GREMLIN Database
Q97YV9 - Exopolyphosphatase (Metaphosphatase), putative
UniProt: Q97YV9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 417 (404)
Sequences: 2210 (1594)
Seq/√Len: 79.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
317_S324_S5.4881.00
291_D295_W4.7261.00
291_D296_L4.3941.00
76_K105_R4.0471.00
291_D294_N3.5521.00
167_E174_V3.5211.00
47_T87_S3.3761.00
163_V255_S3.3651.00
97_S103_E3.1791.00
132_F263_L3.1381.00
195_N256_A3.1261.00
78_V283_V3.1231.00
349_C373_C3.0591.00
313_K324_S3.0271.00
292_K296_L3.0101.00
218_L271_D3.0041.00
50_E95_R2.9991.00
196_V260_V2.8771.00
323_Y398_L2.8661.00
54_E58_R2.8211.00
353_I373_C2.7961.00
96_L104_V2.7871.00
64_K68_N2.7701.00
348_A351_R2.6911.00
67_L75_V2.6711.00
43_K47_T2.5561.00
170_I174_V2.5371.00
313_K317_S2.4611.00
315_V405_K2.4511.00
175_S262_E2.4351.00
345_P376_A2.4261.00
309_F328_A2.4171.00
173_K177_E2.3671.00
141_I263_L2.3471.00
202_L253_I2.3371.00
294_N297_E2.3031.00
61_T99_I2.2671.00
174_V178_L2.2291.00
292_K295_W2.2171.00
264_I272_M2.1581.00
111_E114_S2.1151.00
170_I177_E2.1101.00
177_E180_T2.0991.00
79_A83_F2.0901.00
191_G196_V2.0781.00
340_V352_F2.0291.00
174_V181_I2.0251.00
173_K181_I2.0171.00
77_I102_N1.9881.00
316_M324_S1.9761.00
89_G106_V1.9361.00
91_E94_L1.9311.00
364_D395_K1.9251.00
56_A92_V1.8961.00
8_C104_V1.8741.00
177_E181_I1.8611.00
50_E54_E1.8491.00
109_G140_E1.8301.00
92_V96_L1.8101.00
95_R99_I1.8011.00
368_L399_S1.7591.00
166_P173_K1.7491.00
90_N94_L1.7331.00
301_Y336_I1.7321.00
7_D11_N1.7301.00
225_S261_D1.7241.00
96_L100_I1.7111.00
128_D145_T1.7061.00
362_T365_E1.6971.00
225_S265_K1.6751.00
203_D223_Q1.6541.00
18_Y284_L1.6481.00
17_V70_I1.6341.00
4_A75_V1.6261.00
53_V88_N1.6251.00
166_P181_I1.6181.00
174_V177_E1.6161.00
83_F92_V1.5931.00
309_F332_L1.5841.00
221_S225_S1.5681.00
67_L72_V1.5641.00
4_A67_L1.5631.00
50_E91_E1.5560.99
114_S286_E1.5500.99
202_L245_I1.5490.99
48_I92_V1.5200.99
203_D207_S1.5080.99
247_K250_A1.5040.99
80_T84_R1.4980.99
176_D180_T1.4920.99
235_D238_S1.4770.99
376_A410_K1.4710.99
105_R111_E1.4670.99
14_R278_G1.4440.99
75_V102_N1.4440.99
346_F377_S1.4370.99
166_P170_I1.4360.99
171_R265_K1.4330.99
311_I413_V1.4270.99
8_C13_F1.4270.99
397_L401_G1.4230.99
95_R98_K1.4140.99
293_M297_E1.4070.99
172_K176_D1.4000.99
11_N249_R1.3710.99
116_A193_G1.3700.99
166_P169_E1.3650.99
167_E173_K1.3300.98
231_L253_I1.3210.98
109_G113_G1.3060.98
392_I395_K1.3060.98
167_E170_I1.3040.98
85_Y161_K1.3010.98
93_R106_V1.2980.98
137_G161_K1.2940.98
203_D217_Y1.2790.98
11_N194_G1.2730.98
