Q97YW9 - SULSO - GREMLIN Contacts

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Q97YW9 - Second ORF in transposon ISC1904

UniProt:	Q97YW9	Sequences: MLKNLRIGKFEPEEEYVHFTYSIKNSEREKSKELIKEYRTLLQKAIDYLWNLTKIQVRKKNGNYKITLPKKKEVYKPLREELEKINHLASHYVDKAINDAFSILKSWRKRAIKGRASIEKPRVKKAYVRIKTTLRKVVGESVRITVRPYEYITFSWSKSWFSRRVRELELGEPIIKEEKVYLSFRYKLPWVTPLNFLAIDSNLYTLDAYDGEKFVTISLKQLYSMKYSMEVKRAKVQSFASKYTKRGRELMRKYSHRERNSVLDFVRKFVNALLDLYPITFFAVEKLNKESMFKDANDSLSRKISRTVWRSIHRVLRYKAPLYGSFVKEVNPHLTSRSCPRCGFVSRKVGKTFECERCGFKLDRQLNASLNIYLKMCGFPHIRDIPRVWVGVIPLMGRRGMNVRDFGEAQGLRIDIEYHEIP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	422 (345)
Sequences:	4377 (2834)
Seq/√Len:	152.6

ECOLI - INSQ
HALSA - Q9HSW9 Q9HHJ9 Q9HM87 Q9HSW7 Q9HHG8 Q9HSZ6 Q9HSD4 Q9HHU6 Q9HSY4 Q9HHX8
SULSO - Q97YW9 Q97U51 Q97Z61 Q97UQ8 Q97XQ0 Q97U68 Q97YI5 Q97YU1 Q97XB6 Q97Y48 Q97WZ3 Q97XQ8 Q97V47 Q97X39 Q97V25 Q97YI2 Q97Y67 Q97XP1 Q97Y44 Q97YW4 Q97V53 Q97WY6 Q7LXH2 Q97XA4 Q7LXD9 Q7LXH6 Y2105 Q97YF7 Q97U09 Q7LX59

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
264_D	268_K	5.405	1.00
288_N	291_S	4.388	1.00
340_P	367_N	4.172	1.00
320_A	327_V	3.672	1.00
283_A	376_M	3.053	1.00
206_L	312_I	3.005	1.00
347_R	350_G	2.982	1.00
19_F	322_L	2.972	1.00
313_H	329_E	2.930	1.00
284_V	316_L	2.896	1.00
311_S	315_V	2.734	1.00
271_N	275_D	2.630	1.00
311_S	314_R	2.450	1.00
338_S	345_V	2.446	1.00
173_P	182_L	2.399	1.00
317_R	329_E	2.387	1.00
334_L	337_R	2.376	1.00
312_I	316_L	2.370	1.00
337_R	346_S	2.361	1.00
226_K	302_R	2.314	1.00
330_V	372_I	2.296	1.00
274_L	320_A	2.289	1.00
171_G	187_K	2.259	1.00
293_F	305_S	2.157	1.00
335_T	372_I	2.143	1.00
225_M	261_S	2.131	1.00
232_K	247_G	2.118	1.00
267_R	315_V	2.105	1.00
282_F	320_A	2.079	1.00
284_V	327_V	2.045	1.00
375_K	378_G	2.037	1.00
54_K	120_K	2.034	1.00
51_N	55_I	2.021	1.00
267_R	318_Y	2.019	1.00
298_D	301_S	1.993	1.00
354_E	361_K	1.975	1.00
28_R	31_S	1.965	1.00
342_C	358_C	1.957	1.00
36_K	180_V	1.933	1.00
49_L	97_I	1.926	1.00
206_L	265_F	1.905	1.00
263_L	311_S	1.899	1.00
270_V	315_V	1.852	1.00
247_G	251_M	1.826	1.00
280_T	325_S	1.821	1.00
266_V	315_V	1.815	1.00
37_E	87_H	1.813	1.00
341_R	360_F	1.798	1.00
351_K	364_R	1.792	1.00
339_C	358_C	1.786	1.00
242_K	245_K	1.775	1.00
