Q97YU6 - SULSO - GREMLIN Contacts

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Q97YU6 - Carbon monoxide dehydrogenase, large chain (CutA-1)

UniProt:	Q97YU6	Sequences: MIQEHLPLITGKGSYIDDINPKNVVYLHIIRSPIARGIIKSISKPESALLSLTWEDVKLYMPVRLFPDLAKTAQVAKMPVLADGRVNFVGQPILAFVVEDRYRTEDVAEEVLIDYDELKPVVDPEESLNADPIHPGLKSNISIDQLLEGGNLSLKNKAEVVVSRKLKQQRVVSNPMEPKGFICWWDNDILNVYVSTQAPFGVKNDLREILGISPEKIRVYSAPNVGGGFGNKSGGYPEYVLAAIASLKLGRPVKWIETRSEMLVNTQSLGRGEVSDMRLYATKDGEILGIEGTIIANIGAFDYGIGFIAPLFIARLSNGPYKMKFASIRAMGVFTNTPPMGFYRGAGRPEAALIHETLVEDLAEELGVDSVEIRRRNLIGDNGYVTPLGVRIDPAGYNEVLNEAEKYYRKAKEVYKDKGVSIVTFAEIVRTSPGEGARVKIENGKVHFYLGIGPHGQAYGSTFKRLASEVLGISEDKIEITTGSSEIVKEGIGSFGSRAGTIGGSAVIAAATELLKKLNTNSLNESELVKYEGVEAEVFYKADDIFAPGAHVAVIDVDKETGFIRVLEYYAVDDVGRAMNKEEIEGQIIGSVLQGASQVIIEAMRYDERGIPLCSSIADCGVPTALEAPLKVKTEYIEYPSQLLSRSRGVGEAGTTGALPAVFIAVEKVTKKKFDRTPVDPWILVSST	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	688 (668)
Sequences:	5760 (3754)
Seq/√Len:	145.2

ECOLI - XDHA XDHD YAGR
BACSU - XDHD
SULSO - Q97YU6 Q97UR0 Q7LX54 Q97VI4 Q97UK2 Q97V74 Q97TZ2 Q7LXA2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
50_L	110_E	4.390	1.00
163_S	278_R	4.122	1.00
25_V	58_K	4.053	1.00
30_I	111_V	4.047	1.00
100_D	103_R	3.607	1.00
34_I	37_G	3.463	1.00
165_K	276_D	3.451	1.00
46_E	112_L	3.427	1.00
375_R	402_N	3.417	1.00
282_T	286_E	3.355	1.00
281_A	362_L	3.273	1.00
291_E	327_S	3.265	1.00
50_L	103_R	3.153	1.00
159_E	283_K	3.143	1.00
40_K	114_D	3.053	1.00
38_I	116_D	3.050	1.00
467_A	507_V	3.047	1.00
368_V	376_R	3.029	1.00
159_E	282_T	2.981	1.00
287_I	359_V	2.971	1.00
446_V	473_I	2.940	1.00
163_S	276_D	2.833	1.00
58_K	99_E	2.827	1.00
30_I	108_A	2.823	1.00
34_I	117_E	2.819	1.00
293_T	329_R	2.740	1.00
470_V	512_T	2.679	1.00
37_G	115_Y	2.656	1.00
36_R	118_L	2.612	1.00
41_S	114_D	2.587	1.00
192_V	206_L	2.538	1.00
372_E	376_R	2.515	1.00
97_V	245_A	2.503	1.00
278_R	291_E	2.483	1.00
191_N	220_Y	2.470	1.00
508_I	512_T	2.446	1.00
99_E	103_R	2.444	1.00
27_L	255_W	2.395	1.00
40_K	116_D	2.387	1.00
568_E	633_K	2.341	1.00
286_E	376_R	2.322	1.00
663_F	679_V	2.311	1.00
218_R	484_S	2.309	1.00
125_E	274_V	2.300	1.00
189_I	486_E	2.291	1.00
155_K	280_Y	2.288	1.00
676_R	683_I	2.278	1.00
416_K	556_D	2.255	1.00
99_E	251_R	2.254	1.00
44_K	48_A	2.218	1.00
184_W	193_Y	2.211	1.00
666_V	679_V	2.205	1.00
293_T	331_M	2.183	1.00
556_D	567_L	2.171	1.00
368_V	373_I	2.146	1.00
403_E	406_K	2.120	1.00
126_E	129_N	2.117	1.00
297_N	337_T	2.101	1.00
27_L	95_A	2.095	1.00
362_L	373_I	2.083	1.00
29_I	241_L	2.062	1.00
279_L	358_L	2.052	1.00
403_E	635_E	2.034	1.00
148_E	327_S	2.019	1.00
167_K	676_R	2.001	1.00
158_A	280_Y	1.999	1.00
396_G	399_E	1.983	1.00
445_K	479_E	1.963	1.00
445_K	477_K	1.947	1.00
38_I	84_G	1.936	1.00
466_L	504_G	1.916	1.00
404_A	552_V	1.915	1.00
442_E	447_H	1.913	1.00
375_R	405_E	1.898	1.00
286_E	322_K	1.895	1.00
372_E	375_R	1.882	1.00
123_D	126_E	1.839	1.00
533_G	540_Y	1.837	1.00
593_L	628_A	1.834	1.00
160_V	281_A	1.832	1.00
160_V	283_K	1.828	1.00
43_S	112_L	1.822	1.00
402_N	406_K	1.819	1.00
592_V	632_V	1.815	1.00
515_L	519_N	1.810	1.00
45_P	48_A	1.806	1.00
380_G	398_N	1.805	1.00
97_V	249_L	1.804	1.00
