GREMLIN Database
Q97YW4 - Transposase ISC1316
UniProt: Q97YW4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (351)
Sequences: 4613 (2940)
Seq/√Len: 156.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
259_D263_K5.4681.00
281_H284_Q4.3231.00
333_A363_N4.2451.00
313_L320_L3.6461.00
276_V372_S3.0741.00
200_L305_L2.9971.00
277_M309_L2.9431.00
306_R322_L2.8791.00
266_K270_E2.7581.00
304_E308_V2.6921.00
343_S346_D2.6481.00
161_V173_I2.5361.00
286_V298_S2.4611.00
327_Y330_K2.3751.00
219_L295_R2.3621.00
304_E307_G2.3401.00
331_T338_V2.3401.00
310_K322_L2.3181.00
305_L309_L2.2611.00
323_V368_I2.2571.00
269_A313_L2.2461.00
371_G374_S2.2111.00
275_V313_L2.1881.00
330_K342_L2.1391.00
350_V357_I2.1381.00
13_D16_T2.0881.00
328_T368_I2.0791.00
225_I242_A2.0741.00
159_K178_D2.0731.00
277_M320_L2.0621.00
262_M311_Y2.0511.00
262_M308_V2.0501.00
332_C335_C2.0281.00
335_C354_C2.0151.00
291_R294_R2.0081.00
258_T304_E1.9881.00
218_A256_L1.9861.00
347_R360_R1.9431.00
200_L260_L1.9321.00
39_I97_F1.9241.00
265_G308_V1.9131.00
51_Q55_R1.8981.00
262_M265_G1.8511.00
335_C351_C1.8431.00
242_A246_L1.8391.00
21_K165_L1.8381.00
34_L80_A1.8341.00
351_C354_C1.8331.00
262_M312_Q1.8261.00
261_Y308_V1.8041.00
22_A70_Q1.7821.00
332_C354_C1.7721.00
273_D318_K1.7721.00
310_K314_E1.7601.00
36_W40_Y1.7541.00
334_R356_W1.7321.00
349_F358_A1.7291.00
21_K171_I1.7281.00
237_N240_F1.7201.00
35_R83_Y1.7111.00
52_T55_R1.7041.00
332_C351_C1.6931.00
9_R170_R1.6541.00
82_R110_V1.6441.00
20_L171_I1.6151.00
137_L173_I1.5971.00
193_I201_L1.5971.00
277_M322_L1.5951.00
261_Y304_E1.5921.00
29_E67_E1.5781.00
240_F243_K1.5671.00
232_K242_A1.5511.00
51_Q81_D1.5481.00
342_L346_D1.5251.00
89_R95_A1.5241.00
229_L243_K1.5211.00
74_Q112_T1.5111.00
339_K342_L1.5041.00
265_G311_Y1.5031.00
277_M306_R1.4981.00
228_E232_K1.4851.00
348_V357_I1.4751.00
279_G322_L1.4751.00
74_Q113_Q1.4731.00
18_R22_A1.4721.00
190_V369_L1.4651.00
349_F356_W1.4581.00
339_K349_F1.4331.00
17_L21_K1.4201.00
202_I362_Y1.4061.00
235_L239_W1.4061.00
84_S88_K1.3921.00
344_L347_R1.3681.00
278_E325_P1.3651.00
203_T207_E1.3461.00
191_V203_T1.3251.00
251_E255_N1.3201.00
170_R251_E1.3141.00
199_K202_I1.3101.00
366_L370_R1.3091.00
265_G312_Q1.2991.00
339_K352_P1.2971.00
5_G174_T1.2831.00
337_Y352_P1.2791.00
265_G305_L1.2741.00
225_I228_E1.2731.00
310_K320_L1.2711.00
24_L171_I1.2691.00
55_R81_D1.2621.00
222_V250_Y1.2601.00
330_K341_D1.2591.00
168_S251_E1.2551.00
297_L302_F1.2531.00
218_A253_L1.2521.00
39_I43_Q1.2381.00
34_L83_Y1.2301.00
87_K97_F1.2281.00
221_K225_I1.2091.00
52_T56_Q1.2041.00
269_A316_Y1.1981.00
333_A366_L1.1961.00
222_V246_L1.1781.00
51_Q80_A1.1761.00
225_I249_A1.1711.00
191_V272_Y1.1641.00
38_D54_L1.1521.00
14_E17_L1.1391.00
27_T79_V1.1391.00
190_V274_V1.1381.00