317_R	321_P	1.773	1.00
355_C	358_C	1.771	1.00
342_C	355_C	1.767	1.00
346_S	350_G	1.759	1.00
339_C	342_C	1.733	1.00
353_F	362_L	1.704	1.00
267_R	319_K	1.700	1.00
267_R	270_V	1.698	1.00
50_W	100_A	1.677	1.00
284_V	329_E	1.629	1.00
245_K	248_R	1.628	1.00
35_I	180_V	1.619	1.00
199_I	207_D	1.606	1.00
339_C	355_C	1.586	1.00
44_K	84_K	1.569	1.00
266_V	311_S	1.566	1.00
232_K	235_K	1.559	1.00
208_A	366_L	1.557	1.00
20_T	183_S	1.554	1.00
177_E	256_H	1.536	1.00
286_K	329_E	1.530	1.00
144_I	182_L	1.512	1.00
33_E	37_E	1.504	1.00
236_V	248_R	1.468	1.00
284_V	313_H	1.451	1.00
344_F	356_E	1.450	1.00
145_T	151_Y	1.432	1.00
353_F	360_F	1.431	1.00
106_S	118_I	1.425	1.00
270_V	318_Y	1.422	1.00
196_F	373_Y	1.422	1.00
179_K	256_H	1.418	1.00
101_F	105_K	1.414	1.00
32_K	36_K	1.411	1.00
39_R	180_V	1.406	1.00
110_R	118_I	1.404	1.00
352_T	361_K	1.397	1.00
317_R	327_V	1.390	1.00
205_T	208_A	1.389	1.00
49_L	100_A	1.383	1.00
285_E	332_P	1.371	1.00
111_A	118_I	1.357	1.00
270_V	319_K	1.355	1.00
91_H	131_K	1.355	1.00
69_P	72_K	1.350	1.00
240_A	244_T	1.331	1.00
348_K	351_K	1.322	1.00
197_L	209_Y	1.318	1.00
24_K	179_K	1.316	1.00
370_L	374_L	1.316	1.00
256_H	260_N	1.311	1.00
295_D	301_S	1.303	1.00
347_R	351_K	1.275	1.00
229_M	255_S	1.271	1.00
209_Y	213_K	1.256	1.00
304_I	309_W	1.245	1.00
91_H	133_T	1.236	1.00
217_I	220_K	1.234	1.00
105_K	109_K	1.233	1.00
229_M	251_M	1.223	1.00
232_K	254_Y	1.220	1.00
196_F	281_F	1.218	1.00
99_D	129_R	1.217	1.00
104_L	120_K	1.215	1.00
27_E	31_S	1.208	1.00
68_L	72_K	1.206	1.00
270_V	312_I	1.197	1.00
225_M	258_E	1.185	1.00
102_S	106_S	1.167	1.00
193_P	280_T	1.166	1.00
214_F	363_D	1.164	1.00
29_E	32_K	1.161	1.00
340_P	370_L	1.153	1.00
79_R	93_V	1.143	1.00
42_L	96_A	1.132	1.00
95_K	98_N	1.131	1.00
272_A	276_L	1.130	1.00
288_N	332_P	1.129	1.00
274_L	323_Y	1.127	1.00
198_A	373_Y	1.123	1.00
136_K	145_T	1.120	1.00
199_I	209_Y	1.119	1.00
203_L	307_T	1.116	0.99
276_L	279_I	1.115	0.99
270_V	316_L	1.112	0.99
134_L	147_R	1.110	0.99
266_V	312_I	1.108	0.99
201_S	309_W	1.108	0.99
347_R	364_R	1.107	0.99
201_S	313_H	1.104	0.99
73_E	76_K	1.104	0.99
338_S	375_K	1.104	0.99
335_T	375_K	1.104	0.99
110_R	119_E	1.103	0.99
89_A	92_Y	1.100	0.99
366_L	370_L	1.098	0.99
263_L	315_V	1.098	0.99
