GREMLIN Database
Q97YU9 - Pyruvate synthase alpha chain (Pyruvic-ferredoxin oxidoreductase alpha chain) (PorA-1)
UniProt: Q97YU9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 385 (346)
Sequences: 5352 (3269)
Seq/√Len: 175.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
266_K317_K5.6151.00
145_Q149_D4.1121.00
260_Y284_D3.0301.00
267_Y318_G3.0251.00
283_V295_L2.9131.00
139_I157_I2.7221.00
271_T279_G2.5141.00
17_V147_A2.4701.00
268_V316_M2.4661.00
151_T169_M2.3251.00
79_R159_E2.3051.00
246_E252_K2.2581.00
239_E243_G2.2531.00
286_L367_Q2.2091.00
262_C268_V2.2041.00
305_P308_K2.1881.00
26_P155_F2.1381.00
84_T89_L2.1061.00
243_G247_R2.0911.00
209_I213_P2.0761.00
235_K239_E2.0471.00
8_V184_E2.0441.00
150_M299_R2.0411.00
21_V81_F2.0231.00
23_Q148_Y2.0221.00
109_A154_A1.9841.00
17_V171_F1.9821.00
268_V312_Y1.9781.00
285_R367_Q1.9731.00
336_N340_A1.9391.00
269_F279_G1.9361.00
296_L309_V1.9351.00
27_K78_A1.9101.00
264_D292_K1.8751.00
17_V151_T1.8641.00
355_G365_H1.8541.00
243_G246_E1.8471.00
89_L168_M1.8461.00
148_Y186_L1.8401.00
313_L319_V1.8321.00
96_I136_W1.8171.00
71_Y99_A1.8131.00
19_Y47_Y1.8031.00
67_L108_A1.8021.00
267_Y291_V1.8021.00
271_T295_L1.7931.00
29_L83_A1.7851.00
141_A169_M1.7821.00
209_I212_G1.7721.00
210_A213_P1.7551.00
208_P212_G1.7461.00
96_I108_A1.7381.00
73_A80_V1.7181.00
267_Y320_V1.7101.00
160_D251_R1.7091.00
187_E190_E1.7001.00
146_E297_K1.6851.00
137_I157_I1.6781.00
286_L370_I1.6671.00
308_K311_E1.6551.00
269_F370_I1.6521.00
111_A171_F1.6301.00
266_K292_K1.6261.00
261_K284_D1.6221.00
246_E249_S1.6141.00
279_G322_F1.6071.00
47_Y52_E1.6021.00
268_V313_L1.5961.00
28_V69_S1.5931.00
97_Y130_S1.5821.00
238_I241_I1.5811.00
339_K343_Y1.5711.00
171_F177_T1.5671.00
318_G348_P1.5591.00
67_L95_M1.5471.00
276_S297_K1.5431.00
43_K46_E1.5211.00
306_K341_A1.5131.00
307_E311_E1.5081.00
301_F337_E1.5031.00
342_L349_V1.4861.00
70_I106_I1.4851.00
281_A285_R1.4841.00
335_V339_K1.4501.00
152_I191_V1.4411.00
269_F283_V1.4301.00
8_V182_R1.4271.00
112_T127_D1.4261.00
271_T276_S1.4221.00
96_I168_M1.4131.00
153_Q256_L1.4131.00
71_Y95_M1.4101.00
114_A357_G1.4091.00
296_L308_K1.3881.00
68_A95_M1.3871.00
70_I80_V1.3751.00
298_I334_L1.3641.00
247_R251_R1.3631.00
268_V319_V1.3571.00
257_V305_P1.3521.00
142_E276_S1.3501.00
304_F341_A1.3481.00
22_K83_A1.3461.00
237_V241_I1.3381.00
362_R365_H1.3351.00
137_I165_L1.3201.00
143_N277_G1.3161.00
244_E247_R1.3101.00
26_P81_F1.3081.00
207_D213_P1.3071.00
131_K138_Q1.2781.00
30_A69_S1.2761.00
136_W168_M1.2701.00
89_L110_V1.2681.00
244_E248_I1.2631.00
242_M246_E1.2621.00
99_A106_I1.2621.00
207_D210_A1.2531.00
294_G316_M1.2401.00
276_S280_K1.2381.00
268_V296_L1.2341.00
30_A70_I1.2271.00
28_V73_A1.2211.00
15_H43_K1.2131.00
90_L131_K1.2071.00
29_L41_L1.2041.00
