GREMLIN Database
Q97YW2 - Uncharacterized protein
UniProt: Q97YW2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (244)
Sequences: 8623 (6502)
Seq/√Len: 416.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_L172_D4.4101.00
256_E261_D3.5901.00
138_E175_K3.5791.00
40_D77_L3.4011.00
96_E136_F3.3601.00
251_N254_K3.2781.00
226_D257_K3.1921.00
136_F139_D2.8001.00
131_L173_F2.7961.00
99_Y142_L2.6821.00
215_L219_P2.6001.00
257_K261_D2.5721.00
81_W105_G2.5471.00
260_R264_K2.4251.00
96_E140_H2.2821.00
94_E97_R2.2771.00
225_S254_K2.2621.00
80_Q103_I2.2211.00
65_Y97_R2.1701.00
138_E173_F2.1301.00
225_S257_K2.1251.00
257_K265_R2.0761.00
136_F140_H2.0091.00
82_G98_Q1.9561.00
19_I22_H1.8781.00
179_I266_I1.8421.00
203_F266_I1.8131.00
79_M104_I1.7781.00
71_R80_Q1.7631.00
10_V47_I1.7521.00
177_R266_I1.7441.00
170_A178_I1.7041.00
46_K79_M1.6821.00
138_E176_L1.6801.00
37_L41_N1.6691.00
135_E139_D1.6671.00
229_I262_N1.6661.00
135_E173_F1.6311.00
177_R203_F1.6281.00
256_E260_R1.6271.00
252_V256_E1.5811.00
171_K199_T1.5781.00
69_E73_R1.5601.00
119_A129_Q1.5511.00
254_K257_K1.5491.00
141_G177_R1.5341.00
18_K22_H1.5211.00
95_L133_I1.5041.00
131_L135_E1.5021.00
45_E260_R1.4541.00
36_T74_N1.4541.00
99_Y140_H1.4531.00
68_Y101_L1.4481.00
141_G175_K1.4461.00
261_D264_K1.4151.00
82_G103_I1.4071.00
229_I266_I1.4031.00
257_K262_N1.4001.00
132_Y135_E1.3991.00
244_E247_Y1.3951.00
134_Y169_I1.3841.00
141_G268_K1.3811.00
115_F129_Q1.3791.00
81_W267_L1.3731.00
8_A229_I1.3671.00
203_F265_R1.3591.00
137_A144_I1.3581.00
68_Y72_K1.3491.00
97_R101_L1.3261.00
189_Y193_F1.3261.00
106_I137_A1.2911.00
98_Q103_I1.2791.00
247_Y255_N1.2551.00
17_R21_E1.2551.00
252_V255_N1.2481.00
97_R100_S1.2331.00
61_Y65_Y1.2291.00
34_R37_L1.2161.00
22_H26_F1.2111.00
216_K220_R1.2061.00
6_I46_K1.1981.00
8_A267_L1.1731.00
243_A247_Y1.1731.00
96_E139_D1.1721.00
240_Q244_E1.1681.00
242_L245_Y1.1611.00
95_L106_I1.1531.00
170_A202_I1.1471.00
39_N47_I1.1451.00
128_K131_L1.1361.00
67_D80_Q1.1351.00
61_Y94_E1.1351.00
68_Y103_I1.1311.00
46_K264_K1.1271.00
21_E25_E1.1261.00
95_L140_H1.1211.00
49_L78_Y1.1191.00
98_Q101_L1.1161.00
69_E72_K1.1141.00
210_P213_N1.1141.00
92_K136_F1.1051.00
244_E248_Q1.0991.00
241_D244_E1.0941.00
143_P266_I1.0911.00
253_L257_K1.0861.00
6_I264_K1.0861.00
212_K216_K1.0851.00
170_A201_N1.0831.00
135_E138_E1.0791.00
93_R96_E1.0701.00
66_I69_E1.0691.00
189_Y192_A1.0621.00
66_I70_E1.0601.00
204_L221_I1.0581.00
225_S258_I1.0581.00
33_T73_R1.0571.00
138_E141_G1.0481.00
134_Y173_F1.0371.00
134_Y144_I1.0361.00
263_A267_L1.0361.00
27_L31_E1.0351.00
5_V259_M1.0341.00
255_N259_M1.0251.00
