Q97YX8 - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q97YX8 - Na(+)/Ca(2+) exchanging protein related

UniProt:	Q97YX8	Sequences: MLLFWLEFIGIFIAIFVSAELLAKGADELEDFLGQGITGGIILGFLTALPETIFVIVASLEGSFDVALGSAIGGNVLLFTLGIGLVGVFYAFKWRTALQISSEYSVENVFLVLTTIGMLLVLIYGKLNIISGLLLILIYVIYVVYRVAKFRREGMEREKGNLMKPVGFIIAGGVLLVVFSHYFVEYINEIAIMFNVPAIWLSLVIAPIAGELEEKISAFRLVLMSKDGGSLSILSFVGSKIENATVLLGIIGIFTDYELQQALPEYASSLIANMIALYVLFDKRLKTFESVILIGVYVIIVILSFYL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	307 (298)
Sequences:	2912 (1873)
Seq/√Len:	108.5

ECOLI - YRBG CHAA
BACSU - CHAA
HALSA - Q9HN44 Q9HS69
SULSO - Q97YX8 Q97U31

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
118_M	121_V	4.640	1.00
141_I	291_V	4.080	1.00
163_M	167_G	4.063	1.00
133_L	137_L	3.797	1.00
80_T	272_A	3.184	1.00
150_F	154_G	3.052	1.00
191_A	201_L	2.760	1.00
123_I	126_K	2.664	1.00
282_D	289_E	2.618	1.00
117_G	121_V	2.616	1.00
88_V	294_I	2.506	1.00
298_V	302_I	2.317	1.00
214_E	239_S	2.272	1.00
138_I	295_G	2.210	1.00
144_V	148_A	2.181	1.00
5_W	9_I	2.171	1.00
217_S	223_L	2.145	1.00
74_G	78_L	2.137	1.00
130_I	302_I	2.112	1.00
286_K	289_E	2.106	1.00
123_I	127_L	2.095	1.00
257_Y	260_Q	2.064	1.00
90_Y	97_A	2.038	1.00
124_Y	127_L	2.016	1.00
150_F	153_E	2.001	1.00
51_E	214_E	1.999	1.00
190_I	194_F	1.979	1.00
78_L	240_K	1.978	1.00
167_G	171_A	1.938	1.00
63_S	198_A	1.935	1.00
15_I	19_A	1.876	1.00
243_N	247_L	1.868	1.00
185_E	188_N	1.854	1.00
211_E	243_N	1.834	1.00
30_E	38_T	1.807	1.00
206_A	209_A	1.775	1.00
180_S	246_V	1.766	1.00
140_V	144_V	1.765	1.00
77_L	81_L	1.757	1.00
6_L	14_A	1.751	1.00
134_L	295_G	1.732	1.00
19_A	22_L	1.729	1.00
74_G	211_E	1.716	1.00
192_I	198_A	1.714	1.00
121_V	124_Y	1.647	1.00
29_L	33_L	1.646	1.00
6_L	10_G	1.642	1.00
272_A	276_A	1.633	1.00
273_N	277_L	1.624	1.00
17_V	21_L	1.615	1.00
92_F	95_R	1.604	1.00
71_A	248_L	1.603	1.00
211_E	215_K	1.594	1.00
82_G	211_E	1.564	1.00
111_L	115_T	1.562	1.00
123_I	128_N	1.562	1.00
52_T	247_L	1.561	1.00
137_L	140_V	1.556	1.00
87_G	289_E	1.546	1.00
124_Y	128_N	1.533	1.00
25_G	172_G	1.532	1.00
32_F	162_L	1.526	1.00
240_K	243_N	1.518	1.00
206_A	210_G	1.516	1.00
78_L	211_E	1.512	1.00
78_L	239_S	1.498	1.00
96_T	284_R	1.494	1.00
94_W	227_D	1.484	1.00
48_A	211_E	1.482	1.00
