GREMLIN Database
Q97YW0 - Probable thymidylate kinase
UniProt: Q97YW0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 208 (194)
Sequences: 4700 (3591)
Seq/√Len: 257.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_E191_E3.3671.00
26_Y193_D3.2031.00
33_G87_F3.1881.00
128_L181_S2.9111.00
22_A189_D2.8611.00
104_T164_A2.6281.00
24_K28_E2.4971.00
129_I162_F2.4891.00
183_E187_Y2.3421.00
134_E137_R2.1761.00
162_F166_I2.1591.00
184_N187_Y2.1471.00
35_V87_F2.0721.00
179_I188_T2.0371.00
73_D77_N2.0351.00
37_F74_Q1.9761.00
20_L90_L1.9581.00
20_L36_T1.9371.00
32_Y88_I1.8351.00
76_E80_K1.8251.00
129_I166_I1.8131.00
19_H192_F1.8041.00
24_K36_T1.7831.00
30_E197_K1.7621.00
19_H189_D1.7571.00
4_L88_I1.7531.00
166_I178_S1.7441.00
80_K84_D1.7061.00
177_M195_V1.6731.00
26_Y30_E1.6611.00
131_T182_R1.6431.00
189_D193_D1.6141.00
14_S130_S1.6111.00
24_K90_L1.5711.00
126_L195_V1.5581.00
127_P176_L1.5561.00
114_D117_S1.5381.00
147_D150_E1.5231.00
96_L175_A1.4941.00
130_S134_E1.4831.00
19_H22_A1.4771.00
177_M199_I1.4641.00
5_I91_A1.4561.00
105_R152_G1.4431.00
80_K120_P1.4231.00
25_K29_K1.3871.00
127_P178_S1.3421.00
113_D171_R1.3411.00
134_E182_R1.3411.00
26_Y197_K1.3281.00
159_E163_E1.3281.00
12_E135_I1.3231.00
163_E167_D1.3211.00
169_I178_S1.3201.00
48_R51_Q1.3121.00
7_A91_A1.3121.00
23_T196_Q1.3051.00
26_Y189_D1.3041.00
128_L192_F1.3001.00
47_D70_D1.2951.00
45_I58_F1.2911.00
126_L192_F1.2911.00
167_D171_R1.2741.00
59_E76_E1.2741.00
100_S104_T1.2551.00
11_I158_K1.2501.00
49_I66_A1.2431.00
35_V82_S1.2391.00
82_S87_F1.2221.00
8_F23_T1.2181.00
193_D197_K1.2171.00
22_A186_I1.2091.00
22_A185_I1.2001.00
96_L125_S1.1991.00
64_F68_V1.1941.00
72_A76_E1.1581.00
43_K46_G1.1571.00
179_I195_V1.1561.00
68_V116_L1.1551.00
133_D159_E1.1541.00
195_V199_I1.1441.00
7_A96_L1.1381.00
135_I139_I1.1361.00
95_T116_L1.1331.00
156_C159_E1.1331.00
167_D170_N1.1321.00
168_Y176_L1.1271.00
191_E194_E1.1101.00
189_D192_F1.0981.00
21_E25_K1.0921.00
75_I120_P1.0921.00
130_S135_I1.0901.00
127_P166_I1.0801.00
127_P169_I1.0731.00
110_E114_D1.0721.00
180_S183_E1.0651.00
156_C160_D1.0631.00
111_W118_M1.0631.00
131_T134_E1.0551.00
190_K194_E1.0531.00
37_F91_A1.0431.00
61_R111_W1.0421.00
108_E112_I1.0311.00
124_I177_M1.0301.00
18_S185_I1.0281.00
132_P155_I1.0271.00
30_E193_D1.0191.00
28_E34_V1.0171.00
35_V78_Y1.0171.00
113_D117_S1.0161.00
36_T90_L1.0051.00
9_E97_T1.0031.00
68_V95_T1.0001.00
195_V198_E0.9991.00
191_E195_V0.9971.00
67_Y149_L0.9931.00
121_K172_F0.9911.00
59_E72_A0.9891.00
187_Y191_E0.9871.00
139_I142_K0.9751.00
126_L177_M0.9751.00
185_I189_D0.9751.00
19_H185_I0.9731.00
25_K28_E0.9721.00
68_V98_L0.9701.00
124_I199_I0.9691.00
24_K34_V0.9671.00
116_L119_L0.9441.00
136_V139_I0.9431.00
46_G70_D0.9421.00
132_P162_F0.9271.00
127_P162_F0.9241.00
53_K56_I0.9181.00
26_Y190_K0.9151.00
126_L179_I0.9011.00
166_I169_I0.8981.00
95_T121_K0.8961.00
136_V155_I0.8891.00
61_R76_E0.8831.00
61_R118_M0.8821.00
99_T168_Y0.8751.00
96_L176_L0.8651.00
79_V89_A0.8651.00
26_Y29_K0.8641.00
144_G147_D0.8631.00
70_D74_Q0.8520.99
5_I94_Y0.8490.99
43_K78_Y0.8450.99
194_E197_K0.8410.99
105_R157_I0.8360.99
124_I195_V0.8350.99
130_S181_S0.8310.99
