GREMLIN Database
Q97YW3 - Phytoene dehydrogenase related protein
UniProt: Q97YW3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 430 (395)
Sequences: 16140 (13548)
Seq/√Len: 681.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_D27_K4.3671.00
214_A219_V3.8741.00
29_L222_L3.7231.00
6_I250_S3.6381.00
33_A226_K3.5361.00
4_D251_K3.3871.00
37_P223_F3.3501.00
229_E241_R3.2901.00
74_P200_K3.1191.00
37_P211_M3.0131.00
17_S254_I2.9241.00
31_I248_V2.8651.00
241_R247_I2.7551.00
6_I31_I2.6761.00
205_K208_E2.6691.00
35_D224_N2.6331.00
255_N262_L2.6171.00
231_V241_R2.5921.00
6_I248_V2.5221.00
231_V239_G2.5151.00
239_G247_I2.4891.00
228_S243_D2.4711.00
416_G420_A2.4381.00
27_K220_D2.4231.00
225_T242_T2.3711.00
204_G208_E2.3331.00
10_A37_P2.3191.00
226_K243_D2.3131.00
6_I240_V2.2911.00
242_T248_V2.2581.00
252_I399_Y2.2371.00
211_M215_R2.2211.00
325_G328_M2.1871.00
8_I255_N2.1811.00
31_I250_S2.1761.00
76_I200_K2.1681.00
309_P313_V2.1661.00
256_A401_T2.1281.00
5_V26_L2.1031.00
20_Y417_R2.0841.00
229_E267_N1.9671.00
45_E50_K1.9601.00
31_I222_L1.9571.00
68_E71_I1.9551.00
222_L225_T1.9501.00
309_P312_E1.9441.00
211_M221_F1.9241.00
311_G315_I1.9051.00
309_P314_T1.8811.00
311_G314_T1.8761.00
222_L248_V1.8671.00
285_T291_L1.8411.00
13_N256_A1.8361.00
4_D29_L1.8271.00
209_M212_S1.8191.00
43_T50_K1.7921.00
16_V413_G1.7811.00
239_G249_E1.7741.00
8_I257_A1.7561.00
20_Y23_Q1.7501.00
36_R42_D1.7361.00
228_S241_R1.7331.00
291_L294_L1.7281.00
312_E315_I1.7191.00
338_K343_D1.7141.00
331_M335_E1.6911.00
314_T317_S1.6641.00
160_R164_N1.6471.00
102_L117_E1.6441.00
19_I213_R1.6421.00
254_I423_I1.6301.00
338_K345_E1.5991.00
308_L311_G1.5961.00
310_I314_T1.5931.00
24_K424_M1.5711.00
104_E107_R1.5421.00
26_L424_M1.5381.00
64_R68_E1.5321.00
231_V247_I1.5261.00
225_T244_N1.5171.00
309_P315_I1.5071.00
20_Y421_M1.5041.00
401_T419_A1.4951.00
118_E122_K1.4861.00
18_S30_V1.4771.00
5_V252_I1.4681.00
64_R417_R1.4561.00
327_V331_M1.4441.00
114_P118_E1.4331.00
222_L246_K1.4221.00
227_I240_V1.4211.00
14_G256_A1.4191.00
257_A262_L1.4181.00
29_L250_S1.4121.00
29_L220_D1.4011.00
37_P221_F1.3941.00
37_P207_G1.3741.00
41_A207_G1.3671.00
115_K119_L1.3581.00
40_M403_S1.3471.00
97_N100_K1.3371.00
285_T289_R1.3301.00
142_D145_K1.3291.00
348_V351_I1.3271.00
257_A265_L1.3271.00
312_E316_P1.3261.00
335_E338_K1.3241.00
310_I316_P1.3231.00
349_I352_D1.3221.00
5_V21_L1.3201.00
215_R220_D1.3201.00
399_Y419_A1.3181.00
45_E204_G1.3171.00
311_G316_P1.3131.00
412_T416_G1.2891.00