340_P	362_L	1.090	0.99
236_V	251_M	1.090	0.99
75_Y	78_L	1.087	0.99
275_D	323_Y	1.079	0.99
348_K	364_R	1.077	0.99
315_V	318_Y	1.073	0.99
362_L	370_L	1.071	0.99
54_K	58_R	1.070	0.99
21_Y	186_Y	1.070	0.99
259_R	263_L	1.055	0.99
266_V	270_V	1.050	0.99
128_V	131_K	1.048	0.99
233_R	251_M	1.042	0.99
106_S	111_A	1.037	0.99
319_K	322_L	1.029	0.99
146_V	175_I	1.028	0.99
128_V	132_T	1.026	0.99
233_R	237_Q	1.023	0.99
196_F	377_C	1.022	0.99
274_L	282_F	1.020	0.99
295_D	299_S	1.016	0.99
314_R	317_R	1.016	0.99
208_A	214_F	1.011	0.99
283_A	372_I	1.010	0.99
271_N	323_Y	1.009	0.99
138_V	141_S	1.003	0.99
46_I	96_A	1.003	0.99
274_L	325_S	1.001	0.99
205_T	216_T	1.001	0.99
286_K	332_P	0.996	0.99
27_E	35_I	0.996	0.99
54_K	104_L	0.995	0.99
197_L	210_D	0.990	0.99
228_S	232_K	0.988	0.99
330_V	375_K	0.987	0.99
337_R	345_V	0.982	0.99
70_K	73_E	0.981	0.99
289_K	310_R	0.976	0.99
236_V	247_G	0.975	0.99
244_T	248_R	0.968	0.99
330_V	376_M	0.963	0.98
32_K	180_V	0.961	0.98
229_M	258_E	0.960	0.98
107_W	120_K	0.960	0.98
362_L	366_L	0.957	0.98
344_F	357_R	0.955	0.98
41_L	84_K	0.950	0.98
40_T	43_Q	0.949	0.98
106_S	110_R	0.947	0.98
50_W	104_L	0.947	0.98
346_S	353_F	0.945	0.98
156_W	159_S	0.944	0.98
351_K	363_D	0.931	0.98
44_K	48_Y	0.930	0.98
232_K	251_M	0.927	0.98
53_T	101_F	0.918	0.98
295_D	298_D	0.916	0.98
46_I	103_I	0.911	0.98
71_K	74_V	0.906	0.98
366_L	369_S	0.901	0.98
76_K	79_R	0.901	0.98
266_V	308_V	0.901	0.98
106_S	109_K	0.892	0.98
232_K	250_L	0.891	0.97
213_K	272_A	0.890	0.97
350_G	364_R	0.880	0.97
207_D	269_F	0.879	0.97
340_P	360_F	0.875	0.97
281_F	326_F	0.873	0.97
46_I	100_A	0.872	0.97
196_F	283_A	0.870	0.97
134_L	137_V	0.867	0.97
352_T	362_L	0.867	0.97
332_P	335_T	0.865	0.97
341_R	370_L	0.864	0.97
129_R	172_E	0.859	0.97
334_L	375_K	0.857	0.97
76_K	80_E	0.856	0.97
195_N	280_T	0.855	0.97
197_L	282_F	0.854	0.97
91_H	95_K	0.854	0.97
320_A	325_S	0.853	0.97
273_L	282_F	0.850	0.97
281_F	328_K	0.850	0.97
18_H	187_K	0.848	0.97
230_E	233_R	0.847	0.97
143_R	151_Y	0.844	0.97
95_K	129_R	0.843	0.96
48_Y	52_L	0.840	0.96
257_R	261_S	0.838	0.96
367_N	371_N	0.831	0.96
99_D	174_I	0.829	0.96
221_Q	261_S	0.828	0.96
107_W	121_P	0.827	0.96
94_D	98_N	0.824	0.96
72_K	76_K	0.823	0.96
254_Y	258_E	0.822	0.96
368_A	371_N	0.822	0.96
