GREMLIN Database
Q97YW9 - Second ORF in transposon ISC1904
UniProt: Q97YW9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (345)
Sequences: 4377 (2834)
Seq/√Len: 152.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_D268_K5.4051.00
288_N291_S4.3881.00
340_P367_N4.1721.00
320_A327_V3.6721.00
283_A376_M3.0531.00
206_L312_I3.0051.00
347_R350_G2.9821.00
19_F322_L2.9721.00
313_H329_E2.9301.00
284_V316_L2.8961.00
311_S315_V2.7341.00
271_N275_D2.6301.00
311_S314_R2.4501.00
338_S345_V2.4461.00
173_P182_L2.3991.00
317_R329_E2.3871.00
334_L337_R2.3761.00
312_I316_L2.3701.00
337_R346_S2.3611.00
226_K302_R2.3141.00
330_V372_I2.2961.00
274_L320_A2.2891.00
171_G187_K2.2591.00
293_F305_S2.1571.00
335_T372_I2.1431.00
225_M261_S2.1311.00
232_K247_G2.1181.00
267_R315_V2.1051.00
282_F320_A2.0791.00
284_V327_V2.0451.00
375_K378_G2.0371.00
54_K120_K2.0341.00
51_N55_I2.0211.00
267_R318_Y2.0191.00
298_D301_S1.9931.00
354_E361_K1.9751.00
28_R31_S1.9651.00
342_C358_C1.9571.00
36_K180_V1.9331.00
49_L97_I1.9261.00
206_L265_F1.9051.00
263_L311_S1.8991.00
270_V315_V1.8521.00
247_G251_M1.8261.00
280_T325_S1.8211.00
266_V315_V1.8151.00
37_E87_H1.8131.00
341_R360_F1.7981.00
351_K364_R1.7921.00
339_C358_C1.7861.00
242_K245_K1.7751.00
317_R321_P1.7731.00
355_C358_C1.7711.00
342_C355_C1.7671.00
346_S350_G1.7591.00
339_C342_C1.7331.00
353_F362_L1.7041.00
267_R319_K1.7001.00
267_R270_V1.6981.00
50_W100_A1.6771.00
284_V329_E1.6291.00
245_K248_R1.6281.00
35_I180_V1.6191.00
199_I207_D1.6061.00
339_C355_C1.5861.00
44_K84_K1.5691.00
266_V311_S1.5661.00
232_K235_K1.5591.00
208_A366_L1.5571.00
20_T183_S1.5541.00
177_E256_H1.5361.00
286_K329_E1.5301.00
144_I182_L1.5121.00
33_E37_E1.5041.00
236_V248_R1.4681.00
284_V313_H1.4511.00
344_F356_E1.4501.00
145_T151_Y1.4321.00
353_F360_F1.4311.00
106_S118_I1.4251.00
270_V318_Y1.4221.00
196_F373_Y1.4221.00
179_K256_H1.4181.00
101_F105_K1.4141.00
32_K36_K1.4111.00
39_R180_V1.4061.00
110_R118_I1.4041.00
352_T361_K1.3971.00
317_R327_V1.3901.00
205_T208_A1.3891.00
49_L100_A1.3831.00
285_E332_P1.3711.00
111_A118_I1.3571.00
270_V319_K1.3551.00
91_H131_K1.3551.00
69_P72_K1.3501.00
240_A244_T1.3311.00
348_K351_K1.3221.00
197_L209_Y1.3181.00
24_K179_K1.3161.00
370_L374_L1.3161.00
256_H260_N1.3111.00
295_D301_S1.3031.00
347_R351_K1.2751.00
229_M255_S1.2711.00
209_Y213_K1.2561.00
304_I309_W1.2451.00
91_H133_T1.2361.00
217_I220_K1.2341.00
105_K109_K1.2331.00
229_M251_M1.2231.00
232_K254_Y1.2201.00
196_F281_F1.2181.00
99_D129_R1.2171.00
104_L120_K1.2151.00
27_E31_S1.2081.00
68_L72_K1.2061.00
270_V312_I1.1971.00
225_M258_E1.1851.00
102_S106_S1.1671.00
193_P280_T1.1661.00
214_F363_D1.1641.00
29_E32_K1.1611.00
340_P370_L1.1531.00
79_R93_V1.1431.00
42_L96_A1.1321.00