133_L	253_I	1.481	1.00
269_S	273_N	1.475	1.00
230_S	234_L	1.474	1.00
177_V	181_H	1.445	1.00
84_G	290_S	1.427	1.00
54_F	70_S	1.423	1.00
87_G	285_L	1.420	1.00
162_L	166_V	1.404	1.00
30_E	35_Q	1.398	1.00
103_E	107_E	1.387	1.00
108_N	111_L	1.385	1.00
290_S	293_L	1.383	1.00
164_K	167_G	1.377	1.00
151_R	154_G	1.376	1.00
181_H	185_E	1.373	1.00
30_E	40_G	1.368	1.00
44_G	47_T	1.345	1.00
125_G	128_N	1.339	1.00
75_N	243_N	1.339	1.00
106_V	109_V	1.337	1.00
186_Y	189_E	1.334	1.00
12_F	20_E	1.303	0.99
122_L	128_N	1.298	0.99
274_M	277_L	1.294	0.99
236_F	240_K	1.293	0.99
223_L	231_L	1.281	0.99
7_E	182_Y	1.280	0.99
152_R	155_M	1.277	0.99
218_A	235_S	1.275	0.99
295_G	302_I	1.269	0.99
174_V	178_V	1.267	0.99
29_L	162_L	1.266	0.99
283_K	286_K	1.257	0.99
112_V	274_M	1.249	0.99
26_A	43_L	1.246	0.99
160_G	164_K	1.218	0.99
11_I	179_F	1.198	0.99
87_G	290_S	1.198	0.99
204_V	207_P	1.197	0.99
121_V	131_S	1.188	0.99
140_V	171_A	1.165	0.99
71_A	206_A	1.151	0.99
218_A	236_F	1.150	0.99
145_Y	149_K	1.150	0.99
168_F	171_A	1.150	0.99
202_S	207_P	1.146	0.98
227_D	232_S	1.144	0.98
11_I	182_Y	1.144	0.98
65_D	68_L	1.143	0.98
85_L	294_I	1.127	0.98
72_I	248_L	1.127	0.98
86_V	90_Y	1.118	0.98
25_G	169_I	1.112	0.98
67_A	71_A	1.110	0.98
250_I	254_F	1.107	0.98
44_G	242_E	1.104	0.98
272_A	279_V	1.100	0.98
45_F	48_A	1.098	0.98
98_L	101_S	1.097	0.98
84_G	91_A	1.097	0.98
137_L	141_I	1.092	0.98
66_V	187_I	1.086	0.98
52_T	78_L	1.080	0.98
18_S	179_F	1.080	0.98
66_V	70_S	1.079	0.98
211_E	242_E	1.072	0.98
15_I	20_E	1.071	0.98
33_L	37_I	1.068	0.98
266_Y	269_S	1.065	0.98
269_S	272_A	1.064	0.98
145_Y	154_G	1.062	0.98
77_L	211_E	1.061	0.97
176_L	191_A	1.053	0.97
23_A	215_K	1.052	0.97
171_A	175_L	1.050	0.97
187_I	206_A	1.050	0.97
94_W	97_A	1.046	0.97
59_S	62_G	1.046	0.97
70_S	215_K	1.045	0.97
138_I	288_F	1.036	0.97
210_G	235_S	1.036	0.97
116_I	274_M	1.024	0.97
263_L	270_L	1.020	0.97
104_Y	108_N	1.020	0.97
84_G	90_Y	1.018	0.97
80_T	293_L	1.018	0.97
155_M	158_E	1.010	0.97
17_V	20_E	1.001	0.96
88_V	92_F	1.000	0.96
268_S	272_A	1.000	0.96
44_G	48_A	0.993	0.96
137_L	291_V	0.992	0.96
106_V	110_F	0.987	0.96
16_F	19_A	0.981	0.96
93_K	225_S	0.979	0.96
265_E	270_L	0.978	0.96
120_L	128_N	0.967	0.96
6_L	9_I	0.965	0.96
265_E	273_N	0.960	0.95
201_L	209_A	0.960	0.95
