GREMLIN Database
Q97YU3 - Carbonic anhydrase
UniProt: Q97YU3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 204 (168)
Sequences: 5086 (3197)
Seq/√Len: 246.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_A172_A4.0041.00
29_R81_K3.7961.00
31_W71_A2.9451.00
155_A172_A2.9371.00
148_D183_R2.7231.00
155_A170_I2.6161.00
60_G93_M2.5351.00
7_D11_K2.3011.00
82_E171_S2.2551.00
59_A70_S2.1531.00
89_T174_V2.1411.00
147_P174_V2.0671.00
14_E18_L2.0641.00
11_K15_D1.9811.00
176_E183_R1.9101.00
95_R99_D1.8791.00
14_E181_K1.8561.00
162_P165_P1.8091.00
10_I184_K1.7801.00
68_I161_H1.7601.00
173_Y182_L1.7561.00
31_W80_T1.7151.00
90_D178_E1.7151.00
106_L109_G1.6691.00
72_S76_N1.6651.00
148_D174_V1.6401.00
85_V158_L1.6391.00
109_G113_N1.5991.00
36_M54_H1.5811.00
176_E179_T1.5511.00
11_K14_E1.5501.00
26_N38_E1.5441.00
149_D153_K1.5421.00
81_K167_N1.5391.00
61_G150_I1.5281.00
15_D47_G1.5121.00
82_E169_T1.5111.00
109_G115_L1.5111.00
48_I53_A1.4991.00
112_V116_Q1.4971.00
110_V115_L1.4931.00
111_K114_E1.4641.00
149_D152_L1.4571.00
46_L53_A1.4441.00
63_V67_A1.3751.00
138_F141_D1.3621.00
20_R23_G1.3531.00
13_R17_S1.3281.00
110_V116_Q1.3221.00
75_T164_I1.3221.00
89_T176_E1.3211.00
114_E117_I1.3151.00
113_N117_I1.3061.00
56_Y70_S1.2911.00
111_K115_L1.2881.00
109_G117_I1.2861.00
159_K170_I1.2721.00
31_W83_I1.2501.00
32_I86_I1.2381.00
112_V115_L1.2361.00
71_A158_L1.2331.00
31_W70_S1.2271.00
26_N92_G1.2081.00
86_I173_Y1.2071.00
73_L77_F1.2041.00
151_A155_A1.2031.00
157_I160_N1.1861.00
12_R47_G1.1821.00
84_I173_Y1.1781.00
68_I158_L1.1701.00
98_G146_S1.1631.00
109_G116_Q1.1531.00
109_G112_V1.1441.00
30_L84_I1.1381.00
74_T80_T1.1331.00
173_Y184_K1.1211.00
109_G114_E1.0981.00
33_L63_V1.0751.00
19_R22_K1.0641.00
58_N61_G1.0601.00
106_L110_V1.0571.00
161_H165_P1.0511.00
89_T177_V1.0391.00
110_V114_E1.0261.00
132_F135_W1.0131.00
75_T168_V1.0051.00
75_T80_T1.0011.00
152_L185_P1.0001.00
87_T151_A0.9891.00
138_F142_L0.9891.00
61_G87_T0.9851.00
34_T40_V0.9821.00
17_S181_K0.9731.00
139_F142_L0.9661.00
137_K141_D0.9631.00
114_E118_D0.9621.00
25_P90_D0.9581.00
105_F109_G0.9571.00
110_V113_N0.9571.00
32_I46_L0.9501.00
9_E46_L0.9481.00
12_R15_D0.9421.00
179_T183_R0.9401.00
153_K156_E0.9391.00
113_N116_Q0.9201.00
144_A148_D0.9041.00
151_A174_V0.9021.00
90_D95_R0.8991.00
148_D152_L0.8971.00
131_D145_N0.8891.00
144_A147_P0.8861.00
150_I154_N0.8841.00
75_T83_I0.8841.00
54_H74_T0.8811.00
48_I52_D0.8750.99
106_L112_V0.8750.99
32_I53_A0.8690.99
46_L86_I0.8570.99
12_R16_Y0.8560.99
115_L118_D0.8510.99
164_I168_V0.8490.99
30_L53_A0.8380.99
103_K106_L0.8360.99
73_L92_G0.8320.99
106_L114_E0.8240.99
26_N54_H0.8180.99
33_L71_A0.8170.99
156_E159_K0.8160.99
158_L170_I0.8140.99
67_A71_A0.8140.99
8_E12_R0.8100.99
19_R50_P0.8010.99