96_E100_S1.0251.00
36_T40_D1.0191.00
94_E98_Q1.0151.00
203_F227_K1.0131.00
35_M47_I1.0111.00
161_A180_L1.0091.00
251_N255_N1.0091.00
115_F119_A1.0041.00
8_A263_A1.0031.00
38_K41_N0.9881.00
147_H233_D0.9821.00
250_Y255_N0.9801.00
18_K21_E0.9711.00
36_T77_L0.9651.00
95_L137_A0.9611.00
168_D171_K0.9501.00
6_I263_A0.9461.00
250_Y254_K0.9461.00
81_W145_L0.9391.00
188_W192_A0.9381.00
18_K26_F0.9361.00
130_L134_Y0.9321.00
61_Y97_R0.9271.00
261_D265_R0.9271.00
20_P24_K0.9231.00
90_D93_R0.9221.00
48_L79_M0.9171.00
145_L181_A0.9171.00
47_I78_Y0.9151.00
134_Y176_L0.9141.00
22_H25_E0.9111.00
203_F262_N0.9101.00
188_W191_T0.9071.00
179_I229_I0.9041.00
190_N194_H0.9031.00
188_W193_F0.9011.00
19_I26_F0.8861.00
116_K119_A0.8741.00
183_A221_I0.8701.00
242_L246_A0.8691.00
5_V44_I0.8681.00
216_K219_P0.8601.00
191_T194_H0.8521.00
10_V35_M0.8521.00
181_A205_E0.8511.00
20_P23_C0.8501.00
229_I263_A0.8491.00
180_L202_I0.8431.00
253_L261_D0.8381.00
19_I23_C0.8341.00
177_R265_R0.8331.00
145_L267_L0.8231.00
226_D265_R0.8211.00
241_D245_Y0.8211.00
246_A259_M0.8191.00
17_R20_P0.8181.00
168_D172_D0.8171.00
71_R103_I0.8121.00
143_P179_I0.8111.00
217_V221_I0.8101.00
211_P215_L0.8091.00
132_Y136_F0.8071.00
129_Q132_Y0.8021.00
212_K215_L0.8021.00
131_L134_Y0.7981.00
23_C26_F0.7921.00
8_A179_I0.7911.00
106_I144_I0.7891.00
21_E24_K0.7871.00
210_P214_I0.7801.00
211_P214_I0.7801.00
46_K78_Y0.7751.00
82_G106_I0.7741.00
65_Y69_E0.7691.00
27_L30_V0.7651.00
247_Y259_M0.7641.00
228_V258_I0.7631.00
118_N168_D0.7621.00
186_P192_A0.7621.00
37_L40_D0.7611.00
36_T39_N0.7601.00
33_T37_L0.7591.00
49_L67_D0.7541.00
213_N216_K0.7541.00
12_Y67_D0.7521.00
56_H94_E0.7501.00
7_D232_S0.7501.00
39_N44_I0.7471.00
194_H198_F0.7461.00
215_L218_L0.7451.00
16_A22_H0.7431.00
6_I260_R0.7421.00
164_I170_A0.7371.00
75_P78_Y0.7341.00
71_R78_Y0.7331.00
16_A20_P0.7301.00
20_P26_F0.7291.00
65_Y94_E0.7271.00
95_L136_F0.7271.00
204_L228_V0.7251.00
214_I218_L0.7241.00
92_K132_Y0.7201.00
48_L267_L0.7161.00
167_D171_K0.7121.00
108_L144_I0.7111.00
224_I227_K0.7091.00
106_I142_L0.7051.00
166_A180_L0.7011.00
41_N240_Q0.6971.00
33_T74_N0.6971.00
64_F68_Y0.6971.00
25_E28_E0.6971.00
16_A19_I0.6971.00
42_V240_Q0.6971.00
85_N94_E0.6961.00
147_H185_R0.6951.00
264_K268_K0.6931.00
48_L81_W0.6921.00
62_D65_Y0.6891.00
86_P133_I0.6891.00
148_T184_G0.6831.00
92_K96_E0.6831.00
183_A209_I0.6811.00
9_H205_E0.6801.00
249_V255_N0.6801.00
218_L221_I0.6791.00
230_Y259_M0.6781.00
213_N217_V0.6771.00
224_I254_K0.6751.00
189_Y195_M0.6751.00
161_A202_I0.6670.99
177_R201_N0.6660.99
260_R263_A0.6640.99
84_V106_I0.6640.99
33_T36_T0.6580.99