31_I227_I1.2761.00
141_E149_G1.2691.00
332_G335_E1.2591.00
212_S215_R1.2471.00
7_I18_S1.2461.00
285_T293_N1.2461.00
334_Y338_K1.2341.00
208_E212_S1.2301.00
6_I29_L1.2161.00
285_T288_L1.2121.00
311_G317_S1.2091.00
29_L248_V1.2081.00
67_E72_V1.2071.00
22_A219_V1.1911.00
230_I255_N1.1911.00
233_K249_E1.1871.00
4_D26_L1.1831.00
22_A28_V1.1781.00
285_T295_P1.1771.00
19_I23_Q1.1721.00
23_Q68_E1.1701.00
66_Q71_I1.1641.00
215_R219_V1.1561.00
238_T397_N1.1541.00
419_A422_K1.1531.00
30_V221_F1.1521.00
328_M332_G1.1441.00
233_K236_V1.1211.00
242_T246_K1.1191.00
214_A221_F1.1171.00
405_T418_N1.1131.00
45_E48_G1.1131.00
310_I315_I1.1111.00
250_S253_V1.1101.00
330_I351_I1.1091.00
365_A368_G1.1081.00
287_V291_L1.1071.00
374_P377_T1.1051.00
308_L314_T1.1041.00
13_N401_T1.1021.00
252_I397_N1.0981.00
158_P161_K1.0951.00
19_I210_L1.0931.00
20_Y416_G1.0911.00
144_K148_E1.0861.00
328_M331_M1.0861.00
64_R70_G1.0821.00
336_E339_E1.0811.00
275_P279_P1.0811.00
299_R307_T1.0811.00
115_K118_E1.0761.00
335_E345_E1.0721.00
372_H375_M1.0711.00
292_P295_P1.0681.00
285_T296_D1.0651.00
172_Q175_F1.0641.00
291_L295_P1.0641.00
259_P404_G1.0631.00
252_I423_I1.0621.00
399_Y423_I1.0611.00
399_Y422_K1.0581.00
288_L291_L1.0571.00
119_L122_K1.0541.00
68_E72_V1.0521.00
205_K209_M1.0501.00
141_E145_K1.0491.00
20_Y68_E1.0461.00
308_L312_E1.0421.00
312_E317_S1.0421.00
208_E211_M1.0391.00
7_I28_V1.0321.00
164_N172_Q1.0281.00
330_I334_Y1.0281.00
285_T290_E1.0281.00
201_G205_K1.0261.00
199_V206_V1.0251.00
258_S261_L1.0231.00
22_A214_A1.0181.00
285_T294_L1.0141.00
191_Y195_D1.0141.00
113_Y117_E1.0121.00
185_A191_Y1.0111.00
44_A53_R1.0081.00
189_A192_F1.0041.00
21_L420_A1.0021.00
230_I253_V1.0001.00
31_I225_T0.9951.00
13_N415_P0.9901.00
4_D248_V0.9891.00
310_I313_V0.9891.00
309_P316_P0.9871.00
99_E102_L0.9861.00
118_E121_F0.9851.00
31_I242_T0.9771.00
288_L292_P0.9701.00
418_N422_K0.9681.00
232_I238_T0.9681.00
289_R294_L0.9681.00
285_T292_P0.9671.00
330_I333_S0.9651.00
190_Y194_L0.9581.00
391_Y394_P0.9581.00
373_M376_Y0.9571.00
343_D346_K0.9571.00
233_K239_G0.9561.00
278_R281_W0.9531.00
407_P410_Q0.9511.00
83_V93_N0.9481.00
112_K115_K0.9481.00
369_D374_P0.9481.00
288_L294_L0.9401.00
335_E339_E0.9391.00
242_T245_D0.9381.00
308_L316_P0.9371.00
371_N377_T0.9371.00
293_N296_D0.9331.00
100_K103_E0.9311.00
364_N367_Y0.9301.00
225_T248_V0.9301.00
121_F124_K0.9291.00
312_E318_A0.9261.00
95_W100_K0.9181.00
34_R362_E0.9151.00
65_I70_G0.9141.00
211_M223_F0.9101.00
276_E279_P0.9081.00
