GREMLIN Database
Q97YV7 - Uncharacterized protein
UniProt: Q97YV7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (162)
Sequences: 884 (736)
Seq/√Len: 57.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_V53_N4.9101.00
48_M134_A4.3691.00
48_M167_S3.7831.00
52_I134_A3.5181.00
149_L184_S3.4701.00
24_C34_I3.0571.00
153_G157_A2.7031.00
25_I55_I2.6831.00
49_K158_T2.6671.00
21_V51_V2.6411.00
48_M165_I2.4821.00
19_K22_E2.3271.00
27_Q34_I2.1911.00
33_W166_F2.1571.00
157_A189_R2.0651.00
139_Q142_S2.0541.00
36_I48_M1.9741.00
46_S50_V1.9341.00
38_G42_I1.8941.00
14_L50_V1.7700.99
50_V54_E1.7680.99
75_N79_T1.7610.99
33_W156_Y1.6810.99
70_G145_S1.6380.99
27_Q32_N1.6150.99
157_A185_P1.6060.99
117_V125_L1.5770.98
52_I132_V1.5700.98
39_Q42_I1.5190.98
114_K117_V1.5050.98
154_N158_T1.4700.98
38_G189_R1.3980.97
52_I165_I1.3610.96
18_E22_E1.3600.96
36_I134_A1.3470.96
133_I162_V1.3320.96
87_K124_L1.3320.96
52_I60_Q1.3110.95
135_F166_F1.3040.95
153_G189_R1.2900.95
139_Q170_Y1.2810.95
51_V163_H1.2690.94
139_Q177_L1.2680.94
38_G188_G1.2540.94
114_K118_V1.2470.94
25_I29_L1.2320.93
45_T140_E1.2280.93
118_V122_I1.2250.93
84_E87_K1.2060.93
24_C47_L1.1830.92
14_L33_W1.1760.92
62_A65_Y1.1650.91
119_N155_V1.1630.91
141_L157_A1.1600.91
110_R135_F1.1590.91
60_Q65_Y1.1540.91
16_G138_V1.1440.90
25_I51_V1.1430.90
134_A187_H1.1310.90
20_E47_L1.1280.90
33_W153_G1.1200.89
174_V177_L1.1010.89
178_L190_P1.0880.88
126_N160_P1.0860.88
42_I182_S1.0780.88
45_T149_L1.0770.88
25_I54_E1.0740.87
186_L189_R1.0600.87
16_G139_Q1.0520.86
154_N186_L1.0390.86
16_G173_L1.0330.85
159_N164_M1.0250.85
92_W95_K1.0230.85
60_Q63_G1.0150.84
152_L155_V1.0130.84
128_S131_I1.0070.84
151_I155_V1.0050.84
67_N70_G0.9990.83
48_M174_V0.9930.83
17_R42_I0.9860.82
63_G81_L0.9850.82
50_V148_F0.9800.82
152_L158_T0.9760.82
19_K93_R0.9740.82
16_G130_E0.9670.81
51_V55_I0.9540.80
63_G67_N0.9530.80
178_L184_S0.9430.80
60_Q64_I0.9430.80
122_I125_L0.9420.79
35_I166_F0.9380.79
19_K23_H0.9360.79
68_L141_L0.9330.79
48_M132_V0.9300.79
23_H27_Q0.9080.77
37_G172_G0.9060.77
138_V148_F0.9050.77
22_E53_N0.9040.77
78_L183_D0.8960.76
35_I190_P0.8950.76
139_Q168_G0.8900.75
73_S77_L0.8830.75
132_V165_I0.8750.74
63_G66_I0.8740.74
114_K122_I0.8720.74
72_R77_L0.8680.74
15_V37_G0.8650.73
72_R121_L0.8640.73
139_Q166_F0.8560.73
132_V163_H0.8450.72
115_R139_Q0.8450.72
121_L143_F0.8310.70
61_I65_Y0.8310.70
68_L72_R0.8280.70
42_I165_I0.8270.70
149_L177_L0.8240.70
15_V189_R0.8190.69
73_S87_K0.8120.69
81_L179_S0.8110.68
118_V121_L0.8100.68
167_S181_P0.8070.68
63_G77_L0.8040.68
156_Y189_R0.8020.68
77_L81_L0.8010.67
20_E134_A0.7980.67
74_L78_L0.7980.67
96_V132_V0.7870.66
25_I75_N0.7840.66
65_Y141_L0.7770.65
39_Q156_Y0.7720.65