12_T16_T1.1361.00
343_S347_R1.1331.00
195_V302_F1.1281.00
261_Y265_G1.1271.00
164_K174_T1.1261.00
358_A366_L1.1231.00
88_K92_E1.1221.00
281_H325_P1.1181.00
267_W271_H1.1141.00
78_Q81_D1.1121.00
343_S360_R1.1111.00
362_Y366_L1.1091.00
330_K338_V1.1081.00
78_Q112_T1.1081.00
85_E89_R1.1071.00
266_K316_Y1.1061.00
193_I203_T1.0990.99
344_L360_R1.0990.99
50_T53_E1.0990.99
333_A358_A1.0980.99
308_V311_Y1.0900.99
229_L246_L1.0890.99
192_A369_L1.0890.99
261_Y305_L1.0790.99
229_L242_A1.0780.99
323_V371_G1.0740.99
197_V300_V1.0720.99
55_R80_A1.0670.99
312_Q315_K1.0610.99
37_A57_L1.0610.99
56_Q59_L1.0610.99
40_Y44_R1.0590.99
269_A318_K1.0590.99
58_A77_Q1.0530.99
265_G309_L1.0380.99
258_T308_V1.0350.99
187_T273_D1.0340.99
226_H230_S1.0310.99
72_Y75_V1.0240.99
6_F177_V1.0210.99
286_V294_R1.0110.99
270_E316_Y1.0070.99
269_A275_V0.9940.99
342_L349_F0.9920.99
117_K120_H0.9830.99
331_T371_G0.9810.99
333_A364_A0.9800.99
339_K343_S0.9780.99
78_Q110_V0.9780.99
58_A80_A0.9770.99
239_W243_K0.9750.99
313_L318_K0.9710.99
115_G140_S0.9710.99
35_R87_K0.9680.99
31_Y79_V0.9670.99
74_Q114_S0.9660.99
139_L163_V0.9640.99
110_V160_R0.9610.99
204_S208_Y0.9580.99
358_A362_Y0.9570.99
346_D360_R0.9500.98
328_T371_G0.9470.98
195_V306_R0.9460.98
208_Y359_D0.9430.98
8_F173_I0.9390.98
29_E33_T0.9380.98
225_I246_L0.9340.98
62_R76_V0.9330.98
199_K210_P0.9320.98
41_F45_D0.9290.98
323_V372_S0.9280.98
90_F98_P0.9250.98
111_Y114_S0.9200.98
26_L67_E0.9190.98
282_A303_G0.9180.98
254_K258_T0.9160.98
51_Q54_L0.9140.98
222_V253_L0.9140.98
110_V162_V0.9120.98
333_A356_W0.9090.98
364_A367_N0.9070.98
138_K144_T0.9040.98
74_Q78_Q0.9030.98
347_R359_D0.9010.98
116_W120_H0.9000.98
190_V373_G0.8980.98
149_V152_D0.8960.98
346_D349_F0.8950.98
89_R94_L0.8940.98
90_F97_F0.8930.98
337_Y353_N0.8910.98
279_G325_P0.8900.98
77_Q81_D0.8880.98
104_H107_Y0.8880.98
199_K208_Y0.8840.98
12_T20_L0.8820.98
362_Y365_S0.8820.98
232_K238_N0.8810.98
325_P328_T0.8800.98
348_V358_A0.8770.97
261_Y301_G0.8750.97
245_K248_R0.8740.97
82_R162_V0.8730.97
307_G310_K0.8720.97
31_Y86_A0.8710.97
223_K226_H0.8690.97
39_I87_K0.8650.97
136_T144_T0.8640.97
89_R92_E0.8630.97
276_V368_I0.8590.97
252_H256_L0.8580.97
25_K28_C0.8580.97
349_F360_R0.8550.97
134_L139_L0.8480.97
222_V230_S0.8470.97
31_Y83_Y0.8470.97
53_E56_Q0.8460.97
249_A253_L0.8450.97
303_G307_G0.8420.97
197_V286_V0.8380.97
68_Y76_V0.8360.97
363_N367_N0.8350.97
207_E267_W0.8330.97
33_T37_A0.8290.96
230_S246_L0.8270.96
34_L54_L0.8270.96
342_L360_R0.8260.96
264_L267_W0.8260.96
195_V201_L0.8240.96
17_L171_I0.8210.96
229_L239_W0.8210.96
202_I208_Y0.8200.96
226_H246_L0.8190.96
293_L297_L0.8190.96
162_V174_T0.8160.96
41_F49_L0.8140.96
260_L264_L0.8140.96
214_P256_L0.8130.96
190_V276_V0.8130.96
366_L369_L0.8070.96
333_A370_R0.8040.96
