GREMLIN Database
Q97YT9 - Methylmalonate-semialdehyde dehydrogenase
UniProt: Q97YT9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 492 (452)
Sequences: 36516 (21740)
Seq/√Len: 1022.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
303_G406_K4.8691.00
247_E251_K3.9491.00
303_G404_H3.1201.00
275_N312_K3.0821.00
306_Y404_H2.9161.00
33_K45_E2.8591.00
62_Q229_L2.7841.00
363_R377_G2.7701.00
270_P302_V2.6911.00
350_K389_V2.6201.00
338_K342_K2.6021.00
279_P316_A2.5831.00
385_T388_M2.5771.00
196_F199_R2.5531.00
349_E353_E2.4951.00
270_P304_N2.4711.00
310_K402_I2.4451.00
33_K42_I2.4041.00
90_Y93_T2.4011.00
428_T434_A2.3431.00
88_E121_E2.3171.00
202_D208_R2.2271.00
62_Q231_Q2.1921.00
50_A53_E2.1771.00
345_I349_E2.1701.00
91_S114_R2.1611.00
86_R203_E2.1371.00
348_I376_L2.1291.00
83_L201_F2.1281.00
419_N466_E2.0761.00
408_L433_Y2.0681.00
226_T248_N2.0491.00
222_D226_T2.0171.00
350_K354_E1.9971.00
189_I337_T1.9871.00
357_K383_E1.9811.00
345_I364_D1.9621.00
150_E486_K1.9621.00
93_T196_F1.9341.00
436_K440_E1.9231.00
359_L382_D1.9211.00
266_V281_I1.9191.00
345_I376_L1.9141.00
314_I318_K1.9141.00
308_E312_K1.9081.00
149_R480_D1.8981.00
55_E223_E1.8861.00
335_V344_I1.8711.00
244_Y247_E1.8451.00
243_K466_E1.8381.00
59_Q229_L1.8331.00
79_Y206_L1.8241.00
90_Y203_E1.7941.00
352_I358_L1.7931.00
86_R89_E1.7921.00
271_D433_Y1.7621.00
391_A403_I1.7521.00
300_V414_I1.7401.00
92_E110_R1.7321.00
442_N465_K1.7261.00
42_I45_E1.7241.00
86_R204_I1.7231.00
55_E59_Q1.6911.00
149_R483_T1.6641.00
408_L436_K1.6581.00
357_K382_D1.6551.00
97_I196_F1.6491.00
81_F121_E1.6391.00
314_I359_L1.6271.00
198_I213_V1.6251.00
386_P414_I1.6241.00
302_V405_V1.6091.00
317_S380_V1.6011.00
410_E413_N1.5991.00
406_K410_E1.5951.00
86_R200_I1.5931.00
381_F390_I1.5831.00
88_E117_I1.5791.00
120_V173_P1.5781.00
72_P75_T1.5721.00
311_R315_E1.5711.00
312_K315_E1.5601.00
281_I309_V1.5511.00
286_F317_S1.5491.00
346_G389_V1.5371.00
306_Y310_K1.5341.00
31_I45_E1.5301.00
82_A85_N1.5291.00
300_V411_A1.5271.00
338_K374_Y1.5271.00
55_E227_N1.5251.00
85_N89_E1.5201.00
389_V393_E1.5151.00
134_E475_Q1.5151.00
65_F69_R1.5081.00
274_L312_K1.5021.00
278_I312_K1.4991.00
181_T210_V1.4961.00
75_T78_Q1.4701.00
269_M433_Y1.4661.00
70_E440_E1.4601.00
71_V75_T1.4411.00
199_R203_E1.4331.00
307_D404_H1.4281.00
299_L400_A1.4241.00
96_R100_Q1.4241.00
316_A319_Q1.4161.00
