GREMLIN Database
Q97YX8 - Na(+)/Ca(2+) exchanging protein related
UniProt: Q97YX8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 307 (298)
Sequences: 2912 (1873)
Seq/√Len: 108.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_M121_V4.6401.00
141_I291_V4.0801.00
163_M167_G4.0631.00
133_L137_L3.7971.00
80_T272_A3.1841.00
150_F154_G3.0521.00
191_A201_L2.7601.00
123_I126_K2.6641.00
282_D289_E2.6181.00
117_G121_V2.6161.00
88_V294_I2.5061.00
298_V302_I2.3171.00
214_E239_S2.2721.00
138_I295_G2.2101.00
144_V148_A2.1811.00
5_W9_I2.1711.00
217_S223_L2.1451.00
74_G78_L2.1371.00
130_I302_I2.1121.00
286_K289_E2.1061.00
123_I127_L2.0951.00
257_Y260_Q2.0641.00
90_Y97_A2.0381.00
124_Y127_L2.0161.00
150_F153_E2.0011.00
51_E214_E1.9991.00
190_I194_F1.9791.00
78_L240_K1.9781.00
167_G171_A1.9381.00
63_S198_A1.9351.00
15_I19_A1.8761.00
243_N247_L1.8681.00
185_E188_N1.8541.00
211_E243_N1.8341.00
30_E38_T1.8071.00
206_A209_A1.7751.00
180_S246_V1.7661.00
140_V144_V1.7651.00
77_L81_L1.7571.00
6_L14_A1.7511.00
134_L295_G1.7321.00
19_A22_L1.7291.00
74_G211_E1.7161.00
192_I198_A1.7141.00
121_V124_Y1.6471.00
29_L33_L1.6461.00
6_L10_G1.6421.00
272_A276_A1.6331.00
273_N277_L1.6241.00
17_V21_L1.6151.00
92_F95_R1.6041.00
71_A248_L1.6031.00
211_E215_K1.5941.00
82_G211_E1.5641.00
111_L115_T1.5621.00
123_I128_N1.5621.00
52_T247_L1.5611.00
137_L140_V1.5561.00
87_G289_E1.5461.00
124_Y128_N1.5331.00
25_G172_G1.5321.00
32_F162_L1.5261.00
240_K243_N1.5181.00
206_A210_G1.5161.00
78_L211_E1.5121.00
78_L239_S1.4981.00
96_T284_R1.4941.00
94_W227_D1.4841.00
48_A211_E1.4821.00
133_L253_I1.4811.00
269_S273_N1.4751.00
230_S234_L1.4741.00
177_V181_H1.4451.00
84_G290_S1.4271.00
54_F70_S1.4231.00
87_G285_L1.4201.00
162_L166_V1.4041.00
30_E35_Q1.3981.00
103_E107_E1.3871.00
108_N111_L1.3851.00
290_S293_L1.3831.00
164_K167_G1.3771.00
151_R154_G1.3761.00
181_H185_E1.3731.00
30_E40_G1.3681.00
44_G47_T1.3451.00
125_G128_N1.3391.00
75_N243_N1.3391.00
106_V109_V1.3371.00
186_Y189_E1.3341.00
12_F20_E1.3030.99
122_L128_N1.2980.99
274_M277_L1.2940.99
236_F240_K1.2930.99
223_L231_L1.2810.99
7_E182_Y1.2800.99
152_R155_M1.2770.99
218_A235_S1.2750.99
295_G302_I1.2690.99
174_V178_V1.2670.99
29_L162_L1.2660.99
283_K286_K1.2570.99
112_V274_M1.2490.99
26_A43_L1.2460.99
160_G164_K1.2180.99
11_I179_F1.1980.99
87_G290_S1.1980.99
204_V207_P1.1970.99
121_V131_S1.1880.99