130_E163_H0.7700.64
78_L82_V0.7690.64
85_I129_D0.7660.64
150_D185_P0.7610.63
166_F178_L0.7610.63
68_L135_F0.7600.63
26_S128_S0.7550.63
64_I69_R0.7550.63
33_W164_M0.7450.62
42_I98_I0.7430.62
94_F161_K0.7420.62
164_M189_R0.7370.61
153_G185_P0.7330.61
33_W41_E0.7290.60
80_I84_E0.7250.60
33_W189_R0.7240.60
140_E143_F0.7230.60
14_L153_G0.7200.59
175_K179_S0.7140.59
150_D153_G0.7130.58
138_V157_A0.7080.58
154_N159_N0.7070.58
157_A184_S0.7070.58
22_E29_L0.7020.57
24_C51_V0.6930.56
140_E144_A0.6880.56
46_S145_S0.6870.56
37_G167_S0.6830.55
119_N174_V0.6790.55
26_S83_S0.6690.54
19_K133_I0.6690.54
131_I161_K0.6670.53
149_L167_S0.6670.53
21_V54_E0.6620.53
139_Q178_L0.6610.53
61_I81_L0.6600.53
22_E26_S0.6530.52
73_S177_L0.6500.52
79_T116_R0.6500.52
36_I41_E0.6490.51
78_L85_I0.6460.51
44_K137_E0.6420.51
25_I45_T0.6420.51
119_N125_L0.6410.51
77_L155_V0.6380.50
129_D132_V0.6320.50
110_R116_R0.6300.49
40_R137_E0.6280.49
53_N127_S0.6260.49
28_I51_V0.6260.49
145_S151_I0.6210.48
35_I45_T0.6170.48
64_I84_E0.6160.48
171_V189_R0.6150.48
42_I189_R0.6140.48
142_S170_Y0.6140.48
123_E159_N0.6140.48
132_V164_M0.6120.47
35_I68_L0.6100.47
138_V149_L0.6100.47
22_E36_I0.6060.47
49_K133_I0.6060.47
141_L178_L0.6050.47
136_D169_S0.6040.47
140_E150_D0.5990.46
68_L76_S0.5980.46
121_L161_K0.5940.45
170_Y175_K0.5940.45
118_V126_N0.5940.45
130_E161_K0.5920.45
64_I87_K0.5890.45
19_K29_L0.5850.44
157_A164_M0.5830.44
170_Y174_V0.5820.44
139_Q174_V0.5810.44
84_E123_E0.5800.44
67_N187_H0.5790.44
28_I55_I0.5780.44
77_L133_I0.5740.43
44_K136_D0.5740.43
37_G173_L0.5720.43
24_C55_I0.5710.43
145_S149_L0.5710.43
15_V149_L0.5700.43
22_E92_W0.5670.42
70_G135_F0.5600.42
80_I83_S0.5540.41
23_H26_S0.5530.41
24_C165_I0.5490.41
45_T114_K0.5480.40
49_K65_Y0.5460.40
28_I118_V0.5450.40
149_L156_Y0.5440.40
46_S187_H0.5360.39
66_I85_I0.5320.39
41_E191_P0.5240.38
155_V162_V0.5240.38
61_I135_F0.5230.38
119_N154_N0.5230.38
14_L143_F0.5200.38
14_L150_D0.5190.37
19_K128_S0.5160.37
153_G186_L0.5140.37
30_S187_H0.5130.37
151_I165_I0.5110.37
139_Q149_L0.5090.36
33_W157_A0.5080.36
29_L162_V0.5070.36
43_G137_E0.5060.36
82_V187_H0.5040.36
33_W38_G0.5030.36
120_S124_L0.5000.35
81_L85_I0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fnaA 1 0.9439 100 0.462 Contact Map
2qenA 1 0.9337 100 0.492 Contact Map
1w5sA 1 0.898 99.7 0.649 Contact Map
4xgcE 1 0.8878 99.7 0.672 Contact Map
2qbyA 1 0.8776 99.6 0.69 Contact Map
4xgcA 1 0.6633 99.6 0.69 Contact Map
1fnnA 1 0.8724 99.6 0.69 Contact Map
3te6A 1 0.8673 99.6 0.696 Contact Map
2v1uA 1 0.8622 99.6 0.697 Contact Map
2qbyB 1 0.8571 99.4 0.726 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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