361.00
269_P480_I0.9351.00
213_P223_I0.9351.00
281_N284_Y0.9341.00
319_D323_D0.9321.00
142_A362_S0.9321.00
169_L191_L0.9311.00
168_Y375_K0.9301.00
108_L120_V0.9281.00
182_I191_L0.9271.00
210_V227_V0.9271.00
166_S186_E0.9231.00
255_F278_N0.9221.00
472_S476_E0.9191.00
224_A235_G0.9121.00
110_Q388_Q0.9121.00
208_K211_P0.9041.00
19_A23_V0.9001.00
26_I29_A0.8991.00
227_V231_Y0.8991.00
429_E432_L0.8971.00
278_N282_F0.8971.00
308_L314_T0.8861.00
173_I176_L0.8851.00
163_L362_S0.8851.00
132_Q135_T0.8841.00
166_S191_L0.8831.00
467_N471_A0.8781.00
23_V26_I0.8761.00
223_I316_I0.8751.00
19_A26_I0.8731.00
114_A388_Q0.8731.00
453_S457_Y0.8731.00
471_A475_M0.8721.00
107_T110_Q0.8711.00
457_Y478_A0.8701.00
280_L472_S0.8691.00
228_N290_L0.8601.00
270_A273_S0.8591.00
162_V192_Y0.8571.00
146_Y162_V0.8571.00
252_F276_M0.8561.00
280_L461_F0.8551.00
114_A383_Y0.8551.00
27_V30_I0.8551.00
398_H402_A0.8541.00
432_L436_Q0.8491.00
176_L403_N0.8481.00
157_F162_V0.8461.00
90_I377_A0.8441.00
290_L294_Y0.8431.00
409_E412_T0.8421.00
90_I376_A0.8421.00
274_T277_V0.8411.00
88_V118_I0.8401.00
398_H401_P0.8391.00
258_Q261_T0.8391.00
82_T85_S0.8391.00
186_E189_G0.8391.00
374_I377_A0.8351.00
163_L168_Y0.8341.00
271_L276_M0.8331.00
223_I227_V0.8301.00
92_V145_V0.8281.00
403_N406_A0.8271.00
361_V365_Q0.8261.00
106_E396_V0.8251.00
221_V291_K0.8211.00
410_A413_Q0.8201.00
453_S475_M0.8201.00
178_V404_L0.8201.00
451_W455_H0.8181.00
472_S475_M0.8181.00
213_P338_A0.8171.00
263_N267_I0.8171.00
202_V431_I0.8171.00
32_G35_A0.8151.00
22_I28_I0.8141.00
130_T152_S0.8141.00
377_A381_V0.8121.00
388_Q392_R0.8101.00
325_N329_Q0.8031.00
391_L409_E0.7991.00
163_L361_V0.7981.00
136_A141_Q0.7971.00
168_Y374_I0.7961.00
232_H235_G0.7951.00
103_A106_E0.7941.00
457_Y471_A0.7941.00
106_E392_R0.7931.00
180_T183_K0.7881.00
204_F319_D0.7871.00
24_V27_V0.7871.00
227_V233_V0.7821.00
117_W379_L0.7801.00
478_A482_A0.7781.00
228_N231_Y0.7781.00
232_H313_Q0.7771.00
22_I26_I0.7771.00
21_I27_V0.7731.00
135_T139_A0.7721.00
83_P86_T0.7721.00
25_V28_I0.7691.00
224_A228_N0.7681.00
93_W143_P0.7681.00
253_A439_Q0.7641.00
280_L471_A0.7631.00
286_L291_K0.7591.00
399_D402_A0.7581.00
449_Y482_A0.7571.00
375_K378_L0.7541.00
131_S135_T0.7541.00
14_S21_I0.7521.00
452_N455_H0.7521.00
205_Y213_P0.7511.00
33_V36_F0.7501.00
115_F118_I0.7501.00
163_L167_Q0.7501.00
167_Q171_Q0.7491.00
461_F466_V0.7491.00
406_A409_E0.7461.00
407_Y410_A0.7431.00
110_Q389_A0.7421.00
85_S117_W0.7391.00
426_Q430_G0.7381.00
177_Y182_I0.7361.00
173_I382_L0.7361.00
14_S19_A0.7361.00
225_E228_N0.7341.00
33_V37_L0.7341.00
248_F252_F0.7301.00
453_S482_A0.7291.00
454_F475_M0.7231.00
471_A474_G0.7211.00
172_S378_L0.7191.00
408_N413_Q0.7181.00
208_K333_P0.7171.00
205_Y210_V0.7161.00