329_S361_F1.2660.98
132_F189_M1.2650.98
375_A381_K1.2630.98
49_P52_K1.2610.98
132_F272_M1.2310.97
123_T277_F1.2230.97
167_E181_I1.2230.97
53_V92_V1.2220.97
167_E177_E1.2200.97
221_S265_K1.2180.97
16_V281_E1.2170.97
402_N405_K1.2070.97
228_A232_P1.1980.97
94_L98_K1.1810.97
167_E171_R1.1810.97
170_I173_K1.1780.96
225_S229_S1.1710.96
19_Q27_R1.1700.96
8_C79_A1.1640.96
135_G138_S1.1450.96
194_G249_R1.1400.96
176_D179_S1.1380.96
140_E154_Q1.1320.96
193_G278_G1.1260.95
231_L257_S1.1230.95
7_D194_G1.1210.95
206_L230_L1.1170.95
114_S118_L1.1160.95
166_P174_V1.1120.95
169_E174_V1.1100.95
13_F56_A1.1090.95
78_V279_M1.1010.95
32_S66_I1.0970.95
187_N270_S1.0900.95
333_L353_I1.0870.94
326_Y368_L1.0860.94
226_K230_L1.0850.94
159_A252_T1.0800.94
301_Y306_D1.0740.94
13_F63_F1.0710.94
221_S261_D1.0580.94
133_E249_R1.0580.94
133_E138_S1.0560.94
155_L181_I1.0550.94
292_K297_E1.0540.94
54_E95_R1.0530.93
79_A380_V1.0510.93
65_R68_N1.0510.93
81_S161_K1.0500.93
78_V107_I1.0440.93
37_R251_L1.0440.93
340_V348_A1.0420.93
228_A257_S1.0390.93
219_L224_I1.0370.93
371_L385_V1.0330.93
113_G140_E1.0320.93
174_V258_V1.0320.93
166_P177_E1.0230.92
251_L254_H1.0230.92
308_P312_F1.0170.92
57_E96_L1.0160.92
129_G188_I1.0150.92
124_L190_V1.0140.92
189_M264_I1.0120.92
309_F313_K1.0110.92
42_L82_A1.0100.92
335_L345_P1.0080.92
86_A89_G1.0060.92
52_K88_N1.0060.92
171_R262_E0.9980.92
132_F139_L0.9960.91
305_I413_V0.9950.91
286_E290_L0.9920.91
18_Y26_F0.9890.91
83_F96_L0.9850.91
12_S33_K0.9830.91
173_K176_D0.9720.90
14_R193_G0.9720.90
192_S275_S0.9670.90
32_S62_I0.9660.90
174_V179_S0.9660.90
7_D14_R0.9630.90
238_S241_S0.9600.90
52_K86_A0.9590.90
345_P349_C0.9560.90
194_G280_R0.9490.89
166_P176_D0.9470.89
110_E152_V0.9460.89
354_K367_L0.9450.89
309_F312_F0.9450.89
56_A83_F0.9350.89
122_N147_G0.9320.88
236_D250_A0.9310.88
60_F102_N0.9290.88
307_P311_I0.9260.88
173_K182_N0.9260.88
17_V30_G0.9260.88
261_D265_K0.9180.88
76_K287_G0.9180.88
6_I77_I0.9170.88
11_N14_R0.9150.88
55_K59_T0.9070.87
193_G197_R0.9050.87
322_K365_E0.9010.87
232_P235_D0.8990.87
327_V406_N0.8920.86
133_E154_Q0.8920.86
178_L263_L0.8910.86
168_R172_K0.8890.86
14_R284_L0.8890.86
16_V79_A0.8890.86
138_S249_R0.8820.86
208_S226_K0.8810.85
275_S336_I0.8810.85
15_M31_S0.8810.85
346_F376_A0.8800.85
386_K390_D0.8780.85
113_G133_E0.8770.85
229_S233_S0.8760.85
200_A217_Y0.8750.85
34_S62_I0.8740.85
57_E92_V0.8740.85
275_S281_E0.8730.85
81_S137_G0.8690.85
144_V193_G0.8660.84
14_R280_R0.8660.84
168_R174_V0.8660.84
19_Q29_L0.8590.84
33_K140_E0.8590.84