273_N	279_V	0.959	0.95
132_G	249_G	0.958	0.95
77_L	297_Y	0.955	0.95
211_E	240_K	0.953	0.95
183_F	241_I	0.953	0.95
179_F	241_I	0.947	0.95
104_Y	107_E	0.946	0.95
56_I	60_L	0.937	0.95
39_G	180_S	0.921	0.94
38_T	43_L	0.918	0.94
113_L	117_G	0.913	0.94
100_I	116_I	0.913	0.94
23_A	38_T	0.912	0.94
47_T	212_L	0.911	0.94
7_E	10_G	0.909	0.94
43_L	47_T	0.908	0.94
67_A	70_S	0.907	0.94
130_I	134_L	0.898	0.94
267_A	272_A	0.897	0.94
140_V	281_F	0.893	0.93
116_I	121_V	0.892	0.93
265_E	268_S	0.888	0.93
113_L	159_K	0.883	0.93
200_W	305_F	0.883	0.93
78_L	210_G	0.882	0.93
57_V	60_L	0.880	0.93
114_T	117_G	0.875	0.93
77_L	214_E	0.874	0.93
79_F	276_A	0.873	0.93
34_G	202_S	0.872	0.93
236_F	239_S	0.871	0.92
265_E	269_S	0.867	0.92
183_F	212_L	0.864	0.92
111_L	117_G	0.861	0.92
63_S	66_V	0.861	0.92
217_S	235_S	0.856	0.92
202_S	239_S	0.852	0.92
213_E	240_K	0.850	0.92
115_T	121_V	0.847	0.91
27_D	48_A	0.846	0.91
21_L	168_F	0.845	0.91
21_L	25_G	0.845	0.91
119_L	123_I	0.844	0.91
14_A	175_L	0.837	0.91
15_I	23_A	0.836	0.91
239_S	242_E	0.834	0.91
8_F	186_Y	0.834	0.91
23_A	211_E	0.833	0.91
47_T	51_E	0.833	0.91
295_G	299_I	0.831	0.91
88_V	141_I	0.825	0.90
270_L	273_N	0.823	0.90
204_V	301_V	0.820	0.90
152_R	156_E	0.819	0.90
257_Y	261_Q	0.819	0.90
59_S	255_T	0.818	0.90
40_G	44_G	0.813	0.90
43_L	198_A	0.812	0.90
190_I	193_M	0.811	0.90
189_E	193_M	0.804	0.89
116_I	296_V	0.804	0.89
129_I	133_L	0.801	0.89
9_I	13_I	0.799	0.89
97_A	285_L	0.798	0.89
48_A	56_I	0.793	0.88
123_I	137_L	0.789	0.88
6_L	178_V	0.787	0.88
218_A	222_V	0.785	0.88
208_I	250_I	0.784	0.88
6_L	156_E	0.783	0.88
100_I	103_E	0.782	0.88
15_I	25_G	0.782	0.88
57_V	71_A	0.777	0.87
213_E	235_S	0.776	0.87
19_A	239_S	0.770	0.87
72_I	203_L	0.769	0.87
64_F	257_Y	0.767	0.87
70_S	210_G	0.761	0.86
26_A	42_I	0.759	0.86
63_S	188_N	0.759	0.86
85_L	171_A	0.759	0.86
136_I	140_V	0.759	0.86
8_F	183_F	0.754	0.86
13_I	120_L	0.753	0.86
113_L	122_L	0.752	0.86
75_N	244_A	0.751	0.86
89_F	219_F	0.749	0.85
268_S	273_N	0.741	0.85
132_G	135_L	0.737	0.85
122_L	126_K	0.737	0.85
47_T	82_G	0.737	0.85
58_A	73_G	0.736	0.84
187_I	190_I	0.735	0.84
159_K	178_V	0.734	0.84
57_V	66_V	0.732	0.84
91_A	97_A	0.730	0.84
191_A	202_S	0.729	0.84
189_E	192_I	0.727	0.84
224_M	229_G	0.727	0.84