575_V	578_A	1.792	1.00
44_K	60_Y	1.790	1.00
33_P	93_I	1.788	1.00
17_D	254_K	1.783	1.00
441_I	514_L	1.780	1.00
277_M	358_L	1.775	1.00
553_A	661_A	1.769	1.00
439_V	448_F	1.767	1.00
474_S	477_K	1.738	1.00
464_K	480_I	1.727	1.00
500_G	579_M	1.719	1.00
38_I	85_R	1.718	1.00
27_L	253_V	1.718	1.00
371_V	405_E	1.709	1.00
189_I	216_K	1.704	1.00
418_K	556_D	1.700	1.00
282_T	288_L	1.690	1.00
180_G	256_I	1.687	1.00
442_E	445_K	1.678	1.00
584_I	650_V	1.675	1.00
47_S	111_V	1.668	1.00
34_I	115_Y	1.661	1.00
407_Y	633_K	1.648	1.00
597_S	623_P	1.642	1.00
98_V	104_T	1.640	1.00
680_D	683_I	1.636	1.00
364_E	667_E	1.633	1.00
415_Y	558_D	1.633	1.00
58_K	251_R	1.631	1.00
46_E	110_E	1.622	1.00
21_P	24_V	1.612	1.00
403_E	407_Y	1.609	1.00
165_K	274_V	1.605	1.00
564_I	684_L	1.602	1.00
95_A	245_A	1.587	1.00
553_A	569_Y	1.575	1.00
375_R	398_N	1.573	1.00
59_L	248_K	1.570	1.00
279_L	362_L	1.565	1.00
158_A	288_L	1.562	1.00
569_Y	592_V	1.561	1.00
174_N	617_I	1.559	1.00
551_H	569_Y	1.554	1.00
417_D	559_K	1.546	1.00
160_V	365_E	1.545	1.00
448_F	467_A	1.544	1.00
578_A	636_Y	1.530	1.00
95_A	241_L	1.524	1.00
279_L	287_I	1.513	1.00
144_D	329_R	1.511	1.00
50_L	107_V	1.507	1.00
446_V	471_L	1.505	1.00
175_P	231_N	1.503	1.00
36_R	85_R	1.501	1.00
527_E	532_E	1.500	1.00
398_N	402_N	1.496	1.00
425_F	549_G	1.493	1.00
322_K	384_Y	1.491	1.00
535_E	540_Y	1.487	1.00
584_I	636_Y	1.480	1.00
577_R	638_E	1.475	1.00
437_A	507_V	1.469	1.00
106_D	110_E	1.465	1.00
470_V	645_S	1.459	1.00
528_L	532_E	1.458	1.00
276_D	293_T	1.457	1.00
153_S	327_S	1.455	1.00
57_V	98_V	1.452	1.00
48_A	59_L	1.447	1.00
568_E	631_K	1.445	1.00
439_V	511_A	1.444	1.00
155_K	278_R	1.438	1.00
167_K	274_V	1.436	1.00
16_I	180_G	1.436	1.00
191_N	218_R	1.433	1.00
29_I	255_W	1.418	1.00
213_S	216_K	1.414	1.00
85_R	135_P	1.406	1.00
46_E	49_L	1.401	1.00
161_V	278_R	1.400	1.00
415_Y	560_E	1.398	1.00
364_E	668_K	1.396	1.00
509_A	513_E	1.393	1.00
21_P	184_W	1.393	1.00
566_V	596_A	1.392	1.00
154_L	289_G	1.388	1.00
465_R	580_N	1.387	1.00
407_Y	635_E	1.384	1.00
108_A	111_V	1.383	1.00
462_T	500_G	1.373	1.00
206_L	217_I	1.369	1.00
155_K	289_G	1.369	1.00
207_R	217_I	1.364	1.00
210_L	243_A	1.361	1.00
204_N	214_P	1.359	1.00
17_D	256_I	1.350	1.00
360_E	664_I	1.348	1.00
513_E	516_K	1.345	1.00
470_V	508_I	1.343	1.00
61_M	249_L	1.343	1.00
154_L	325_F	1.338	1.00
595_G	658_A	1.337	1.00
61_M	245_A	1.337	1.00
281_A	366_L	1.336	1.00
529_V	532_E	1.335	1.00
188_D	216_K	1.332	1.00
64_R	84_G	1.325	1.00
212_I	217_I	1.324	1.00
24_V	254_K	1.320	1.00
564_I	666_V	1.319	1.00
148_E	151_N	1.312	1.00
415_Y	559_K	1.310	1.00
287_I	323_M	1.306	1.00
468_S	478_I	1.297	1.00
160_V	282_T	1.297	1.00
153_S	156_N	1.296	1.00
534_V	541_K	1.295	1.00
356_E	374_R	1.293	1.00
25_V	251_R	1.286	1.00
160_V	366_L	1.286	1.00
160_V	362_L	1.284	1.00
39_I	113_I	1.284	1.00
190_L	243_A	1.284	1.00
438_R	449_Y	1.281	1.00
164_R	365_E	1.273	1.00
39_I	42_I	1.269	1.00
21_P	182_I	1.267	1.00
183_C	192_V	1.265	1.00
605_R	614_C	1.256	1.00
164_R	361_D	1.256	1.00
284_D	376_R	1.252	1.00
7_P	12_K	1.247	1.00
404_A	550_A	1.246	1.00
463_F	507_V	1.242	1.00
578_A	584_I	1.238	1.00
407_Y	572_V	1.237	1.00
28_H	105_E	1.235	1.00
