GREMLIN Database
Q97YX9 - Amino acid permease related protein
UniProt: Q97YX9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 417 (399)
Sequences: 24522 (16341)
Seq/√Len: 818.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
288_I299_N4.4201.00
130_A305_L4.3791.00
291_S299_N3.1571.00
48_T221_G3.0731.00
207_K211_I2.9971.00
7_S203_K2.8721.00
204_N207_K2.7581.00
202_I208_I2.7101.00
293_K298_Y2.7051.00
88_G279_M2.6391.00
347_L351_A2.6241.00
288_I291_S2.5961.00
162_L230_A2.5801.00
72_F282_K2.5681.00
280_S290_S2.5281.00
123_F309_T2.4621.00
160_V164_L2.3431.00
12_F215_I2.3151.00
337_L340_S2.3041.00
8_V215_I2.2691.00
201_D274_R2.2621.00
200_E281_L2.1971.00
240_E243_L2.1731.00
131_F135_R2.1661.00
364_I368_S2.1641.00
277_H281_L2.1351.00
76_F84_G2.1091.00
11_A202_I2.1081.00
127_L309_T2.0841.00
134_I298_Y2.0481.00
302_V306_I2.0411.00
8_V208_I2.0381.00
123_F312_L2.0301.00
138_D142_K2.0181.00
211_I215_I1.9931.00
337_L343_A1.9861.00
130_A301_E1.9651.00
8_V12_F1.9601.00
122_A312_L1.9531.00
7_S10_E1.9471.00
249_I252_Y1.9381.00
149_I153_V1.9341.00
92_L304_S1.9211.00
76_F81_E1.9091.00
352_L355_L1.9011.00
361_E364_I1.9001.00
366_I370_L1.8851.00
174_I178_P1.8811.00
340_S343_A1.8751.00
240_E244_D1.8631.00
289_I303_I1.8481.00
372_S375_I1.8431.00
400_I404_V1.8191.00
363_T367_T1.7991.00
75_A87_T1.7941.00
31_I40_L1.7841.00
283_N287_S1.7751.00
49_I53_V1.7561.00
172_L175_P1.7331.00
127_L305_L1.7311.00
322_Y325_F1.6791.00
80_T83_L1.6761.00
334_L337_L1.6721.00
12_F219_L1.6671.00
399_F403_E1.6661.00
204_N208_I1.6621.00
10_E145_E1.6591.00
126_I308_Y1.6491.00
134_I302_V1.6471.00
133_V266_I1.6401.00
392_F396_I1.6341.00
354_K357_K1.6301.00
368_S372_S1.6231.00
214_V218_L1.6101.00
153_V157_V1.6031.00
361_E368_S1.5971.00
398_G401_Y1.5951.00
375_I378_Y1.5941.00
348_F351_A1.5811.00
82_R402_A1.5631.00
109_I121_V1.5531.00
293_K296_R1.5501.00
370_L374_I1.5481.00
43_A181_V1.5481.00
15_S216_V1.5371.00
6_L10_E1.5291.00
79_L83_L1.5221.00
238_L247_G1.5101.00
89_W398_G1.4881.00
55_G217_I1.4761.00
272_M304_S1.4671.00
198_M270_I1.4591.00
276_L300_A1.4581.00
393_A396_I1.4531.00
277_H292_V1.4471.00
102_L106_S1.4401.00
154_A256_S1.4341.00
353_K357_K1.4321.00
365_A369_T1.4221.00
130_A302_V1.4221.00
47_G185_A1.4141.00
123_F127_L1.4091.00
163_L230_A1.4081.00
243_L250_F1.3981.00
340_S344_N1.3871.00
238_L246_V1.3781.00
168_P171_N1.3671.00
349_R352_L1.3661.00
173_T177_N1.3651.00
39_F174_I1.3641.00
174_I177_N1.3621.00
299_N303_I1.3621.00
348_F352_L1.3621.00
287_S290_S1.3601.00
204_N211_I1.3601.00