12_S140_E0.8580.84
139_L351_R0.8580.84
120_M370_G0.8570.84
37_R252_T0.8520.84
6_I353_I0.8520.84
349_C372_I0.8510.83
224_I264_I0.8500.83
11_N112_E0.8480.83
368_L372_I0.8420.83
171_R175_S0.8360.82
11_N140_E0.8340.82
313_K328_A0.8310.82
160_L252_T0.8280.82
109_G135_G0.8270.82
113_G152_V0.8270.82
93_R99_I0.8240.81
84_R140_E0.8230.81
133_E136_G0.8180.81
140_E194_G0.8160.81
39_G161_K0.8160.81
53_V95_R0.8150.81
77_I104_V0.8120.80
18_Y281_E0.8100.80
136_G249_R0.8070.80
170_I178_L0.8040.80
64_K102_N0.8040.80
178_L182_N0.8020.80
250_A254_H0.8020.80
374_E381_K0.8000.79
170_I180_T0.7990.79
305_I308_P0.7970.79
33_K37_R0.7900.79
113_G134_L0.7890.79
249_R280_R0.7890.79
347_R384_H0.7860.78
314_E318_E0.7850.78
133_E194_G0.7800.78
49_P53_V0.7750.77
292_K333_L0.7720.77
387_L390_D0.7720.77
52_K55_K0.7710.77
174_V182_N0.7710.77
157_I259_I0.7700.77
145_T150_I0.7680.77
177_E182_N0.7680.77
67_L161_K0.7670.77
384_H409_D0.7660.76
112_E194_G0.7650.76
84_R137_G0.7630.76
199_L377_S0.7620.76
363_L366_V0.7610.76
113_G249_R0.7610.76
7_D140_E0.7600.76
391_D399_S0.7580.76
220_S223_Q0.7570.76
257_S261_D0.7540.75
46_D85_Y0.7530.75
175_S266_Y0.7510.75
133_E140_E0.7510.75
197_R278_G0.7490.75
178_L275_S0.7480.75
8_C42_L0.7470.75
199_L257_S0.7460.75
8_C36_V0.7460.75
12_S256_A0.7460.75
7_D135_G0.7450.74
15_M67_L0.7400.74
350_Y367_L0.7380.74
221_S272_M0.7380.74
398_L402_N0.7370.74
264_I269_G0.7370.74
160_L256_A0.7360.74
136_G282_G0.7360.74
347_R385_V0.7350.73
228_A261_D0.7330.73
160_L190_V0.7290.73
81_S374_E0.7290.73
324_S328_A0.7280.73
337_F349_C0.7280.73
199_L224_I0.7270.73
235_D239_R0.7260.73
291_D297_E0.7250.72
77_I99_I0.7250.72
33_K109_G0.7250.72
115_Y286_E0.7230.72
50_E57_E0.7220.72
20_V26_F0.7210.72
56_A96_L0.7200.72
203_D219_L0.7200.72
41_G56_A0.7200.72
57_E100_I0.7180.72
175_S265_K0.7180.72
112_E249_R0.7170.72
347_R374_E0.7170.72
119_G277_F0.7160.72
303_N306_D0.7160.72
120_M131_F0.7150.71
230_L304_A0.7130.71
381_K385_V0.7110.71
83_F89_G0.7100.71
197_R367_L0.7100.71
136_G140_E0.7090.71
7_D136_G0.7090.71
6_I64_K0.7080.71
345_P410_K0.7080.71
138_S154_Q0.7080.71
357_V361_F0.7070.71
134_L139_L0.7060.70
236_D239_R0.7050.70
135_G140_E0.7030.70
337_F348_A0.7030.70
112_E140_E0.7020.70
132_F260_V0.6990.70
351_R355_E0.6990.70
122_N359_P0.6980.70
129_G197_R0.6980.70
337_F352_F0.6970.69
171_R228_A0.6960.69
7_D80_T0.6950.69
310_G314_E0.6880.68
46_D77_I0.6880.68
119_G285_T0.6880.68
4_A9_G0.6870.68
162_L173_K0.6860.68
61_T98_K0.6860.68
113_G138_S0.6850.68
135_G249_R0.6850.68
60_F333_L0.6850.68