240_E244_E1.2021.00
264_D287_R1.2001.00
19_Y23_Q1.1991.00
37_Q83_A1.1881.00
339_K344_G1.1841.00
24_A155_F1.1841.00
255_G258_E1.1821.00
320_V353_V1.1811.00
210_A214_I1.1791.00
203_I206_S1.1751.00
279_G366_F1.1721.00
157_I241_I1.1721.00
285_R288_D1.1721.00
235_K238_I1.1711.00
142_E146_E1.1701.00
89_L112_T1.1651.00
139_I167_V1.1631.00
265_A294_G1.1591.00
361_V366_F1.1561.00
296_L312_Y1.1551.00
289_S367_Q1.1401.00
132_R333_I1.1401.00
271_T275_W1.1281.00
111_A177_T1.1281.00
270_V309_V1.1261.00
107_V154_A1.1211.00
311_E314_R1.1181.00
139_I300_V1.1161.00
321_V338_I1.1151.00
48_I55_A1.1091.00
74_A104_V1.1001.00
298_I301_F1.1001.00
93_T131_K1.1001.00
275_W361_V1.0971.00
272_M325_A1.0921.00
12_V15_H1.0891.00
20_A148_Y1.0881.00
67_L106_I1.0831.00
262_C265_A1.0821.00
307_E310_E1.0821.00
146_E299_R1.0811.00
234_A237_V1.0771.00
236_G307_E1.0761.00
129_V336_N1.0661.00
237_V240_E1.0611.00
160_D244_E1.0601.00
209_I214_I1.0581.00
201_N205_F1.0581.00
248_I251_R1.0511.00
268_V294_G1.0431.00
18_A40_M1.0421.00
312_Y316_M1.0370.99
43_K47_Y1.0280.99
131_K168_M1.0200.99
286_L291_V1.0170.99
97_Y133_D1.0100.99
106_I158_S1.0100.99
259_C262_C1.0090.99
201_N204_D1.0080.99
245_Y248_I1.0080.99
287_R293_T1.0070.99
234_A238_I1.0060.99
250_G307_E1.0060.99
310_E345_Y1.0030.99
107_V155_F0.9970.99
60_V69_S0.9940.99
275_W366_F0.9940.99
17_V169_M0.9930.99
142_E297_K0.9930.99
27_K55_A0.9890.99
20_A151_T0.9870.99
79_R155_F0.9860.99
306_K310_E0.9800.99
138_Q168_M0.9730.99
241_I248_I0.9710.99
161_E234_A0.9590.99
304_F309_V0.9570.99
283_V287_R0.9550.99
18_A43_K0.9510.99
31_V83_A0.9450.99
81_F155_F0.9420.99
202_L205_F0.9410.99
140_M170_G0.9400.99
280_K297_K0.9380.99
261_K287_R0.9350.99
139_I154_A0.9320.99
249_S306_K0.9310.99
349_V352_V0.9310.99
236_G240_E0.9310.99
193_N196_P0.9300.99
129_V331_G0.9300.99
247_R250_G0.9290.99
241_I244_E0.9280.99
14_N39_T0.9230.99
11_L183_I0.9230.99
309_V338_I0.9200.99
9_L185_V0.9160.99
262_C287_R0.9080.99
114_A120_S0.9030.99
23_Q152_I0.9020.99
123_D127_D0.9010.99
121_I127_D0.8950.98
66_A92_M0.8940.98
109_A151_T0.8920.98
332_G335_V0.8880.98
276_S279_G0.8850.98
364_R367_Q0.8820.98
31_V41_L0.8800.98
270_V313_L0.8780.98
190_E193_N0.8780.98
161_E251_R0.8700.98
154_A169_M0.8690.98
12_V180_M0.8670.98
139_I150_M0.8660.98
128_F140_M0.8660.98
279_G282_A0.8650.98
258_E299_R0.8630.98
241_I249_S0.8610.98
153_Q157_I0.8580.98
97_Y134_A0.8550.98
153_Q156_R0.8530.98
70_I82_T0.8490.98
308_K312_Y0.8470.98
233_R236_G0.8440.98
269_F366_F0.8390.98
153_Q255_G0.8390.98
239_E308_K0.8380.98
150_M153_Q0.8380.98
128_F170_G0.8370.98
119_W127_D0.8340.98
267_Y370_I0.8320.98
160_D240_E0.8300.98
188_D192_D0.8300.98
90_L115_I0.8290.97
40_M111_A0.8250.97
337_E340_A0.8250.97
123_D324_R0.8190.97
152_I156_R0.8180.97
24_A188_D0.8180.97