570_Y	633_K	1.234	1.00
152_L	155_K	1.228	1.00
183_C	246_S	1.225	1.00
400_V	550_A	1.224	1.00
528_L	542_A	1.224	1.00
33_P	115_Y	1.213	1.00
449_Y	481_T	1.213	1.00
13_G	224_N	1.212	1.00
146_L	329_R	1.210	1.00
674_F	679_V	1.208	1.00
93_I	113_I	1.205	1.00
31_R	261_E	1.205	1.00
418_K	554_V	1.204	1.00
532_E	543_D	1.199	1.00
36_R	119_K	1.199	1.00
183_C	242_A	1.198	1.00
343_Y	594_Q	1.197	1.00
572_V	635_E	1.196	1.00
466_L	500_G	1.196	1.00
193_Y	220_Y	1.188	1.00
87_N	91_Q	1.188	1.00
366_L	373_I	1.184	1.00
57_V	107_V	1.183	1.00
403_E	572_V	1.183	1.00
536_A	541_K	1.182	1.00
103_R	107_V	1.180	1.00
416_K	558_D	1.179	1.00
360_E	370_S	1.176	1.00
464_K	475_E	1.176	1.00
6_L	10_T	1.175	1.00
416_K	565_R	1.173	1.00
28_H	101_R	1.173	1.00
505_S	508_I	1.171	1.00
534_V	543_D	1.170	1.00
281_A	373_I	1.169	1.00
153_S	291_E	1.167	1.00
36_R	336_N	1.165	1.00
85_R	118_L	1.164	1.00
28_H	108_A	1.164	1.00
157_K	288_L	1.159	1.00
275_S	354_I	1.157	1.00
353_L	663_F	1.157	1.00
86_V	115_Y	1.152	1.00
128_L	141_I	1.151	1.00
272_G	297_N	1.150	1.00
528_L	533_G	1.149	1.00
298_I	305_I	1.147	0.99
295_I	331_M	1.145	0.99
228_G	455_H	1.144	0.99
399_E	403_E	1.142	0.99
245_A	253_V	1.135	0.99
190_L	212_I	1.135	0.99
146_L	327_S	1.135	0.99
20_N	24_V	1.130	0.99
175_P	262_M	1.127	0.99
38_I	118_L	1.127	0.99
513_E	517_K	1.127	0.99
562_G	684_L	1.126	0.99
174_N	622_V	1.119	0.99
155_K	161_V	1.119	0.99
361_D	675_D	1.117	0.99
378_L	401_L	1.117	0.99
588_I	592_V	1.117	0.99
557_V	564_I	1.109	0.99
527_E	533_G	1.107	0.99
28_H	104_T	1.105	0.99
527_E	542_A	1.105	0.99
519_N	533_G	1.102	0.99
185_W	247_L	1.099	0.99
527_E	534_V	1.091	0.99
144_D	331_M	1.085	0.99
516_K	520_T	1.084	0.99
59_L	249_L	1.083	0.99
564_I	600_I	1.083	0.99
447_H	481_T	1.079	0.99
461_S	465_R	1.073	0.99
186_D	191_N	1.068	0.99
166_L	358_L	1.066	0.99
534_V	540_Y	1.065	0.99
107_V	110_E	1.064	0.99
404_A	572_V	1.064	0.99
172_V	604_M	1.062	0.99
574_D	639_Y	1.058	0.99
63_V	83_D	1.056	0.99
3_Q	461_S	1.048	0.99
280_Y	289_G	1.048	0.99
24_V	182_I	1.044	0.99
184_W	191_N	1.043	0.99
532_E	542_A	1.041	0.99
61_M	248_K	1.041	0.99
152_L	291_E	1.039	0.99
66_F	244_I	1.036	0.99
279_L	290_I	1.035	0.99
267_Q	341_G	1.034	0.99
42_I	113_I	1.034	0.99
25_V	249_L	1.032	0.99
50_L	106_D	1.031	0.99
467_A	511_A	1.029	0.99
41_S	112_L	1.027	0.99
359_V	373_I	1.026	0.99
128_L	333_V	1.026	0.99
162_V	365_E	1.026	0.99
23_N	251_R	1.023	0.99
157_K	282_T	1.022	0.99
134_H	334_F	1.020	0.99
418_K	567_L	1.020	0.99
555_I	666_V	1.018	0.99
57_V	104_T	1.018	0.99
600_I	662_V	1.017	0.99
512_T	516_K	1.015	0.99
125_E	167_K	1.012	0.99
371_V	422_I	1.011	0.99
295_I	333_V	1.009	0.99
470_V	511_A	1.006	0.99
378_L	398_N	1.004	0.99
27_L	245_A	1.003	0.99
606_Y	612_P	1.002	0.99
679_V	684_L	1.002	0.99
186_D	189_I	1.000	0.99
553_A	566_V	0.998	0.99
101_R	105_E	0.997	0.99
569_Y	658_A	0.996	0.99
185_W	246_S	0.995	0.99
280_Y	288_L	0.989	0.99
37_G	118_L	0.987	0.98
314_A	328_I	0.985	0.98
159_E	288_L	0.984	0.98
56_D	107_V	0.982	0.98
63_V	84_G	0.980	0.98
93_I	115_Y	0.979	0.98
181_F	242_A	0.977	0.98
3_Q	464_K	0.975	0.98
465_R	581_K	0.974	0.98
440_K	449_Y	0.972	0.98
154_L	280_Y	0.971	0.98
96_F	108_A	0.969	0.98
162_V	281_A	0.965	0.98