113_G135_G0.6850.68
249_R278_G0.6840.68
111_E115_Y0.6840.68
250_A373_C0.6800.68
116_A142_A0.6790.67
116_A256_A0.6780.67
109_G195_N0.6780.67
328_A332_L0.6770.67
262_E265_K0.6770.67
301_Y318_E0.6760.67
109_G136_G0.6750.67
34_S59_T0.6740.67
70_I75_V0.6730.67
347_R376_A0.6720.67
99_I102_N0.6700.66
116_A140_E0.6680.66
322_K325_F0.6670.66
89_G93_R0.6650.66
353_I397_L0.6640.66
236_D240_K0.6640.66
113_G195_N0.6630.66
172_K180_T0.6620.66
368_L395_K0.6620.66
276_L343_F0.6610.65
52_K63_F0.6600.65
199_L260_V0.6570.65
109_G256_A0.6560.65
30_G66_I0.6540.65
271_D317_S0.6540.65
327_V402_N0.6530.64
306_D333_L0.6510.64
111_E286_E0.6470.64
332_L336_I0.6450.64
157_I162_L0.6450.64
37_R160_L0.6450.64
77_I100_I0.6430.63
13_F36_V0.6400.63
195_N202_L0.6390.63
14_R194_G0.6390.63
79_A289_K0.6370.63
39_G85_Y0.6370.63
136_G154_Q0.6360.62
7_D280_R0.6360.62
109_G138_S0.6360.62
14_R281_E0.6350.62
14_R31_S0.6350.62
222_K268_N0.6340.62
73_D222_K0.6340.62
11_N113_G0.6320.62
21_F27_R0.6320.62
195_N249_R0.6320.62
112_E133_E0.6310.62
7_D10_Y0.6310.62
12_S195_N0.6310.62
6_I99_I0.6280.61
132_F201_K0.6270.61
350_Y370_G0.6270.61
88_N137_G0.6270.61
221_S264_I0.6250.61
80_T112_E0.6250.61
139_L259_I0.6240.61
33_K133_E0.6240.61
203_D227_Y0.6220.61
116_A192_S0.6200.60
368_L398_L0.6190.60
189_M193_G0.6180.60
310_G313_K0.6160.60
16_V31_S0.6150.60
11_N195_N0.6150.60
172_K179_S0.6140.60
15_M30_G0.6140.60
406_N409_D0.6110.59
349_C376_A0.6110.59
12_S109_G0.6100.59
184_K187_N0.6090.59
175_S178_L0.6090.59
170_I181_I0.6080.59
84_R133_E0.6070.59
311_I379_K0.6050.59
135_G256_A0.6050.59
83_F106_V0.6040.58
169_E173_K0.6040.58
7_D113_G0.6030.58
8_C56_A0.6030.58
113_G136_G0.6020.58
130_I186_A0.6010.58
299_I340_V0.6000.58
109_G260_V0.6000.58
245_I264_I0.5990.58
11_N119_G0.5990.58
90_N97_S0.5970.58
113_G194_G0.5960.57
172_K177_E0.5960.57
7_D12_S0.5950.57
30_G274_V0.5950.57
400_F404_V0.5950.57
135_G194_G0.5930.57
170_I336_I0.5920.57
109_G133_E0.5910.57
114_S139_L0.5910.57
6_I19_Q0.5900.57
151_R185_K0.5880.56
224_I261_D0.5870.56
276_L342_Y0.5860.56
255_S352_F0.5860.56
136_G280_R0.5850.56
178_L266_Y0.5840.56
91_E95_R0.5840.56
231_L240_K0.5840.56
47_T91_E0.5830.56
38_I82_A0.5820.56
222_K310_G0.5800.55
167_E172_K0.5800.55
326_Y365_E0.5790.55
62_I66_I0.5780.55
8_C15_M0.5750.55
49_P63_F0.5750.55
33_K162_L0.5720.54
140_E280_R0.5710.54
202_L227_Y0.5710.54
358_L362_T0.5700.54
157_I174_V0.5680.54
53_V71_N0.5680.54
79_A260_V0.5670.54
121_L125_P0.5670.54
175_S181_I0.5670.54
319_V327_V0.5670.54
330_S369_I0.5650.54
12_S56_A0.5650.54