250_L	253_K	0.820	0.96
85_I	93_V	0.818	0.96
203_L	303_K	0.818	0.96
233_R	255_S	0.817	0.96
229_M	237_Q	0.815	0.96
346_S	364_R	0.809	0.96
230_E	234_A	0.806	0.95
221_Q	225_M	0.803	0.95
293_F	301_S	0.802	0.95
375_K	379_F	0.801	0.95
175_I	182_L	0.800	0.95
53_T	104_L	0.800	0.95
340_P	368_A	0.799	0.95
57_V	61_N	0.799	0.95
59_K	62_G	0.794	0.95
289_K	309_W	0.794	0.95
18_H	185_R	0.784	0.95
271_N	319_K	0.783	0.95
174_I	183_S	0.781	0.95
91_H	132_T	0.780	0.95
130_I	146_V	0.778	0.95
230_E	237_Q	0.777	0.94
340_P	374_L	0.773	0.94
24_K	181_Y	0.772	0.94
353_F	364_R	0.772	0.94
75_Y	79_R	0.771	0.94
146_V	149_Y	0.770	0.94
338_S	371_N	0.769	0.94
194_L	280_T	0.769	0.94
88_L	91_H	0.768	0.94
157_S	160_W	0.767	0.94
291_S	332_P	0.766	0.94
291_S	304_I	0.765	0.94
74_V	78_L	0.764	0.94
77_P	81_E	0.760	0.94
235_K	247_G	0.759	0.94
248_R	252_R	0.758	0.94
58_R	61_N	0.753	0.94
52_L	74_V	0.752	0.93
241_S	244_T	0.751	0.93
201_S	207_D	0.751	0.93
205_T	214_F	0.749	0.93
287_L	332_P	0.748	0.93
95_K	99_D	0.748	0.93
69_P	73_E	0.746	0.93
41_L	44_K	0.744	0.93
215_V	265_F	0.743	0.93
328_K	376_M	0.742	0.93
214_F	366_L	0.742	0.93
231_V	235_K	0.741	0.93
45_A	96_A	0.741	0.93
344_F	353_F	0.740	0.93
25_N	182_L	0.739	0.93
286_K	313_H	0.738	0.93
300_L	304_I	0.737	0.93
144_I	173_P	0.736	0.93
72_K	97_I	0.735	0.93
41_L	88_L	0.734	0.93
34_L	38_Y	0.733	0.93
192_T	195_N	0.727	0.92
229_M	233_R	0.725	0.92
23_I	182_L	0.722	0.92
40_T	44_K	0.721	0.92
200_D	365_Q	0.721	0.92
370_L	373_Y	0.718	0.92
265_F	269_F	0.717	0.92
206_L	307_T	0.717	0.92
269_F	272_A	0.716	0.92
202_N	208_A	0.712	0.92
95_K	131_K	0.712	0.92
204_Y	208_A	0.712	0.92
91_H	94_D	0.711	0.91
90_S	131_K	0.711	0.91
283_A	373_Y	0.709	0.91
29_E	33_E	0.708	0.91
129_R	174_I	0.708	0.91
156_W	160_W	0.708	0.91
235_K	238_S	0.707	0.91
258_E	306_R	0.706	0.91
136_K	139_G	0.699	0.91
282_F	316_L	0.697	0.91
71_K	75_Y	0.696	0.91
135_R	170_L	0.693	0.90
172_E	185_R	0.691	0.90
38_Y	42_L	0.689	0.90
283_A	328_K	0.689	0.90
310_R	314_R	0.688	0.90
97_I	101_F	0.687	0.90
37_E	41_L	0.686	0.90
154_F	157_S	0.685	0.90
104_L	107_W	0.684	0.90
60_K	64_Y	0.681	0.90
236_V	244_T	0.680	0.90
334_L	338_S	0.679	0.89
275_D	281_F	0.675	0.89
276_L	280_T	0.674	0.89
206_L	270_V	0.674	0.89
225_M	229_M	0.674	0.89