107_T389_A0.7151.00
206_N334_N0.7141.00
428_M432_L0.7131.00
229_K232_H0.7111.00
112_E120_V0.7111.00
217_T282_F0.7111.00
456_Q459_S0.7111.00
20_V24_V0.7101.00
22_I25_V0.7061.00
171_Q375_K0.7051.00
145_V359_F0.7031.00
277_V473_Q0.7031.00
18_V21_I0.6991.00
269_P476_E0.6961.00
19_A22_I0.6941.00
307_Q310_V0.6911.00
164_N192_Y0.6911.00
199_N357_T0.6901.00
273_S276_M0.6891.00
397_A401_P0.6871.00
90_I365_Q0.6841.00
179_P182_I0.6831.00
264_N267_I0.6821.00
447_M451_W0.6811.00
86_T117_W0.6811.00
217_T221_V0.6801.00
427_I430_G0.6801.00
234_W293_N0.6781.00
230_T233_V0.6781.00
278_N343_V0.6761.00
257_G276_M0.6761.00
196_D359_F0.6741.00
23_V29_A0.6731.00
21_I24_V0.6731.00
427_I431_I0.6731.00
115_F380_F0.6721.00
303_G306_G0.6691.00
279_A283_W0.6691.00
206_N312_N0.6681.00
221_V224_A0.6681.00
149_T152_S0.6671.00
273_S277_V0.6651.00
391_L406_A0.6591.00
77_L80_I0.6581.00
167_Q378_L0.6581.00
261_T270_A0.6581.00
344_S348_L0.6541.00
153_G193_G0.6531.00
107_T383_Y0.6531.00
177_Y385_T0.6521.00
300_G308_L0.6501.00
213_P219_Q0.6491.00
174_T186_E0.6481.00
217_T254_G0.6481.00
365_Q372_L0.6471.00
293_N308_L0.6461.00
176_L387_Y0.6461.00
21_I25_V0.6431.00
206_N333_P0.6431.00
288_Y464_N0.6421.00
271_L479_F0.6421.00
137_A362_S0.6421.00
153_G162_V0.6421.00
168_Y172_S0.6411.00
85_S88_V0.6391.00
253_A256_G0.6361.00
107_T384_F0.6341.00
92_V108_L0.6331.00
424_L427_I0.6321.00
155_A159_A0.6321.00
284_Y467_N0.6261.00
214_P223_I0.6261.00
31_G35_A0.6261.00
93_W123_T0.6241.00
430_G434_Q0.6221.00
446_Q449_Y0.6211.00
134_E155_A0.6201.00
30_I33_V0.6191.00
81_S84_P0.6171.00
99_S102_Q0.6151.00
227_V316_I0.6151.00
228_N234_W0.6131.00
204_F337_A0.6101.00
17_L20_V0.6091.00
237_A308_L0.6061.00
123_T136_A0.6061.00
404_L408_N0.6061.00
342_V347_G0.6051.00
253_A257_G0.6041.00
326_A330_A0.6031.00
263_N268_V0.6021.00
112_E118_I0.6021.00
209_F231_Y0.6011.00
204_F335_L0.6011.00
241_G301_A0.6011.00
92_V147_R0.6001.00
156_L162_V0.5991.00
20_V23_V0.5991.00
153_G157_F0.5971.00
30_I35_A0.5951.00
163_L378_L0.5951.00
272_N472_S0.5941.00
154_G158_A0.5941.00
435_A438_G0.5931.00
168_Y171_Q0.5921.00
468_A472_S0.5911.00
359_F384_F0.5911.00
233_V315_A0.5891.00
131_S134_E0.5881.00
448_A452_N0.5851.00
90_I145_V0.5851.00
16_T27_V0.5851.00
104_F107_T0.5851.00
273_S476_E0.5841.00
212_Y223_I0.5841.00
398_H404_L0.5831.00
425_N428_M0.5831.00
204_F324_L0.5821.00
303_G307_Q0.5811.00
305_E317_I0.5811.00
397_A402_A0.5811.00
227_V230_T0.5801.00
167_Q190_S0.5801.00
409_E413_Q0.5791.00
438_G441_F0.5781.00
87_P115_F0.5781.00
287_T292_V0.5761.00
283_W287_T0.5761.00
115_F376_A0.5741.00
87_P118_I0.5741.00
23_V28_I0.5741.00
324_L328_L0.5741.00
148_D156_L0.5731.00
16_T21_I0.5731.00
308_L311_A0.5721.00
158_A188_N0.5721.00
36_F39_S0.5701.00
284_Y287_T0.5701.00