126_I305_L1.3491.00
10_E141_V1.3471.00
166_T233_L1.3451.00
65_Y77_Y1.3421.00
242_L247_G1.3391.00
159_S226_L1.3361.00
377_V381_Q1.3361.00
273_S301_E1.3331.00
218_L222_L1.3321.00
55_G213_T1.3271.00
291_S298_Y1.3271.00
341_L344_N1.3251.00
251_P255_F1.3241.00
287_S291_S1.3231.00
49_I367_T1.3211.00
205_A210_G1.3161.00
363_T368_S1.3151.00
243_L248_F1.2891.00
238_L243_L1.2851.00
374_I378_Y1.2801.00
208_I211_I1.2791.00
68_H200_E1.2661.00
222_L226_L1.2641.00
393_A397_A1.2621.00
337_L341_L1.2531.00
73_T77_Y1.2481.00
236_T240_E1.2471.00
56_I214_V1.2441.00
389_Y393_A1.2421.00
158_S162_L1.2391.00
361_E365_A1.2381.00
19_Q220_G1.2301.00
173_T176_T1.2221.00
375_I379_S1.2151.00
41_T229_Y1.2141.00
8_V211_I1.2121.00
173_T178_P1.2061.00
351_A354_K1.1941.00
92_L276_L1.1941.00
152_I156_I1.1921.00
363_T366_I1.1911.00
330_G333_V1.1881.00
401_Y405_L1.1881.00
53_V367_T1.1781.00
129_S265_G1.1751.00
237_D245_K1.1721.00
394_W398_G1.1681.00
376_L379_S1.1671.00
15_S195_L1.1641.00
67_Q73_T1.1611.00
62_S74_Y1.1581.00
336_Y340_S1.1561.00
385_P388_N1.1561.00
103_L107_I1.1401.00
327_V330_G1.1371.00
101_T104_A1.1261.00
276_L285_M1.1151.00
58_I71_Y1.1091.00
389_Y392_F1.1071.00
9_F13_S1.1071.00
380_I383_N1.1061.00
348_F355_L1.1031.00
384_T387_I1.1031.00
328_L332_T1.0981.00
6_L11_A1.0891.00
299_N302_V1.0891.00
60_R63_L1.0871.00
203_K208_I1.0861.00
385_P389_Y1.0861.00
120_L124_L1.0811.00
6_L141_V1.0791.00
281_L290_S1.0781.00
85_L89_W1.0781.00
98_Y308_Y1.0771.00
143_Y147_I1.0751.00
5_K203_K1.0751.00
373_L377_V1.0721.00
144_A266_I1.0691.00
102_L265_G1.0671.00
82_R399_F1.0631.00
132_L143_Y1.0631.00
322_Y337_L1.0611.00
142_K146_F1.0601.00
329_G337_L1.0591.00
350_I353_K1.0511.00
57_V365_A1.0481.00
386_I389_Y1.0461.00
362_I366_I1.0451.00
371_L378_Y1.0391.00
320_G323_T1.0381.00
130_A134_I1.0321.00
14_L198_M1.0291.00
318_F321_L1.0221.00
306_I310_V1.0141.00
371_L375_I1.0141.00
349_R353_K1.0131.00
333_V336_Y1.0071.00
32_G40_L1.0021.00
11_A212_I1.0001.00
321_L324_T1.0001.00
20_A23_T0.9991.00
105_G258_L0.9981.00
390_I393_A0.9961.00
291_S294_Y0.9951.00
237_D242_L0.9931.00
16_F219_L0.9871.00
334_L338_I0.9861.00
124_L128_F0.9851.00
229_Y233_L0.9821.00
137_L270_I0.9801.00
237_D240_E0.9801.00
75_A83_L0.9801.00
128_F262_I0.9791.00
292_V295_N0.9731.00
365_A368_S0.9721.00
337_L344_N0.9681.00
105_G125_V0.9641.00
102_L126_I0.9571.00
72_F278_A0.9561.00
242_L246_V0.9561.00
157_V161_V0.9501.00
193_G197_P0.9471.00
67_Q77_Y0.9471.00
339_I343_A0.9391.00
351_A355_L0.9391.00
117_S120_L0.9381.00
45_I225_A0.9321.00