34_T86_I0.7950.99
140_R145_N0.7940.99
63_V154_N0.7940.99
105_F110_V0.7890.99
62_I154_N0.7810.99
36_M56_Y0.7780.99
99_D139_F0.7770.99
153_K157_I0.7530.98
135_W138_F0.7520.98
87_T150_I0.7510.98
36_M78_F0.7510.98
133_T137_K0.7480.98
145_N149_D0.7470.98
171_S184_K0.7410.98
103_K107_D0.7380.98
38_E54_H0.7380.98
19_R23_G0.7360.98
56_Y67_A0.7320.98
105_F115_L0.7310.98
84_I171_S0.7220.98
152_L172_A0.7200.98
95_R142_L0.7170.98
95_R98_G0.7150.98
25_P38_E0.7130.98
102_A107_D0.7130.98
46_L173_Y0.7130.98
13_R182_L0.7110.98
107_D110_V0.7100.98
137_K140_R0.7090.98
76_N163_L0.7060.98
41_H45_A0.7040.98
108_K112_V0.6970.98
59_A93_M0.6970.98
41_H55_I0.6940.97
141_D145_N0.6920.97
131_D135_W0.6780.97
33_L58_N0.6750.97
34_T41_H0.6730.97
104_Y107_D0.6700.97
174_V183_R0.6650.97
66_D80_T0.6610.97
112_V153_K0.6580.96
58_N66_D0.6550.96
107_D114_E0.6540.96
97_T113_N0.6530.96
99_D103_K0.6510.96
66_D69_R0.6440.96
6_V82_E0.6430.96
136_F139_F0.6400.96
88_H91_C0.6400.96
64_T67_A0.6370.96
40_V45_A0.6340.96
36_M73_L0.6270.95
44_E50_P0.6250.95
144_A174_V0.6250.95
43_E48_I0.6230.95
145_N148_D0.6230.95
8_E29_R0.6220.95
32_I42_V0.6210.95
59_A92_G0.6190.95
34_T42_V0.6180.95
108_K114_E0.6140.95
15_D18_L0.6130.95
27_D79_G0.6110.95
42_V50_P0.6100.95
8_E11_K0.6070.95
159_K165_P0.6060.94
31_W74_T0.6040.94
58_N67_A0.6020.94
61_G154_N0.5990.94
54_H73_L0.5930.94
111_K117_I0.5910.94
135_W141_D0.5900.94
102_A105_F0.5900.94
73_L78_F0.5890.94
22_K50_P0.5880.94
116_Q153_K0.5870.93
10_I182_L0.5870.93
62_I150_I0.5860.93
107_D111_K0.5830.93
131_D134_K0.5800.93
136_F141_D0.5750.93
83_I164_I0.5740.93
49_R52_D0.5730.93
156_E160_N0.5660.92
31_W56_Y0.5640.92
118_D133_T0.5640.92
94_I97_T0.5600.92
23_G27_D0.5570.92
94_I146_S0.5550.91
159_K162_P0.5550.91
36_M59_A0.5510.91
7_D14_E0.5500.91
72_S180_H0.5490.91
34_T55_I0.5490.91
74_T83_I0.5480.91
106_L116_Q0.5480.91
133_T136_F0.5420.90
108_K167_N0.5410.90
144_A176_E0.5410.90
30_L81_K0.5390.90
30_L82_E0.5360.90
9_E30_L0.5330.90
89_T178_E0.5290.89
112_V117_I0.5290.89
26_N96_F0.5190.89
100_E114_E0.5150.88
17_S179_T0.5140.88
100_E104_Y0.5140.88
59_A69_R0.5120.88
74_T78_F0.5110.88
102_A106_L0.5070.87
173_Y185_P0.5060.87
46_L182_L0.5050.87
106_L111_K0.5050.87
135_W139_F0.5020.87
17_S32_I0.5000.87
32_I154_N0.5000.87
106_L115_L0.5000.87
54_H80_T0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3teoA 7 0.9902 100 0.142 Contact Map
1ddzA 2 0.9559 100 0.162 Contact Map
3qy1A 4 0.9363 100 0.166 Contact Map
4rxyA 4 0.9363 100 0.167 Contact Map
3e3iA 6 0.9314 100 0.167 Contact Map
4o1kA 4 0.9412 100 0.175 Contact Map
3ucjA 4 0.9265 100 0.178 Contact Map
2w3qA 2 0.8578 100 0.186 Contact Map
3vqjA 3 0.902 100 0.187 Contact Map
4o1jA 4 0.8775 100 0.187 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0073 seconds.