114_A220_Y0.8160.97
270_V296_L0.8160.97
156_R160_D0.8160.97
189_N193_N0.8150.97
285_R289_S0.8150.97
246_E251_R0.8140.97
208_P213_P0.8140.97
129_V333_I0.8130.97
236_G239_E0.8040.97
118_P127_D0.8000.97
224_R227_A0.7970.97
125_H128_F0.7960.97
248_I252_K0.7950.97
9_L19_Y0.7950.97
146_E149_D0.7930.97
148_Y185_V0.7920.97
114_A119_W0.7890.97
279_G295_L0.7870.97
258_E261_K0.7860.97
304_F334_L0.7830.96
28_V78_A0.7830.96
262_C294_G0.7830.96
232_E235_K0.7810.96
81_F109_A0.7810.96
272_M334_L0.7770.96
223_Y226_E0.7770.96
331_G335_V0.7740.96
364_R368_K0.7730.96
207_D212_G0.7720.96
339_K349_V0.7700.96
280_K295_L0.7680.96
262_C292_K0.7650.96
118_P121_I0.7640.96
263_E315_S0.7640.96
157_I238_I0.7630.96
243_G252_K0.7600.96
10_A180_M0.7510.96
246_E250_G0.7500.95
21_V40_M0.7500.95
119_W122_W0.7490.95
14_N177_T0.7450.95
269_F320_V0.7430.95
93_T134_A0.7410.95
258_E297_K0.7400.95
58_I69_S0.7380.95
82_T108_A0.7360.95
219_E223_Y0.7320.95
151_T155_F0.7290.95
367_Q370_I0.7280.95
140_M272_M0.7270.95
334_L338_I0.7260.95
137_I167_V0.7260.95
14_N37_Q0.7250.95
24_A152_I0.7230.95
147_A169_M0.7220.94
220_Y223_Y0.7210.94
21_V155_F0.7210.94
298_I309_V0.7210.94
265_A268_V0.7150.94
366_F369_V0.7150.94
17_V109_A0.7130.94
138_Q301_F0.7130.94
287_R290_G0.7130.94
41_L57_L0.7120.94
128_F272_M0.7090.94
238_I242_M0.7080.94
40_M81_F0.7080.94
267_Y293_T0.7060.94
130_S134_A0.7050.94
34_I87_Q0.7050.94
19_Y185_V0.7020.94
104_V158_S0.7020.94
241_I245_Y0.7010.94
18_A44_L0.7010.94
233_R240_E0.7000.94
333_I337_E0.7000.94
282_A286_L0.7000.94
41_L45_S0.7000.94
44_L57_L0.6970.93
287_R292_K0.6960.93
19_Y52_E0.6940.93
259_C294_G0.6940.93
222_K359_K0.6930.93
9_L15_H0.6910.93
20_A24_A0.6900.93
23_Q186_L0.6890.93
252_K255_G0.6850.93
64_H92_M0.6820.93
144_V181_E0.6820.93
22_K52_E0.6800.93
118_P123_D0.6780.92
119_W124_D0.6780.92
320_V369_V0.6780.92
67_L70_I0.6780.92
90_L93_T0.6770.92
256_L308_K0.6770.92
233_R237_V0.6740.92
19_Y148_Y0.6740.92
245_Y249_S0.6700.92
242_M245_Y0.6650.92
310_E314_R0.6630.92
202_L206_S0.6630.92
172_D274_A0.6580.91
107_V159_E0.6570.91
29_L81_F0.6560.91
338_I342_L0.6560.91
312_Y315_S0.6550.91
311_E315_S0.6550.91
335_V351_S0.6540.91
26_P44_L0.6530.91
270_V338_I0.6530.91
318_G351_S0.6470.91
260_Y283_V0.6470.91
139_I169_M0.6470.91
75_L211_I0.6460.91
320_V350_Y0.6460.91
21_V151_T0.6400.90
239_E356_I0.6390.90
132_R336_N0.6380.90
118_P125_H0.6350.90
264_D294_G0.6320.90
80_V108_A0.6290.89
247_R252_K0.6260.89
336_N341_A0.6260.89
141_A150_M0.6250.89
73_A78_A0.6210.89
156_R244_E0.6190.89
147_A171_F0.6160.88
12_V39_T0.6140.88
155_F159_E0.6120.88
282_A363_P0.6110.88
63_E88_G0.6060.88
161_E165_L0.6060.88
121_I125_H0.6050.87
44_L55_A0.6040.87
306_K340_A0.6040.87
21_V29_L0.6040.87
122_W127_D0.6040.87
332_G336_N0.6020.87
24_A151_T0.6000.87