352_L357_K0.9271.00
372_S376_L0.9271.00
348_F357_K0.9261.00
239_I243_L0.9251.00
347_L350_I0.9221.00
13_S145_E0.9211.00
199_S209_V0.9201.00
147_I263_L0.9191.00
99_G102_L0.9171.00
69_G73_T0.9151.00
156_I160_V0.9141.00
369_T373_L0.9081.00
60_R349_R0.9061.00
94_Y106_S0.9011.00
180_L184_Y0.9011.00
76_F282_K0.9001.00
16_F220_G0.8961.00
236_T239_I0.8941.00
24_S28_F0.8931.00
64_R357_K0.8891.00
329_G332_T0.8881.00
134_I293_K0.8871.00
159_S230_A0.8861.00
134_I296_R0.8831.00
127_L131_F0.8821.00
330_G337_L0.8801.00
129_S266_I0.8771.00
319_V323_T0.8761.00
69_G72_F0.8691.00
227_L231_S0.8681.00
237_D247_G0.8681.00
48_T189_P0.8681.00
50_L371_L0.8671.00
79_L347_L0.8611.00
305_L309_T0.8571.00
237_D241_I0.8561.00
10_E142_K0.8551.00
368_S383_N0.8541.00
175_P178_P0.8541.00
344_N347_L0.8531.00
269_I305_L0.8511.00
221_G225_A0.8501.00
322_Y326_L0.8501.00
131_F134_I0.8481.00
238_L241_I0.8481.00
401_Y404_V0.8471.00
41_T232_A0.8461.00
386_I390_I0.8451.00
53_V57_V0.8451.00
248_F251_P0.8441.00
396_I400_I0.8421.00
215_I219_L0.8421.00
402_A406_E0.8411.00
365_A379_S0.8381.00
5_K138_D0.8381.00
298_Y302_V0.8281.00
319_V322_Y0.8241.00
376_L380_I0.8241.00
325_F329_G0.8241.00
82_R86_V0.8211.00
361_E367_T0.8131.00
142_K145_E0.8121.00
79_L342_S0.8101.00
89_W285_M0.8101.00
119_D123_F0.8081.00
95_A99_G0.8061.00
371_L374_I0.8061.00
101_T264_G0.8031.00
331_L334_L0.8011.00
289_I299_N0.8001.00
159_S163_L0.7981.00
329_G333_V0.7971.00
237_D246_V0.7951.00
397_A401_Y0.7861.00
320_G324_T0.7811.00
348_F353_K0.7801.00
194_N271_A0.7801.00
387_I391_F0.7781.00
152_I223_L0.7771.00
52_L56_I0.7761.00
64_R355_L0.7761.00
365_A382_E0.7721.00
377_V380_I0.7711.00
294_Y298_Y0.7701.00
345_L349_R0.7671.00
109_I113_Y0.7671.00
135_R139_V0.7591.00
374_I377_V0.7551.00
362_I365_A0.7521.00
355_L358_R0.7511.00
121_V124_L0.7501.00
103_L106_S0.7501.00
151_E260_G0.7471.00
42_I46_I0.7471.00
285_M289_I0.7441.00
338_I369_T0.7411.00
338_I342_S0.7361.00
52_L214_V0.7351.00
306_I309_T0.7351.00
94_Y105_G0.7351.00
9_F145_E0.7321.00
323_T327_V0.7321.00
323_T326_L0.7281.00
368_S371_L0.7261.00
8_V212_I0.7251.00
336_Y339_I0.7251.00
344_N348_F0.7221.00
371_L377_V0.7201.00
80_T403_E0.7201.00
129_S269_I0.7191.00
57_V341_L0.7181.00
126_I312_L0.7161.00
9_F142_K0.7121.00
98_Y102_L0.7111.00
337_L345_L0.7111.00
237_D243_L0.7101.00
331_L335_S0.7091.00
326_L329_G0.7081.00
161_V165_G0.7081.00
280_S289_I0.7071.00
338_I341_L0.7071.00
45_I49_I0.7011.00
365_A380_I0.7001.00
400_I403_E0.6971.00
317_H321_L0.6971.00
388_N391_F0.6931.00
242_L245_K0.6931.00