320_A	323_Y	0.672	0.89
104_L	108_R	0.671	0.89
350_G	353_F	0.671	0.89
195_N	211_G	0.669	0.89
91_H	134_L	0.666	0.89
103_I	121_P	0.666	0.89
237_Q	251_M	0.663	0.88
207_D	312_I	0.663	0.88
190_W	325_S	0.662	0.88
145_T	148_P	0.660	0.88
17_V	187_K	0.660	0.88
374_L	379_F	0.656	0.88
169_E	187_K	0.656	0.88
129_R	132_T	0.655	0.88
346_S	351_K	0.654	0.88
44_K	82_L	0.652	0.88
71_K	98_N	0.651	0.87
57_V	104_L	0.650	0.87
127_Y	130_I	0.648	0.87
127_Y	131_K	0.647	0.87
76_K	97_I	0.645	0.87
92_Y	128_V	0.645	0.87
223_Y	303_K	0.643	0.87
244_T	251_M	0.641	0.87
283_A	375_K	0.641	0.87
133_T	136_K	0.639	0.86
217_I	307_T	0.639	0.86
263_L	267_R	0.639	0.86
23_I	158_K	0.639	0.86
41_L	85_I	0.638	0.86
67_T	71_K	0.636	0.86
138_V	145_T	0.636	0.86
52_L	78_L	0.636	0.86
244_T	247_G	0.634	0.86
362_L	367_N	0.634	0.86
190_W	193_P	0.633	0.86
66_I	69_P	0.633	0.86
341_R	362_L	0.632	0.86
27_E	32_K	0.631	0.86
334_L	345_V	0.630	0.86
96_A	100_A	0.629	0.86
262_V	306_R	0.628	0.86
69_P	75_Y	0.625	0.85
243_Y	246_R	0.625	0.85
197_L	279_I	0.624	0.85
209_Y	215_V	0.622	0.85
74_V	97_I	0.621	0.85
26_S	155_S	0.621	0.85
356_E	364_R	0.621	0.85
225_M	257_R	0.620	0.85
55_I	59_K	0.615	0.84
372_I	375_K	0.614	0.84
30_K	33_E	0.614	0.84
18_H	171_G	0.613	0.84
100_A	104_L	0.611	0.84
48_Y	78_L	0.609	0.84
377_C	380_P	0.609	0.84
60_K	63_N	0.609	0.84
376_M	380_P	0.608	0.84
255_S	262_V	0.608	0.84
70_K	75_Y	0.607	0.84
66_I	70_K	0.607	0.84
35_I	39_R	0.606	0.83
338_S	353_F	0.606	0.83
154_F	158_K	0.606	0.83
51_N	123_V	0.605	0.83
143_R	146_V	0.599	0.83
22_S	183_S	0.599	0.83
131_K	134_L	0.598	0.83
21_Y	158_K	0.596	0.82
79_R	85_I	0.596	0.82
75_Y	94_D	0.595	0.82
20_T	185_R	0.594	0.82
27_E	152_I	0.594	0.82
295_D	304_I	0.592	0.82
233_R	238_S	0.591	0.82
255_S	259_R	0.590	0.82
289_K	292_M	0.588	0.82
38_Y	89_A	0.586	0.81
61_N	64_Y	0.586	0.81
48_Y	84_K	0.585	0.81
298_D	305_S	0.583	0.81
203_L	294_K	0.583	0.81
206_L	266_V	0.583	0.81
42_L	128_V	0.582	0.81
93_V	96_A	0.582	0.81
222_L	225_M	0.581	0.81
107_W	110_R	0.581	0.81
232_K	236_V	0.581	0.81
51_N	54_K	0.581	0.81
49_L	74_V	0.580	0.81
90_S	134_L	0.579	0.81
38_Y	88_L	0.577	0.80
269_F	312_I	0.577	0.80
146_V	152_I	0.575	0.80
109_K	118_I	0.572	0.80
313_H	317_R	0.572	0.80
331_N	334_L	0.572	0.80
203_L	293_F	0.572	0.80
