GREMLIN Database
Q97YU1 - Second ORF in transposon ISC1904
UniProt: Q97YU1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (346)
Sequences: 4406 (2820)
Seq/√Len: 151.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_D268_K5.4511.00
288_D291_G4.4221.00
340_P367_N4.2121.00
320_A327_V3.6681.00
206_L312_I3.0441.00
283_A376_M3.0201.00
284_V316_L2.9561.00
313_H329_E2.9351.00
347_R350_G2.9121.00
19_F322_L2.9011.00
311_S315_V2.8051.00
271_N275_D2.7271.00
337_R346_S2.4521.00
311_S314_R2.3941.00
338_S345_V2.3921.00
173_P182_L2.3871.00
317_K329_E2.3871.00
312_I316_L2.3641.00
226_K302_R2.3391.00
334_L337_R2.3291.00
274_L320_A2.2851.00
330_V372_I2.2731.00
293_F305_S2.1361.00
282_F320_A2.1281.00
267_H315_V2.0891.00
225_L261_R2.0821.00
335_T372_I2.0681.00
171_G187_K2.0651.00
375_K378_G2.0641.00
267_H318_Y2.0621.00
284_V327_V2.0421.00
354_E361_K2.0321.00
232_K247_G2.0301.00
49_L97_I2.0141.00
28_R31_S2.0101.00
206_L265_F2.0101.00
54_K120_K2.0051.00
297_N301_S1.9901.00
342_C358_C1.9781.00
270_V315_V1.9371.00
36_K180_V1.8981.00
51_S56_Q1.8931.00
247_G251_M1.8701.00
351_K364_R1.8511.00
341_R360_F1.8501.00
298_E301_S1.8431.00
263_L311_S1.8351.00
266_V315_V1.8311.00
339_C342_C1.8291.00
267_H319_K1.8131.00
339_C358_C1.8071.00
37_E87_H1.8051.00
342_C355_C1.8041.00
317_K321_P1.7951.00
355_C358_C1.7661.00
50_W100_A1.7431.00
353_F362_L1.7341.00
267_H270_V1.7071.00
242_K245_K1.6881.00
284_V329_E1.6621.00
44_K84_K1.6551.00
20_T183_P1.6451.00
199_I207_D1.6371.00
339_C355_C1.6301.00
35_I180_V1.6181.00
266_V311_S1.6161.00
232_K235_K1.6111.00
346_S350_G1.6011.00
284_V313_H1.5991.00
286_K329_E1.5531.00
33_E37_E1.5481.00
39_R180_V1.5431.00
245_K248_R1.5241.00
270_V318_Y1.5061.00
278_P325_S1.5021.00
208_A366_L1.4701.00
196_F373_Y1.4701.00
106_S118_I1.4671.00
177_E256_H1.4551.00
353_F360_F1.4491.00
344_F356_E1.4381.00
101_F105_K1.4281.00
348_K351_K1.4051.00
352_T361_K1.3931.00
205_T208_A1.3891.00
236_V248_R1.3871.00
285_E332_P1.3791.00
49_L100_A1.3621.00
270_V319_K1.3611.00
179_K256_H1.3611.00
32_K36_K1.3561.00
110_R118_I1.3521.00
111_A118_I1.3411.00
317_K327_V1.3371.00
197_L209_Y1.3371.00
145_T151_Y1.3271.00
66_I69_P1.3081.00
370_L374_L1.3061.00
105_K109_K1.2961.00
209_Y213_K1.2941.00
91_H131_K1.2701.00
256_H260_N1.2701.00
304_I309_W1.2691.00
217_I220_K1.2611.00
347_R351_K1.2521.00
54_K59_K1.2311.00
232_K254_Y1.2301.00
272_A276_L1.2241.00
79_R93_V1.2241.00
196_F281_F1.2221.00
197_L277_Y1.2191.00
288_D332_P1.2171.00
42_L96_A1.2111.00
229_M255_S1.2091.00
24_K179_K1.2061.00
270_V312_I1.1931.00
104_L120_K1.1771.00
229_M251_M1.1721.00
95_K98_N1.1671.00
201_S309_W1.1621.00
91_H133_T1.1601.00
315_V318_Y1.1591.00
274_L323_Y1.1551.00
29_E32_K1.1551.00
99_D129_R1.1461.00
156_W159_S1.1461.00
139_G142_V1.1451.00