178_L381_K0.5640.53
80_T137_G0.5640.53
11_N280_R0.5640.53
350_Y354_K0.5630.53
113_G154_Q0.5630.53
308_P406_N0.5630.53
393_T396_E0.5630.53
174_V262_E0.5620.53
128_D188_I0.5610.53
14_R197_R0.5610.53
319_V405_K0.5570.52
7_D249_R0.5570.52
277_F281_E0.5570.52
126_I146_S0.5560.52
130_I334_S0.5560.52
234_L239_R0.5550.52
98_K179_S0.5550.52
80_T154_Q0.5540.52
49_P233_S0.5540.52
14_R37_R0.5540.52
264_I267_L0.5530.52
116_A119_G0.5520.52
74_E90_N0.5510.52
168_R177_E0.5510.52
398_L401_G0.5510.52
334_S345_P0.5500.52
39_G82_A0.5500.52
136_G194_G0.5490.51
84_R194_G0.5490.51
195_N252_T0.5480.51
28_A31_S0.5480.51
15_M66_I0.5480.51
234_L242_L0.5480.51
41_G52_K0.5470.51
53_V57_E0.5460.51
388_L391_D0.5460.51
55_K256_A0.5450.51
234_L240_K0.5450.51
109_G112_E0.5450.51
16_V197_R0.5440.51
169_E172_K0.5430.51
100_I103_E0.5420.51
7_D84_R0.5420.51
305_I334_S0.5420.51
33_K194_G0.5410.50
231_L234_L0.5410.50
196_V272_M0.5400.50
116_A136_G0.5400.50
111_E139_L0.5400.50
365_E368_L0.5380.50
132_F196_V0.5370.50
85_Y156_P0.5370.50
116_A279_M0.5360.50
84_R249_R0.5310.49
92_V256_A0.5300.49
97_S341_G0.5290.49
258_V262_E0.5290.49
207_S223_Q0.5290.49
207_S226_K0.5280.49
11_N33_K0.5280.49
303_N332_L0.5270.49
94_L304_A0.5250.48
18_Y376_A0.5240.48
138_S194_G0.5230.48
47_T222_K0.5230.48
112_E136_G0.5210.48
170_I199_L0.5210.48
116_A278_G0.5210.48
39_G185_K0.5210.48
299_I312_F0.5210.48
272_M360_G0.5200.48
43_K49_P0.5200.48
220_S270_S0.5160.47
312_F327_V0.5160.47
105_R119_G0.5150.47
220_S271_D0.5120.47
292_K329_S0.5110.47
229_S232_P0.5110.47
270_S321_S0.5090.46
191_G312_F0.5090.46
18_Y28_A0.5090.46
110_E153_H0.5090.46
301_Y308_P0.5080.46
64_K73_D0.5080.46
336_I352_F0.5070.46
11_N133_E0.5070.46
131_F142_A0.5060.46
109_G154_Q0.5060.46
81_S140_E0.5060.46
337_F351_R0.5050.46
402_N406_N0.5050.46
17_V311_I0.5050.46
236_D245_I0.5040.46
315_V348_A0.5040.46
8_C283_V0.5040.46
7_D282_G0.5030.46
222_K241_S0.5030.46
344_N347_R0.5030.46
255_S259_I0.5030.46
36_V56_A0.5010.45
193_G217_Y0.5000.45
50_E88_N0.5000.45
308_P376_A0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u6zA 2 0.9736 100 0.174 Contact Map
3hi0A 2 0.988 100 0.197 Contact Map
3cerA 1 0.7026 100 0.444 Contact Map
1t6cA 1 0.7002 100 0.449 Contact Map
3mdqA 1 0.705 100 0.46 Contact Map
4brcA 2 0.6739 100 0.639 Contact Map
3cj1A 1 0.729 100 0.736 Contact Map
3zx3A 3 0.7122 100 0.738 Contact Map
3rf0A 1 0.3165 100 0.757 Contact Map
4a2aA 1 0.5372 99.6 0.864 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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