Q97YT9 - SULSO - GREMLIN Contacts

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Q97YT9 - Methylmalonate-semialdehyde dehydrogenase

UniProt:	Q97YT9	Sequences: MGKVLGEVKKDYGKLKLYINGEFIDSKTDTIGKAYNPAKDEIIAEVPFSAKDEVEEAIQSAQEAFEKWREVPITTRIQYLFALKNRLEEYSETIARIIVQNHGKTIQEARGDMRRTIENVEAAISAAYTLYKGEHLDQVSQEVDETVVREPLGVFGIITPFNFPTMVPFWFLPYAIVLGNTVVVKPSEITPVPMDFIIRIFDEIKLPRGVVNVVHGAKDVVDEFLTNKLVQGVTFVGSTRVGKYIYENAGKNGKKAIVQAGAKNFVVVMPDADLNKAIPSIVSAFFGNAGQRCLAAANLVAVGNIYDEVKRKFIEASKQLKIGYGLDESVDMGPVVTKDAKKRIIGYIEKGIEEGAKLLLDGRDVKVPEYPNGYFLGPTVFDEVTPEMVIAKEEIFGPVASIIHVKNLDEAINIINRSNYGNASSIFTTSGYYARKFRREVNTGNIGINIGVAAPMAFFPFGGRKESFFGILHGQIDSVDFFTDKKVVITRW	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	492 (452)
Sequences:	36516 (21740)
Seq/√Len:	1022.6

ECOLI - PUUC GABD BETB ALDB FEAB ABDH ALDA ASTD EUTE SAD PUTA PAAZ PROA
BACSU - ROCA2 ROCA ALDH4 ALDH1 ALDH5 IOLA ALDY BETB GABD ALDH3 ALDH2 PROA
HALSA - Q9HQZ2 Q9HMJ6 Q9HRB5 Q9HR91
SULSO - Q97YT9 GAPN KGSDH Q97XS9 Q97XA5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
303_G	406_K	4.869	1.00
247_E	251_K	3.949	1.00
303_G	404_H	3.120	1.00
275_N	312_K	3.082	1.00
306_Y	404_H	2.916	1.00
33_K	45_E	2.859	1.00
62_Q	229_L	2.784	1.00
363_R	377_G	2.770	1.00
270_P	302_V	2.691	1.00
350_K	389_V	2.620	1.00
338_K	342_K	2.602	1.00
279_P	316_A	2.583	1.00
385_T	388_M	2.577	1.00
196_F	199_R	2.553	1.00
349_E	353_E	2.495	1.00
270_P	304_N	2.471	1.00
310_K	402_I	2.445	1.00
33_K	42_I	2.404	1.00
90_Y	93_T	2.401	1.00
428_T	434_A	2.343	1.00
88_E	121_E	2.317	1.00
202_D	208_R	2.227	1.00
62_Q	231_Q	2.192	1.00
50_A	53_E	2.177	1.00
345_I	349_E	2.170	1.00
91_S	114_R	2.161	1.00
86_R	203_E	2.137	1.00
348_I	376_L	2.129	1.00
83_L	201_F	2.128	1.00
419_N	466_E	2.076	1.00
408_L	433_Y	2.068	1.00
226_T	248_N	2.049	1.00
222_D	226_T	2.017	1.00
350_K	354_E	1.997	1.00
189_I	337_T	1.987	1.00
357_K	383_E	1.981	1.00
345_I	364_D	1.962	1.00
150_E	486_K	1.962	1.00
93_T	196_F	1.934	1.00
436_K	440_E	1.923	1.00
359_L	382_D	1.921	1.00
266_V	281_I	1.919	1.00
345_I	376_L	1.914	1.00
314_I	318_K	1.914	1.00
308_E	312_K	1.908	1.00
149_R	480_D	1.898	1.00
55_E	223_E	1.886	1.00
335_V	344_I	1.871	1.00
244_Y	247_E	1.845	1.00
243_K	466_E	1.838	1.00
59_Q	229_L	1.833	1.00
79_Y	206_L	1.824	1.00
90_Y	203_E	1.794	1.00
352_I	358_L	1.793	1.00
86_R	89_E	1.792	1.00
271_D	433_Y	1.762	1.00
391_A	403_I	1.752	1.00
300_V	414_I	1.740	1.00
92_E	110_R	1.732	1.00
442_N	465_K	1.726	1.00