410_E414_I1.4151.00
300_V405_V1.4151.00
280_S427_F1.4101.00
349_E352_I1.4101.00
306_Y382_D1.4051.00
281_I299_L1.4051.00
40_D372_N1.4031.00
358_L381_F1.4031.00
81_F128_Y1.4021.00
35_Y42_I1.4021.00
92_E96_R1.3951.00
321_K329_S1.3941.00
308_E311_R1.3901.00
84_K121_E1.3881.00
90_Y196_F1.3801.00
120_V169_F1.3801.00
148_V439_R1.3791.00
126_A129_T1.3771.00
409_D440_E1.3661.00
424_S443_T1.3651.00
222_D248_N1.3641.00
301_A309_V1.3631.00
30_T48_F1.3571.00
53_E56_E1.3441.00
270_P433_Y1.3421.00
344_I397_G1.3411.00
341_K345_I1.3391.00
157_I182_V1.3371.00
96_R326_L1.3361.00
85_N121_E1.3221.00
246_Y469_F1.3191.00
341_K364_D1.3141.00
342_K346_G1.3081.00
232_G257_I1.3051.00
41_E372_N1.3031.00
347_Y395_I1.2911.00
307_D311_R1.2841.00
354_E389_V1.2811.00
310_K314_I1.2761.00
51_K223_E1.2751.00
226_T251_K1.2711.00
338_K341_K1.2661.00
405_V414_I1.2641.00
198_I211_V1.2611.00
36_N39_K1.2591.00
168_P184_V1.2581.00
341_K376_L1.2571.00
269_M437_F1.2551.00
269_M405_V1.2531.00
315_E318_K1.2491.00
99_V109_A1.2471.00
318_K360_L1.2451.00
321_K331_D1.2431.00
106_I110_R1.2381.00
65_F181_T1.2381.00
267_V411_A1.2381.00
84_K88_E1.2341.00
475_Q480_D1.2301.00
48_F217_A1.2161.00
305_I308_E1.2121.00
302_V407_N1.2101.00
58_I227_N1.2071.00
222_D244_Y1.2031.00
59_Q63_E1.2021.00
412_I437_F1.2011.00
302_V305_I1.2001.00
312_K316_A1.1991.00
346_G350_K1.1991.00
407_N410_E1.1971.00
54_V220_V1.1951.00
146_T435_R1.1941.00
149_R485_K1.1911.00
323_G330_V1.1891.00
387_E392_K1.1811.00
96_R106_I1.1801.00
455_P458_F1.1701.00
71_V79_Y1.1691.00
438_R488_V1.1571.00
315_E319_Q1.1501.00
386_P417_R1.1471.00
94_I196_F1.1461.00
188_E217_A1.1391.00
310_K382_D1.1381.00
244_Y248_N1.1371.00
313_F400_A1.1361.00
201_F211_V1.1351.00
58_I229_L1.1321.00
424_S446_I1.1251.00
58_I230_V1.1221.00
152_L232_G1.1201.00
32_G48_F1.1181.00
195_D215_H1.1171.00
309_V313_F1.1121.00
409_D436_K1.1101.00
99_V325_G1.1081.00
209_G212_N1.1051.00
82_A86_R1.1051.00
240_R244_Y1.1031.00
434_A448_I1.1031.00
310_K359_L1.0991.00
241_V244_Y1.0961.00
91_S110_R1.0911.00
392_K419_N1.0881.00
188_E218_K1.0851.00
409_D413_N1.0791.00
60_S212_N1.0781.00
266_V296_A1.0771.00
172_L211_V1.0761.00
81_F125_S1.0761.00
83_L200_I1.0741.00
354_E388_M1.0721.00
156_G224_F1.0631.00
44_A192_V1.0591.00
408_L437_F1.0541.00
246_Y256_A1.0531.00
267_V437_F1.0521.00
83_L206_L1.0511.00
314_I360_L1.0481.00
36_N324_Y1.0441.00