75_Y78_L1.1421.00
225_L258_E1.1371.00
214_F363_D1.1341.00
73_E76_K1.1321.00
266_V312_I1.1311.00
102_S106_S1.1301.00
340_P370_L1.1190.99
366_L370_L1.1170.99
144_I182_L1.1130.99
27_E31_S1.1080.99
340_P362_L1.1040.99
106_S111_A1.1030.99
347_R364_R1.0990.99
330_V375_K1.0900.99
138_V141_S1.0890.99
199_I209_Y1.0830.99
74_V78_L1.0800.99
271_N323_Y1.0790.99
263_L315_V1.0790.99
335_T375_K1.0780.99
203_L307_T1.0650.99
259_R263_L1.0610.99
228_S232_K1.0550.99
198_A373_Y1.0540.99
89_A92_Y1.0500.99
319_K322_L1.0490.99
128_V132_T1.0490.99
236_V251_M1.0480.99
110_R119_E1.0470.99
346_S353_F1.0460.99
128_V131_K1.0420.99
362_L370_L1.0410.99
21_Y186_Y1.0350.99
46_I96_A1.0320.99
348_K364_R1.0320.99
274_L325_S1.0260.99
337_R345_V1.0240.99
338_S375_K1.0220.99
283_A372_I1.0200.99
213_K272_A1.0200.99
27_E35_I1.0140.99
136_K139_G1.0120.99
270_V316_L1.0090.99
56_Q60_K1.0000.99
106_S110_R0.9970.99
362_L366_L0.9960.99
286_K332_P0.9940.99
233_R251_M0.9940.99
274_L282_F0.9940.99
107_W120_K0.9870.99
266_V270_V0.9870.99
77_P81_E0.9830.99
275_D323_Y0.9800.99
44_K48_Y0.9780.99
54_K104_L0.9780.99
233_R237_Q0.9710.99
351_K363_D0.9700.99
340_P360_F0.9700.99
58_R62_G0.9690.99
201_S313_H0.9660.98
40_T43_Q0.9660.98
314_R317_K0.9640.98
196_F377_C0.9610.98
281_F326_F0.9610.98
332_P335_T0.9560.98
289_K310_R0.9550.98
232_K251_M0.9550.98
229_M258_E0.9390.98
232_K250_L0.9330.98
46_I103_I0.9300.98
196_F283_A0.9290.98
366_L369_S0.9240.98
330_V376_M0.9220.98
346_S364_R0.9190.98
197_L210_D0.9180.98
91_H95_K0.9170.98
41_L84_K0.9160.98
50_W104_L0.9140.98
208_A214_F0.9140.98
46_I100_A0.9110.98
72_K76_K0.9110.98
240_A244_T0.9070.98
107_W121_P0.9070.98
18_H185_R0.8990.98
368_A371_N0.8980.98
344_F357_R0.8970.98
106_S109_K0.8930.97
52_L74_V0.8930.97
129_R172_E0.8910.97
250_L253_K0.8870.97
99_D174_I0.8870.97
32_K180_V0.8860.97
244_T248_R0.8860.97
293_F297_N0.8830.97
281_F328_K0.8820.97
266_V308_V0.8810.97
154_F157_S0.8810.97
297_N300_L0.8780.97
273_L282_F0.8770.97
85_I93_V0.8720.97
134_L137_V0.8710.97
350_G364_R0.8700.97
205_T216_T0.8640.97
53_T101_F0.8640.97
230_E233_R0.8610.97
367_N371_N0.8600.97
91_H132_T0.8590.97
352_T362_L0.8580.97
68_L72_K0.8570.97
257_R261_R0.8570.97
341_R370_L0.8510.97
221_Q261_R0.8480.97
193_P278_P0.8430.96
340_P368_A0.8430.96
215_V265_F0.8430.96
67_T98_N0.8420.96
320_A325_S0.8400.96
207_D269_F0.8390.96
293_F301_S0.8380.96
57_V61_N0.8370.96
18_H187_K0.8360.96
95_K129_R0.8300.96
94_D98_N0.8290.96
233_R255_S0.8290.96
236_V244_T0.8260.96
334_L375_K0.8250.96
203_L303_K0.8250.96
265_F269_F0.8230.96
221_Q225_L0.8210.96
72_K97_I0.8210.96
52_L56_Q0.8200.96
271_N319_K0.8120.96
236_V247_G0.8100.96
338_S371_N0.8060.95
144_I173_P0.8050.95
291_G332_P0.8010.95
142_V145_T0.7990.95
231_V235_K0.7960.95