42_I	45_E	1.724	1.00
86_R	204_I	1.723	1.00
55_E	59_Q	1.691	1.00
149_R	483_T	1.664	1.00
408_L	436_K	1.658	1.00
357_K	382_D	1.655	1.00
97_I	196_F	1.649	1.00
81_F	121_E	1.639	1.00
314_I	359_L	1.627	1.00
198_I	213_V	1.625	1.00
386_P	414_I	1.624	1.00
302_V	405_V	1.609	1.00
317_S	380_V	1.601	1.00
410_E	413_N	1.599	1.00
406_K	410_E	1.595	1.00
86_R	200_I	1.593	1.00
381_F	390_I	1.583	1.00
88_E	117_I	1.579	1.00
120_V	173_P	1.578	1.00
72_P	75_T	1.572	1.00
311_R	315_E	1.571	1.00
312_K	315_E	1.560	1.00
281_I	309_V	1.551	1.00
286_F	317_S	1.549	1.00
346_G	389_V	1.537	1.00
306_Y	310_K	1.534	1.00
31_I	45_E	1.530	1.00
82_A	85_N	1.529	1.00
300_V	411_A	1.527	1.00
338_K	374_Y	1.527	1.00
55_E	227_N	1.525	1.00
85_N	89_E	1.520	1.00
389_V	393_E	1.515	1.00
134_E	475_Q	1.515	1.00
65_F	69_R	1.508	1.00
274_L	312_K	1.502	1.00
278_I	312_K	1.499	1.00
181_T	210_V	1.496	1.00
75_T	78_Q	1.470	1.00
269_M	433_Y	1.466	1.00
70_E	440_E	1.460	1.00
71_V	75_T	1.441	1.00
199_R	203_E	1.433	1.00
307_D	404_H	1.428	1.00
299_L	400_A	1.424	1.00
96_R	100_Q	1.424	1.00
316_A	319_Q	1.416	1.00
410_E	414_I	1.415	1.00
300_V	405_V	1.415	1.00
280_S	427_F	1.410	1.00
349_E	352_I	1.410	1.00
306_Y	382_D	1.405	1.00
281_I	299_L	1.405	1.00
40_D	372_N	1.403	1.00
358_L	381_F	1.403	1.00
81_F	128_Y	1.402	1.00
35_Y	42_I	1.402	1.00
92_E	96_R	1.395	1.00
321_K	329_S	1.394	1.00
308_E	311_R	1.390	1.00
84_K	121_E	1.388	1.00
90_Y	196_F	1.380	1.00
120_V	169_F	1.380	1.00
148_V	439_R	1.379	1.00
126_A	129_T	1.377	1.00
409_D	440_E	1.366	1.00
424_S	443_T	1.365	1.00
222_D	248_N	1.364	1.00
301_A	309_V	1.363	1.00
30_T	48_F	1.357	1.00
53_E	56_E	1.344	1.00
270_P	433_Y	1.342	1.00
344_I	397_G	1.341	1.00
341_K	345_I	1.339	1.00
157_I	182_V	1.337	1.00
96_R	326_L	1.336	1.00
85_N	121_E	1.322	1.00
246_Y	469_F	1.319	1.00
341_K	364_D	1.314	1.00
342_K	346_G	1.308	1.00
232_G	257_I	1.305	1.00
41_E	372_N	1.303	1.00
347_Y	395_I	1.291	1.00
307_D	311_R	1.284	1.00
354_E	389_V	1.281	1.00
310_K	314_I	1.276	1.00
51_K	223_E	1.275	1.00
226_T	251_K	1.271	1.00
338_K	341_K	1.266	1.00
405_V	414_I	1.264	1.00
198_I	211_V	1.261	1.00
36_N	39_K	1.259	1.00
168_P	184_V	1.258	1.00
341_K	376_L	1.257	1.00
269_M	437_F	1.255	1.00
269_M	405_V	1.253	1.00
315_E	318_K	1.249	1.00
99_V	109_A	1.247	1.00
318_K	360_L	1.245	1.00
321_K	331_D	1.243	1.00
106_I	110_R	1.238	1.00
65_F	181_T	1.238	1.00
267_V	411_A	1.238	1.00
84_K	88_E	1.234	1.00
475_Q	480_D	1.230	1.00
48_F	217_A	1.216	1.00
305_I	308_E	1.212	1.00
