GREMLIN Database
Q97YX4 - Uncharacterized protein
UniProt: Q97YX4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 176 (144)
Sequences: 22821 (17312)
Seq/√Len: 1442.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_V55_K2.7671.00
40_C58_C2.6571.00
113_K154_F2.6041.00
39_G98_S2.5321.00
57_Y90_V2.2311.00
116_L120_G2.1841.00
93_I112_V2.1801.00
47_K73_F2.1761.00
36_V90_V2.1301.00
30_G33_G2.0491.00
111_E114_R2.0361.00
91_D117_K2.0211.00
46_C56_L1.9971.00
38_Y112_V1.9701.00
69_V78_T1.9491.00
104_D107_H1.9131.00
112_V122_V1.9031.00
63_V67_K1.8401.00
85_I90_V1.7971.00
106_Q110_S1.7901.00
57_Y79_L1.7731.00
93_I116_L1.7691.00
55_K77_I1.7561.00
40_C46_C1.7301.00
33_G92_F1.7111.00
34_V57_Y1.6871.00
68_E71_E1.6851.00
46_C58_C1.5951.00
98_S102_M1.5851.00
60_D66_L1.5771.00
111_E115_I1.5501.00
35_I92_F1.5021.00
35_I49_L1.5001.00
148_M152_S1.4851.00
47_K72_K1.4831.00
34_V117_K1.4781.00
106_Q150_W1.4681.00
38_Y80_S1.4661.00
95_F98_S1.4571.00
116_L122_V1.4531.00
100_H126_D1.4261.00
66_L78_T1.4141.00
105_K150_W1.3921.00
34_V90_V1.3761.00
102_M108_V1.3751.00
116_L154_F1.3721.00
86_P89_S1.3371.00
101_D126_D1.3211.00
97_N100_H1.3121.00
87_D114_R1.3001.00
143_D146_D1.2991.00
29_E33_G1.2981.00
73_F78_T1.2961.00
37_D40_C1.2811.00
64_I67_K1.2271.00
50_L75_S1.2111.00
66_L70_K1.1771.00
34_V89_S1.1671.00
60_D65_A1.1641.00
22_E25_P1.1421.00
109_I151_F1.1401.00
97_N101_D1.1381.00
62_N65_A1.1301.00
107_H110_S1.1021.00
57_Y77_I1.0981.00
57_Y85_I1.0931.00
47_K51_E1.0921.00
34_V91_D1.0871.00
108_V112_V1.0841.00
67_K70_K1.0811.00
40_C69_V1.0661.00
48_Y51_E1.0581.00
58_C69_V1.0511.00
45_Y94_L1.0251.00
99_F102_M1.0241.00
48_Y52_F1.0141.00
83_K111_E1.0131.00
32_K54_T1.0111.00
93_I115_I1.0041.00
22_E26_N0.9941.00
79_L85_I0.9911.00
45_Y96_A0.9811.00
33_G54_T0.9781.00
49_L94_L0.9711.00
26_N160_F0.9681.00
99_F109_I0.9611.00
80_S102_M0.9531.00
149_G152_S0.9521.00
42_N65_A0.9521.00
148_M159_R0.9301.00
40_C66_L0.9201.00
73_F76_V0.9161.00
83_K115_I0.8961.00
47_K50_L0.8961.00
144_E161_N0.8941.00
97_N125_I0.8941.00
96_A125_I0.8931.00
105_K142_M0.8821.00
39_G95_F0.8801.00
21_E25_P0.8731.00
43_G69_V0.8681.00
46_C78_T0.8661.00
36_V93_I0.8561.00
68_E72_K0.8521.00
23_Y123_I0.8441.00
22_E160_F0.8391.00
100_H127_W0.8301.00
97_N127_W0.8271.00
136_P139_S0.8221.00
144_E148_M0.8161.00
99_F108_V0.8161.00
90_V115_I0.8131.00
36_V115_I0.8131.00
21_E48_Y0.8101.00
38_Y93_I0.8031.00
33_G91_D0.8001.00