266_K312_Q0.8040.96
36_W100_E0.8020.96
163_V173_I0.8020.96
337_Y349_F0.8010.96
42_Y87_K0.7960.96
222_V226_H0.7930.95
25_K29_E0.7910.95
71_L74_Q0.7910.95
268_F275_V0.7880.95
218_A222_V0.7880.95
189_K273_D0.7870.95
59_L62_R0.7830.95
226_H250_Y0.7820.95
229_L232_K0.7820.95
188_G273_D0.7800.95
160_R176_V0.7800.95
38_D84_S0.7790.95
23_Q27_T0.7790.95
34_L58_A0.7750.95
93_G96_R0.7720.95
74_Q77_Q0.7720.95
330_K339_K0.7710.95
225_I245_K0.7700.95
274_V321_I0.7650.94
274_V319_K0.7650.94
26_L68_Y0.7640.94
291_R298_S0.7640.94
37_A54_L0.7630.94
191_V204_S0.7580.94
78_Q82_R0.7570.94
243_K247_A0.7570.94
214_P218_A0.7560.94
137_L161_V0.7510.94
228_E231_R0.7500.94
165_L171_I0.7480.94
191_V275_V0.7470.94
197_V296_R0.7470.94
59_L63_K0.7460.94
279_G306_R0.7460.94
224_H228_E0.7450.94
327_Y371_G0.7440.94
211_N214_P0.7400.93
334_R366_L0.7360.93
223_K227_R0.7360.93
10_A173_I0.7350.93
30_I79_V0.7350.93
198_E202_I0.7340.93
7_R164_K0.7310.93
276_V321_I0.7270.93
11_Y148_I0.7230.93
8_F151_R0.7220.93
209_F260_L0.7200.92
117_K138_K0.7190.92
280_I325_P0.7160.92
12_T145_F0.7160.92
139_L145_F0.7150.92
218_A249_A0.7140.92
215_Y218_A0.7100.92
331_T367_N0.7080.92
201_L264_L0.7020.92
284_Q325_P0.7020.92
119_L138_K0.7020.92
136_T139_L0.7010.91
186_N189_K0.7010.91
139_L142_L0.7000.91
196_G202_I0.6990.91
211_N300_V0.6980.91
42_Y46_G0.6970.91
157_K178_D0.6970.91
327_Y331_T0.6960.91
268_F272_Y0.6920.91
26_L71_L0.6910.91
194_D361_D0.6900.91
223_K230_S0.6880.91
342_L347_R0.6870.91
74_Q115_G0.6850.91
19_A23_Q0.6850.91
218_A252_H0.6840.90
87_K91_F0.6840.90
14_E18_R0.6820.90
238_N241_K0.6800.90
282_A302_F0.6800.90
235_L240_F0.6780.90
181_F314_E0.6750.90
275_V309_L0.6680.89
80_A84_S0.6650.89
204_S362_Y0.6640.89
253_L299_D0.6640.89
79_V83_Y0.6630.89
184_L187_T0.6620.89
339_K346_D0.6620.89
201_L209_F0.6610.89
38_D87_K0.6600.89
147_V150_H0.6600.89
22_A26_L0.6590.89
138_K142_L0.6580.89
321_I372_S0.6550.88
83_Y87_K0.6510.88
201_L305_L0.6500.88
341_D346_D0.6490.88
40_Y43_Q0.6470.88
87_K90_F0.6460.88
189_K205_D0.6440.88
327_Y338_V0.6440.88
335_C339_K0.6400.87
358_A363_N0.6390.87
20_L24_L0.6350.87
208_Y362_Y0.6340.87
26_L29_E0.6340.87
233_K236_S0.6340.87
313_L316_Y0.6330.87
5_G164_K0.6320.87
344_L359_D0.6320.87
72_Y111_Y0.6310.87
38_D48_G0.6260.86
311_Y315_K0.6260.86
71_L76_V0.6250.86
200_L300_V0.6230.86
368_I371_G0.6230.86
107_Y165_L0.6230.86
134_L138_K0.6220.86
204_S365_S0.6190.86
216_E219_L0.6180.85
216_E295_R0.6170.85
81_D112_T0.6170.85
48_G54_L0.6170.85
308_V312_Q0.6170.85
45_D48_G0.6150.85
19_A22_A0.6150.85
37_A41_F0.6130.85
15_Q18_R0.6110.85
284_Q297_L0.6100.85
170_R255_N0.6100.85
337_Y341_D0.6100.85
285_L297_L0.6080.85
276_V369_L0.6070.84
255_N258_T0.6040.84
111_Y115_G0.6040.84
184_L318_K0.6030.84
250_Y257_R0.6030.84
228_E242_A0.6020.84