302_V	407_N	1.210	1.00
58_I	227_N	1.207	1.00
222_D	244_Y	1.203	1.00
59_Q	63_E	1.202	1.00
412_I	437_F	1.201	1.00
302_V	305_I	1.200	1.00
312_K	316_A	1.199	1.00
346_G	350_K	1.199	1.00
407_N	410_E	1.197	1.00
54_V	220_V	1.195	1.00
146_T	435_R	1.194	1.00
149_R	485_K	1.191	1.00
323_G	330_V	1.189	1.00
387_E	392_K	1.181	1.00
96_R	106_I	1.180	1.00
455_P	458_F	1.170	1.00
71_V	79_Y	1.169	1.00
438_R	488_V	1.157	1.00
315_E	319_Q	1.150	1.00
386_P	417_R	1.147	1.00
94_I	196_F	1.146	1.00
188_E	217_A	1.139	1.00
310_K	382_D	1.138	1.00
244_Y	248_N	1.137	1.00
313_F	400_A	1.136	1.00
201_F	211_V	1.135	1.00
58_I	229_L	1.132	1.00
424_S	446_I	1.125	1.00
58_I	230_V	1.122	1.00
152_L	232_G	1.120	1.00
32_G	48_F	1.118	1.00
195_D	215_H	1.117	1.00
309_V	313_F	1.112	1.00
409_D	436_K	1.110	1.00
99_V	325_G	1.108	1.00
209_G	212_N	1.105	1.00
82_A	86_R	1.105	1.00
240_R	244_Y	1.103	1.00
434_A	448_I	1.103	1.00
310_K	359_L	1.099	1.00
241_V	244_Y	1.096	1.00
91_S	110_R	1.091	1.00
392_K	419_N	1.088	1.00
188_E	218_K	1.085	1.00
409_D	413_N	1.079	1.00
60_S	212_N	1.078	1.00
266_V	296_A	1.077	1.00
172_L	211_V	1.076	1.00
81_F	125_S	1.076	1.00
83_L	200_I	1.074	1.00
354_E	388_M	1.072	1.00
156_G	224_F	1.063	1.00
44_A	192_V	1.059	1.00
408_L	437_F	1.054	1.00
246_Y	256_A	1.053	1.00
267_V	437_F	1.052	1.00
83_L	206_L	1.051	1.00
314_I	360_L	1.048	1.00
36_N	324_Y	1.044	1.00
392_K	417_R	1.043	1.00
412_I	440_E	1.043	1.00
356_A	381_F	1.041	1.00
318_K	377_G	1.041	1.00
157_I	234_T	1.039	1.00
48_F	219_D	1.038	1.00
351_G	381_F	1.038	1.00
172_L	182_V	1.034	1.00
156_G	230_V	1.029	1.00
27_K	56_E	1.025	1.00
77_I	128_Y	1.017	1.00
83_L	120_V	1.016	1.00
341_K	374_Y	1.015	1.00
40_D	374_Y	1.013	1.00
223_E	227_N	1.011	1.00
116_T	169_F	1.006	1.00
430_S	433_Y	1.004	1.00
405_V	411_A	1.000	1.00
62_Q	66_E	0.997	1.00
64_A	181_T	0.994	1.00
94_I	200_I	0.991	1.00
350_K	353_E	0.989	1.00
320_L	332_M	0.986	1.00
273_D	276_K	0.985	1.00
38_A	325_G	0.984	1.00
154_V	181_T	0.984	1.00
276_K	280_S	0.981	1.00
127_A	177_V	0.980	1.00
267_V	415_I	0.980	1.00
273_D	429_T	0.979	1.00
462_G	471_I	0.978	1.00
243_K	253_G	0.976	1.00
81_F	124_I	0.972	1.00
66_E	442_N	0.970	1.00
199_R	202_D	0.964	1.00
163_F	292_R	0.963	1.00
93_T	96_R	0.963	1.00
282_V	316_A	0.963	1.00
464_R	484_D	0.963	1.00
90_Y	200_I	0.962	1.00
66_E	413_N	0.962	1.00
471_I	484_D	0.961	1.00
90_Y	199_R	0.958	1.00
152_L	255_K	0.953	1.00
195_D	213_V	0.951	1.00
324_Y	327_D	0.948	1.00
148_V	488_V	0.947	1.00
51_K	55_E	0.946	1.00