95_K98_N1.1311.00
272_A276_L1.1301.00
288_N332_P1.1291.00
274_L323_Y1.1271.00
198_A373_Y1.1231.00
136_K145_T1.1201.00
199_I209_Y1.1191.00
203_L307_T1.1160.99
276_L279_I1.1150.99
270_V316_L1.1120.99
134_L147_R1.1100.99
266_V312_I1.1080.99
201_S309_W1.1080.99
347_R364_R1.1070.99
201_S313_H1.1040.99
73_E76_K1.1040.99
338_S375_K1.1040.99
335_T375_K1.1040.99
110_R119_E1.1030.99
89_A92_Y1.1000.99
366_L370_L1.0980.99
263_L315_V1.0980.99
340_P362_L1.0900.99
236_V251_M1.0900.99
75_Y78_L1.0870.99
275_D323_Y1.0790.99
348_K364_R1.0770.99
315_V318_Y1.0730.99
362_L370_L1.0710.99
54_K58_R1.0700.99
21_Y186_Y1.0700.99
259_R263_L1.0550.99
266_V270_V1.0500.99
128_V131_K1.0480.99
233_R251_M1.0420.99
106_S111_A1.0370.99
319_K322_L1.0290.99
146_V175_I1.0280.99
128_V132_T1.0260.99
233_R237_Q1.0230.99
196_F377_C1.0220.99
274_L282_F1.0200.99
295_D299_S1.0160.99
314_R317_R1.0160.99
208_A214_F1.0110.99
283_A372_I1.0100.99
271_N323_Y1.0090.99
138_V141_S1.0030.99
46_I96_A1.0030.99
274_L325_S1.0010.99
205_T216_T1.0010.99
286_K332_P0.9960.99
27_E35_I0.9960.99
54_K104_L0.9950.99
197_L210_D0.9900.99
228_S232_K0.9880.99
330_V375_K0.9870.99
337_R345_V0.9820.99
70_K73_E0.9810.99
289_K310_R0.9760.99
236_V247_G0.9750.99
244_T248_R0.9680.99
330_V376_M0.9630.98
32_K180_V0.9610.98
229_M258_E0.9600.98
107_W120_K0.9600.98
362_L366_L0.9570.98
344_F357_R0.9550.98
41_L84_K0.9500.98
40_T43_Q0.9490.98
106_S110_R0.9470.98
50_W104_L0.9470.98
346_S353_F0.9450.98
156_W159_S0.9440.98
351_K363_D0.9310.98
44_K48_Y0.9300.98
232_K251_M0.9270.98
53_T101_F0.9180.98
295_D298_D0.9160.98
46_I103_I0.9110.98
71_K74_V0.9060.98
366_L369_S0.9010.98
76_K79_R0.9010.98
266_V308_V0.9010.98
106_S109_K0.8920.98
232_K250_L0.8910.97
213_K272_A0.8900.97
350_G364_R0.8800.97
207_D269_F0.8790.97
340_P360_F0.8750.97
281_F326_F0.8730.97
46_I100_A0.8720.97
196_F283_A0.8700.97
134_L137_V0.8670.97
352_T362_L0.8670.97
332_P335_T0.8650.97
341_R370_L0.8640.97
129_R172_E0.8590.97
334_L375_K0.8570.97
76_K80_E0.8560.97
195_N280_T0.8550.97
197_L282_F0.8540.97
91_H95_K0.8540.97
320_A325_S0.8530.97
273_L282_F0.8500.97
281_F328_K0.8500.97
18_H187_K0.8480.97
230_E233_R0.8470.97
143_R151_Y0.8440.97
95_K129_R0.8430.96
48_Y52_L0.8400.96
257_R261_S0.8380.96
367_N371_N0.8310.96
99_D174_I0.8290.96
221_Q261_S0.8280.96
107_W121_P0.8270.96
94_D98_N0.8240.96
72_K76_K0.8230.96
254_Y258_E0.8220.96
368_A371_N0.8220.96
250_L253_K0.8200.96
85_I93_V0.8180.96
203_L303_K0.8180.96
233_R255_S0.8170.96
229_M237_Q0.8150.96
346_S364_R0.8090.96
230_E234_A0.8060.95
221_Q225_M0.8030.95
293_F301_S0.8020.95
375_K379_F0.8010.95
175_I182_L0.8000.95
53_T104_L0.8000.95
340_P368_A0.7990.95
57_V61_N0.7990.95
59_K62_G0.7940.95
289_K309_W0.7940.95
18_H185_R0.7840.95
271_N319_K0.7830.95