47_K74_D0.7961.00
58_C78_T0.7911.00
35_I56_L0.7731.00
70_K74_D0.7701.00
112_V116_L0.7691.00
44_F48_Y0.7631.00
67_K71_E0.7621.00
42_N72_K0.7531.00
95_F124_I0.7501.00
26_N158_K0.7431.00
28_F121_R0.7431.00
29_E32_K0.7391.00
92_F121_R0.7391.00
82_P107_H0.7391.00
40_C60_D0.7361.00
146_D149_G0.7331.00
76_V79_L0.7251.00
53_A56_L0.7221.00
80_S98_S0.7161.00
89_S117_K0.7101.00
24_L52_F0.7071.00
59_I79_L0.7031.00
139_S142_M0.6971.00
87_D111_E0.6931.00
34_V54_T0.6881.00
129_K143_D0.6871.00
20_P45_Y0.6841.00
65_A97_N0.6811.00
145_K148_M0.6801.00
44_F72_K0.6781.00
81_D102_M0.6771.00
45_Y48_Y0.6771.00
95_F112_V0.6741.00
18_E21_E0.6731.00
124_I151_F0.6671.00
39_G61_I0.6611.00
42_N68_E0.6601.00
25_P52_F0.6581.00
64_I68_E0.6521.00
107_H111_E0.6511.00
35_I94_L0.6461.00
156_V159_R0.6431.00
61_I81_D0.6421.00
88_N118_D0.6411.00
122_V154_F0.6361.00
96_A100_H0.6351.00
99_F124_I0.6331.00
95_F102_M0.6331.00
92_F120_G0.6321.00
82_P111_E0.6291.00
85_I115_I0.6261.00
27_I123_I0.6251.00
84_E111_E0.6221.00
37_D94_L0.6191.00
87_D115_I0.6141.00
37_D59_I0.6011.00
33_G121_R0.5991.00
135_G138_L0.5931.00
21_E52_F0.5911.00
71_E74_D0.5871.00
38_Y59_I0.5791.00
89_S115_I0.5741.00
138_L141_R0.5711.00
133_G136_P0.5711.00
70_K73_F0.5691.00
45_Y49_L0.5681.00
110_S114_R0.5681.00
65_A100_H0.5651.00
61_I80_S0.5631.00
138_L142_M0.5581.00
70_K78_T0.5571.00
134_I137_P0.5561.00
127_W131_N0.5561.00
105_K108_V0.5541.00
98_S101_D0.5531.00
100_H137_P0.5501.00
38_Y108_V0.5441.00
81_D104_D0.5431.00
144_E147_Y0.5421.00
44_F47_K0.5401.00
63_V70_K0.5401.00
128_R131_N0.5301.00
137_P141_R0.5281.00
122_V151_F0.5281.00
24_L27_I0.5281.00
137_P140_I0.5271.00
36_V59_I0.5271.00
128_R161_N0.5231.00
109_I150_W0.5231.00
127_W139_S0.5221.00
80_S83_K0.5201.00
37_D56_L0.5191.00
37_D101_D0.5151.00
110_S113_K0.5131.00
30_G54_T0.5091.00
80_S108_V0.5081.00
70_K77_I0.5061.00
20_P48_Y0.5031.00
45_Y100_H0.5031.00
65_A101_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9fA 3 0.9148 100 0.374 Contact Map
3dh0A 1 0.9886 99.9 0.395 Contact Map
4obxA 2 0.9773 99.9 0.405 Contact Map
1vl5A 1 0.9091 99.9 0.408 Contact Map
3ccfA 1 0.9318 99.9 0.417 Contact Map
4pneA 2 0.9943 99.9 0.422 Contact Map
2o57A 2 1 99.9 0.422 Contact Map
3ujcA 1 0.9659 99.9 0.425 Contact Map
3vc1A 5 0.9943 99.9 0.426 Contact Map
4kdcA 1 0.9261 99.9 0.429 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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