679_V	683_I	0.963	0.98
416_K	559_K	0.960	0.98
571_A	592_V	0.956	0.98
173_S	231_N	0.955	0.98
81_L	241_L	0.950	0.98
44_K	111_V	0.947	0.98
470_V	515_L	0.947	0.98
152_L	325_F	0.945	0.98
400_V	572_V	0.943	0.98
281_A	287_I	0.939	0.98
195_S	232_K	0.937	0.98
273_E	313_I	0.936	0.98
520_T	530_K	0.936	0.98
616_S	619_D	0.934	0.98
39_I	115_Y	0.933	0.98
596_A	628_A	0.932	0.98
212_I	247_L	0.932	0.98
527_E	540_Y	0.932	0.98
585_E	589_I	0.930	0.98
532_E	544_D	0.930	0.98
44_K	62_P	0.929	0.98
30_I	94_L	0.928	0.98
58_K	103_R	0.926	0.98
212_I	216_K	0.924	0.98
62_P	81_L	0.923	0.98
509_A	512_T	0.918	0.98
162_V	279_L	0.917	0.98
29_I	92_P	0.916	0.98
58_K	97_V	0.914	0.97
601_I	627_E	0.911	0.97
94_L	111_V	0.910	0.97
357_T	663_F	0.910	0.97
401_L	422_I	0.910	0.97
128_L	295_I	0.909	0.97
448_F	478_I	0.908	0.97
532_E	540_Y	0.907	0.97
242_A	255_W	0.907	0.97
26_Y	254_K	0.906	0.97
7_P	460_G	0.906	0.97
533_G	542_A	0.905	0.97
447_H	479_E	0.905	0.97
595_G	655_T	0.904	0.97
39_I	93_I	0.904	0.97
441_I	446_V	0.901	0.97
36_R	120_P	0.901	0.97
271_R	350_E	0.899	0.97
462_T	579_M	0.897	0.97
414_V	417_D	0.893	0.97
360_E	374_R	0.892	0.97
124_P	295_I	0.892	0.97
30_I	113_I	0.891	0.97
104_T	108_A	0.891	0.97
467_A	478_I	0.889	0.97
94_L	113_I	0.889	0.97
132_P	136_G	0.889	0.97
197_Q	228_G	0.888	0.97
125_E	165_K	0.887	0.97
203_K	214_P	0.887	0.97
260_S	615_S	0.885	0.97
607_D	611_I	0.885	0.97
291_E	329_R	0.884	0.97
148_E	153_S	0.883	0.97
217_I	243_A	0.881	0.97
184_W	246_S	0.881	0.97
60_Y	94_L	0.879	0.97
371_V	401_L	0.879	0.97
29_I	95_A	0.878	0.97
218_R	486_E	0.877	0.97
554_V	568_E	0.876	0.97
152_L	327_S	0.874	0.97
531_Y	543_D	0.873	0.97
61_M	97_V	0.871	0.97
50_L	56_D	0.871	0.97
527_E	535_E	0.867	0.97
37_G	113_I	0.865	0.97
526_S	533_G	0.865	0.97
399_E	402_N	0.862	0.96
273_E	296_A	0.861	0.96
603_A	683_I	0.859	0.96
441_I	518_L	0.859	0.96
446_V	514_L	0.858	0.96
55_E	99_E	0.858	0.96
56_D	99_E	0.856	0.96
124_P	274_V	0.856	0.96
533_G	537_E	0.851	0.96
321_Y	374_R	0.849	0.96
155_K	291_E	0.849	0.96
225_V	455_H	0.848	0.96
48_A	64_R	0.847	0.96
288_L	325_F	0.845	0.96
531_Y	534_V	0.842	0.96
467_A	470_V	0.841	0.96
607_D	613_L	0.840	0.96
121_V	127_S	0.840	0.96
321_Y	356_E	0.839	0.96
473_I	477_K	0.838	0.96
152_L	289_G	0.834	0.96
527_E	530_K	0.833	0.96
148_E	152_L	0.832	0.96
42_I	111_V	0.829	0.96
458_A	583_E	0.829	0.96
45_P	49_L	0.829	0.96
399_E	637_I	0.829	0.96
537_E	540_Y	0.829	0.96
195_S	225_V	0.826	0.95
585_E	636_Y	0.825	0.95
185_W	188_D	0.823	0.95
7_P	224_N	0.822	0.95
462_T	583_E	0.822	0.95
65_L	248_K	0.822	0.95
91_Q	301_F	0.821	0.95
519_N	540_Y	0.820	0.95
452_I	499_A	0.818	0.95
553_A	662_V	0.815	0.95
526_S	540_Y	0.815	0.95
68_D	72_T	0.815	0.95
154_L	158_A	0.813	0.95
439_V	514_L	0.812	0.95
532_E	535_E	0.808	0.95
190_L	247_L	0.805	0.95
26_Y	101_R	0.805	0.95
43_S	47_S	0.805	0.95
575_V	584_I	0.804	0.95
555_I	566_V	0.802	0.95
161_V	280_Y	0.799	0.95
151_N	325_F	0.798	0.95
3_Q	475_E	0.796	0.94
285_G	368_V	0.796	0.94
154_L	288_L	0.795	0.94
258_T	261_E	0.794	0.94
47_S	57_V	0.794	0.94
123_D	274_V	0.794	0.94
166_L	361_D	0.793	0.94
551_H	658_A	0.793	0.94
469_E	577_R	0.792	0.94
39_I	86_V	0.792	0.94
233_S	495_F	0.792	0.94
466_L	579_M	0.789	0.94
