GREMLIN Database
Q97YX0 - First ORF in transposon ISC1904
UniProt: Q97YX0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 195 (183)
Sequences: 478 (332)
Seq/√Len: 24.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_V117_R4.3481.00
60_A78_L4.0261.00
82_V119_V3.5671.00
117_R144_E3.4801.00
58_L148_L2.7430.99
103_F126_L2.6520.99
7_A11_L2.6430.99
110_I138_C2.5910.99
13_I21_Y2.4380.98
17_T21_Y2.3940.98
91_D102_G2.3840.98
85_Y146_V2.3590.98
135_E139_K2.3100.98
5_K9_Q2.2610.97
111_L141_H2.2030.97
2_L7_A2.1590.97
16_A19_R2.1550.96
106_L115_V2.0570.95
75_V88_V2.0490.95
58_L78_L1.9580.94
18_L39_F1.9520.94
98_M132_E1.9450.94
22_V37_W1.9100.93
96_L129_F1.8370.92
110_I115_V1.7590.90
55_K109_M1.7430.89
77_Y121_T1.7420.89
119_V132_E1.7210.89
75_V90_T1.6380.86
110_I118_V1.6220.86
131_F145_I1.6020.85
3_R34_S1.5950.85
58_L88_V1.5920.84
89_I102_G1.5740.84
138_C143_C1.5340.82
72_V76_K1.5310.82
98_M167_S1.5280.82
127_V131_F1.5260.82
109_M114_E1.5120.81
4_P19_R1.5050.81
22_V29_P1.5010.81
27_I30_V1.4610.79
26_Y33_Q1.4600.79
40_R43_D1.4480.78
166_V177_S1.4420.78
16_A24_K1.4250.77
131_F147_V1.4230.77
12_G142_N1.4000.76
56_V144_E1.3720.74
122_Y159_E1.3630.74
70_D73_N1.3540.73
31_I37_W1.3370.72
155_E159_E1.3240.72
119_V146_V1.3130.71
121_T178_H1.3010.70
17_T20_E1.2900.70
96_L130_G1.2800.69
167_S170_G1.2730.69
8_C13_I1.2630.68
76_K79_E1.2470.67
57_I75_V1.2230.65
107_L111_L1.2170.65
4_P18_L1.2150.65
22_V27_I1.2140.65
7_A44_V1.2040.64
89_I118_V1.1880.63
7_A27_I1.1790.62
138_C172_L1.1790.62
95_K126_L1.1680.62
3_R38_R1.1670.62
91_D167_S1.1600.61
15_Y19_R1.1340.59
78_L148_L1.1340.59
14_S20_E1.1320.59
2_L38_R1.1170.58
170_G175_M1.1160.58
20_E23_K1.1070.57
110_I120_V1.1060.57
166_V170_G1.1060.57
62_V67_Q1.0940.57
8_C15_Y1.0860.56
57_I89_I1.0810.56
22_V39_F1.0690.55
14_S172_L1.0650.55
67_Q70_D1.0620.54
58_L82_V1.0490.53
56_V119_V1.0420.53
173_Y176_R1.0320.52
56_V93_G1.0280.52
62_V71_L1.0270.52
89_I106_L1.0180.51
27_I134_L1.0170.51
54_R142_N0.9990.50
164_I174_G0.9990.50
127_V134_L0.9960.50
43_D46_R0.9810.49
117_R146_V0.9750.48
28_K43_D0.9750.48
75_V107_L0.9570.47
138_C169_S0.9560.47
81_Q146_V0.9490.46
8_C18_L0.9410.46
26_Y34_S0.9320.45
131_F134_L0.9200.44
13_I20_E0.9190.44
159_E170_G0.9170.44
91_D121_T0.9090.43
95_K103_F0.9040.43
129_F160_D0.8920.42
51_I147_V0.8910.42
170_G177_S0.8870.42
3_R33_Q0.8780.41
171_K175_M0.8770.41
158_V161_L0.8630.40
110_I143_C0.8630.40
161_L165_L0.8580.40
27_I43_D0.8550.40
11_L18_L0.8520.39
22_V31_I0.8510.39
82_V85_Y0.8430.39
18_L22_V0.8420.39
68_K179_E0.8330.38
98_M127_V0.8300.38
67_Q73_N0.8290.38
4_P15_Y0.8290.38
19_R39_F0.8220.37
42_E73_N0.8180.37
8_C171_K0.8180.37
4_P29_P0.8130.37
5_K34_S0.8110.37
2_L11_L0.8060.36
4_P7_A0.8060.36
19_R22_V0.8030.36
39_F43_D0.8010.36
77_Y149_N0.7970.36
64_S73_N0.7950.36
44_V118_V0.7890.35
155_E158_V0.7860.35
73_N162_V0.7860.35
7_A18_L0.7830.35
134_L138_C0.7800.35
157_L166_V0.7800.35
97_N141_H0.7700.34
103_F127_V0.7550.33
72_V75_V0.7540.33
156_E168_L0.7540.33