140_V171_A1.1650.99
71_A206_A1.1510.99
218_A236_F1.1500.99
145_Y149_K1.1500.99
168_F171_A1.1500.99
202_S207_P1.1460.98
227_D232_S1.1440.98
11_I182_Y1.1440.98
65_D68_L1.1430.98
85_L294_I1.1270.98
72_I248_L1.1270.98
86_V90_Y1.1180.98
25_G169_I1.1120.98
67_A71_A1.1100.98
250_I254_F1.1070.98
44_G242_E1.1040.98
272_A279_V1.1000.98
45_F48_A1.0980.98
98_L101_S1.0970.98
84_G91_A1.0970.98
137_L141_I1.0920.98
66_V187_I1.0860.98
52_T78_L1.0800.98
18_S179_F1.0800.98
66_V70_S1.0790.98
211_E242_E1.0720.98
15_I20_E1.0710.98
33_L37_I1.0680.98
266_Y269_S1.0650.98
269_S272_A1.0640.98
145_Y154_G1.0620.98
77_L211_E1.0610.97
176_L191_A1.0530.97
23_A215_K1.0520.97
171_A175_L1.0500.97
187_I206_A1.0500.97
94_W97_A1.0460.97
59_S62_G1.0460.97
70_S215_K1.0450.97
138_I288_F1.0360.97
210_G235_S1.0360.97
116_I274_M1.0240.97
263_L270_L1.0200.97
104_Y108_N1.0200.97
84_G90_Y1.0180.97
80_T293_L1.0180.97
155_M158_E1.0100.97
17_V20_E1.0010.96
88_V92_F1.0000.96
268_S272_A1.0000.96
44_G48_A0.9930.96
137_L291_V0.9920.96
106_V110_F0.9870.96
16_F19_A0.9810.96
93_K225_S0.9790.96
265_E270_L0.9780.96
120_L128_N0.9670.96
6_L9_I0.9650.96
265_E273_N0.9600.95
201_L209_A0.9600.95
273_N279_V0.9590.95
132_G249_G0.9580.95
77_L297_Y0.9550.95
211_E240_K0.9530.95
183_F241_I0.9530.95
179_F241_I0.9470.95
104_Y107_E0.9460.95
56_I60_L0.9370.95
39_G180_S0.9210.94
38_T43_L0.9180.94
113_L117_G0.9130.94
100_I116_I0.9130.94
23_A38_T0.9120.94
47_T212_L0.9110.94
7_E10_G0.9090.94
43_L47_T0.9080.94
67_A70_S0.9070.94
130_I134_L0.8980.94
267_A272_A0.8970.94
140_V281_F0.8930.93
116_I121_V0.8920.93
265_E268_S0.8880.93
113_L159_K0.8830.93
200_W305_F0.8830.93
78_L210_G0.8820.93
57_V60_L0.8800.93
114_T117_G0.8750.93
77_L214_E0.8740.93
79_F276_A0.8730.93
34_G202_S0.8720.93
236_F239_S0.8710.92
265_E269_S0.8670.92
183_F212_L0.8640.92
111_L117_G0.8610.92
63_S66_V0.8610.92
217_S235_S0.8560.92
202_S239_S0.8520.92
213_E240_K0.8500.92
115_T121_V0.8470.91
27_D48_A0.8460.91
21_L168_F0.8450.91
21_L25_G0.8450.91
119_L123_I0.8440.91
14_A175_L0.8370.91
15_I23_A0.8360.91
239_S242_E0.8340.91
8_F186_Y0.8340.91
23_A211_E0.8330.91
47_T51_E0.8330.91
295_G299_I0.8310.91
88_V141_I0.8250.90
270_L273_N0.8230.90
204_V301_V0.8200.90
152_R156_E0.8190.90
257_Y261_Q0.8190.90
59_S255_T0.8180.90
40_G44_G0.8130.90
43_L198_A0.8120.90
190_I193_M0.8110.90
189_E193_M0.8040.89
116_I296_V0.8040.89