392_K417_R1.0431.00
412_I440_E1.0431.00
356_A381_F1.0411.00
318_K377_G1.0411.00
157_I234_T1.0391.00
48_F219_D1.0381.00
351_G381_F1.0381.00
172_L182_V1.0341.00
156_G230_V1.0291.00
27_K56_E1.0251.00
77_I128_Y1.0171.00
83_L120_V1.0161.00
341_K374_Y1.0151.00
40_D374_Y1.0131.00
223_E227_N1.0111.00
116_T169_F1.0061.00
430_S433_Y1.0041.00
405_V411_A1.0001.00
62_Q66_E0.9971.00
64_A181_T0.9941.00
94_I200_I0.9911.00
350_K353_E0.9891.00
320_L332_M0.9861.00
273_D276_K0.9851.00
38_A325_G0.9841.00
154_V181_T0.9841.00
276_K280_S0.9811.00
127_A177_V0.9801.00
267_V415_I0.9801.00
273_D429_T0.9791.00
462_G471_I0.9781.00
243_K253_G0.9761.00
81_F124_I0.9721.00
66_E442_N0.9701.00
199_R202_D0.9641.00
163_F292_R0.9631.00
93_T96_R0.9631.00
282_V316_A0.9631.00
464_R484_D0.9631.00
90_Y200_I0.9621.00
66_E413_N0.9621.00
471_I484_D0.9611.00
90_Y199_R0.9581.00
152_L255_K0.9531.00
195_D213_V0.9511.00
324_Y327_D0.9481.00
148_V488_V0.9471.00
51_K55_E0.9461.00
86_R90_Y0.9391.00
413_N417_R0.9391.00
361_D379_T0.9371.00
89_E203_E0.9371.00
100_Q326_L0.9331.00
263_K297_A0.9291.00
425_S451_G0.9261.00
246_Y250_G0.9251.00
36_N100_Q0.9241.00
384_V388_M0.9221.00
346_G349_E0.9201.00
284_A296_A0.9201.00
150_E439_R0.9191.00
344_I399_V0.9191.00
275_N308_E0.9161.00
155_F232_G0.9151.00
361_D377_G0.9141.00
77_I81_F0.9081.00
243_K247_E0.9071.00
347_Y350_K0.9051.00
307_D310_K0.9041.00
78_Q82_A0.9031.00
274_L278_I0.9001.00
265_F424_S0.8991.00
69_R442_N0.8971.00
116_T165_T0.8951.00
231_Q442_N0.8941.00
189_I339_D0.8931.00
56_E60_S0.8931.00
102_H190_T0.8861.00
73_I77_I0.8851.00
266_V427_F0.8841.00
35_Y374_Y0.8841.00
36_N41_E0.8761.00
145_E459_F0.8751.00
435_R439_R0.8731.00
198_I202_D0.8711.00
285_F297_A0.8691.00
27_K50_A0.8691.00
70_E439_R0.8681.00
104_K112_D0.8681.00
150_E464_R0.8641.00
66_E70_E0.8641.00
54_V156_G0.8621.00
342_K345_I0.8611.00
403_I414_I0.8611.00
27_K52_D0.8561.00
246_Y249_A0.8551.00
306_Y402_I0.8531.00
87_L116_T0.8521.00
154_V230_V0.8521.00
269_M428_T0.8521.00
38_A375_F0.8491.00
269_M408_L0.8491.00
84_K124_I0.8481.00
278_I316_A0.8451.00
178_L483_T0.8431.00
344_I395_I0.8421.00
52_D56_E0.8401.00
51_K219_D0.8391.00
347_Y389_V0.8371.00
356_A388_M0.8371.00
216_G220_V0.8361.00
459_F487_V0.8361.00
278_I313_F0.8351.00
195_D199_R0.8321.00
64_A210_V0.8321.00
52_D55_E0.8311.00
255_K484_D0.8291.00
32_G217_A0.8281.00
424_S441_V0.8271.00
77_I124_I0.8271.00