39_N78_Y0.6560.99
46_K76_D0.6520.99
145_L179_I0.6520.99
84_V133_I0.6500.99
192_A195_M0.6490.99
63_G66_I0.6480.99
27_L32_G0.6470.99
262_N265_R0.6430.99
191_T195_M0.6420.99
11_H147_H0.6420.99
11_H233_D0.6420.99
128_K172_D0.6420.99
20_P25_E0.6400.99
177_R227_K0.6340.99
250_Y258_I0.6300.99
167_D195_M0.6290.99
243_A246_A0.6290.99
214_I217_V0.6280.99
257_K260_R0.6270.99
8_A48_L0.6270.99
68_Y100_S0.6240.99
133_I137_A0.6220.99
39_N77_L0.6220.99
95_L99_Y0.6210.99
151_S162_D0.6210.99
72_K102_G0.6200.99
245_Y248_Q0.6190.99
131_L169_I0.6130.99
18_K23_C0.6110.99
82_G95_L0.6080.99
107_K182_H0.6070.99
70_E78_Y0.6030.99
105_G145_L0.6030.99
190_N195_M0.6020.99
14_I29_N0.6000.99
221_I224_I0.5980.99
146_I178_I0.5960.99
31_E34_R0.5950.99
196_A224_I0.5870.99
225_S262_N0.5830.99
67_D71_R0.5830.99
205_E231_G0.5810.99
99_Y136_F0.5790.99
188_W196_A0.5770.99
167_D199_T0.5740.98
137_A140_H0.5700.98
186_P195_M0.5690.98
48_L105_G0.5690.98
64_F80_Q0.5690.98
5_V260_R0.5680.98
9_H182_H0.5660.98
36_T78_Y0.5650.98
103_I106_I0.5640.98
143_P177_R0.5640.98
34_R38_K0.5630.98
192_A196_A0.5620.98
50_V145_L0.5610.98
179_I267_L0.5600.98
186_P190_N0.5590.98
7_D10_V0.5550.98
52_S55_C0.5550.98
173_F176_L0.5550.98
38_K234_F0.5520.98
206_I258_I0.5510.98
148_T166_A0.5470.98
206_I228_V0.5450.98
72_K75_P0.5450.98
17_R23_C0.5450.98
212_K219_P0.5450.98
74_N77_L0.5440.98
204_L207_S0.5440.98
92_K139_D0.5440.98
5_V247_Y0.5440.98
207_S231_G0.5440.98
68_Y80_Q0.5430.98
160_Y163_P0.5400.98
182_H233_D0.5390.98
79_M267_L0.5370.98
53_H109_H0.5370.98
164_I168_D0.5340.98
38_K42_V0.5330.98
211_P248_Q0.5330.98
107_K181_A0.5320.97
214_I220_R0.5310.97
180_L192_A0.5270.97
9_H181_A0.5250.97
166_A170_A0.5250.97
28_E31_E0.5240.97
107_K145_L0.5220.97
218_L228_V0.5210.97
145_L205_E0.5200.97
211_P216_K0.5170.97
214_I221_I0.5160.97
96_E99_Y0.5150.97
196_A204_L0.5140.97
217_V220_R0.5130.97
99_Y102_G0.5120.97
84_V88_K0.5120.97
137_A176_L0.5110.97
188_W195_M0.5110.97
215_L249_V0.5090.97
186_P191_T0.5090.97
99_Y104_I0.5070.97
53_H56_H0.5060.97
91_V133_I0.5040.97
240_Q243_A0.5020.96
211_P218_L0.5010.96
210_P221_I0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hbvA 3 0.9407 100 0.308 Contact Map
3irsA 3 0.9296 100 0.319 Contact Map
4dziA 2 0.9481 100 0.322 Contact Map
4lanA 2 0.9407 100 0.331 Contact Map
3nurA 2 0.9185 100 0.333 Contact Map
4ofcA 4 0.937 100 0.334 Contact Map
4qrnA 2 0.9444 100 0.335 Contact Map
4di9A 1 0.8963 100 0.336 Contact Map
4l6dA 4 0.9444 100 0.34 Contact Map
3cjpA 2 0.8481 100 0.348 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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