152_S155_A0.5701.00
237_A305_E0.5691.00
387_Y390_D0.5691.00
255_F282_F0.5661.00
129_G133_F0.5661.00
251_W279_A0.5641.00
431_I435_A0.5641.00
458_A462_F0.5621.00
163_L364_P0.5621.00
17_L21_I0.5611.00
80_I83_P0.5611.00
90_I120_V0.5601.00
342_V348_L0.5601.00
123_T132_Q0.5591.00
126_V130_T0.5591.00
203_M318_F0.5591.00
26_I30_I0.5581.00
161_L164_N0.5571.00
408_N412_T0.5561.00
165_L381_V0.5551.00
224_A286_L0.5551.00
309_F317_I0.5541.00
87_P112_E0.5541.00
310_V330_A0.5531.00
215_N220_L0.5531.00
107_T392_R0.5501.00
258_Q263_N0.5501.00
275_A279_A0.5501.00
210_V315_A0.5501.00
21_I28_I0.5491.00
228_N233_V0.5471.00
103_A107_T0.5461.00
24_V29_A0.5461.00
136_A143_P0.5451.00
117_W376_A0.5441.00
35_A38_S0.5441.00
459_S463_A0.5441.00
88_V115_F0.5431.00
289_N292_V0.5431.00
215_N342_V0.5431.00
21_I26_I0.5431.00
457_Y461_F0.5421.00
219_Q223_I0.5421.00
425_N432_L0.5421.00
468_A471_A0.5421.00
480_I483_L0.5421.00
359_F381_V0.5411.00
405_Q409_E0.5411.00
469_T472_S0.5401.00
460_E471_A0.5391.00
269_P479_F0.5391.00
228_N232_H0.5391.00
387_Y403_N0.5391.00
128_V132_Q0.5381.00
90_I144_I0.5381.00
208_K312_N0.5381.00
119_H122_V0.5361.00
173_I178_V0.5351.00
274_T469_T0.5331.00
169_L378_L0.5321.00
130_T155_A0.5321.00
386_N390_D0.5311.00
439_Q442_P0.5311.00
20_V27_V0.5301.00
401_P407_Y0.5281.00
33_V38_S0.5271.00
165_L378_L0.5271.00
91_T143_P0.5261.00
461_F475_M0.5261.00
135_T138_K0.5261.00
276_M279_A0.5261.00
305_E314_T0.5241.00
92_V380_F0.5231.00
218_E282_F0.5231.00
475_M479_F0.5231.00
194_L378_L0.5221.00
175_S178_V0.5221.00
325_N328_L0.5211.00
87_P116_P0.5201.00
286_L292_V0.5191.00
144_I372_L0.5181.00
112_E380_F0.5181.00
426_Q435_A0.5171.00
16_T19_A0.5161.00
276_M280_L0.5131.00
373_Q377_A0.5131.00
154_G187_L0.5121.00
92_V122_V0.5121.00
185_W193_G0.5121.00
114_A386_N0.5121.00
425_N430_G0.5111.00
432_L435_A0.5111.00
343_V347_G0.5111.00
378_L381_V0.5101.00
18_V25_V0.5101.00
126_V129_G0.5091.00
284_Y464_N0.5081.00
233_V237_A0.5081.00
293_N296_A0.5071.00
142_A364_P0.5061.00
28_I32_G0.5061.00
32_G36_F0.5051.00
144_I374_I0.5051.00
361_V374_I0.5041.00
272_N276_M0.5041.00
166_S378_L0.5041.00
253_A258_Q0.5041.00
246_Y250_A0.5031.00
181_A198_V0.5021.00
433_E437_Y0.5021.00
79_G82_T0.5011.00
323_D326_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r2fA 1 0.7094 100 0.347 Contact Map
4r9fA 1 0.7094 100 0.358 Contact Map
3uorA 1 0.7304 100 0.365 Contact Map
4mfiA 1 0.738 100 0.377 Contact Map
4r6kA 1 0.7228 100 0.384 Contact Map
2xd3A 1 0.6979 100 0.395 Contact Map
4ovjA 1 0.7208 100 0.401 Contact Map
3vxbA 1 0.7075 100 0.402 Contact Map
4r6hA 1 0.717 100 0.406 Contact Map
2zyoA 1 0.7208 100 0.407 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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