GREMLIN Database
Q97YT8 - Uncharacterized protein
UniProt: Q97YT8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 228 (199)
Sequences: 1824 (1452)
Seq/√Len: 102.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_I179_I4.5651.00
168_F198_E4.2171.00
161_L165_N4.1181.00
95_I100_G3.5191.00
158_T183_I3.3721.00
175_K178_K3.2521.00
186_S189_T3.2141.00
165_N182_L3.1731.00
189_T193_H3.1001.00
100_G118_L3.0021.00
165_N179_I2.9691.00
169_D173_R2.9621.00
154_Y193_H2.9231.00
29_T32_F2.8621.00
174_I178_K2.7501.00
163_Y203_K2.7161.00
23_G110_G2.7041.00
161_L179_I2.6731.00
176_S190_F2.5001.00
170_F191_T2.2211.00
11_S111_K2.1891.00
176_S191_T2.0671.00
154_Y158_T2.0481.00
154_Y157_K1.9571.00
185_I190_F1.9091.00
103_L117_L1.9001.00
47_V54_L1.8611.00
156_L160_I1.8591.00
193_H196_S1.8281.00
11_S137_E1.7591.00
159_L202_I1.6601.00
202_I205_Y1.6521.00
158_T193_H1.6521.00
187_K191_T1.6471.00
172_R195_R1.6311.00
119_Y122_Y1.5731.00
158_T179_I1.5491.00
8_I123_V1.4941.00
179_I190_F1.4931.00
159_L168_F1.4821.00
178_K181_K1.4821.00
176_S193_H1.4561.00
193_H200_R1.4501.00
181_K184_N1.4481.00
64_F67_Y1.4191.00
69_L79_I1.3901.00
166_G173_R1.3791.00
167_Y172_R1.3600.99
170_F192_Y1.3490.99
174_I182_L1.3060.99
163_Y206_I1.3030.99
192_Y196_S1.2990.99
168_F194_L1.2830.99
43_S83_F1.2830.99
158_T197_A1.2740.99
68_S174_I1.2560.99
177_D187_K1.2540.99
18_W22_V1.2380.99
10_F116_V1.2080.99
22_V61_N1.2020.99
158_T185_I1.1870.99
202_I206_I1.1800.99
180_S190_F1.1620.98
8_I11_S1.1540.98
165_N174_I1.1500.98
151_L197_A1.1420.98
201_I205_Y1.1380.98
199_S203_K1.1280.98
30_L33_S1.1250.98
189_T192_Y1.1190.98
128_E132_S1.1000.98
170_F188_S1.0890.97
188_S192_Y1.0820.97
189_T194_L1.0800.97
154_Y192_Y1.0740.97
82_D89_N1.0690.97
50_K53_E1.0600.97
51_Y54_L1.0600.97
46_V127_R1.0550.97
11_S139_I1.0540.97
46_V78_K1.0430.97
29_T33_S1.0340.97
53_E57_K1.0310.96
113_Y139_I1.0290.96
127_R136_V1.0240.96
170_F199_S1.0210.96
55_I79_I1.0200.96
100_G104_D1.0120.96
183_I190_F0.9940.96
170_F193_H0.9940.96
102_I116_V0.9910.96
51_Y55_I0.9860.95
10_F127_R0.9850.95
117_L168_F0.9780.95
98_V129_K0.9750.95
176_S187_K0.9750.95
167_Y176_S0.9740.95
99_D119_Y0.9630.95
105_G168_F0.9600.95
34_V168_F0.9580.95
160_I164_K0.9450.94
158_T190_F0.9430.94
83_F92_M0.9410.94
125_E128_E0.9370.94
176_S189_T0.9310.94
122_Y125_E0.9220.94
55_I67_Y0.9200.93
186_S195_R0.9110.93
138_F141_F0.9050.93
9_T113_Y0.9050.93
163_Y168_F0.9040.93
189_T196_S0.8990.93
63_S103_L0.8900.92
150_E204_R0.8850.92
75_D86_R0.8840.92
60_R75_D0.8820.92
126_L187_K0.8820.92
45_I83_F0.8730.92
124_N127_R0.8690.91
86_R184_N0.8630.91
170_F177_D0.8610.91
70_V107_K0.8510.90
94_N175_K0.8510.90
74_T133_K0.8480.90
194_L198_E0.8330.90
66_G69_L0.8310.89
118_L137_E0.8300.89
56_N106_F0.8260.89
179_I183_I0.8200.89
177_D195_R0.8170.89
66_G133_K0.8150.88
146_I169_D0.8140.88
168_F197_A0.8120.88
32_F46_V0.8110.88
93_D97_S0.8100.88
197_A202_I0.8090.88
125_E173_R0.8070.88
167_Y194_L0.8070.88
17_C23_G0.8050.88
90_S93_D0.8050.88
187_K196_S0.7990.87
127_R189_T0.7950.87
161_L174_I0.7920.87
137_E145_D0.7850.87
84_R187_K0.7850.87
174_I190_F0.7780.86
185_I188_S0.7770.86
102_I125_E0.7690.85
123_V140_S0.7680.85
60_R148_E0.7670.85
176_S197_A0.7620.85
31_R45_I0.7620.85
141_F167_Y0.7610.85
63_S152_T0.7600.85
189_T197_A0.7570.85