118_P122_W0.5990.87
263_E294_G0.5970.87
39_T43_K0.5970.87
98_W102_Q0.5950.87
86_S118_P0.5930.86
40_M109_A0.5920.86
282_A367_Q0.5900.86
212_G215_A0.5890.86
29_L44_L0.5890.86
97_Y131_K0.5880.86
71_Y74_A0.5880.86
294_G315_S0.5870.86
145_Q148_Y0.5860.86
15_H19_Y0.5860.86
137_I248_I0.5850.86
232_E236_G0.5830.85
70_I99_A0.5820.85
66_A70_I0.5810.85
173_G178_H0.5800.85
38_T42_E0.5800.85
211_I214_I0.5780.85
30_A66_A0.5780.85
41_L83_A0.5770.85
123_D126_Q0.5760.85
15_H180_M0.5750.85
112_T170_G0.5750.85
22_K47_Y0.5750.85
124_D127_D0.5750.85
119_W123_D0.5740.85
30_A60_V0.5730.84
239_E242_M0.5710.84
318_G350_Y0.5710.84
119_W126_Q0.5700.84
126_Q220_Y0.5690.84
158_S167_V0.5690.84
309_V313_L0.5680.84
75_L104_V0.5680.84
101_G117_E0.5680.84
36_P88_G0.5670.84
240_E247_R0.5670.84
71_Y102_Q0.5660.84
260_Y280_K0.5640.84
103_R230_A0.5620.83
107_V158_S0.5610.83
21_V24_A0.5600.83
79_R107_V0.5590.83
355_G359_K0.5590.83
7_K184_E0.5570.83
279_G283_V0.5570.83
313_L316_M0.5530.82
313_L342_L0.5530.82
243_G248_I0.5530.82
280_K284_D0.5530.82
184_E191_V0.5510.82
249_S252_K0.5500.82
116_A119_W0.5470.82
229_K233_R0.5460.82
16_A20_A0.5450.81
332_G353_V0.5440.81
156_R193_N0.5430.81
120_S357_G0.5420.81
127_D168_M0.5420.81
126_Q325_A0.5420.81
325_A333_I0.5420.81
355_G361_V0.5410.81
109_A155_F0.5410.81
23_Q188_D0.5410.81
236_G243_G0.5380.81
19_Y43_K0.5380.81
354_A358_G0.5370.80
118_P124_D0.5350.80
27_K53_L0.5350.80
262_C296_L0.5310.80
235_K241_I0.5300.80
40_M171_F0.5250.79
44_L48_I0.5250.79
259_C263_E0.5240.79
266_K318_G0.5210.78
194_F241_I0.5210.78
142_E280_K0.5200.78
320_V370_I0.5200.78
35_T113_R0.5200.78
344_G348_P0.5180.78
140_M301_F0.5170.78
101_G104_V0.5160.78
107_V167_V0.5160.78
62_S121_I0.5150.78
234_A241_I0.5150.78
207_D214_I0.5120.77
283_V293_T0.5120.77
160_D196_P0.5120.77
270_V298_I0.5120.77
288_D291_V0.5110.77
11_L16_A0.5110.77
40_M83_A0.5110.77
150_M300_V0.5100.77
186_L189_N0.5100.77
132_R337_E0.5090.77
365_H368_K0.5070.77
122_W128_F0.5070.77
35_T39_T0.5060.76
260_Y287_R0.5060.76
238_I300_V0.5050.76
99_A136_W0.5050.76
109_A171_F0.5040.76
270_V319_V0.5030.76
161_E248_I0.5030.76
256_L259_C0.5030.76
215_A223_Y0.5020.76
148_Y183_I0.5020.76
310_E343_Y0.5010.76
272_M298_I0.5010.76
103_R162_R0.5000.76
201_N228_M0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c42A 2 0.9766 100 0.263 Contact Map
5c4iA 2 0.9792 100 0.349 Contact Map
1yd7A 1 0.4338 100 0.435 Contact Map
1qs0B 2 0.8026 100 0.69 Contact Map
1umdB 2 0.7636 100 0.698 Contact Map
1w85B 2 0.7558 100 0.716 Contact Map
1ik6A 3 0.6909 100 0.722 Contact Map
2ozlB 2 0.7636 100 0.729 Contact Map
3komA 2 0.787 100 0.732 Contact Map
2bfdB 2 0.761 99.9 0.733 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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