77_P	80_E	0.571	0.80
92_Y	130_I	0.571	0.80
38_Y	130_I	0.570	0.80
338_S	343_G	0.569	0.79
56_Q	62_G	0.568	0.79
221_Q	306_R	0.566	0.79
350_G	356_E	0.565	0.79
279_I	325_S	0.564	0.79
97_I	100_A	0.563	0.79
138_V	143_R	0.562	0.79
222_L	226_K	0.562	0.79
316_L	327_V	0.562	0.79
318_Y	322_L	0.562	0.79
58_R	62_G	0.560	0.78
266_V	269_F	0.557	0.78
204_Y	351_K	0.557	0.78
45_A	93_V	0.556	0.78
310_R	313_H	0.556	0.78
198_A	283_A	0.555	0.78
289_K	304_I	0.555	0.78
195_N	279_I	0.554	0.78
348_K	352_T	0.553	0.78
75_Y	97_I	0.553	0.78
315_V	319_K	0.553	0.78
245_K	249_E	0.553	0.78
200_D	336_S	0.551	0.77
37_E	40_T	0.549	0.77
234_A	238_S	0.549	0.77
96_A	99_D	0.548	0.77
39_R	42_L	0.548	0.77
71_K	94_D	0.548	0.77
215_V	272_A	0.548	0.77
57_V	108_R	0.546	0.77
34_L	37_E	0.545	0.77
348_K	363_D	0.544	0.76
333_H	337_R	0.544	0.76
88_L	93_V	0.543	0.76
39_R	128_V	0.542	0.76
223_Y	226_K	0.539	0.76
293_F	298_D	0.533	0.75
346_S	349_V	0.533	0.75
176_K	179_K	0.532	0.75
336_S	346_S	0.532	0.75
149_Y	152_I	0.531	0.75
291_S	294_K	0.531	0.75
179_K	260_N	0.530	0.75
260_N	264_D	0.530	0.75
22_S	263_L	0.530	0.75
52_L	56_Q	0.530	0.75
292_M	304_I	0.530	0.75
25_N	154_F	0.529	0.74
201_S	284_V	0.529	0.74
68_L	98_N	0.525	0.74
37_E	88_L	0.525	0.74
22_S	181_Y	0.523	0.74
268_K	271_N	0.522	0.73
225_M	254_Y	0.522	0.73
90_S	133_T	0.521	0.73
300_L	303_K	0.520	0.73
89_A	149_Y	0.519	0.73
52_L	55_I	0.517	0.73
291_S	295_D	0.515	0.72
67_T	98_N	0.515	0.72
274_L	327_V	0.515	0.72
258_E	262_V	0.515	0.72
204_Y	347_R	0.513	0.72
337_R	347_R	0.513	0.72
233_R	236_V	0.513	0.72
123_V	126_A	0.512	0.72
210_D	366_L	0.509	0.72
56_Q	60_K	0.508	0.71
274_L	316_L	0.507	0.71
219_L	307_T	0.503	0.71
56_Q	61_N	0.503	0.71
235_K	250_L	0.500	0.70

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nu0A	1	0.3081	94.7	0.935	Contact Map
1vhxA	2	0.3246	93.7	0.938	Contact Map
1iv0A	1	0.2299	90.4	0.944	Contact Map
2k4xA	1	0.1256	86.3	0.948	Contact Map
3j20Y	1	0.1137	85.1	0.949	Contact Map
4aybP	1	0.0948	83.7	0.95	Contact Map
1qypA	1	0.1019	83.5	0.95	Contact Map
4ep4A	2	0.372	81.5	0.951	Contact Map
1ffkW	1	0.1564	76.4	0.953	Contact Map
1vd4A	1	0.1256	75.5	0.953	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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