8_I116_V0.7530.84
42_R45_I0.7510.84
99_D129_K0.7460.84
35_D102_I0.7440.83
16_N45_I0.7420.83
149_D205_Y0.7380.83
169_D199_S0.7350.83
17_C20_N0.7330.83
86_R91_V0.7250.82
54_L144_L0.7230.82
170_F195_R0.7160.81
106_F113_Y0.7150.81
21_L63_S0.7150.81
120_E186_S0.7120.81
17_C112_E0.7100.81
196_S199_S0.7070.80
157_K161_L0.7020.80
70_V74_T0.6930.79
58_I67_Y0.6910.79
113_Y180_S0.6880.78
53_E79_I0.6870.78
14_H17_C0.6800.78
201_I204_R0.6780.77
83_F107_K0.6730.77
155_E200_R0.6690.76
23_G193_H0.6690.76
29_T47_V0.6650.76
42_R114_W0.6630.76
66_G122_Y0.6620.76
63_S74_T0.6610.76
58_I121_S0.6570.75
116_V119_Y0.6560.75
23_G202_I0.6550.75
16_N185_I0.6500.74
100_G105_G0.6490.74
14_H114_W0.6480.74
143_E146_I0.6430.74
107_K112_E0.6420.74
159_L198_E0.6410.73
45_I81_F0.6380.73
134_G189_T0.6380.73
51_Y79_I0.6350.73
13_E60_R0.6350.73
165_N190_F0.6300.72
129_K133_K0.6280.72
62_N129_K0.6270.72
157_K160_I0.6260.72
32_F202_I0.6190.71
67_Y70_V0.6150.70
13_E20_N0.6110.70
51_Y66_G0.6090.70
64_F69_L0.6090.70
154_Y198_E0.6080.69
92_M190_F0.6060.69
68_S148_E0.6050.69
53_E173_R0.6050.69
124_N189_T0.6040.69
37_E60_R0.6010.69
26_V32_F0.5970.68
55_I58_I0.5960.68
118_L195_R0.5950.68
166_G169_D0.5950.68
150_E203_K0.5950.68
13_E110_G0.5940.68
14_H112_E0.5920.67
53_E181_K0.5910.67
17_C114_W0.5900.67
21_L139_I0.5890.67
10_F114_W0.5840.66
53_E56_N0.5840.66
17_C91_V0.5830.66
8_I120_E0.5820.66
166_G191_T0.5820.66
50_K113_Y0.5800.66
189_T205_Y0.5750.65
39_N182_L0.5730.65
7_E142_H0.5730.65
130_L134_G0.5710.65
161_L183_I0.5710.65
85_K131_K0.5660.64
119_Y156_L0.5630.64
171_P195_R0.5620.63
91_V95_I0.5620.63
138_F185_I0.5610.63
21_L24_K0.5600.63
168_F176_S0.5590.63
113_Y132_S0.5590.63
173_R204_R0.5590.63
51_Y146_I0.5580.63
56_N206_I0.5580.63
161_L182_L0.5560.63
44_L174_I0.5560.63
23_G111_K0.5540.62
172_R175_K0.5530.62
19_T32_F0.5530.62
137_E199_S0.5510.62
137_E169_D0.5510.62
97_S207_D0.5490.62
50_K109_D0.5470.61
196_S201_I0.5460.61
24_K121_S0.5440.61
177_D181_K0.5420.61
18_W21_L0.5410.61
118_L126_L0.5400.60
124_N168_F0.5390.60
68_S82_D0.5370.60
39_N169_D0.5350.60
92_M102_I0.5350.60
75_D133_K0.5330.59
100_G127_R0.5290.59
153_P163_Y0.5290.59
27_V165_N0.5280.59
36_T184_N0.5280.59
159_L197_A0.5270.59
56_N60_R0.5230.58
23_G107_K0.5220.58
60_R165_N0.5210.58
58_I61_N0.5200.58
110_G132_S0.5200.58
167_Y201_I0.5200.58
52_K207_D0.5180.57
100_G103_L0.5180.57
65_I132_S0.5160.57
124_N128_E0.5150.57
83_F126_L0.5150.57
94_N97_S0.5140.57
81_F186_S0.5130.57
75_D109_D0.5130.57
33_S92_M0.5100.56
116_V200_R0.5100.56
105_G188_S0.5100.56
71_S80_L0.5070.56
59_K125_E0.5060.56
45_I207_D0.5050.55
52_K59_K0.5050.55
191_T196_S0.5050.55
175_K190_F0.5030.55
111_K153_P0.5030.55
123_V157_K0.5020.55
89_N180_S0.5010.55
157_K182_L0.5000.55
163_Y202_I0.5000.55
10_F31_R0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o8xA 7 0.2675 97.5 0.849 Contact Map
1ku3A 1 0.2675 97.4 0.853 Contact Map
4wszA 2 0.2895 97.3 0.856 Contact Map
1x3uA 1 0.3465 97 0.861 Contact Map
1ttyA 1 0.3816 97 0.862 Contact Map
1s7oA 3 0.3904 96.9 0.864 Contact Map
1je8A 2 0.2939 96.9 0.864 Contact Map
3hugA 3 0.3509 96.8 0.865 Contact Map
3c57A 2 0.2237 96.8 0.865 Contact Map
2lfwA 1 0.6754 96.8 0.865 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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