GREMLIN Database
Q97YU0 - First ORF in transposon ISC1904
UniProt: Q97YU0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 195 (184)
Sequences: 474 (332)
Seq/√Len: 24.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_V117_R4.1851.00
60_A78_L4.0571.00
82_V119_V3.5021.00
117_R144_E3.4221.00
58_L148_L2.7220.99
7_A11_L2.6780.99
110_I138_C2.6270.99
13_I21_Y2.5530.99
103_F126_L2.5210.99
91_D102_G2.4930.99
17_T21_Y2.4010.98
85_Y146_V2.3010.98
5_K9_Q2.2630.97
135_E139_K2.2450.97
111_L141_H2.2040.97
16_A19_R2.0860.96
106_L115_V2.0820.96
18_L39_F2.0500.95
2_L7_A2.0410.95
75_V88_V1.9900.94
119_V132_E1.9650.94
22_V37_Q1.9170.93
58_L78_L1.8860.93
98_M132_E1.8200.91
96_L129_V1.7990.91
110_I115_V1.7820.90
75_V90_T1.7750.90
55_K109_M1.7010.88
77_Y121_A1.6820.88
58_L88_V1.6140.85
110_I118_V1.5940.84
27_I30_V1.5930.84
89_I102_G1.5660.83
127_V131_F1.5600.83
98_M167_S1.5590.83
131_F145_I1.5570.83
3_R34_S1.5540.83
131_F147_V1.5410.82
22_V29_P1.5020.81
4_P19_R1.4970.80
109_M114_E1.4890.80
138_C143_C1.4490.78
16_A24_K1.4450.78
166_V177_S1.4450.78
12_G142_N1.4280.77
40_G43_D1.4010.76
110_I120_V1.3890.75
17_T20_E1.3730.74
57_I75_V1.3650.74
155_E159_E1.3650.74
56_V144_E1.3630.74
70_E73_N1.3530.73
8_C13_I1.3520.73
122_Y159_E1.3310.72
72_V76_K1.3310.72
119_V146_V1.3310.72
4_P18_L1.3060.70
14_S20_E1.3000.70
96_L130_G1.2960.70
26_Y33_Q1.2780.69
167_S170_G1.2730.68
22_V27_I1.2510.67
7_A44_V1.2470.67
31_I37_Q1.2430.67
121_A178_H1.2260.65
107_L111_L1.2130.65
76_K79_E1.1920.63
7_A27_I1.1790.62
91_D167_S1.1620.61
2_L38_R1.1610.61
183_V186_C1.1440.60
22_V39_F1.1390.60
64_S67_Q1.1380.60
138_C172_L1.1340.59
62_V67_Q1.1210.58
56_V119_V1.1190.58
166_V170_G1.1020.57
8_C15_Y1.0960.57
67_Q70_E1.0950.57
15_Y19_R1.0910.56
56_V93_G1.0800.55
3_R38_R1.0760.55
89_I118_V1.0720.55
50_I114_E1.0680.55
170_G175_M1.0660.54
54_R142_N1.0630.54
20_E23_K1.0540.54
58_L82_V1.0520.53
78_L148_L1.0510.53
164_A174_G1.0500.53
89_I106_L1.0490.53
95_G126_L1.0360.52
173_Y176_R1.0250.52
62_V71_L1.0180.51
57_I89_I1.0060.50
131_F134_L0.9990.50
28_K43_D0.9930.49
27_I134_L0.9930.49
8_C18_L0.9860.49
68_K179_E0.9860.49
43_D46_R0.9710.48
81_Q146_V0.9710.48
14_S172_L0.9640.47
13_I20_E0.9620.47
82_V85_Y0.9470.46
138_C169_S0.9440.46
170_G177_S0.9350.45
75_V107_L0.9340.45
127_V134_L0.9280.45
161_L165_L0.9270.45
117_R146_V0.9260.44
134_L138_C0.9250.44
171_K175_M0.9140.44
11_L18_L0.9110.43
19_R31_I0.9080.43
129_V160_D0.9060.43
3_R33_Q0.9010.43
158_V161_L0.9010.43
27_I43_D0.8940.42
44_V118_V0.8930.42
91_D121_A0.8840.42
19_R39_F0.8830.41
67_Q73_N0.8780.41
159_E170_G0.8770.41
156_E168_F0.8580.40
42_E73_N0.8540.39
26_Y34_S0.8540.39
8_C171_K0.8480.39
18_L22_V0.8420.39
4_P29_P0.8380.38
22_V31_I0.8310.38
39_F43_D0.8230.37
110_I143_C0.8170.37
98_M127_V0.8110.37
73_N162_M0.8070.36
7_A18_L0.8030.36
19_R22_V0.7980.36
4_P15_Y0.7970.36
157_L166_V0.7920.35
23_K31_I0.7920.35
153_K175_M0.7790.34
97_N141_H0.7740.34
5_K34_S0.7740.34
79_E88_V0.7730.34
84_E119_V0.7730.34
4_P7_A0.7690.34
93_G163_S0.7680.34