12_H41_A0.9081.00
236_V239_G0.9021.00
371_N375_M0.9011.00
313_V317_S0.8981.00
192_F195_D0.8961.00
176_S180_M0.8931.00
255_N398_L0.8921.00
395_I398_L0.8891.00
64_R67_E0.8871.00
19_I68_E0.8831.00
191_Y194_L0.8831.00
368_G371_N0.8811.00
293_N297_Y0.8811.00
227_I242_T0.8761.00
290_E293_N0.8761.00
375_M380_L0.8741.00
372_H376_Y0.8681.00
414_V418_N0.8681.00
405_T415_P0.8671.00
19_I214_A0.8611.00
376_Y379_Y0.8611.00
114_P117_E0.8581.00
20_Y24_K0.8571.00
331_M345_E0.8551.00
289_R293_N0.8551.00
230_I240_V0.8541.00
318_A321_N0.8521.00
286_L289_R0.8521.00
308_L313_V0.8501.00
368_G372_H0.8491.00
114_P119_L0.8491.00
32_E223_F0.8491.00
185_A188_V0.8461.00
162_F166_Y0.8441.00
373_M377_T0.8441.00
236_V249_E0.8401.00
10_A30_V0.8401.00
294_L297_Y0.8321.00
23_Q213_R0.8271.00
278_R282_K0.8241.00
95_W104_E0.8231.00
187_V191_Y0.8201.00
186_Y190_Y0.8151.00
313_V316_P0.8151.00
40_M54_A0.8141.00
263_N279_P0.8121.00
417_R421_M0.8091.00
324_G328_M0.8091.00
167_L175_F0.8081.00
291_L296_D0.8071.00
266_T270_L0.8071.00
175_F178_G0.8061.00
13_N412_T0.8031.00
12_H412_T0.8031.00
29_L251_K0.8031.00
233_K238_T0.8001.00
295_P298_M0.7991.00
326_H358_K0.7991.00
347_K351_I0.7951.00
290_E295_P0.7941.00
159_S169_E0.7941.00
213_R216_Q0.7931.00
139_S142_D0.7881.00
124_K128_E0.7871.00
188_V192_F0.7861.00
4_D249_E0.7851.00
289_R292_P0.7821.00
172_Q176_S0.7811.00
10_A223_F0.7791.00
326_H329_T0.7771.00
337_A341_F0.7761.00
238_T253_V0.7751.00
17_S416_G0.7741.00
181_Y184_P0.7741.00
308_L315_I0.7731.00
419_A423_I0.7731.00
261_L264_K0.7731.00
287_V290_E0.7701.00
43_T204_G0.7671.00
187_V195_D0.7671.00
190_Y193_S0.7651.00
147_V151_E0.7641.00
115_K122_K0.7631.00
310_I317_S0.7621.00
289_R296_D0.7611.00
77_D197_K0.7601.00
232_I397_N0.7591.00
103_E107_R0.7581.00
290_E294_L0.7541.00
174_Y178_G0.7541.00
276_E280_R0.7511.00
100_K104_E0.7491.00
177_Y180_M0.7481.00
116_M119_L0.7461.00
254_I419_A0.7441.00
228_S242_T0.7421.00
368_G373_M0.7411.00
370_M374_P0.7391.00
289_R295_P0.7371.00
207_G211_M0.7361.00
278_R283_R0.7361.00
117_E121_F0.7301.00
15_L214_A0.7291.00
314_T318_A0.7271.00
52_S203_M0.7271.00
99_E103_E0.7271.00
376_Y380_L0.7231.00
286_L290_E0.7231.00
99_E105_L0.7231.00
286_L291_L0.7211.00
189_A194_L0.7191.00
232_I398_L0.7191.00
327_V330_I0.7171.00
366_P372_H0.7141.00
402_G415_P0.7141.00
408_G411_V0.7141.00
370_M373_M0.7121.00
16_V20_Y0.7101.00
170_E173_P0.7101.00
157_Q165_E0.7061.00
226_K264_K0.7051.00
12_H413_G0.7041.00
334_Y337_A0.7041.00
103_E106_K0.7031.00
102_L106_K0.7021.00