174_I183_S0.7810.95
91_H132_T0.7800.95
130_I146_V0.7780.95
230_E237_Q0.7770.94
340_P374_L0.7730.94
24_K181_Y0.7720.94
353_F364_R0.7720.94
75_Y79_R0.7710.94
146_V149_Y0.7700.94
338_S371_N0.7690.94
194_L280_T0.7690.94
88_L91_H0.7680.94
157_S160_W0.7670.94
291_S332_P0.7660.94
291_S304_I0.7650.94
74_V78_L0.7640.94
77_P81_E0.7600.94
235_K247_G0.7590.94
248_R252_R0.7580.94
58_R61_N0.7530.94
52_L74_V0.7520.93
241_S244_T0.7510.93
201_S207_D0.7510.93
205_T214_F0.7490.93
287_L332_P0.7480.93
95_K99_D0.7480.93
69_P73_E0.7460.93
41_L44_K0.7440.93
215_V265_F0.7430.93
328_K376_M0.7420.93
214_F366_L0.7420.93
231_V235_K0.7410.93
45_A96_A0.7410.93
344_F353_F0.7400.93
25_N182_L0.7390.93
286_K313_H0.7380.93
300_L304_I0.7370.93
144_I173_P0.7360.93
72_K97_I0.7350.93
41_L88_L0.7340.93
34_L38_Y0.7330.93
192_T195_N0.7270.92
229_M233_R0.7250.92
23_I182_L0.7220.92
40_T44_K0.7210.92
200_D365_Q0.7210.92
370_L373_Y0.7180.92
265_F269_F0.7170.92
206_L307_T0.7170.92
269_F272_A0.7160.92
202_N208_A0.7120.92
95_K131_K0.7120.92
204_Y208_A0.7120.92
91_H94_D0.7110.91
90_S131_K0.7110.91
283_A373_Y0.7090.91
29_E33_E0.7080.91
129_R174_I0.7080.91
156_W160_W0.7080.91
235_K238_S0.7070.91
258_E306_R0.7060.91
136_K139_G0.6990.91
282_F316_L0.6970.91
71_K75_Y0.6960.91
135_R170_L0.6930.90
172_E185_R0.6910.90
38_Y42_L0.6890.90
283_A328_K0.6890.90
310_R314_R0.6880.90
97_I101_F0.6870.90
37_E41_L0.6860.90
154_F157_S0.6850.90
104_L107_W0.6840.90
60_K64_Y0.6810.90
236_V244_T0.6800.90
334_L338_S0.6790.89
275_D281_F0.6750.89
276_L280_T0.6740.89
206_L270_V0.6740.89
225_M229_M0.6740.89
320_A323_Y0.6720.89
104_L108_R0.6710.89
350_G353_F0.6710.89
195_N211_G0.6690.89
91_H134_L0.6660.89
103_I121_P0.6660.89
237_Q251_M0.6630.88
207_D312_I0.6630.88
190_W325_S0.6620.88
145_T148_P0.6600.88
17_V187_K0.6600.88
374_L379_F0.6560.88
169_E187_K0.6560.88
129_R132_T0.6550.88
346_S351_K0.6540.88
44_K82_L0.6520.88
71_K98_N0.6510.87
57_V104_L0.6500.87
127_Y130_I0.6480.87
127_Y131_K0.6470.87
76_K97_I0.6450.87
92_Y128_V0.6450.87
223_Y303_K0.6430.87
244_T251_M0.6410.87
283_A375_K0.6410.87
133_T136_K0.6390.86
217_I307_T0.6390.86
263_L267_R0.6390.86
23_I158_K0.6390.86
41_L85_I0.6380.86
67_T71_K0.6360.86
138_V145_T0.6360.86
52_L78_L0.6360.86
244_T247_G0.6340.86
362_L367_N0.6340.86
190_W193_P0.6330.86
66_I69_P0.6330.86
341_R362_L0.6320.86
27_E32_K0.6310.86
334_L345_V0.6300.86
96_A100_A0.6290.86
262_V306_R0.6280.86
69_P75_Y0.6250.85
243_Y246_R0.6250.85
197_L279_I0.6240.85
209_Y215_V0.6220.85
74_V97_I0.6210.85
26_S155_S0.6210.85
356_E364_R0.6210.85
225_M257_R0.6200.85
55_I59_K0.6150.84
372_I375_K0.6140.84
30_K33_E0.6140.84
18_H171_G0.6130.84
100_A104_L0.6110.84
48_Y78_L0.6090.84
377_C380_P0.6090.84
60_K63_N0.6090.84
376_M380_P0.6080.84
255_S262_V0.6080.84