33_Q113_N0.7510.33
120_V145_I0.7510.33
64_S67_Q0.7440.32
63_S67_Q0.7370.32
111_L137_V0.7320.32
93_G163_S0.7310.31
19_R31_I0.7310.31
118_V145_I0.7280.31
54_R143_C0.7230.31
166_V178_H0.7210.31
84_E119_V0.7160.31
30_V38_R0.7160.31
81_Q149_N0.7150.30
57_I106_L0.7120.30
78_L143_C0.7120.30
97_N128_R0.7090.30
121_T166_V0.7090.30
6_E146_V0.7010.30
85_Y148_L0.6990.30
79_E88_V0.6980.29
118_V171_K0.6970.29
70_D121_T0.6900.29
97_N106_L0.6870.29
7_A38_R0.6840.29
108_R140_A0.6810.28
148_L154_E0.6810.28
87_L100_R0.6810.28
153_K175_M0.6800.28
120_V147_V0.6790.28
147_V165_L0.6750.28
120_V143_C0.6730.28
130_G169_S0.6670.28
99_K171_K0.6650.28
19_R36_K0.6640.27
100_R127_V0.6630.27
48_M51_I0.6530.27
134_L157_L0.6470.27
14_S22_V0.6450.26
26_Y165_L0.6450.26
56_V116_S0.6400.26
120_V160_D0.6370.26
107_L146_V0.6350.26
101_K154_E0.6310.26
103_F167_S0.6310.26
6_E157_L0.6300.26
160_D174_G0.6280.25
139_K171_K0.6260.25
8_C103_F0.6220.25
31_I36_K0.6210.25
92_I145_I0.6200.25
161_L164_I0.6180.25
77_Y163_S0.6170.25
96_L133_I0.6170.25
6_E43_D0.6170.25
119_V181_E0.6170.25
85_Y96_L0.6160.25
63_S128_R0.6140.25
30_V43_D0.6140.25
66_T122_Y0.6100.25
9_Q68_K0.6090.24
19_R37_W0.6090.24
86_D148_L0.6060.24
92_I100_R0.6050.24
64_S120_V0.6050.24
3_R36_K0.6020.24
107_L118_V0.6010.24
20_E29_P0.6000.24
57_I150_Q0.6000.24
129_F174_G0.6000.24
54_R112_N0.6000.24
130_G146_V0.5970.24
46_R122_Y0.5970.24
118_V126_L0.5950.24
119_V136_E0.5940.24
126_L133_I0.5920.24
22_V32_L0.5890.23
160_D164_I0.5880.23
55_K116_S0.5870.23
4_P8_C0.5850.23
81_Q85_Y0.5850.23
103_F116_S0.5790.23
85_Y121_T0.5790.23
91_D145_I0.5750.23
57_I115_V0.5750.23
178_H182_K0.5730.23
161_L174_G0.5730.23
36_K39_F0.5700.22
23_K31_I0.5690.22
129_F164_I0.5680.22
45_E48_M0.5680.22
66_T121_T0.5650.22
115_V143_C0.5650.22
104_L134_L0.5640.22
6_E57_I0.5640.22
13_I16_A0.5620.22
175_M182_K0.5610.22
123_S165_L0.5600.22
76_K80_E0.5570.22
16_A20_E0.5550.22
2_L22_V0.5550.22
69_D164_I0.5520.22
2_L13_I0.5520.22
15_Y37_W0.5520.22
77_Y91_D0.5520.22
23_K101_K0.5510.22
65_N113_N0.5490.21
110_I147_V0.5490.21
181_E184_K0.5480.21
119_V134_L0.5480.21
177_S180_Y0.5470.21
39_F44_V0.5460.21
12_G129_F0.5400.21
157_L160_D0.5390.21
70_D132_E0.5380.21
165_L169_S0.5360.21
34_S113_N0.5310.21
81_Q148_L0.5290.20
5_K25_G0.5200.20
98_M118_V0.5190.20
145_I148_L0.5150.20
55_K91_D0.5150.20
137_V140_A0.5130.20
98_M103_F0.5120.20
41_E49_G0.5100.20
73_N76_K0.5050.19
31_I40_R0.5030.19
142_N161_L0.5030.19
91_D98_M0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ilxA 2 0.7077 100 0.655 Contact Map
3lhkA 2 0.7231 99.9 0.663 Contact Map
3g13A 2 0.7179 99.8 0.74 Contact Map
3bvpA 4 0.6154 99.8 0.748 Contact Map
4bqqA 2 0.7026 99.8 0.748 Contact Map
2mhcA 1 0.5538 99.8 0.75 Contact Map
3guvA 2 0.6769 99.8 0.752 Contact Map
2gm5A 4 0.6051 99.8 0.759 Contact Map
3pkzA 4 0.5744 99.7 0.765 Contact Map
1gdtA 2 0.6923 99.7 0.766 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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