GREMLIN Database
Q97YV8 - Phosphohistidine phosphatase (SixA)
UniProt: Q97YV8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (140)
Sequences: 9535 (7048)
Seq/√Len: 595.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_V61_Q3.2381.00
3_T137_V2.8991.00
3_T106_T2.7841.00
11_D29_K2.7041.00
7_V66_I2.6161.00
3_T139_D2.5991.00
11_D27_V2.2921.00
13_E27_V2.2411.00
31_V65_V2.1981.00
35_R65_V2.0641.00
5_I48_V2.0541.00
7_V37_V2.0311.00
111_G115_Y1.9671.00
51_I63_A1.9551.00
25_K57_L1.9541.00
7_V108_L1.9171.00
49_D105_S1.8521.00
48_V108_L1.8391.00
61_Q64_E1.8151.00
51_I67_L1.7851.00
39_N69_E1.7581.00
130_I136_A1.7141.00
13_E17_D1.6881.00
5_I106_T1.6561.00
140_Y147_G1.6531.00
25_K61_Q1.6421.00
60_Y64_E1.5941.00
14_P24_R1.5871.00
111_G116_L1.5631.00
32_K35_R1.5381.00
29_K33_Q1.5231.00
28_K31_V1.4721.00
32_K36_R1.4681.00
6_L116_L1.4501.00
90_E115_Y1.4421.00
11_D16_V1.4301.00
49_D106_T1.4181.00
31_V35_R1.4161.00
20_E23_D1.3861.00
116_L130_I1.3451.00
5_I137_V1.3181.00
101_F107_I1.3101.00
21_D55_P1.2761.00
91_P122_T1.2711.00
48_V106_T1.2501.00
34_M62_S1.2491.00
53_S63_A1.2361.00
39_N42_E1.2321.00
15_Q132_K1.2101.00
35_R69_E1.1871.00
113_E117_S1.1821.00
5_I135_V1.1671.00
35_R68_E1.1531.00
53_S60_Y1.1501.00
81_T84_D1.1431.00
34_M133_G1.1341.00
89_K93_L1.1331.00
66_I110_V1.1311.00
138_L147_G1.1291.00
95_L99_K1.1211.00
75_S84_D1.1181.00
28_K32_K1.1171.00
120_V136_A1.1081.00
50_R105_S1.1061.00
90_E95_L1.0771.00
124_S138_L1.0751.00
29_K32_K1.0661.00
22_K55_P1.0291.00
57_L61_Q1.0241.00
14_P19_K1.0231.00
90_E93_L1.0151.00
15_Q19_K1.0121.00
42_E69_E1.0101.00
50_R107_I1.0081.00
38_A65_V1.0071.00
5_I46_F0.9991.00
63_A67_L0.9951.00
67_L72_D0.9801.00
6_L119_F0.9641.00
104_N107_I0.9531.00
52_V101_F0.9521.00
64_E73_D0.9391.00
13_E25_K0.9381.00
91_P95_L0.9361.00
36_R39_N0.9231.00
19_K24_R0.9201.00
34_M38_A0.9161.00
65_V68_E0.9121.00
11_D33_Q0.9101.00
93_L96_E0.9101.00
53_S59_A0.9091.00
63_A110_V0.9081.00
47_N72_D0.9071.00
38_A69_E0.9021.00
97_K101_F0.8981.00
24_R27_V0.8961.00
12_A27_V0.8961.00
52_V107_I0.8931.00
7_V110_V0.8881.00
51_I108_L0.8831.00
46_F106_T0.8681.00
89_K95_L0.8671.00
7_V135_V0.8581.00
88_D92_S0.8581.00
57_L60_Y0.8581.00
64_E68_E0.8461.00
23_D57_L0.8441.00
130_I134_G0.8391.00
93_L97_K0.8371.00
96_E99_K0.8351.00
90_E97_K0.8281.00
89_K97_K0.8181.00