60_S209_G0.8221.00
233_V249_A0.8211.00
56_E59_Q0.8151.00
61_A212_N0.8141.00
152_L484_D0.8121.00
339_D342_K0.8111.00
184_V194_M0.8101.00
238_S241_V0.8101.00
26_S53_E0.8101.00
175_A182_V0.8091.00
426_I437_F0.8071.00
277_A281_I0.8071.00
431_G434_A0.8061.00
362_G379_T0.8031.00
225_L245_I0.8021.00
186_P215_H0.8021.00
311_R314_I0.8011.00
278_I309_V0.8001.00
168_P172_L0.8001.00
174_Y478_S0.7971.00
411_A414_I0.7961.00
49_S53_E0.7961.00
81_F85_N0.7951.00
152_L180_N0.7951.00
348_I399_V0.7911.00
352_I381_F0.7871.00
355_G388_M0.7841.00
386_P403_I0.7841.00
68_W210_V0.7841.00
268_V309_V0.7811.00
169_F197_I0.7801.00
405_V410_E0.7781.00
43_I100_Q0.7771.00
242_G260_A0.7761.00
100_Q192_V0.7751.00
246_Y253_G0.7751.00
443_T446_I0.7741.00
26_S31_I0.7731.00
26_S47_P0.7721.00
412_I416_N0.7701.00
88_E91_S0.7691.00
63_E67_K0.7681.00
79_Y204_I0.7671.00
80_L177_V0.7631.00
74_T128_Y0.7631.00
233_V245_I0.7621.00
242_G258_V0.7601.00
27_K53_E0.7601.00
239_T466_E0.7601.00
102_H336_V0.7591.00
243_K251_K0.7571.00
382_D404_H0.7561.00
225_L248_N0.7561.00
88_E114_R0.7561.00
156_G221_V0.7551.00
107_Q331_D0.7551.00
63_E66_E0.7551.00
99_V106_I0.7541.00
274_L305_I0.7531.00
95_A110_R0.7531.00
165_T193_P0.7511.00
306_Y383_E0.7501.00
206_L210_V0.7471.00
313_F380_V0.7441.00
265_F415_I0.7441.00
225_L233_V0.7441.00
352_I363_R0.7421.00
344_I376_L0.7401.00
351_G395_I0.7381.00
157_I171_F0.7371.00
66_E69_R0.7341.00
317_S360_L0.7321.00
106_I326_L0.7301.00
235_F241_V0.7301.00
320_L331_D0.7301.00
302_V408_L0.7271.00
223_E226_T0.7261.00
67_K71_V0.7251.00
95_A106_I0.7241.00
95_A99_V0.7241.00
249_A256_A0.7231.00
49_S57_A0.7221.00
61_A181_T0.7211.00
275_N316_A0.7201.00
87_L117_I0.7191.00
264_N297_A0.7161.00
152_L231_Q0.7141.00
110_R114_R0.7141.00
156_G233_V0.7141.00
347_Y393_E0.7131.00
206_L211_V0.7131.00
429_T432_Y0.7121.00
343_R346_G0.7111.00
248_N251_K0.7111.00
30_T219_D0.7111.00
327_D330_V0.7101.00
277_A309_V0.7091.00
145_E487_V0.7081.00
82_A204_I0.7071.00
168_P194_M0.7051.00
35_Y40_D0.7031.00
159_T168_P0.6991.00
184_V211_V0.6991.00
282_V313_F0.6971.00
62_Q65_F0.6961.00
278_I282_V0.6961.00
189_I336_V0.6951.00
54_V223_E0.6941.00
314_I317_S0.6901.00
68_W79_Y0.6901.00
73_I127_A0.6891.00
93_T199_R0.6871.00
69_R440_E0.6811.00
92_E106_I0.6811.00
216_G221_V0.6791.00
97_I192_V0.6781.00
301_A305_I0.6771.00
40_D338_K0.6771.00
340_A343_R0.6761.00
269_M302_V0.6741.00