180_S	196_V	0.727	0.84
144_V	274_M	0.727	0.84
134_L	298_V	0.726	0.84
279_V	288_F	0.725	0.84
21_L	175_L	0.725	0.84
129_I	132_G	0.724	0.84
134_L	138_I	0.723	0.83
18_S	175_L	0.720	0.83
189_E	266_Y	0.716	0.83
171_A	267_A	0.710	0.82
87_G	91_A	0.710	0.82
210_G	240_K	0.703	0.82
31_D	36_G	0.702	0.82
46_L	78_L	0.701	0.82
148_A	151_R	0.698	0.81
55_V	70_S	0.697	0.81
225_S	271_I	0.696	0.81
39_G	43_L	0.695	0.81
145_Y	287_T	0.691	0.81
23_A	183_F	0.691	0.81
122_L	266_Y	0.690	0.80
38_T	214_E	0.689	0.80
155_M	171_A	0.685	0.80
204_V	300_I	0.685	0.80
5_W	155_M	0.683	0.80
76_V	269_S	0.681	0.80
165_P	169_I	0.681	0.80
186_Y	193_M	0.681	0.80
178_V	182_Y	0.678	0.79
48_A	53_I	0.677	0.79
6_L	171_A	0.676	0.79
210_G	213_E	0.676	0.79
250_I	253_I	0.676	0.79
250_I	255_T	0.674	0.79
99_Q	285_L	0.674	0.79
267_A	271_I	0.671	0.79
164_K	171_A	0.667	0.78
6_L	13_I	0.666	0.78
52_T	77_L	0.666	0.78
134_L	299_I	0.663	0.78
204_V	209_A	0.663	0.78
103_E	133_L	0.663	0.78
265_E	279_V	0.662	0.78
273_N	280_L	0.661	0.78
77_L	80_T	0.658	0.77
176_L	246_V	0.657	0.77
189_E	219_F	0.655	0.77
26_A	30_E	0.655	0.77
187_I	201_L	0.652	0.77
95_R	174_V	0.651	0.77
20_E	206_A	0.649	0.76
5_W	60_L	0.648	0.76
120_L	158_E	0.647	0.76
118_M	248_L	0.647	0.76
239_S	243_N	0.647	0.76
48_A	78_L	0.645	0.76
203_L	232_S	0.644	0.76
100_I	105_S	0.643	0.76
104_Y	279_V	0.641	0.75
265_E	272_A	0.640	0.75
19_A	215_K	0.639	0.75
132_G	150_F	0.637	0.75
148_A	152_R	0.636	0.75
159_K	295_G	0.635	0.75
12_F	16_F	0.634	0.75
46_L	239_S	0.630	0.74
210_G	242_E	0.628	0.74
53_I	176_L	0.627	0.74
152_R	157_R	0.627	0.74
282_D	286_K	0.627	0.74
39_G	58_A	0.626	0.74
73_G	80_T	0.626	0.74
78_L	206_A	0.626	0.74
46_L	49_L	0.625	0.74
25_G	45_F	0.622	0.73
74_G	82_G	0.622	0.73
44_G	51_E	0.620	0.73
41_I	47_T	0.620	0.73
137_L	156_E	0.619	0.73
70_S	247_L	0.616	0.73
176_L	213_E	0.616	0.73
44_G	211_E	0.615	0.72
167_G	284_R	0.612	0.72
99_Q	169_I	0.612	0.72
301_V	305_F	0.612	0.72
157_R	299_I	0.611	0.72
114_T	121_V	0.610	0.72
187_I	209_A	0.610	0.72
117_G	170_I	0.609	0.72
191_A	210_G	0.608	0.72
244_A	248_L	0.608	0.72
66_V	202_S	0.607	0.71
100_I	234_L	0.601	0.71
135_L	145_Y	0.600	0.71
185_E	189_E	0.600	0.71
54_F	58_A	0.600	0.71
6_L	284_R	0.597	0.70
85_L	89_F	0.596	0.70
171_A	256_D	0.594	0.70
274_M	280_L	0.591	0.69