60_D64_Q0.6010.84
5_G176_V0.5990.84
270_E274_V0.5980.84
233_K239_W0.5980.84
257_R299_D0.5970.83
6_F151_R0.5960.83
284_Q293_L0.5950.83
200_L265_G0.5950.83
216_E220_W0.5950.83
215_Y219_L0.5940.83
309_L320_L0.5940.83
192_A276_V0.5930.83
86_A98_P0.5930.83
109_L113_Q0.5920.83
23_Q109_L0.5890.83
272_Y275_V0.5890.83
339_K360_R0.5880.83
236_S239_W0.5870.82
9_R172_Y0.5850.82
200_L261_Y0.5830.82
37_A40_Y0.5820.82
23_Q111_Y0.5810.82
111_Y139_L0.5790.82
36_W39_I0.5780.81
350_V356_W0.5770.81
194_D329_S0.5770.81
116_W161_V0.5760.81
334_R358_A0.5760.81
209_F267_W0.5740.81
55_R59_L0.5740.81
42_Y90_F0.5720.81
306_R310_K0.5710.81
223_K291_R0.5700.81
198_E347_R0.5700.81
108_S162_V0.5680.80
189_K272_Y0.5660.80
73_S112_T0.5610.79
116_W140_S0.5600.79
227_R230_S0.5590.79
331_T336_G0.5590.79
29_E65_D0.5580.79
331_T337_Y0.5560.79
209_F264_L0.5560.79
54_L58_A0.5560.79
216_E296_R0.5560.79
326_A330_K0.5550.79
15_Q19_A0.5550.79
342_L345_S0.5530.79
370_R373_G0.5530.79
205_D272_Y0.5520.78
31_Y35_R0.5520.78
75_V109_L0.5520.78
50_T55_R0.5510.78
12_T17_L0.5500.78
54_L57_L0.5500.78
22_A25_K0.5470.78
294_R298_S0.5470.78
301_G304_E0.5470.78
139_L161_V0.5450.78
261_Y264_L0.5450.78
75_V111_Y0.5430.77
293_L296_R0.5430.77
276_V371_G0.5410.77
49_L54_L0.5410.77
329_S343_S0.5400.77
57_L61_L0.5390.77
164_K167_R0.5370.77
59_L80_A0.5370.77
23_Q72_Y0.5350.76
142_L145_F0.5350.76
258_T262_M0.5340.76
73_S115_G0.5320.76
195_V282_A0.5310.76
262_M266_K0.5310.76
352_P360_R0.5310.76
80_A83_Y0.5300.76
203_T268_F0.5300.76
33_T67_E0.5290.75
224_H227_R0.5270.75
192_A365_S0.5260.75
72_Y113_Q0.5260.75
286_V297_L0.5250.75
72_Y109_L0.5250.75
276_V373_G0.5230.75
8_F149_V0.5230.75
228_E245_K0.5220.74
219_L299_D0.5210.74
23_Q71_L0.5210.74
359_D364_A0.5200.74
253_L257_R0.5190.74
59_L73_S0.5190.74
200_L309_L0.5190.74
41_F47_K0.5180.74
192_A204_S0.5170.74
53_E57_L0.5160.74
111_Y118_I0.5160.74
76_V79_V0.5150.74
324_N327_Y0.5140.73
20_L109_L0.5140.73
48_G84_S0.5130.73
250_Y254_K0.5130.73
264_L305_L0.5110.73
151_R154_P0.5100.73
214_P299_D0.5090.73
183_K314_E0.5080.73
330_K343_S0.5070.72
269_A309_L0.5070.72
196_G199_K0.5060.72
331_T349_F0.5050.72
217_K220_W0.5050.72
38_D45_D0.5050.72
266_K308_V0.5020.72
116_W158_V0.5020.72
231_R242_A0.5020.72
38_D41_F0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 0.3486 93.5 0.932 Contact Map
1nu0A 1 0.3308 92.8 0.934 Contact Map
1iv0A 1 0.2468 88.8 0.94 Contact Map
4aybP 1 0.1094 87.8 0.941 Contact Map
1ffkW 1 0.1705 84.9 0.943 Contact Map
1vq8Z 1 0.1756 84.1 0.944 Contact Map
1qypA 1 0.117 83.5 0.944 Contact Map
2k4xA 1 0.1399 82.8 0.945 Contact Map
3j20Y 1 0.1272 82.6 0.945 Contact Map
1vd4A 1 0.1425 81.7 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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