289_A332_M0.6731.00
480_D483_T0.6711.00
480_D485_K0.6701.00
431_G435_R0.6691.00
337_T340_A0.6681.00
54_V58_I0.6661.00
247_E250_G0.6661.00
268_V277_A0.6651.00
84_K117_I0.6651.00
300_V391_A0.6641.00
31_I47_P0.6631.00
386_P391_A0.6631.00
85_N88_E0.6601.00
442_N464_R0.6601.00
281_I313_F0.6601.00
171_F472_L0.6591.00
300_V386_P0.6591.00
219_D222_D0.6591.00
317_S320_L0.6571.00
255_K481_F0.6571.00
271_D428_T0.6561.00
438_R448_I0.6561.00
144_D435_R0.6551.00
299_L309_V0.6551.00
68_W176_I0.6541.00
217_A220_V0.6521.00
188_E343_R0.6501.00
180_N483_T0.6501.00
148_V486_K0.6481.00
168_P197_I0.6481.00
66_E440_E0.6481.00
274_L308_E0.6481.00
67_K70_E0.6461.00
36_N326_L0.6461.00
221_V225_L0.6451.00
98_I101_N0.6451.00
201_F206_L0.6451.00
313_F402_I0.6441.00
276_K279_P0.6431.00
55_E229_L0.6431.00
75_T79_Y0.6421.00
338_K364_D0.6391.00
354_E387_E0.6381.00
145_E489_I0.6371.00
282_V320_L0.6371.00
376_L379_T0.6351.00
414_I417_R0.6351.00
130_L483_T0.6351.00
91_S95_A0.6351.00
188_E244_Y0.6341.00
276_K429_T0.6341.00
339_D343_R0.6331.00
407_N413_N0.6291.00
322_I332_M0.6291.00
408_L412_I0.6271.00
51_K226_T0.6261.00
384_V391_A0.6261.00
434_A438_R0.6251.00
60_S208_R0.6241.00
358_L361_D0.6231.00
69_R151_P0.6231.00
69_R150_E0.6221.00
432_Y435_R0.6211.00
324_Y330_V0.6211.00
99_V326_L0.6181.00
34_A44_A0.6171.00
73_I177_V0.6161.00
113_M117_I0.6141.00
386_P413_N0.6131.00
57_A214_V0.6131.00
360_L380_V0.6131.00
34_A101_N0.6121.00
257_I481_F0.6111.00
246_Y258_V0.6111.00
384_V390_I0.6111.00
322_I331_D0.6101.00
165_T197_I0.6071.00
171_F234_T0.6061.00
64_A67_K0.6061.00
59_Q62_Q0.6051.00
104_K108_E0.6051.00
271_D429_T0.6051.00
428_T433_Y0.6041.00
381_F384_V0.6021.00
172_L184_V0.6011.00
98_I193_P0.6001.00
96_R99_V0.5991.00
345_I348_I0.5981.00
47_P215_H0.5971.00
432_Y436_K0.5961.00
196_F200_I0.5961.00
87_L120_V0.5951.00
183_V212_N0.5941.00
87_L197_I0.5931.00
284_A451_G0.5921.00
98_I109_A0.5911.00
104_K163_F0.5891.00
426_I434_A0.5891.00
130_L479_V0.5881.00
335_V340_A0.5871.00
348_I381_F0.5861.00
412_I436_K0.5861.00
294_L454_A0.5851.00
43_I192_V0.5851.00
275_N315_E0.5851.00
395_I399_V0.5841.00
49_S214_V0.5841.00
271_D430_S0.5811.00
239_T243_K0.5811.00
98_I112_D0.5801.00
94_I165_T0.5801.00
122_A126_A0.5781.00
84_K120_V0.5761.00
133_G148_V0.5761.00
46_V191_P0.5761.00
60_S64_A0.5751.00
274_L277_A0.5741.00
266_V425_S0.5741.00
285_F400_A0.5731.00