70_K75_Y0.6070.84
66_I70_K0.6070.84
35_I39_R0.6060.83
338_S353_F0.6060.83
154_F158_K0.6060.83
51_N123_V0.6050.83
143_R146_V0.5990.83
22_S183_S0.5990.83
131_K134_L0.5980.83
21_Y158_K0.5960.82
79_R85_I0.5960.82
75_Y94_D0.5950.82
20_T185_R0.5940.82
27_E152_I0.5940.82
295_D304_I0.5920.82
233_R238_S0.5910.82
255_S259_R0.5900.82
289_K292_M0.5880.82
38_Y89_A0.5860.81
61_N64_Y0.5860.81
48_Y84_K0.5850.81
298_D305_S0.5830.81
203_L294_K0.5830.81
206_L266_V0.5830.81
42_L128_V0.5820.81
93_V96_A0.5820.81
222_L225_M0.5810.81
107_W110_R0.5810.81
232_K236_V0.5810.81
51_N54_K0.5810.81
49_L74_V0.5800.81
90_S134_L0.5790.81
38_Y88_L0.5770.80
269_F312_I0.5770.80
146_V152_I0.5750.80
109_K118_I0.5720.80
313_H317_R0.5720.80
331_N334_L0.5720.80
203_L293_F0.5720.80
77_P80_E0.5710.80
92_Y130_I0.5710.80
38_Y130_I0.5700.80
338_S343_G0.5690.79
56_Q62_G0.5680.79
221_Q306_R0.5660.79
350_G356_E0.5650.79
279_I325_S0.5640.79
97_I100_A0.5630.79
138_V143_R0.5620.79
222_L226_K0.5620.79
316_L327_V0.5620.79
318_Y322_L0.5620.79
58_R62_G0.5600.78
266_V269_F0.5570.78
204_Y351_K0.5570.78
45_A93_V0.5560.78
310_R313_H0.5560.78
198_A283_A0.5550.78
289_K304_I0.5550.78
195_N279_I0.5540.78
348_K352_T0.5530.78
75_Y97_I0.5530.78
315_V319_K0.5530.78
245_K249_E0.5530.78
200_D336_S0.5510.77
37_E40_T0.5490.77
234_A238_S0.5490.77
96_A99_D0.5480.77
39_R42_L0.5480.77
71_K94_D0.5480.77
215_V272_A0.5480.77
57_V108_R0.5460.77
34_L37_E0.5450.77
348_K363_D0.5440.76
333_H337_R0.5440.76
88_L93_V0.5430.76
39_R128_V0.5420.76
223_Y226_K0.5390.76
293_F298_D0.5330.75
346_S349_V0.5330.75
176_K179_K0.5320.75
336_S346_S0.5320.75
149_Y152_I0.5310.75
291_S294_K0.5310.75
179_K260_N0.5300.75
260_N264_D0.5300.75
22_S263_L0.5300.75
52_L56_Q0.5300.75
292_M304_I0.5300.75
25_N154_F0.5290.74
201_S284_V0.5290.74
68_L98_N0.5250.74
37_E88_L0.5250.74
22_S181_Y0.5230.74
268_K271_N0.5220.73
225_M254_Y0.5220.73
90_S133_T0.5210.73
300_L303_K0.5200.73
89_A149_Y0.5190.73
52_L55_I0.5170.73
291_S295_D0.5150.72
67_T98_N0.5150.72
274_L327_V0.5150.72
258_E262_V0.5150.72
204_Y347_R0.5130.72
337_R347_R0.5130.72
233_R236_V0.5130.72
123_V126_A0.5120.72
210_D366_L0.5090.72
56_Q60_K0.5080.71
274_L316_L0.5070.71
219_L307_T0.5030.71
56_Q61_N0.5030.71
235_K250_L0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3081 94.7 0.935 Contact Map
1vhxA 2 0.3246 93.7 0.938 Contact Map
1iv0A 1 0.2299 90.4 0.944 Contact Map
2k4xA 1 0.1256 86.3 0.948 Contact Map
3j20Y 1 0.1137 85.1 0.949 Contact Map
4aybP 1 0.0948 83.7 0.95 Contact Map
1qypA 1 0.1019 83.5 0.95 Contact Map
4ep4A 2 0.372 81.5 0.951 Contact Map
1ffkW 1 0.1564 76.4 0.953 Contact Map
1vd4A 1 0.1256 75.5 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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