452_I	459_Y	0.786	0.94
122_V	610_G	0.785	0.94
31_R	265_N	0.785	0.94
37_G	86_V	0.784	0.94
420_V	668_K	0.784	0.94
540_Y	543_D	0.783	0.94
570_Y	635_E	0.783	0.94
196_T	202_V	0.782	0.94
61_M	244_I	0.782	0.94
439_V	467_A	0.780	0.94
44_K	47_S	0.779	0.94
194_V	202_V	0.778	0.94
185_W	190_L	0.777	0.94
429_V	545_I	0.777	0.94
465_R	469_E	0.776	0.94
435_E	503_G	0.775	0.94
385_V	391_R	0.775	0.94
203_K	485_S	0.775	0.94
281_A	358_L	0.775	0.94
105_E	258_T	0.774	0.94
448_F	507_V	0.772	0.94
457_Q	494_S	0.771	0.93
353_L	677_T	0.771	0.93
50_L	57_V	0.770	0.93
298_I	332_G	0.770	0.93
617_I	622_V	0.769	0.93
535_E	539_F	0.769	0.93
358_L	362_L	0.769	0.93
465_R	475_E	0.768	0.93
35_A	120_P	0.766	0.93
353_L	357_T	0.766	0.93
158_A	289_G	0.766	0.93
426_A	546_F	0.766	0.93
179_K	262_M	0.766	0.93
299_G	339_P	0.762	0.93
612_P	615_S	0.761	0.93
34_I	86_V	0.761	0.93
534_V	537_E	0.761	0.93
575_V	650_V	0.758	0.93
516_K	530_K	0.758	0.93
64_R	83_D	0.758	0.93
98_V	107_V	0.757	0.93
361_D	673_K	0.756	0.93
290_I	323_M	0.756	0.93
527_E	544_D	0.756	0.93
48_A	107_V	0.755	0.93
275_S	292_G	0.755	0.93
14_S	19_I	0.754	0.93
155_K	158_A	0.749	0.92
257_E	262_M	0.748	0.92
149_G	326_A	0.748	0.92
82_A	86_V	0.747	0.92
533_G	543_D	0.747	0.92
477_K	538_V	0.746	0.92
309_A	330_A	0.744	0.92
182_I	254_K	0.743	0.92
188_D	247_L	0.742	0.92
533_G	536_A	0.742	0.92
106_D	109_E	0.741	0.92
519_N	535_E	0.740	0.92
47_S	56_D	0.739	0.92
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119_K	126_E	0.738	0.92
178_P	256_I	0.737	0.92
163_S	291_E	0.736	0.92
87_N	301_F	0.736	0.92
210_L	244_I	0.735	0.92
121_V	131_D	0.734	0.92
527_E	537_E	0.734	0.92
245_A	249_L	0.734	0.92
437_A	506_A	0.733	0.92
101_R	258_T	0.733	0.92
8_L	15_Y	0.732	0.92
355_H	358_L	0.732	0.92
200_F	485_S	0.731	0.92
605_R	613_L	0.731	0.92
361_D	365_E	0.730	0.91
667_E	673_K	0.729	0.91
368_V	372_E	0.729	0.91
190_L	217_I	0.727	0.91
277_M	354_I	0.726	0.91
373_I	376_R	0.726	0.91
443_N	479_E	0.726	0.91
528_L	531_Y	0.726	0.91
410_K	414_V	0.724	0.91
521_N	525_E	0.724	0.91
358_L	361_D	0.724	0.91
511_A	514_L	0.723	0.91
103_R	106_D	0.722	0.91
300_A	336_N	0.720	0.91
558_D	563_F	0.719	0.91
628_A	632_V	0.718	0.91
555_I	564_I	0.717	0.91
517_K	520_T	0.716	0.91
589_I	634_T	0.715	0.91
19_I	193_Y	0.714	0.91
383_G	386_T	0.713	0.91
297_N	335_T	0.712	0.90
23_N	252_P	0.712	0.90
401_L	424_T	0.710	0.90
21_P	193_Y	0.710	0.90
528_L	543_D	0.709	0.90
539_F	542_A	0.709	0.90
42_I	93_I	0.709	0.90
378_L	395_A	0.709	0.90
166_L	675_D	0.708	0.90
413_E	417_D	0.708	0.90
202_V	206_L	0.708	0.90
141_I	333_V	0.705	0.90
154_L	157_K	0.704	0.90
62_P	65_L	0.704	0.90
4_E	224_N	0.704	0.90
131_D	134_H	0.701	0.90
155_K	288_L	0.700	0.90
551_H	657_G	0.700	0.90
20_N	254_K	0.697	0.90
290_I	317_S	0.697	0.90
171_V	598_Q	0.696	0.89
203_K	486_E	0.695	0.89
528_L	540_Y	0.695	0.89
102_Y	106_D	0.693	0.89
42_I	60_Y	0.693	0.89
529_V	533_G	0.692	0.89
249_L	253_V	0.692	0.89
318_N	326_A	0.692	0.89
527_E	539_F	0.692	0.89
531_Y	540_Y	0.690	0.89
292_G	354_I	0.690	0.89
569_Y	632_V	0.690	0.89
405_E	552_V	0.689	0.89
573_D	588_I	0.689	0.89
34_I	93_I	0.689	0.89
604_M	612_P	0.687	0.89
280_Y	291_E	0.687	0.89
56_D	103_R	0.686	0.89