95_A113_M0.5721.00
232_G481_F0.5711.00
301_A402_I0.5691.00
74_T78_Q0.5691.00
348_I379_T0.5671.00
362_G377_G0.5661.00
87_L165_T0.5651.00
266_V299_L0.5651.00
426_I448_I0.5641.00
146_T488_V0.5641.00
274_L309_V0.5641.00
57_A212_N0.5631.00
364_D377_G0.5621.00
155_F180_N0.5621.00
383_E404_H0.5621.00
303_G306_Y0.5601.00
125_S128_Y0.5601.00
113_M165_T0.5581.00
321_K327_D0.5561.00
358_L379_T0.5561.00
154_V231_Q0.5561.00
442_N484_D0.5551.00
447_G450_I0.5551.00
408_L440_E0.5541.00
178_L479_V0.5541.00
411_A415_I0.5541.00
345_I352_I0.5531.00
225_L252_N0.5531.00
197_I201_F0.5521.00
176_I211_V0.5511.00
415_I441_V0.5491.00
150_E442_N0.5491.00
314_I380_V0.5461.00
62_Q154_V0.5461.00
78_Q81_F0.5441.00
188_E240_R0.5431.00
123_A174_Y0.5431.00
292_R295_A0.5421.00
272_A277_A0.5421.00
256_A469_F0.5421.00
437_F441_V0.5421.00
218_K221_V0.5411.00
390_I395_I0.5401.00
110_R328_E0.5401.00
83_L86_R0.5401.00
30_T50_A0.5381.00
299_L402_I0.5381.00
34_A191_P0.5361.00
181_T212_N0.5351.00
412_I441_V0.5351.00
301_A306_Y0.5331.00
279_P283_S0.5321.00
270_P405_V0.5321.00
343_R347_Y0.5301.00
155_F182_V0.5301.00
202_D209_G0.5281.00
61_A154_V0.5251.00
166_M170_W0.5251.00
446_I486_K0.5251.00
218_K222_D0.5231.00
102_H288_N0.5231.00
335_V376_L0.5231.00
94_I113_M0.5221.00
296_A425_S0.5221.00
95_A109_A0.5221.00
264_N423_A0.5221.00
48_F188_E0.5211.00
87_L94_I0.5211.00
91_S117_I0.5201.00
135_H146_T0.5191.00
157_I172_L0.5181.00
115_R166_M0.5171.00
61_A183_V0.5161.00
250_G253_G0.5161.00
126_A475_Q0.5151.00
46_V192_V0.5141.00
228_K419_N0.5121.00
34_A43_I0.5121.00
286_F320_L0.5111.00
359_L383_E0.5101.00
147_V485_K0.5081.00
114_R117_I0.5081.00
60_S63_E0.5081.00
79_Y83_L0.5071.00
81_F84_K0.5071.00
240_R339_D0.5061.00
93_T97_I0.5061.00
57_A183_V0.5041.00
469_F484_D0.5031.00
176_I206_L0.5021.00
143_V450_I0.5011.00
424_S437_F0.5011.00
354_E385_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qf6A 4 0.9797 100 0.035 Contact Map
4o5hA 4 0.9817 100 0.036 Contact Map
4yweA 5 0.9593 100 0.037 Contact Map
4pxlA 4 0.9654 100 0.041 Contact Map
1a4sA 4 0.9898 100 0.041 Contact Map
4lihA 5 0.9817 100 0.041 Contact Map
4pz2A 4 0.9654 100 0.042 Contact Map
4iymA 6 0.9797 100 0.042 Contact Map
2d4eA 4 0.9878 100 0.042 Contact Map
4qtoA 4 0.9837 100 0.042 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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