86_R	90_Y	0.939	1.00
413_N	417_R	0.939	1.00
361_D	379_T	0.937	1.00
89_E	203_E	0.937	1.00
100_Q	326_L	0.933	1.00
263_K	297_A	0.929	1.00
425_S	451_G	0.926	1.00
246_Y	250_G	0.925	1.00
36_N	100_Q	0.924	1.00
384_V	388_M	0.922	1.00
346_G	349_E	0.920	1.00
284_A	296_A	0.920	1.00
150_E	439_R	0.919	1.00
344_I	399_V	0.919	1.00
275_N	308_E	0.916	1.00
155_F	232_G	0.915	1.00
361_D	377_G	0.914	1.00
77_I	81_F	0.908	1.00
243_K	247_E	0.907	1.00
347_Y	350_K	0.905	1.00
307_D	310_K	0.904	1.00
78_Q	82_A	0.903	1.00
274_L	278_I	0.900	1.00
265_F	424_S	0.899	1.00
69_R	442_N	0.897	1.00
116_T	165_T	0.895	1.00
231_Q	442_N	0.894	1.00
189_I	339_D	0.893	1.00
56_E	60_S	0.893	1.00
102_H	190_T	0.886	1.00
73_I	77_I	0.885	1.00
266_V	427_F	0.884	1.00
35_Y	374_Y	0.884	1.00
36_N	41_E	0.876	1.00
145_E	459_F	0.875	1.00
435_R	439_R	0.873	1.00
198_I	202_D	0.871	1.00
285_F	297_A	0.869	1.00
27_K	50_A	0.869	1.00
70_E	439_R	0.868	1.00
104_K	112_D	0.868	1.00
150_E	464_R	0.864	1.00
66_E	70_E	0.864	1.00
54_V	156_G	0.862	1.00
342_K	345_I	0.861	1.00
403_I	414_I	0.861	1.00
27_K	52_D	0.856	1.00
246_Y	249_A	0.855	1.00
306_Y	402_I	0.853	1.00
87_L	116_T	0.852	1.00
154_V	230_V	0.852	1.00
269_M	428_T	0.852	1.00
38_A	375_F	0.849	1.00
269_M	408_L	0.849	1.00
84_K	124_I	0.848	1.00
278_I	316_A	0.845	1.00
178_L	483_T	0.843	1.00
344_I	395_I	0.842	1.00
52_D	56_E	0.840	1.00
51_K	219_D	0.839	1.00
347_Y	389_V	0.837	1.00
356_A	388_M	0.837	1.00
216_G	220_V	0.836	1.00
459_F	487_V	0.836	1.00
278_I	313_F	0.835	1.00
195_D	199_R	0.832	1.00
64_A	210_V	0.832	1.00
52_D	55_E	0.831	1.00
255_K	484_D	0.829	1.00
32_G	217_A	0.828	1.00
424_S	441_V	0.827	1.00
77_I	124_I	0.827	1.00
60_S	209_G	0.822	1.00
233_V	249_A	0.821	1.00
56_E	59_Q	0.815	1.00
61_A	212_N	0.814	1.00
152_L	484_D	0.812	1.00
339_D	342_K	0.811	1.00
184_V	194_M	0.810	1.00
238_S	241_V	0.810	1.00
26_S	53_E	0.810	1.00
175_A	182_V	0.809	1.00
426_I	437_F	0.807	1.00
277_A	281_I	0.807	1.00
431_G	434_A	0.806	1.00
362_G	379_T	0.803	1.00
225_L	245_I	0.802	1.00
186_P	215_H	0.802	1.00
311_R	314_I	0.801	1.00
278_I	309_V	0.800	1.00
168_P	172_L	0.800	1.00
174_Y	478_S	0.797	1.00
411_A	414_I	0.796	1.00
49_S	53_E	0.796	1.00
81_F	85_N	0.795	1.00
152_L	180_N	0.795	1.00
348_I	399_V	0.791	1.00
352_I	381_F	0.787	1.00
355_G	388_M	0.784	1.00
386_P	403_I	0.784	1.00
68_W	210_V	0.784	1.00
268_V	309_V	0.781	1.00
169_F	197_I	0.780	1.00
405_V	410_E	0.778	1.00
43_I	100_Q	0.777	1.00
242_G	260_A	0.776	1.00