12_A15_Q0.8131.00
61_Q65_V0.8071.00
65_V69_E0.8011.00
60_Y81_T0.7861.00
117_S121_K0.7831.00
21_D56_Y0.7821.00
142_L145_G0.7811.00
83_D88_D0.7791.00
13_E16_V0.7641.00
53_S81_T0.7471.00
56_Y59_A0.7391.00
40_F135_V0.7341.00
49_D108_L0.7241.00
67_L70_L0.7241.00
59_A63_A0.7241.00
14_P22_K0.7231.00
89_K115_Y0.7171.00
38_A66_I0.7111.00
21_D24_R0.7041.00
52_V97_K0.7041.00
120_V138_L0.7041.00
39_N43_E0.7021.00
89_K94_F0.6991.00
16_V29_K0.6981.00
96_E100_D0.6881.00
84_D88_D0.6851.00
15_Q20_E0.6811.00
37_V135_V0.6791.00
141_D146_R0.6731.00
97_K100_D0.6721.00
47_N106_T0.6711.00
131_K134_G0.6701.00
33_Q132_K0.6701.00
83_D86_T0.6661.00
52_V100_D0.6641.00
33_Q36_R0.6641.00
35_R39_N0.6551.00
41_L46_F0.6471.00
76_E79_V0.6431.00
4_L140_Y0.6411.00
79_V84_D0.6351.00
26_L34_M0.6351.00
88_D91_P0.6301.00
91_P94_F0.6301.00
80_E89_K0.6231.00
6_L120_V0.6191.00
24_R114_P0.6171.00
19_K132_K0.6151.00
38_A70_L0.6101.00
41_L66_I0.6051.00
33_Q133_G0.6041.00
53_S110_V0.6001.00
75_S86_T0.5981.00
100_D105_S0.5961.00
34_M65_V0.5951.00
90_E94_F0.5941.00
85_L115_Y0.5931.00
20_E56_Y0.5911.00
101_F105_S0.5901.00
70_L73_D0.5891.00
78_K81_T0.5841.00
64_E67_L0.5841.00
12_A24_R0.5821.00
120_V130_I0.5801.00
22_K56_Y0.5771.00
74_N77_K0.5741.00
82_F118_S0.5731.00
95_L122_T0.5681.00
120_V124_S0.5671.00
99_K102_V0.5621.00
82_F85_L0.5621.00
79_V85_L0.5601.00
119_F123_I0.5591.00
92_S96_E0.5550.99
19_K22_K0.5530.99
117_S129_E0.5520.99
101_F104_N0.5510.99
54_S112_H0.5510.99
6_L109_V0.5470.99
85_L90_E0.5470.99
41_L48_V0.5410.99
86_T122_T0.5400.99
94_F98_L0.5390.99
11_D132_K0.5390.99
54_S59_A0.5330.99
59_A112_H0.5330.99
74_N79_V0.5320.99
66_I108_L0.5300.99
15_Q27_V0.5240.99
68_E73_D0.5230.99
38_A42_E0.5230.99
5_I108_L0.5220.99
36_R40_F0.5110.99
89_K92_S0.5100.99
50_R100_D0.5080.99
114_P117_S0.5060.99
12_A19_K0.5030.99
115_Y119_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rflA 1 0.9255 100 0.24 Contact Map
3gp3A 1 0.9441 100 0.245 Contact Map
2yn2A 1 0.9814 100 0.253 Contact Map
1e58A 2 0.9938 100 0.255 Contact Map
3d8hA 2 0.9503 100 0.257 Contact Map
3kkkA 3 0.9441 100 0.258 Contact Map
4ij5A 2 0.9627 100 0.258 Contact Map
1h2eA 1 0.9627 100 0.258 Contact Map
4embA 2 0.9938 100 0.263 Contact Map
1ujcA 1 0.9441 100 0.266 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.006 seconds.