27_K251_K0.7011.00
4_D250_S0.7011.00
279_P282_K0.7011.00
189_A193_S0.7001.00
143_F146_A0.6991.00
157_Q162_F0.6951.00
390_G393_T0.6951.00
370_M375_M0.6941.00
315_I318_A0.6891.00
171_F175_F0.6891.00
225_T246_K0.6881.00
292_P296_D0.6871.00
162_F165_E0.6851.00
166_Y169_E0.6851.00
69_L72_V0.6851.00
231_V267_N0.6851.00
366_P369_D0.6851.00
337_A344_L0.6811.00
161_K165_E0.6811.00
34_R42_D0.6811.00
22_A220_D0.6801.00
392_A422_K0.6791.00
287_V292_P0.6781.00
317_S320_D0.6771.00
315_I321_N0.6751.00
348_V353_R0.6751.00
113_Y116_M0.6751.00
236_V396_K0.6731.00
67_E70_G0.6721.00
288_L293_N0.6711.00
228_S244_N0.6701.00
49_V349_I0.6691.00
78_S81_A0.6641.00
232_I395_I0.6621.00
368_G375_M0.6611.00
125_E128_E0.6611.00
365_A370_M0.6591.00
171_F174_Y0.6561.00
102_L108_L0.6561.00
364_N368_G0.6551.00
287_V293_N0.6551.00
187_V194_L0.6541.00
12_H16_V0.6531.00
158_P163_L0.6521.00
12_H207_G0.6501.00
46_Y352_D0.6491.00
122_K125_E0.6481.00
228_S231_V0.6471.00
67_E71_I0.6471.00
333_S336_E0.6471.00
26_L29_L0.6461.00
292_P297_Y0.6461.00
155_F158_P0.6451.00
121_F125_E0.6441.00
365_A371_N0.6431.00
26_L251_K0.6421.00
366_P370_M0.6401.00
7_I14_G0.6391.00
147_V150_T0.6381.00
146_A150_T0.6371.00
36_R204_G0.6331.00
16_V416_G0.6321.00
163_L167_L0.6311.00
66_Q69_L0.6301.00
271_K395_I0.6281.00
308_L317_S0.6271.00
331_M334_Y0.6271.00
171_F178_G0.6261.00
127_I130_E0.6251.00
309_P317_S0.6241.00
18_S214_A0.6241.00
65_I68_E0.6231.00
358_K361_R0.6231.00
365_A372_H0.6221.00
332_G336_E0.6211.00
316_P321_N0.6211.00
185_A192_F0.6211.00
55_S203_M0.6201.00
272_V276_E0.6191.00
238_T242_T0.6181.00
329_T332_G0.6181.00
187_V190_Y0.6171.00
126_K130_E0.6161.00
74_P77_D0.6161.00
312_E321_N0.6151.00
338_K341_F0.6121.00
122_K126_K0.6091.00
91_V94_I0.6091.00
16_V210_L0.6081.00
52_S57_V0.6081.00
314_T319_V0.6081.00
175_F179_F0.6071.00
274_H277_F0.6051.00
212_S216_Q0.6051.00
113_Y118_E0.6051.00
168_D176_S0.6031.00
407_P411_V0.6031.00
275_P282_K0.6011.00
199_V205_K0.6001.00
158_P162_F0.5971.00
364_N370_M0.5971.00
157_Q161_K0.5961.00
41_A55_S0.5941.00
287_V294_L0.5941.00
420_A423_I0.5931.00
369_D372_H0.5921.00
167_L170_E0.5911.00
238_T398_L0.5911.00
98_K101_R0.5911.00
338_K344_L0.5901.00
372_H379_Y0.5901.00
342_P345_E0.5881.00
350_Y353_R0.5881.00
78_S82_D0.5881.00
143_F147_V0.5881.00
186_Y189_A0.5881.00
133_Y136_K0.5881.00
253_V397_N0.5871.00
98_K102_L0.5841.00
346_K349_I0.5831.00
203_M411_V0.5821.00
185_A190_Y0.5821.00
330_I353_R0.5791.00
274_H394_P0.5781.00
317_S321_N0.5781.00
326_H330_I0.5771.00