100_Q	192_V	0.775	1.00
246_Y	253_G	0.775	1.00
443_T	446_I	0.774	1.00
26_S	31_I	0.773	1.00
26_S	47_P	0.772	1.00
412_I	416_N	0.770	1.00
88_E	91_S	0.769	1.00
63_E	67_K	0.768	1.00
79_Y	204_I	0.767	1.00
80_L	177_V	0.763	1.00
74_T	128_Y	0.763	1.00
233_V	245_I	0.762	1.00
242_G	258_V	0.760	1.00
27_K	53_E	0.760	1.00
239_T	466_E	0.760	1.00
102_H	336_V	0.759	1.00
243_K	251_K	0.757	1.00
382_D	404_H	0.756	1.00
225_L	248_N	0.756	1.00
88_E	114_R	0.756	1.00
156_G	221_V	0.755	1.00
107_Q	331_D	0.755	1.00
63_E	66_E	0.755	1.00
99_V	106_I	0.754	1.00
274_L	305_I	0.753	1.00
95_A	110_R	0.753	1.00
165_T	193_P	0.751	1.00
306_Y	383_E	0.750	1.00
206_L	210_V	0.747	1.00
313_F	380_V	0.744	1.00
265_F	415_I	0.744	1.00
225_L	233_V	0.744	1.00
352_I	363_R	0.742	1.00
344_I	376_L	0.740	1.00
351_G	395_I	0.738	1.00
157_I	171_F	0.737	1.00
66_E	69_R	0.734	1.00
317_S	360_L	0.732	1.00
106_I	326_L	0.730	1.00
235_F	241_V	0.730	1.00
320_L	331_D	0.730	1.00
302_V	408_L	0.727	1.00
223_E	226_T	0.726	1.00
67_K	71_V	0.725	1.00
95_A	106_I	0.724	1.00
95_A	99_V	0.724	1.00
249_A	256_A	0.723	1.00
49_S	57_A	0.722	1.00
61_A	181_T	0.721	1.00
275_N	316_A	0.720	1.00
87_L	117_I	0.719	1.00
264_N	297_A	0.716	1.00
152_L	231_Q	0.714	1.00
110_R	114_R	0.714	1.00
156_G	233_V	0.714	1.00
347_Y	393_E	0.713	1.00
206_L	211_V	0.713	1.00
429_T	432_Y	0.712	1.00
343_R	346_G	0.711	1.00
248_N	251_K	0.711	1.00
30_T	219_D	0.711	1.00
327_D	330_V	0.710	1.00
277_A	309_V	0.709	1.00
145_E	487_V	0.708	1.00
82_A	204_I	0.707	1.00
168_P	194_M	0.705	1.00
35_Y	40_D	0.703	1.00
159_T	168_P	0.699	1.00
184_V	211_V	0.699	1.00
282_V	313_F	0.697	1.00
62_Q	65_F	0.696	1.00
278_I	282_V	0.696	1.00
189_I	336_V	0.695	1.00
54_V	223_E	0.694	1.00
314_I	317_S	0.690	1.00
68_W	79_Y	0.690	1.00
73_I	127_A	0.689	1.00
93_T	199_R	0.687	1.00
69_R	440_E	0.681	1.00
92_E	106_I	0.681	1.00
216_G	221_V	0.679	1.00
97_I	192_V	0.678	1.00
301_A	305_I	0.677	1.00
40_D	338_K	0.677	1.00
340_A	343_R	0.676	1.00
269_M	302_V	0.674	1.00
289_A	332_M	0.673	1.00
480_D	483_T	0.671	1.00
480_D	485_K	0.670	1.00
431_G	435_R	0.669	1.00
337_T	340_A	0.668	1.00
54_V	58_I	0.666	1.00
247_E	250_G	0.666	1.00
268_V	277_A	0.665	1.00
84_K	117_I	0.665	1.00
300_V	391_A	0.664	1.00
31_I	47_P	0.663	1.00
386_P	391_A	0.663	1.00
85_N	88_E	0.660	1.00
442_N	464_R	0.660	1.00
281_I	313_F	0.660	1.00
171_F	472_L	0.659	1.00
300_V	386_P	0.659	1.00
219_D	222_D	0.659	1.00
317_S	320_L	0.657	1.00
255_K	481_F	0.657	1.00
271_D	428_T	0.656	1.00