17_T21_E0.8270.99
33_G85_S0.8260.99
22_A25_K0.8240.99
194_E198_E0.8230.99
113_D172_F0.8090.99
155_I159_E0.8040.99
129_I178_S0.8020.99
78_Y82_S0.7980.99
39_L74_Q0.7970.99
140_I146_L0.7890.99
21_E36_T0.7780.99
137_R141_K0.7750.99
68_V112_I0.7720.99
11_I135_I0.7690.99
64_F112_I0.7670.99
7_A175_A0.7630.99
187_Y190_K0.7560.99
8_F192_F0.7550.99
12_E158_K0.7540.99
34_V88_I0.7520.99
59_E62_T0.7430.99
21_E24_K0.7420.99
65_L115_V0.7390.99
164_A167_D0.7390.99
55_N58_F0.7390.99
99_T109_K0.7390.99
179_I192_F0.7310.98
125_S175_A0.7300.98
160_D163_E0.7220.98
136_V140_I0.7150.98
81_P85_S0.7140.98
74_Q91_A0.7110.98
126_L196_Q0.7070.98
100_S164_A0.7010.98
113_D121_K0.7010.98
34_V87_F0.7010.98
40_Q71_L0.6990.98
8_F20_L0.6970.98
172_F175_A0.6920.98
64_F115_V0.6920.98
109_K167_D0.6900.98
108_E111_W0.6810.97
28_E33_G0.6770.97
34_V90_L0.6730.97
143_R146_L0.6680.97
13_G139_I0.6670.97
172_F176_L0.6660.97
99_T113_D0.6660.97
109_K113_D0.6660.97
169_I176_L0.6620.97
105_R149_L0.6610.97
71_L98_L0.6560.97
188_T191_E0.6560.97
94_Y120_P0.6550.97
101_W157_I0.6540.97
17_T38_G0.6510.97
19_H23_T0.6500.97
63_L105_R0.6490.97
117_S121_K0.6480.97
38_G47_D0.6400.96
68_V119_L0.6370.96
4_L123_S0.6360.96
46_G73_D0.6340.96
8_F126_L0.6330.96
7_A176_L0.6310.96
82_S85_S0.6290.96
28_E36_T0.6290.96
115_V118_M0.6290.96
11_I127_P0.6280.96
48_R55_N0.6280.96
132_P159_E0.6200.96
19_H188_T0.6200.96
75_I79_V0.6160.96
46_G49_I0.6130.95
39_L71_L0.6110.95
67_Y70_D0.6110.95
62_T72_A0.6090.95
4_L199_I0.6080.95
62_T69_T0.6020.95
110_E113_D0.6000.95
6_I123_S0.6000.95
8_F128_L0.6000.95
53_K58_F0.6000.95
31_G34_V0.5980.95
5_I83_I0.5970.95
98_L112_I0.5960.95
140_I144_G0.5890.94
19_H181_S0.5840.94
41_M50_A0.5830.94
67_Y99_T0.5820.94
7_A125_S0.5770.94
185_I188_T0.5750.94
64_F98_L0.5700.93
82_S89_A0.5680.93
65_L118_M0.5620.93
8_F19_H0.5620.93
53_K151_T0.5590.93
75_I80_K0.5580.93
40_Q67_Y0.5560.92
109_K164_A0.5560.92
133_D137_R0.5550.92
114_D118_M0.5510.92
9_E101_W0.5500.92
132_P135_I0.5480.92
157_I161_T0.5460.92
106_G160_D0.5450.92
73_D149_L0.5420.91
96_L172_F0.5420.91
64_F95_T0.5400.91
9_E127_P0.5390.91
75_I119_L0.5370.91
146_L151_T0.5370.91
37_F89_A0.5360.91
19_H128_L0.5340.91
99_T116_L0.5290.90
22_A192_F0.5270.90
152_G157_I0.5240.90
97_T165_Y0.5230.90
59_E73_D0.5230.90
14_S135_I0.5220.90
133_D155_I0.5220.90
98_L102_G0.5180.90
168_Y172_F0.5160.89
6_I196_Q0.5140.89
125_S176_L0.5140.89
62_T73_D0.5140.89
192_F196_Q0.5130.89
100_S161_T0.5130.89
110_E171_R0.5130.89
98_L116_L0.5120.89
190_K193_D0.5110.89
71_L116_L0.5110.89
158_K161_T0.5090.89
95_T98_L0.5090.89
48_R54_R0.5080.89
149_L152_G0.5070.88
38_G42_S0.5070.88
63_L149_L0.5030.88
44_L48_R0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3czpA 2 0.8125 100 0.379 Contact Map
2plrA 2 0.9615 100 0.388 Contact Map
4edhA 2 0.976 100 0.42 Contact Map
2yogA 1 0.9038 100 0.426 Contact Map
1nn5A 2 0.9279 100 0.431 Contact Map
1p6xA 3 0.9615 100 0.442 Contact Map
4eaqA 2 0.9375 100 0.443 Contact Map
1gtvA 2 0.899 100 0.444 Contact Map
4tmkA 3 0.9567 100 0.445 Contact Map
4hlcA 2 0.9279 100 0.448 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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