522_S	525_E	0.686	0.89
439_V	510_A	0.686	0.89
424_T	550_A	0.683	0.89
534_V	544_D	0.682	0.88
134_H	301_F	0.682	0.88
574_D	640_P	0.680	0.88
535_E	541_K	0.680	0.88
423_V	661_A	0.678	0.88
313_I	351_A	0.676	0.88
35_A	89_V	0.675	0.88
16_I	19_I	0.675	0.88
294_I	313_I	0.674	0.88
528_L	535_E	0.674	0.88
527_E	536_A	0.674	0.88
181_F	194_V	0.673	0.88
518_L	527_E	0.672	0.88
141_I	331_M	0.672	0.88
528_L	534_V	0.671	0.88
521_N	524_N	0.670	0.88
287_I	373_I	0.670	0.88
417_D	557_V	0.669	0.88
96_F	111_V	0.669	0.88
664_I	673_K	0.668	0.87
278_R	327_S	0.666	0.87
531_Y	535_E	0.666	0.87
290_I	358_L	0.665	0.87
279_L	373_I	0.664	0.87
133_I	336_N	0.663	0.87
306_G	310_P	0.662	0.87
520_T	524_N	0.661	0.87
247_L	250_G	0.661	0.87
534_V	542_A	0.661	0.87
519_N	522_S	0.660	0.87
655_T	659_L	0.660	0.87
352_A	660_P	0.660	0.87
163_S	365_E	0.660	0.87
65_L	68_D	0.660	0.87
667_E	670_T	0.658	0.87
209_I	240_V	0.657	0.87
537_E	541_K	0.657	0.87
515_L	535_E	0.656	0.87
290_I	355_H	0.655	0.86
117_E	120_P	0.655	0.86
89_V	611_I	0.655	0.86
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400_V	637_I	0.652	0.86
43_S	46_E	0.652	0.86
96_F	107_V	0.652	0.86
168_Q	273_E	0.651	0.86
539_F	543_D	0.651	0.86
516_K	519_N	0.650	0.86
167_K	272_G	0.650	0.86
378_L	424_T	0.649	0.86
151_N	154_L	0.647	0.86
442_E	479_E	0.646	0.86
203_K	207_R	0.645	0.86
41_S	45_P	0.644	0.85
552_V	570_Y	0.642	0.85
455_H	494_S	0.642	0.85
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185_W	189_I	0.641	0.85
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323_M	326_A	0.639	0.85
198_A	495_F	0.639	0.85
121_V	336_N	0.639	0.85
132_P	135_P	0.639	0.85
529_V	540_Y	0.639	0.85
82_A	91_Q	0.637	0.85
164_R	675_D	0.637	0.85
410_K	417_D	0.636	0.85
492_I	495_F	0.635	0.85
39_I	63_V	0.635	0.85
16_I	256_I	0.635	0.85
125_E	295_I	0.634	0.85
494_S	499_A	0.634	0.85
601_I	621_G	0.633	0.85
151_N	158_A	0.633	0.85
289_G	325_F	0.632	0.84
499_A	503_G	0.630	0.84
262_M	266_T	0.630	0.84
555_I	665_A	0.630	0.84
571_A	588_I	0.629	0.84
168_Q	598_Q	0.629	0.84
459_Y	500_G	0.628	0.84
274_V	295_I	0.628	0.84
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396_G	637_I	0.626	0.84
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588_I	636_Y	0.625	0.84
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531_Y	542_A	0.624	0.84
218_R	485_S	0.622	0.83
577_R	640_P	0.622	0.83
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413_E	556_D	0.619	0.83
278_R	293_T	0.618	0.83
86_V	113_I	0.617	0.83
402_N	405_E	0.617	0.83
154_L	324_K	0.617	0.83
529_V	544_D	0.617	0.83
36_R	133_I	0.616	0.83
174_N	604_M	0.615	0.83
527_E	531_Y	0.615	0.83
31_R	92_P	0.615	0.83
20_N	182_I	0.615	0.83
557_V	562_G	0.614	0.83
107_V	111_V	0.614	0.83
337_T	606_Y	0.613	0.83
24_V	252_P	0.613	0.83
296_A	332_G	0.613	0.83
282_T	376_R	0.612	0.82
357_T	667_E	0.612	0.82
123_D	295_I	0.612	0.82
296_A	313_I	0.611	0.82
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564_I	681_P	0.610	0.82
48_A	65_L	0.609	0.82
97_V	253_V	0.609	0.82
670_T	684_L	0.608	0.82
166_L	354_I	0.605	0.82
551_H	571_A	0.605	0.82
159_E	286_E	0.605	0.82
412_K	417_D	0.605	0.82
322_K	380_G	0.604	0.82
531_Y	537_E	0.604	0.82
452_I	503_G	0.604	0.82