259_L	262_A	0.591	0.69
160_G	168_F	0.591	0.69
47_T	243_N	0.590	0.69
150_F	158_E	0.587	0.69
141_I	145_Y	0.585	0.69
214_E	217_S	0.584	0.68
222_V	225_S	0.584	0.68
133_L	136_I	0.584	0.68
144_V	152_R	0.584	0.68
196_V	200_W	0.583	0.68
6_L	159_K	0.582	0.68
276_A	280_L	0.579	0.68
33_L	241_I	0.579	0.68
266_Y	270_L	0.578	0.68
138_I	292_I	0.576	0.67
71_A	251_I	0.575	0.67
132_G	139_Y	0.574	0.67
97_A	100_I	0.574	0.67
116_I	253_I	0.570	0.67
210_G	215_K	0.569	0.67
80_T	242_E	0.569	0.67
149_K	153_E	0.568	0.66
71_A	75_N	0.567	0.66
118_M	244_A	0.565	0.66
93_K	103_E	0.562	0.66
51_E	74_G	0.561	0.65
69_G	202_S	0.559	0.65
163_M	299_I	0.558	0.65
8_F	190_I	0.555	0.65
58_A	184_V	0.552	0.64
159_K	162_L	0.551	0.64
260_Q	269_S	0.549	0.64
39_G	73_G	0.548	0.64
216_I	250_I	0.547	0.63
56_I	79_F	0.546	0.63
10_G	161_N	0.546	0.63
75_N	240_K	0.543	0.63
152_R	170_I	0.543	0.63
143_V	147_V	0.542	0.63
120_L	303_L	0.541	0.63
179_F	233_I	0.540	0.63
23_A	210_G	0.540	0.63
234_L	238_G	0.539	0.62
282_D	288_F	0.539	0.62
287_T	293_L	0.538	0.62
51_E	239_S	0.537	0.62
209_A	213_E	0.534	0.62
146_R	169_I	0.534	0.62
48_A	215_K	0.532	0.61
9_I	141_I	0.532	0.61
46_L	53_I	0.528	0.61
15_I	27_D	0.527	0.61
9_I	166_V	0.525	0.60
75_N	257_Y	0.524	0.60
43_L	243_N	0.522	0.60
153_E	157_R	0.522	0.60
254_F	280_L	0.521	0.60
262_A	265_E	0.521	0.60
74_G	243_N	0.519	0.59
11_I	14_A	0.516	0.59
149_K	154_G	0.516	0.59
111_L	114_T	0.513	0.59
47_T	211_E	0.512	0.58
60_L	85_L	0.512	0.58
47_T	236_F	0.511	0.58
84_G	215_K	0.510	0.58
36_G	39_G	0.510	0.58
207_P	211_E	0.509	0.58
118_M	122_L	0.509	0.58
82_G	86_V	0.508	0.58
166_V	189_E	0.508	0.58
60_L	174_V	0.507	0.58
167_G	193_M	0.506	0.58
113_L	141_I	0.503	0.57
52_T	56_I	0.503	0.57
78_L	215_K	0.503	0.57
160_G	165_P	0.502	0.57
249_G	253_I	0.501	0.57
68_L	258_E	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k1cA	4	0.987	100	0.144	Contact Map
4kjrA	3	0.9414	100	0.169	Contact Map
3v5uA	1	0.9511	100	0.174	Contact Map
4kppA	1	0.987	100	0.232	Contact Map
3l1lA	2	0.4821	16.5	0.952	Contact Map
4pgrA	1	0.4397	7.6	0.958	Contact Map
3zuxA	1	0.645	6.2	0.96	Contact Map
3o7qA	1	0.456	5.7	0.961	Contact Map
4w6vA	1	0.4853	5.6	0.961	Contact Map
2m20A	2	0.1954	5.6	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0097 seconds.