81_Q85_Y0.7640.33
77_Y149_N0.7620.33
64_S73_N0.7610.33
7_A38_R0.7600.33
120_V147_V0.7590.33
63_S67_Q0.7570.33
101_K154_E0.7510.33
155_E158_V0.7510.33
129_V164_A0.7470.32
6_E146_V0.7380.32
166_V178_H0.7370.32
118_V183_V0.7230.31
2_L11_L0.7210.31
161_L174_G0.7200.31
57_I106_L0.7190.31
54_R143_C0.7170.31
72_V75_V0.7100.30
95_G103_F0.7090.30
87_L100_R0.7020.30
33_Q113_N0.6920.29
107_L146_V0.6890.29
24_K52_R0.6860.29
108_R140_A0.6860.29
96_L133_I0.6760.28
78_L143_C0.6740.28
120_V160_D0.6740.28
6_E43_D0.6720.28
55_K116_S0.6660.28
111_L137_V0.6640.27
30_V38_R0.6610.27
100_R127_V0.6600.27
81_Q149_N0.6570.27
9_Q68_K0.6550.27
130_G169_S0.6540.27
63_S128_R0.6530.27
19_R36_K0.6510.27
103_F167_S0.6500.27
92_I145_I0.6460.26
177_S183_V0.6460.26
23_K101_K0.6440.26
103_F116_S0.6410.26
70_E121_A0.6410.26
139_K171_K0.6390.26
104_L134_L0.6380.26
19_R37_Q0.6370.26
134_L157_L0.6290.25
50_I116_S0.6240.25
6_E57_I0.6230.25
161_L164_A0.6210.25
120_V145_I0.6200.25
57_I115_V0.6170.25
4_P8_C0.6160.25
13_I16_A0.6130.25
121_A166_V0.6120.25
160_D174_G0.6120.25
57_I150_Q0.6080.24
6_E157_L0.6070.24
15_Y37_Q0.6050.24
103_F127_V0.6030.24
160_D164_A0.6010.24
14_S22_V0.5990.24
148_L154_E0.5960.24
77_Y163_S0.5960.24
85_Y96_L0.5940.24
86_D119_V0.5930.24
76_K80_E0.5900.23
2_L22_V0.5890.23
85_Y148_L0.5890.23
118_V145_I0.5880.23
115_V143_C0.5860.23
129_V174_G0.5830.23
8_C103_F0.5820.23
12_G129_V0.5800.23
3_R36_K0.5780.23
10_R90_T0.5770.23
44_V48_M0.5680.22
64_S174_G0.5670.22
30_V43_D0.5660.22
147_V165_L0.5620.22
118_V171_K0.5610.22
54_R112_N0.5600.22
73_N76_K0.5590.22
110_I147_V0.5590.22
165_L169_S0.5590.22
107_L118_V0.5580.22
16_A20_E0.5570.22
29_P175_M0.5570.22
5_K8_C0.5570.22
98_M103_F0.5540.22
99_K162_M0.5530.22
26_Y165_L0.5520.22
91_D145_I0.5490.21
8_C12_G0.5470.21
130_G146_V0.5460.21
81_Q148_L0.5460.21
51_I106_L0.5440.21
137_V140_A0.5430.21
34_S113_N0.5430.21
13_I31_I0.5410.21
58_L149_N0.5370.21
64_S120_V0.5340.21
21_Y38_R0.5340.21
119_V134_L0.5330.21
97_N106_L0.5290.20
2_L13_I0.5290.20
32_L41_E0.5270.20
99_K141_H0.5270.20
28_K47_L0.5250.20
120_V143_C0.5240.20
127_V163_S0.5220.20
119_V136_E0.5210.20
56_V116_S0.5210.20
96_L156_E0.5180.20
169_S175_M0.5170.20
21_Y157_L0.5160.20
157_L160_D0.5150.20
70_E132_E0.5150.20
126_L133_I0.5140.20
118_V126_L0.5140.20
157_L168_F0.5130.20
118_V147_V0.5110.20
119_V181_E0.5060.19
92_I100_R0.5060.19
181_E185_K0.5040.19
66_T166_V0.5030.19
124_D128_R0.5020.19
177_S180_Y0.5020.19
5_K19_R0.5010.19
77_Y178_H0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ilxA 2 0.7077 100 0.652 Contact Map
3lhkA 2 0.7231 99.9 0.662 Contact Map
3g13A 2 0.7179 99.8 0.74 Contact Map
3bvpA 4 0.6154 99.8 0.746 Contact Map
4bqqA 2 0.7026 99.8 0.749 Contact Map
3guvA 2 0.6769 99.8 0.75 Contact Map
2mhcA 1 0.5538 99.8 0.752 Contact Map
2gm5A 4 0.6051 99.8 0.759 Contact Map
1gdtA 2 0.6923 99.7 0.765 Contact Map
3pkzA 4 0.5744 99.7 0.766 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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