519_N	523_L	0.604	0.82
557_V	684_L	0.602	0.81
125_E	129_N	0.602	0.81
169_Q	272_G	0.602	0.81
179_K	231_N	0.601	0.81
440_K	447_H	0.601	0.81
523_L	526_S	0.601	0.81
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531_Y	539_F	0.601	0.81
529_V	535_E	0.601	0.81
19_I	223_P	0.601	0.81
481_T	487_I	0.600	0.81
535_E	543_D	0.600	0.81
8_L	224_N	0.600	0.81
86_V	89_V	0.599	0.81
507_V	511_A	0.599	0.81
205_D	235_G	0.599	0.81
60_Y	64_R	0.598	0.81
150_G	154_L	0.598	0.81
557_V	666_V	0.598	0.81
466_L	645_S	0.597	0.81
360_E	673_K	0.596	0.81
614_C	619_D	0.596	0.81
79_P	83_D	0.596	0.81
172_V	263_L	0.595	0.81
57_V	60_Y	0.595	0.81
394_P	648_R	0.595	0.81
528_L	539_F	0.594	0.81
526_S	529_V	0.594	0.81
292_G	317_S	0.594	0.81
410_K	413_E	0.594	0.81
160_V	368_V	0.594	0.81
25_V	253_V	0.593	0.80
430_R	502_I	0.593	0.80
47_S	110_E	0.591	0.80
42_I	62_P	0.590	0.80
585_E	634_T	0.590	0.80
89_V	612_P	0.590	0.80
128_L	331_M	0.589	0.80
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288_L	373_I	0.588	0.80
126_E	130_A	0.587	0.80
526_S	542_A	0.587	0.80
144_D	148_E	0.587	0.80
463_F	467_A	0.585	0.80
87_N	300_A	0.584	0.79
672_K	684_L	0.583	0.79
305_I	308_I	0.583	0.79
529_V	542_A	0.582	0.79
305_I	309_A	0.582	0.79
183_C	253_V	0.582	0.79
421_S	424_T	0.582	0.79
277_M	362_L	0.581	0.79
296_A	309_A	0.578	0.79
566_V	569_Y	0.578	0.79
198_A	201_G	0.577	0.79
362_L	365_E	0.577	0.79
39_I	82_A	0.576	0.79
532_E	539_F	0.575	0.78
364_E	673_K	0.574	0.78
162_V	362_L	0.574	0.78
154_L	159_E	0.573	0.78
531_Y	541_K	0.572	0.78
593_L	596_A	0.572	0.78
439_V	446_V	0.571	0.78
196_T	222_A	0.571	0.78
435_E	491_G	0.571	0.78
422_I	552_V	0.570	0.78
168_Q	275_S	0.570	0.78
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533_G	541_K	0.569	0.78
348_R	427_E	0.569	0.78
370_S	664_I	0.569	0.78
206_L	235_G	0.569	0.78
471_L	478_I	0.568	0.78
589_I	632_V	0.567	0.77
419_G	668_K	0.567	0.77
179_K	266_T	0.567	0.77
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454_P	460_G	0.565	0.77
541_K	544_D	0.565	0.77
357_T	664_I	0.564	0.77
285_G	373_I	0.564	0.77
379_I	395_A	0.562	0.77
63_V	67_P	0.561	0.77
32_S	89_V	0.561	0.77
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416_K	567_L	0.560	0.77
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149_G	322_K	0.560	0.77
19_I	182_I	0.559	0.76
575_V	636_Y	0.559	0.76
128_L	274_V	0.559	0.76
59_L	97_V	0.559	0.76
530_K	534_V	0.558	0.76
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407_Y	570_Y	0.558	0.76
533_G	539_F	0.558	0.76
272_G	340_M	0.558	0.76
168_Q	353_L	0.557	0.76
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55_E	103_R	0.556	0.76
558_D	561_T	0.556	0.76
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174_N	262_M	0.554	0.76
95_A	255_W	0.554	0.76
536_A	544_D	0.554	0.76
381_D	398_N	0.554	0.76
463_F	466_L	0.553	0.76
535_E	542_A	0.552	0.76
326_A	387_P	0.552	0.76
514_L	518_L	0.552	0.76
272_G	337_T	0.551	0.75
195_S	202_V	0.551	0.75
463_F	480_I	0.550	0.75
78_M	91_Q	0.550	0.75
220_Y	484_S	0.550	0.75
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49_L	112_L	0.548	0.75
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142_S	334_F	0.547	0.75
501_T	647_S	0.547	0.75