438_R	448_I	0.656	1.00
144_D	435_R	0.655	1.00
299_L	309_V	0.655	1.00
68_W	176_I	0.654	1.00
217_A	220_V	0.652	1.00
188_E	343_R	0.650	1.00
180_N	483_T	0.650	1.00
148_V	486_K	0.648	1.00
168_P	197_I	0.648	1.00
66_E	440_E	0.648	1.00
274_L	308_E	0.648	1.00
67_K	70_E	0.646	1.00
36_N	326_L	0.646	1.00
221_V	225_L	0.645	1.00
98_I	101_N	0.645	1.00
201_F	206_L	0.645	1.00
313_F	402_I	0.644	1.00
276_K	279_P	0.643	1.00
55_E	229_L	0.643	1.00
75_T	79_Y	0.642	1.00
338_K	364_D	0.639	1.00
354_E	387_E	0.638	1.00
145_E	489_I	0.637	1.00
282_V	320_L	0.637	1.00
376_L	379_T	0.635	1.00
414_I	417_R	0.635	1.00
130_L	483_T	0.635	1.00
91_S	95_A	0.635	1.00
188_E	244_Y	0.634	1.00
276_K	429_T	0.634	1.00
339_D	343_R	0.633	1.00
407_N	413_N	0.629	1.00
322_I	332_M	0.629	1.00
408_L	412_I	0.627	1.00
51_K	226_T	0.626	1.00
384_V	391_A	0.626	1.00
434_A	438_R	0.625	1.00
60_S	208_R	0.624	1.00
358_L	361_D	0.623	1.00
69_R	151_P	0.623	1.00
69_R	150_E	0.622	1.00
432_Y	435_R	0.621	1.00
324_Y	330_V	0.621	1.00
99_V	326_L	0.618	1.00
34_A	44_A	0.617	1.00
73_I	177_V	0.616	1.00
113_M	117_I	0.614	1.00
386_P	413_N	0.613	1.00
57_A	214_V	0.613	1.00
360_L	380_V	0.613	1.00
34_A	101_N	0.612	1.00
257_I	481_F	0.611	1.00
246_Y	258_V	0.611	1.00
384_V	390_I	0.611	1.00
322_I	331_D	0.610	1.00
165_T	197_I	0.607	1.00
171_F	234_T	0.606	1.00
64_A	67_K	0.606	1.00
59_Q	62_Q	0.605	1.00
104_K	108_E	0.605	1.00
271_D	429_T	0.605	1.00
428_T	433_Y	0.604	1.00
381_F	384_V	0.602	1.00
172_L	184_V	0.601	1.00
98_I	193_P	0.600	1.00
96_R	99_V	0.599	1.00
345_I	348_I	0.598	1.00
47_P	215_H	0.597	1.00
432_Y	436_K	0.596	1.00
196_F	200_I	0.596	1.00
87_L	120_V	0.595	1.00
183_V	212_N	0.594	1.00
87_L	197_I	0.593	1.00
284_A	451_G	0.592	1.00
98_I	109_A	0.591	1.00
104_K	163_F	0.589	1.00
426_I	434_A	0.589	1.00
130_L	479_V	0.588	1.00
335_V	340_A	0.587	1.00
348_I	381_F	0.586	1.00
412_I	436_K	0.586	1.00
294_L	454_A	0.585	1.00
43_I	192_V	0.585	1.00
275_N	315_E	0.585	1.00
395_I	399_V	0.584	1.00
49_S	214_V	0.584	1.00
271_D	430_S	0.581	1.00
239_T	243_K	0.581	1.00
98_I	112_D	0.580	1.00
94_I	165_T	0.580	1.00
122_A	126_A	0.578	1.00
84_K	120_V	0.576	1.00
133_G	148_V	0.576	1.00
46_V	191_P	0.576	1.00
60_S	64_A	0.575	1.00
274_L	277_A	0.574	1.00
266_V	425_S	0.574	1.00
285_F	400_A	0.573	1.00
95_A	113_M	0.572	1.00
232_G	481_F	0.571	1.00
301_A	402_I	0.569	1.00
74_T	78_Q	0.569	1.00
348_I	379_T	0.567	1.00
362_G	377_G	0.566	1.00
87_L	165_T	0.565	1.00
266_V	299_L	0.565	1.00
426_I	448_I	0.564	1.00