101_T107_I0.6931.00
341_L345_L0.6911.00
102_L107_I0.6911.00
332_T337_L0.6901.00
209_V213_T0.6881.00
158_S242_L0.6861.00
219_L223_L0.6861.00
5_K137_L0.6861.00
239_I247_G0.6851.00
97_S102_L0.6831.00
340_S345_L0.6801.00
123_F313_F0.6801.00
397_A400_I0.6761.00
87_T339_I0.6761.00
141_V145_E0.6741.00
28_F31_I0.6741.00
113_Y116_I0.6721.00
210_G213_T0.6721.00
340_S350_I0.6721.00
353_K356_R0.6711.00
238_L245_K0.6681.00
236_T247_G0.6681.00
40_L228_F0.6671.00
95_A104_A0.6661.00
21_P224_S0.6661.00
200_E277_H0.6661.00
68_H277_H0.6651.00
77_Y352_L0.6631.00
42_I45_I0.6631.00
61_L74_Y0.6631.00
375_I380_I0.6631.00
379_S383_N0.6621.00
99_G106_S0.6611.00
12_F212_I0.6611.00
387_I395_I0.6571.00
350_I354_K0.6571.00
100_G187_G0.6561.00
226_L230_A0.6531.00
51_V192_Y0.6491.00
322_Y329_G0.6481.00
72_F76_F0.6481.00
364_I367_T0.6461.00
327_V337_L0.6451.00
392_F395_I0.6441.00
365_A383_N0.6431.00
133_V270_I0.6431.00
28_F228_F0.6411.00
172_L178_P0.6401.00
367_T370_L0.6401.00
388_N392_F0.6391.00
129_S262_I0.6381.00
110_I118_A0.6381.00
106_S121_V0.6371.00
269_I273_S0.6371.00
395_I399_F0.6371.00
159_S227_L0.6371.00
104_A107_I0.6371.00
390_I394_W0.6351.00
239_I242_L0.6351.00
26_I104_A0.6351.00
109_I258_L0.6351.00
384_T388_N0.6351.00
166_T230_A0.6341.00
388_N394_W0.6331.00
274_R277_H0.6321.00
17_G148_S0.6311.00
97_S100_G0.6301.00
273_S300_A0.6301.00
41_T225_A0.6291.00
19_Q216_V0.6281.00
339_I342_S0.6271.00
334_L341_L0.6241.00
336_Y341_L0.6231.00
100_G104_A0.6231.00
137_L198_M0.6221.00
204_N210_G0.6211.00
327_V340_S0.6211.00
335_S340_S0.6201.00
24_S27_T0.6201.00
379_S382_E0.6201.00
289_I300_A0.6191.00
108_Y257_A0.6191.00
18_G267_A0.6191.00
41_T45_I0.6161.00
139_V142_K0.6141.00
12_F15_S0.6141.00
347_L353_K0.6141.00
20_A151_E0.6141.00
317_H320_G0.6131.00
57_V368_S0.6131.00
18_G268_Y0.6121.00
20_A25_I0.6111.00
172_L176_T0.6111.00
361_E371_L0.6101.00
201_D292_V0.6091.00
150_A154_A0.6071.00
55_G192_Y0.6071.00
162_L166_T0.6061.00
163_L226_L0.6051.00
322_Y340_S0.6051.00
394_W397_A0.6051.00
372_S378_Y0.6041.00
16_F148_S0.6011.00
329_G334_L0.6001.00
37_G232_A0.5961.00
215_I218_L0.5951.00
99_G104_A0.5941.00
361_E378_Y0.5921.00
288_I303_I0.5921.00
361_E379_S0.5911.00
172_L177_N0.5901.00
343_A347_L0.5881.00
387_I398_G0.5871.00
133_V301_E0.5871.00
403_E406_E0.5861.00
24_S227_L0.5861.00
260_G263_L0.5841.00
352_L356_R0.5831.00
332_T336_Y0.5831.00
328_L331_L0.5811.00
102_L105_G0.5791.00
388_N402_A0.5791.00
327_V333_V0.5791.00
164_L167_K0.5781.00
391_F395_I0.5781.00
82_R403_E0.5771.00
59_Y63_L0.5761.00
