GREMLIN Database
Q97YW7 - Isochorismatase related protein (EntB-like1)
UniProt: Q97YW7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 185 (162)
Sequences: 10037 (7000)
Seq/√Len: 550.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_E113_R3.2841.00
119_S144_I2.7451.00
109_E143_F2.6811.00
50_A55_V2.6351.00
61_M96_R2.6271.00
101_S137_H2.5851.00
18_S119_S2.3811.00
109_E141_L2.3571.00
43_L123_T2.3171.00
157_K161_E2.2141.00
25_V43_L2.1661.00
119_S146_I2.1531.00
46_L148_A2.1111.00
17_N118_Y2.0911.00
122_F135_A2.0691.00
28_G79_P2.0061.00
138_A145_P1.9211.00
107_N111_M1.9111.00
132_E136_R1.8251.00
95_L111_M1.8211.00
42_K151_A1.8051.00
19_V117_I1.8041.00
102_I134_S1.7981.00
49_S53_Y1.7961.00
175_T178_E1.7941.00
27_E78_N1.7531.00
42_K176_N1.7441.00
42_K45_E1.7401.00
58_V111_M1.6591.00
18_S121_V1.6171.00
30_V83_Y1.5701.00
27_E84_K1.5671.00
93_V111_M1.5491.00
149_K175_T1.5241.00
149_K173_V1.5171.00
22_V47_I1.5021.00
127_T160_H1.4941.00
60_T102_I1.4711.00
51_R92_D1.4611.00
78_N81_D1.4501.00
121_V148_A1.4331.00
35_N38_E1.4181.00
154_S160_H1.3991.00
150_E176_N1.3951.00
44_K48_E1.3901.00
56_P115_A1.3851.00
120_I138_A1.3751.00
22_V123_T1.3651.00
63_T80_G1.3631.00
45_E177_K1.3461.00
128_D154_S1.3321.00
50_A121_V1.3321.00
44_K85_E1.3051.00
111_M115_A1.2951.00
131_V147_V1.2931.00
127_T152_V1.2781.00
122_F134_S1.2601.00
21_V122_F1.2571.00
132_E166_N1.2561.00
127_T164_L1.2551.00
158_E161_E1.2551.00
147_V152_V1.2341.00
48_E52_K1.2201.00
137_H141_L1.2201.00
161_E165_L1.2201.00
39_F43_L1.2161.00
110_L114_N1.2001.00
61_M82_I1.1961.00
23_W130_G1.1911.00
20_L50_A1.1781.00
63_T96_R1.1721.00
22_V43_L1.1551.00
22_V25_V1.1551.00
151_A176_N1.1511.00
113_R143_F1.1191.00
41_A85_E1.1051.00
132_E163_S1.0871.00
46_L151_A1.0831.00
149_K164_L1.0831.00
61_M94_I1.0751.00
47_I51_R1.0681.00
27_E81_D1.0441.00
167_M171_M1.0361.00
121_V146_I1.0221.00
107_N110_L1.0121.00
133_T136_R0.9981.00
135_A147_V0.9931.00
42_K150_E0.9821.00
82_I94_I0.9771.00
120_I145_P0.9561.00
24_D97_K0.9331.00
19_V58_V0.9311.00
18_S55_V0.9281.00
112_L143_F0.9231.00
47_I59_Y0.9191.00
158_E162_R0.9061.00
111_M114_N0.9021.00
146_I172_L0.8941.00
89_K92_D0.8941.00
103_F138_A0.8911.00
160_H164_L0.8841.00
27_E31_N0.8811.00
127_T154_S0.8791.00
135_A167_M0.8731.00
152_V160_H0.8701.00
146_I174_L0.8681.00
104_V141_L0.8621.00
156_D159_A0.8581.00
144_I172_L0.8531.00
49_S52_K0.8471.00
39_F153_S0.8391.00
46_L123_T0.8351.00
25_V125_I0.8331.00
148_A174_L0.8271.00
99_T142_G0.8251.00
174_L178_E0.8141.00
148_A151_A0.8141.00
44_K88_P0.8131.00
58_V115_A0.8111.00
99_T105_G0.8111.00
81_D87_Y0.8111.00
102_I108_F0.8101.00
158_E165_L0.8091.00
45_E49_S0.8081.00
21_V108_F0.8041.00
118_Y144_I0.8021.00
45_E176_N0.7991.00