45_A96_A0.7950.95
340_P374_L0.7920.95
241_S244_T0.7920.95
136_K145_T0.7860.95
344_F353_F0.7850.95
95_K99_D0.7840.95
291_G304_I0.7830.95
248_R252_R0.7820.95
254_Y258_E0.7810.95
205_T214_F0.7800.95
48_Y52_L0.7790.94
75_Y79_R0.7770.94
72_K75_Y0.7750.94
229_M237_Q0.7740.94
145_T148_P0.7730.94
269_F272_A0.7720.94
289_K309_W0.7710.94
41_L88_L0.7700.94
143_R151_Y0.7680.94
76_K79_R0.7650.94
69_P73_E0.7640.94
375_K379_F0.7620.94
174_I183_P0.7560.94
23_I165_V0.7550.94
197_L282_F0.7540.93
204_Y208_A0.7530.93
53_T104_L0.7520.93
63_N66_I0.7510.93
298_E305_S0.7460.93
273_L277_Y0.7460.93
258_E306_R0.7460.93
24_K181_Y0.7460.93
287_L332_P0.7450.93
376_M380_P0.7450.93
201_S207_D0.7440.93
88_L91_H0.7420.93
230_E234_A0.7400.93
95_K131_K0.7400.93
76_K80_E0.7360.93
100_A104_L0.7350.93
225_L257_R0.7340.93
134_L147_R0.7330.92
235_K247_G0.7320.92
23_I158_K0.7290.92
334_L338_S0.7290.92
370_L373_Y0.7290.92
97_I101_F0.7280.92
34_L38_Y0.7280.92
23_I182_L0.7260.92
58_R104_L0.7260.92
172_E185_R0.7250.92
41_L44_K0.7220.92
206_L270_V0.7180.92
353_F364_R0.7170.92
310_R314_R0.7150.92
38_Y130_I0.7150.92
200_D365_Q0.7150.92
44_K82_L0.7140.91
38_Y42_L0.7110.91
229_M233_R0.7090.91
40_T44_K0.7090.91
29_E33_E0.7070.91
286_K313_H0.7050.91
104_L107_W0.7030.91
71_K74_V0.6990.91
25_N182_L0.6990.91
328_K376_M0.6980.91
192_T195_N0.6980.91
41_L85_I0.6960.90
91_H94_D0.6950.90
214_F366_L0.6940.90
230_E237_Q0.6940.90
37_E41_L0.6930.90
350_G353_F0.6930.90
77_P80_E0.6920.90
243_H246_R0.6920.90
334_L345_V0.6900.90
374_L379_F0.6890.90
195_N211_G0.6880.90
146_V175_I0.6850.90
300_L304_I0.6820.90
35_I39_R0.6790.89
283_A373_Y0.6780.89
175_I182_L0.6770.89
282_F316_L0.6770.89
146_V149_H0.6740.89
135_R170_L0.6720.89
104_L108_R0.6690.89
262_V306_R0.6680.89
129_R132_T0.6650.88
356_E364_R0.6620.88
190_W193_P0.6610.88
316_L327_V0.6600.88
206_L307_T0.6600.88
202_N208_A0.6580.88
169_E187_K0.6580.88
217_I307_T0.6570.88
283_A328_K0.6570.88
190_W325_S0.6560.88
154_F158_K0.6540.88
91_H134_L0.6510.87
129_R174_I0.6510.87
237_Q251_M0.6490.87
275_D281_F0.6490.87
222_L225_L0.6490.87
90_S134_L0.6460.87
149_H152_I0.6440.87
30_K33_E0.6410.86
67_T71_K0.6400.86
61_N64_Y0.6400.86
293_F298_E0.6390.86
202_N205_T0.6380.86
26_S155_P0.6380.86
244_T251_M0.6370.86
59_K62_G0.6360.86
225_L254_Y0.6350.86
313_H317_K0.6330.86
75_Y80_E0.6270.85
245_K249_E0.6270.85
57_V62_G0.6270.85
73_E78_L0.6270.85
27_E32_K0.6220.85
209_Y215_V0.6220.85
207_D312_I0.6200.85
255_S262_V0.6170.84
39_R128_V0.6170.84
362_L367_N0.6170.84
97_I100_A0.6160.84
22_S183_P0.6150.84
92_Y128_V0.6140.84
289_K304_I0.6130.84
72_K78_L0.6120.84
372_I375_K0.6120.84
232_K236_V0.6110.84
320_A323_Y0.6090.84
289_K292_M0.6090.84
225_L229_M0.6080.83
51_S123_V0.6080.83
133_T136_K0.6050.83
20_T185_R0.6040.83