347_K350_Y0.5731.00
113_Y119_L0.5721.00
288_L296_D0.5721.00
309_P318_A0.5721.00
286_L292_P0.5721.00
59_G196_W0.5711.00
119_L123_I0.5711.00
403_S412_T0.5711.00
161_K166_Y0.5701.00
156_T159_S0.5681.00
286_L296_D0.5671.00
331_M351_I0.5671.00
186_Y192_F0.5661.00
189_A195_D0.5661.00
372_H377_T0.5651.00
169_E173_P0.5631.00
73_F76_I0.5631.00
166_Y170_E0.5631.00
240_V253_V0.5621.00
55_S59_G0.5611.00
259_P281_W0.5601.00
163_L176_S0.5601.00
18_S219_V0.5591.00
393_T400_I0.5581.00
167_L176_S0.5571.00
338_K346_K0.5571.00
370_M377_T0.5571.00
368_G374_P0.5561.00
80_I83_V0.5561.00
228_S245_D0.5541.00
211_M219_V0.5521.00
277_F282_K0.5511.00
83_V86_T0.5501.00
71_I216_Q0.5491.00
114_P121_F0.5481.00
226_K365_A0.5481.00
209_M213_R0.5481.00
254_I399_Y0.5451.00
15_L30_V0.5451.00
112_K118_E0.5451.00
169_E174_Y0.5441.00
293_N298_M0.5441.00
413_G416_G0.5441.00
123_I126_K0.5411.00
294_L298_M0.5391.00
273_H276_E0.5391.00
376_Y381_F0.5381.00
8_I227_I0.5381.00
120_L124_K0.5381.00
132_Q136_K0.5371.00
173_P178_G0.5361.00
15_L207_G0.5351.00
239_G242_T0.5351.00
17_S419_A0.5331.00
140_F145_K0.5311.00
10_A32_E0.5301.00
117_E122_K0.5301.00
357_Y362_E0.5301.00
288_L295_P0.5291.00
291_L297_Y0.5281.00
187_V192_F0.5281.00
188_V194_L0.5251.00
66_Q70_G0.5251.00
309_P321_N0.5251.00
166_Y175_F0.5241.00
75_T78_S0.5241.00
163_L169_E0.5231.00
271_K274_H0.5221.00
367_Y371_N0.5221.00
299_R311_G0.5221.00
185_A189_A0.5190.99
334_Y345_E0.5190.99
174_Y177_Y0.5180.99
124_K127_I0.5170.99
290_E334_Y0.5170.99
369_D373_M0.5170.99
73_F80_I0.5170.99
377_T380_L0.5160.99
116_M120_L0.5150.99
348_V352_D0.5150.99
371_N376_Y0.5140.99
64_R72_V0.5140.99
322_S326_H0.5140.99
208_E215_R0.5110.99
114_P122_K0.5110.99
358_K362_E0.5080.99
42_D53_R0.5080.99
324_G329_T0.5080.99
102_L105_L0.5060.99
43_T52_S0.5060.99
118_E124_K0.5060.99
164_N168_D0.5050.99
176_S179_F0.5050.99
101_R104_E0.5040.99
313_V318_A0.5040.99
258_S366_P0.5030.99
188_V191_Y0.5020.99
315_I319_V0.5020.99
140_F146_A0.5010.99
65_I69_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dgkA 1 0.8023 100 0.391 Contact Map
2yg5A 2 0.9442 100 0.421 Contact Map
4i59A 1 0.9395 100 0.423 Contact Map
1s3eA 2 0.9535 100 0.43 Contact Map
4repA 1 0.9767 100 0.44 Contact Map
2vvmA 2 0.9465 100 0.444 Contact Map
3i6dA 1 0.8767 100 0.46 Contact Map
1b37A 4 0.9302 100 0.464 Contact Map
3nrnA 1 0.8093 100 0.469 Contact Map
3lovA 1 0.9302 100 0.47 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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