146_T	488_V	0.564	1.00
274_L	309_V	0.564	1.00
57_A	212_N	0.563	1.00
364_D	377_G	0.562	1.00
155_F	180_N	0.562	1.00
383_E	404_H	0.562	1.00
303_G	306_Y	0.560	1.00
125_S	128_Y	0.560	1.00
113_M	165_T	0.558	1.00
321_K	327_D	0.556	1.00
358_L	379_T	0.556	1.00
154_V	231_Q	0.556	1.00
442_N	484_D	0.555	1.00
447_G	450_I	0.555	1.00
408_L	440_E	0.554	1.00
178_L	479_V	0.554	1.00
411_A	415_I	0.554	1.00
345_I	352_I	0.553	1.00
225_L	252_N	0.553	1.00
197_I	201_F	0.552	1.00
176_I	211_V	0.551	1.00
415_I	441_V	0.549	1.00
150_E	442_N	0.549	1.00
314_I	380_V	0.546	1.00
62_Q	154_V	0.546	1.00
78_Q	81_F	0.544	1.00
188_E	240_R	0.543	1.00
123_A	174_Y	0.543	1.00
292_R	295_A	0.542	1.00
272_A	277_A	0.542	1.00
256_A	469_F	0.542	1.00
437_F	441_V	0.542	1.00
218_K	221_V	0.541	1.00
390_I	395_I	0.540	1.00
110_R	328_E	0.540	1.00
83_L	86_R	0.540	1.00
30_T	50_A	0.538	1.00
299_L	402_I	0.538	1.00
34_A	191_P	0.536	1.00
181_T	212_N	0.535	1.00
412_I	441_V	0.535	1.00
301_A	306_Y	0.533	1.00
279_P	283_S	0.532	1.00
270_P	405_V	0.532	1.00
343_R	347_Y	0.530	1.00
155_F	182_V	0.530	1.00
202_D	209_G	0.528	1.00
61_A	154_V	0.525	1.00
166_M	170_W	0.525	1.00
446_I	486_K	0.525	1.00
218_K	222_D	0.523	1.00
102_H	288_N	0.523	1.00
335_V	376_L	0.523	1.00
94_I	113_M	0.522	1.00
296_A	425_S	0.522	1.00
95_A	109_A	0.522	1.00
264_N	423_A	0.522	1.00
48_F	188_E	0.521	1.00
87_L	94_I	0.521	1.00
91_S	117_I	0.520	1.00
135_H	146_T	0.519	1.00
157_I	172_L	0.518	1.00
115_R	166_M	0.517	1.00
61_A	183_V	0.516	1.00
250_G	253_G	0.516	1.00
126_A	475_Q	0.515	1.00
46_V	192_V	0.514	1.00
228_K	419_N	0.512	1.00
34_A	43_I	0.512	1.00
286_F	320_L	0.511	1.00
359_L	383_E	0.510	1.00
147_V	485_K	0.508	1.00
114_R	117_I	0.508	1.00
60_S	63_E	0.508	1.00
79_Y	83_L	0.507	1.00
81_F	84_K	0.507	1.00
240_R	339_D	0.506	1.00
93_T	97_I	0.506	1.00
57_A	183_V	0.504	1.00
469_F	484_D	0.503	1.00
176_I	206_L	0.502	1.00
143_V	450_I	0.501	1.00
424_S	437_F	0.501	1.00
354_E	385_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qf6A	4	0.9797	100	0.035	Contact Map
4o5hA	4	0.9817	100	0.036	Contact Map
4yweA	5	0.9593	100	0.037	Contact Map
4pxlA	4	0.9654	100	0.041	Contact Map
1a4sA	4	0.9898	100	0.041	Contact Map
4lihA	5	0.9817	100	0.041	Contact Map
4pz2A	4	0.9654	100	0.042	Contact Map
4iymA	6	0.9797	100	0.042	Contact Map
2d4eA	4	0.9878	100	0.042	Contact Map
4qtoA	4	0.9837	100	0.042	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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