96_A100_A0.6030.83
346_S351_K0.6030.83
71_K75_Y0.6030.83
146_V152_I0.6020.83
255_S259_R0.6020.83
103_I121_P0.6010.83
38_Y89_A0.6000.83
318_Y322_L0.5990.83
109_K118_I0.5960.82
315_V319_K0.5960.82
93_V96_A0.5950.82
143_R146_V0.5940.82
269_F312_I0.5930.82
18_H171_G0.5930.82
294_V297_N0.5920.82
107_W110_R0.5920.82
234_A238_S0.5910.82
142_V146_V0.5900.82
223_Y226_K0.5880.81
223_Y303_K0.5880.81
48_Y78_L0.5880.81
215_V272_A0.5870.81
38_Y88_L0.5870.81
263_L267_H0.5840.81
374_L377_C0.5840.81
244_T247_G0.5810.81
206_L266_V0.5780.80
350_G356_E0.5760.80
338_S343_G0.5740.80
195_N277_Y0.5740.80
90_S131_K0.5730.80
71_K78_L0.5720.80
25_N154_F0.5710.79
76_K97_I0.5700.79
203_L293_F0.5690.79
17_V187_K0.5670.79
223_Y302_R0.5620.78
203_L294_V0.5620.78
348_K352_T0.5620.78
96_A99_D0.5620.78
90_S133_T0.5590.78
277_Y282_F0.5580.78
235_K238_S0.5560.78
233_R238_S0.5550.78
235_K250_L0.5550.78
52_L78_L0.5550.78
260_N264_D0.5550.78
79_R85_I0.5550.78
200_D336_S0.5510.77
58_R108_R0.5510.77
342_C345_V0.5500.77
363_D368_A0.5490.77
69_P72_K0.5490.77
49_L74_V0.5470.77
341_R362_L0.5470.77
260_N263_L0.5460.76
204_Y347_R0.5450.76
348_K363_D0.5440.76
331_N334_L0.5440.76
333_Y337_R0.5430.76
88_L93_V0.5420.76
48_Y84_K0.5420.76
57_V64_Y0.5390.76
201_S284_V0.5380.75
176_K179_K0.5380.75
221_Q306_R0.5380.75
92_Y130_I0.5380.75
266_V269_F0.5370.75
297_N304_I0.5370.75
58_R64_Y0.5360.75
152_I156_W0.5360.75
283_A375_K0.5350.75
198_A283_A0.5350.75
204_Y351_K0.5340.75
67_T97_I0.5340.75
39_R42_L0.5330.75
52_L57_V0.5320.75
300_L303_K0.5320.75
98_N131_K0.5290.74
338_S353_F0.5290.74
274_L327_V0.5280.74
181_Y256_H0.5280.74
71_K98_N0.5280.74
337_R347_R0.5260.74
179_K260_N0.5250.74
219_L307_T0.5220.73
21_Y158_K0.5220.73
268_K271_N0.5210.73
210_D366_L0.5190.73
65_K70_K0.5190.73
198_A369_S0.5190.73
283_A377_C0.5160.72
291_G294_V0.5160.72
71_K94_D0.5150.72
42_L128_V0.5150.72
41_L93_V0.5140.72
334_L353_F0.5140.72
56_Q59_K0.5130.72
354_E360_F0.5110.72
75_Y94_D0.5100.71
271_N274_L0.5100.71
54_K58_R0.5090.71
332_P375_K0.5080.71
343_G371_N0.5060.71
58_R61_N0.5060.71
336_S346_S0.5060.71
290_E310_R0.5050.71
130_I146_V0.5030.70
271_N315_V0.5020.70
127_Y131_K0.5020.70
127_Y130_I0.5020.70
210_D216_T0.5010.70
135_R173_P0.5010.70
228_S254_Y0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3081 94.8 0.933 Contact Map
1vhxA 2 0.3246 94 0.935 Contact Map
1iv0A 1 0.2299 90.5 0.942 Contact Map
1qypA 1 0.1019 85.6 0.947 Contact Map
2k4xA 1 0.1256 85.1 0.947 Contact Map
3j20Y 1 0.1137 82.3 0.949 Contact Map
4aybP 1 0.0948 81.5 0.949 Contact Map
1ffkW 1 0.1659 78.9 0.951 Contact Map
1twfI 1 0.1991 72.6 0.953 Contact Map
3h0gI 1 0.1801 69.1 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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