141_V266_I0.5741.00
78_S343_A0.5731.00
241_I247_G0.5721.00
272_M276_L0.5721.00
288_I292_V0.5711.00
190_I193_G0.5701.00
61_L78_S0.5701.00
378_Y381_Q0.5691.00
39_F173_T0.5681.00
101_T106_S0.5681.00
325_F330_G0.5681.00
72_F88_G0.5661.00
136_G139_V0.5661.00
322_Y327_V0.5661.00
98_Y101_T0.5641.00
378_Y382_E0.5641.00
170_F232_A0.5631.00
274_R297_P0.5621.00
64_R358_R0.5621.00
106_S122_A0.5611.00
62_S196_N0.5601.00
5_K9_F0.5581.00
125_V265_G0.5581.00
112_S254_I0.5581.00
36_G39_F0.5571.00
62_S209_V0.5551.00
380_I388_N0.5541.00
385_P392_F0.5531.00
351_A357_K0.5521.00
297_P300_A0.5491.00
344_N350_I0.5491.00
44_T188_M0.5481.00
23_T31_I0.5471.00
391_F402_A0.5471.00
276_L303_I0.5461.00
72_F84_G0.5461.00
126_I309_T0.5461.00
94_Y268_Y0.5451.00
127_L130_A0.5441.00
398_G402_A0.5441.00
148_S151_E0.5441.00
196_N213_T0.5431.00
324_T327_V0.5431.00
252_Y256_S0.5411.00
332_T343_A0.5401.00
325_F337_L0.5401.00
70_G196_N0.5391.00
111_T115_K0.5391.00
205_A208_I0.5391.00
15_S19_Q0.5391.00
330_G340_S0.5381.00
239_I245_K0.5371.00
79_L82_R0.5371.00
333_V343_A0.5361.00
368_S375_I0.5341.00
101_T105_G0.5341.00
369_T372_S0.5341.00
139_V143_Y0.5341.00
140_S270_I0.5341.00
345_L350_I0.5331.00
238_L242_L0.5321.00
71_Y193_G0.5301.00
94_Y104_A0.5291.00
348_F354_K0.5281.00
364_I372_S0.5271.00
371_L376_L0.5261.00
111_T254_I0.5251.00
338_I345_L0.5251.00
274_R292_V0.5241.00
24_S29_G0.5241.00
354_K358_R0.5231.00
134_I301_E0.5231.00
230_A233_L0.5231.00
27_T30_T0.5211.00
119_D312_L0.5201.00
333_V337_L0.5201.00
330_G338_I0.5191.00
71_Y197_P0.5191.00
374_I381_Q0.5191.00
55_G59_Y0.5191.00
202_I209_V0.5171.00
21_P28_F0.5171.00
84_G88_G0.5171.00
110_I114_L0.5171.00
11_A198_M0.5161.00
334_L340_S0.5151.00
393_A400_I0.5151.00
325_F340_S0.5141.00
361_E366_I0.5121.00
364_I383_N0.5121.00
321_L327_V0.5101.00
402_A405_L0.5091.00
326_L340_S0.5091.00
369_T379_S0.5091.00
359_K362_I0.5081.00
207_K210_G0.5081.00
391_F396_I0.5061.00
332_T340_S0.5051.00
395_I398_G0.5051.00
219_L226_L0.5031.00
310_V313_F0.5011.00
183_L187_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9568 100 0.313 Contact Map
3giaA 1 0.9688 100 0.342 Contact Map
4djkA 2 0.9305 100 0.385 Contact Map
2jlnA 1 0.9472 98.8 0.852 Contact Map
3dh4A 3 0.94 98.4 0.869 Contact Map
2xq2A 2 0.9376 98.3 0.874 Contact Map
2a65A 2 0.9616 97.9 0.886 Contact Map
4xp4A 1 0.9712 97.8 0.889 Contact Map
4wgvA 2 0.8297 96.6 0.908 Contact Map
4us3A 1 0.8777 96.3 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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