129_I133_L0.8010.89
9_I13_I0.7990.89
97_A285_L0.7980.89
48_A56_I0.7930.88
123_I137_L0.7890.88
6_L178_V0.7870.88
218_A222_V0.7850.88
208_I250_I0.7840.88
6_L156_E0.7830.88
100_I103_E0.7820.88
15_I25_G0.7820.88
57_V71_A0.7770.87
213_E235_S0.7760.87
19_A239_S0.7700.87
72_I203_L0.7690.87
64_F257_Y0.7670.87
70_S210_G0.7610.86
26_A42_I0.7590.86
63_S188_N0.7590.86
85_L171_A0.7590.86
136_I140_V0.7590.86
8_F183_F0.7540.86
13_I120_L0.7530.86
113_L122_L0.7520.86
75_N244_A0.7510.86
89_F219_F0.7490.85
268_S273_N0.7410.85
132_G135_L0.7370.85
122_L126_K0.7370.85
47_T82_G0.7370.85
58_A73_G0.7360.84
187_I190_I0.7350.84
159_K178_V0.7340.84
57_V66_V0.7320.84
91_A97_A0.7300.84
191_A202_S0.7290.84
189_E192_I0.7270.84
224_M229_G0.7270.84
180_S196_V0.7270.84
144_V274_M0.7270.84
134_L298_V0.7260.84
279_V288_F0.7250.84
21_L175_L0.7250.84
129_I132_G0.7240.84
134_L138_I0.7230.83
18_S175_L0.7200.83
189_E266_Y0.7160.83
171_A267_A0.7100.82
87_G91_A0.7100.82
210_G240_K0.7030.82
31_D36_G0.7020.82
46_L78_L0.7010.82
148_A151_R0.6980.81
55_V70_S0.6970.81
225_S271_I0.6960.81
39_G43_L0.6950.81
145_Y287_T0.6910.81
23_A183_F0.6910.81
122_L266_Y0.6900.80
38_T214_E0.6890.80
155_M171_A0.6850.80
204_V300_I0.6850.80
5_W155_M0.6830.80
76_V269_S0.6810.80
165_P169_I0.6810.80
186_Y193_M0.6810.80
178_V182_Y0.6780.79
48_A53_I0.6770.79
6_L171_A0.6760.79
210_G213_E0.6760.79
250_I253_I0.6760.79
250_I255_T0.6740.79
99_Q285_L0.6740.79
267_A271_I0.6710.79
164_K171_A0.6670.78
6_L13_I0.6660.78
52_T77_L0.6660.78
134_L299_I0.6630.78
204_V209_A0.6630.78
103_E133_L0.6630.78
265_E279_V0.6620.78
273_N280_L0.6610.78
77_L80_T0.6580.77
176_L246_V0.6570.77
189_E219_F0.6550.77
26_A30_E0.6550.77
187_I201_L0.6520.77
95_R174_V0.6510.77
20_E206_A0.6490.76
5_W60_L0.6480.76
120_L158_E0.6470.76
118_M248_L0.6470.76
239_S243_N0.6470.76
48_A78_L0.6450.76
203_L232_S0.6440.76
100_I105_S0.6430.76
104_Y279_V0.6410.75
265_E272_A0.6400.75
19_A215_K0.6390.75
132_G150_F0.6370.75
148_A152_R0.6360.75
159_K295_G0.6350.75
12_F16_F0.6340.75
46_L239_S0.6300.74
210_G242_E0.6280.74
53_I176_L0.6270.74
152_R157_R0.6270.74
282_D286_K0.6270.74
39_G58_A0.6260.74
73_G80_T0.6260.74
78_L206_A0.6260.74
46_L49_L0.6250.74
25_G45_F0.6220.73
74_G82_G0.6220.73
44_G51_E0.6200.73
41_I47_T0.6200.73
137_L156_E0.6190.73
70_S247_L0.6160.73
176_L213_E0.6160.73
44_G211_E0.6150.72
167_G284_R0.6120.72
99_Q169_I0.6120.72