59_Y82_I0.7941.00
17_N119_S0.7821.00
162_R166_N0.7801.00
59_Y88_P0.7801.00
72_R75_R0.7741.00
122_F131_V0.7741.00
56_P117_I0.7711.00
45_E48_E0.7651.00
23_W122_F0.7641.00
77_F80_G0.7571.00
125_I153_S0.7561.00
43_L151_A0.7501.00
40_I44_K0.7471.00
47_I57_I0.7431.00
136_R170_L0.7371.00
164_L173_V0.7331.00
88_P94_I0.7241.00
70_Q73_I0.7111.00
67_E70_Q0.7091.00
31_N37_N0.7081.00
88_P92_D0.7081.00
135_A145_P0.7081.00
128_D166_N0.7071.00
137_H140_A0.7071.00
29_L130_G0.7061.00
19_V112_L0.7041.00
41_A45_E0.7021.00
41_A44_K0.7001.00
159_A162_R0.6981.00
123_T151_A0.6951.00
27_E83_Y0.6941.00
38_E41_A0.6881.00
128_D159_A0.6871.00
39_F125_I0.6851.00
46_L176_N0.6831.00
70_Q74_R0.6821.00
59_Y91_G0.6811.00
128_D155_A0.6811.00
122_F145_P0.6771.00
84_K87_Y0.6751.00
78_N84_K0.6731.00
159_A165_L0.6681.00
93_V115_A0.6561.00
56_P111_M0.6531.00
51_R91_G0.6531.00
67_E74_R0.6501.00
165_L168_Q0.6441.00
71_P75_R0.6421.00
20_L46_L0.6411.00
76_S79_P0.6411.00
126_A154_S0.6381.00
152_V164_L0.6371.00
44_K87_Y0.6371.00
22_V59_Y0.6331.00
51_R89_K0.6301.00
110_L113_R0.6281.00
48_E87_Y0.6251.00
25_V83_Y0.6241.00
83_Y86_V0.6181.00
36_K125_I0.6171.00
59_Y94_I0.6171.00
162_R165_L0.6171.00
20_L123_T0.6161.00
34_F38_E0.6141.00
59_Y92_D0.6081.00
61_M80_G0.6041.00
40_I83_Y0.6031.00
58_V93_V0.5961.00
101_S140_A0.5931.00
76_S81_D0.5921.00
104_V137_H0.5881.00
126_A129_I0.5861.00
33_I36_K0.5841.00
34_F153_S0.5790.99
48_E89_K0.5740.99
30_V36_K0.5700.99
30_V40_I0.5670.99
88_P91_G0.5650.99
145_P148_A0.5610.99
50_A56_P0.5590.99
40_I85_E0.5570.99
25_V86_V0.5570.99
56_P93_V0.5570.99
59_Y86_V0.5560.99
47_I92_D0.5560.99
40_I86_V0.5560.99
139_Q145_P0.5550.99
17_N116_G0.5550.99
147_V164_L0.5540.99
126_A155_A0.5510.99
71_P74_R0.5490.99
25_V39_F0.5480.99
58_V95_L0.5460.99
163_S167_M0.5440.99
61_M81_D0.5430.99
104_V140_A0.5360.99
147_V167_M0.5360.99
65_Y68_R0.5350.99
47_I50_A0.5280.99
23_W131_V0.5280.99
149_K160_H0.5260.99
31_N78_N0.5260.99
26_Q61_M0.5250.99
100_P139_Q0.5250.99
129_I155_A0.5200.99
131_V152_V0.5170.99
51_R90_E0.5160.99
65_Y98_N0.5130.99
159_A163_S0.5110.99
36_K39_F0.5100.99
69_F73_I0.5090.99
20_L47_I0.5070.99
99_T104_V0.5060.99
160_H163_S0.5040.99
20_L57_I0.5010.99
100_P129_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3irvA 2 0.973 100 0.182 Contact Map
2fq1A 2 1 100 0.184 Contact Map
3kl2A 4 0.9568 100 0.188 Contact Map
1nbaA 4 1 100 0.197 Contact Map
3hb7A 3 0.9459 100 0.198 Contact Map
3mcwA 2 0.9568 100 0.199 Contact Map
3tg2A 2 0.9946 100 0.204 Contact Map
1nf9A 2 0.9784 100 0.204 Contact Map
3hu5A 3 0.9243 100 0.206 Contact Map
3ot4A 4 0.9946 100 0.208 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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