199_P	453_G	0.547	0.75
287_I	362_L	0.546	0.75
30_I	33_P	0.546	0.75
194_V	238_E	0.546	0.75
526_S	532_E	0.546	0.75
44_K	50_L	0.546	0.75
5_H	8_L	0.546	0.75
472_G	515_L	0.545	0.75
500_G	647_S	0.545	0.75
302_D	334_F	0.545	0.75
534_V	539_F	0.544	0.75
362_L	368_V	0.544	0.75
588_I	634_T	0.544	0.75
411_A	418_K	0.544	0.75
491_G	503_G	0.543	0.74
621_G	624_T	0.543	0.74
363_A	373_I	0.540	0.74
160_V	373_I	0.540	0.74
133_I	334_F	0.540	0.74
414_V	559_K	0.538	0.74
492_I	498_R	0.537	0.74
529_V	534_V	0.537	0.74
537_E	543_D	0.537	0.74
527_E	543_D	0.536	0.73
429_V	501_T	0.536	0.73
263_L	617_I	0.536	0.73
164_R	358_L	0.536	0.73
404_A	570_Y	0.535	0.73
383_G	389_G	0.535	0.73
517_K	521_N	0.534	0.73
202_V	219_V	0.534	0.73
463_F	503_G	0.534	0.73
114_D	117_E	0.533	0.73
345_G	655_T	0.533	0.73
373_I	377_N	0.533	0.73
162_V	373_I	0.532	0.73
352_A	656_T	0.532	0.73
181_F	192_V	0.531	0.73
423_V	664_I	0.530	0.73
579_M	647_S	0.529	0.73
159_E	281_A	0.528	0.72
47_S	94_L	0.528	0.72
459_Y	494_S	0.528	0.72
170_R	604_M	0.528	0.72
298_I	340_M	0.528	0.72
141_I	144_D	0.527	0.72
554_V	567_L	0.527	0.72
363_A	368_V	0.527	0.72
5_H	9_I	0.527	0.72
93_I	111_V	0.526	0.72
569_Y	662_V	0.526	0.72
462_T	465_R	0.525	0.72
78_M	82_A	0.525	0.72
85_R	133_I	0.524	0.72
162_V	366_L	0.523	0.72
572_V	637_I	0.522	0.72
370_S	374_R	0.521	0.71
157_K	325_F	0.521	0.71
530_K	533_G	0.521	0.71
574_D	648_R	0.520	0.71
386_T	546_F	0.519	0.71
405_E	409_R	0.518	0.71
450_L	463_F	0.518	0.71
396_G	639_Y	0.518	0.71
48_A	57_V	0.518	0.71
174_N	263_L	0.518	0.71
437_A	510_A	0.517	0.71
28_H	261_E	0.517	0.71
518_L	540_Y	0.517	0.71
573_D	653_A	0.517	0.71
154_L	282_T	0.516	0.71
413_E	559_K	0.516	0.71
42_I	115_Y	0.516	0.71
379_I	392_I	0.516	0.71
367_G	370_S	0.514	0.70
522_S	533_G	0.514	0.70
286_E	324_K	0.513	0.70
439_V	507_V	0.513	0.70
392_I	548_P	0.513	0.70
305_I	332_G	0.512	0.70
527_E	541_K	0.512	0.70
222_A	455_H	0.511	0.70
353_L	659_L	0.511	0.70
588_I	654_G	0.511	0.70
598_Q	677_T	0.510	0.70
151_N	156_N	0.510	0.70
432_S	498_R	0.510	0.70
273_E	350_E	0.510	0.70
35_A	607_D	0.509	0.70
96_F	104_T	0.509	0.70
281_A	365_E	0.508	0.69
25_V	59_L	0.508	0.69
181_F	237_P	0.507	0.69
50_L	55_E	0.507	0.69
455_H	459_Y	0.507	0.69
121_V	132_P	0.506	0.69
533_G	538_V	0.506	0.69
316_L	428_I	0.505	0.69
460_G	480_I	0.505	0.69
206_L	211_G	0.505	0.69
569_Y	596_A	0.505	0.69
60_Y	96_F	0.505	0.69
182_I	193_Y	0.504	0.69
177_E	232_K	0.504	0.69
98_V	103_R	0.503	0.69
357_T	673_K	0.503	0.69
87_N	133_I	0.503	0.69
378_L	397_Y	0.503	0.69
59_L	245_A	0.503	0.69
405_E	422_I	0.503	0.69
318_N	323_M	0.502	0.69
32_S	35_A	0.502	0.69
413_E	418_K	0.502	0.69
189_I	218_R	0.500	0.68
375_R	378_L	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1rm6A	2	0.9855	100	0.095	Contact Map
1t3qB	2	0.9869	100	0.1	Contact Map
1ffvB	2	0.9869	100	0.103	Contact Map
1n62B	2	0.9898	100	0.104	Contact Map
3uncA	2	0.9782	100	0.119	Contact Map
2w3sB	2	0.9782	100	0.124	Contact Map
3nvzC	2	0.9782	100	0.132	Contact Map
3zyvA	3	0.9695	100	0.132	Contact Map
4usaA	2	0.9797	100	0.136	Contact Map
1dgjA	1	0.9767	100	0.139	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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