301_V305_F0.6120.72
157_R299_I0.6110.72
114_T121_V0.6100.72
187_I209_A0.6100.72
117_G170_I0.6090.72
191_A210_G0.6080.72
244_A248_L0.6080.72
66_V202_S0.6070.71
100_I234_L0.6010.71
135_L145_Y0.6000.71
185_E189_E0.6000.71
54_F58_A0.6000.71
6_L284_R0.5970.70
85_L89_F0.5960.70
171_A256_D0.5940.70
274_M280_L0.5910.69
259_L262_A0.5910.69
160_G168_F0.5910.69
47_T243_N0.5900.69
150_F158_E0.5870.69
141_I145_Y0.5850.69
214_E217_S0.5840.68
222_V225_S0.5840.68
133_L136_I0.5840.68
144_V152_R0.5840.68
196_V200_W0.5830.68
6_L159_K0.5820.68
276_A280_L0.5790.68
33_L241_I0.5790.68
266_Y270_L0.5780.68
138_I292_I0.5760.67
71_A251_I0.5750.67
132_G139_Y0.5740.67
97_A100_I0.5740.67
116_I253_I0.5700.67
210_G215_K0.5690.67
80_T242_E0.5690.67
149_K153_E0.5680.66
71_A75_N0.5670.66
118_M244_A0.5650.66
93_K103_E0.5620.66
51_E74_G0.5610.65
69_G202_S0.5590.65
163_M299_I0.5580.65
8_F190_I0.5550.65
58_A184_V0.5520.64
159_K162_L0.5510.64
260_Q269_S0.5490.64
39_G73_G0.5480.64
216_I250_I0.5470.63
56_I79_F0.5460.63
10_G161_N0.5460.63
75_N240_K0.5430.63
152_R170_I0.5430.63
143_V147_V0.5420.63
120_L303_L0.5410.63
179_F233_I0.5400.63
23_A210_G0.5400.63
234_L238_G0.5390.62
282_D288_F0.5390.62
287_T293_L0.5380.62
51_E239_S0.5370.62
209_A213_E0.5340.62
146_R169_I0.5340.62
48_A215_K0.5320.61
9_I141_I0.5320.61
46_L53_I0.5280.61
15_I27_D0.5270.61
9_I166_V0.5250.60
75_N257_Y0.5240.60
43_L243_N0.5220.60
153_E157_R0.5220.60
254_F280_L0.5210.60
262_A265_E0.5210.60
74_G243_N0.5190.59
11_I14_A0.5160.59
149_K154_G0.5160.59
111_L114_T0.5130.59
47_T211_E0.5120.58
60_L85_L0.5120.58
47_T236_F0.5110.58
84_G215_K0.5100.58
36_G39_G0.5100.58
207_P211_E0.5090.58
118_M122_L0.5090.58
82_G86_V0.5080.58
166_V189_E0.5080.58
60_L174_V0.5070.58
167_G193_M0.5060.58
113_L141_I0.5030.57
52_T56_I0.5030.57
78_L215_K0.5030.57
160_G165_P0.5020.57
249_G253_I0.5010.57
68_L258_E0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k1cA 4 0.987 100 0.144 Contact Map
4kjrA 3 0.9414 100 0.169 Contact Map
3v5uA 1 0.9511 100 0.174 Contact Map
4kppA 1 0.987 100 0.232 Contact Map
3l1lA 2 0.4821 16.5 0.952 Contact Map
4pgrA 1 0.4397 7.6 0.958 Contact Map
3zuxA 1 0.645 6.2 0.96 Contact Map
3o7qA 1 0.456 5.7 0.961 Contact Map
4w6vA 1 0.4853 5.6 0.961 Contact Map
2m20A 2 0.1954 5.6 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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