Q97YT8 - SULSO - GREMLIN Contacts

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Q97YT8 - Uncharacterized protein

UniProt:	Q97YT8	Sequences: MSDRLLEITFSVEHENCWTNLVGKYVVKTLRFSVDTERNFIRSLIVVDKKYKELINKIKRNNSFIGYSLVSLTTDNKKILFDFRKRYKNSVMDNINSVDGIILDGFKYDGKEYWRVLLYESYVNELREKLKSKGNVEFISFHELDITEDELTPYELKTLILAYKNGYFDFPRRIKSDKISKLINISKSTFTYHLRSAESRIIKRYIDDLKFYNVINNVSKQEEEKKDS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	228 (199)
Sequences:	1824 (1452)
Seq/√Len:	102.9

HALSA - O54637 Q9HSM9 Q9HSR5 Q9HR58 Q9HPS7 Q9HQD9 DMSR Q9HQU9
SULSO - Q97YT8 Q97YL7 Q97WR0 Q7LXI8 Q97Y14 Q97X87 Q97ZB6 Q97UD7 Q97UC0 Q97ZX5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
174_I	179_I	4.565	1.00
168_F	198_E	4.217	1.00
161_L	165_N	4.118	1.00
95_I	100_G	3.519	1.00
158_T	183_I	3.372	1.00
175_K	178_K	3.252	1.00
186_S	189_T	3.214	1.00
165_N	182_L	3.173	1.00
189_T	193_H	3.100	1.00
100_G	118_L	3.002	1.00
165_N	179_I	2.969	1.00
169_D	173_R	2.962	1.00
154_Y	193_H	2.923	1.00
29_T	32_F	2.862	1.00
174_I	178_K	2.750	1.00
163_Y	203_K	2.716	1.00
23_G	110_G	2.704	1.00
161_L	179_I	2.673	1.00
176_S	190_F	2.500	1.00
170_F	191_T	2.221	1.00
11_S	111_K	2.189	1.00
176_S	191_T	2.067	1.00
154_Y	158_T	2.048	1.00
154_Y	157_K	1.957	1.00
185_I	190_F	1.909	1.00
103_L	117_L	1.900	1.00
47_V	54_L	1.861	1.00
156_L	160_I	1.859	1.00
193_H	196_S	1.828	1.00
11_S	137_E	1.759	1.00
159_L	202_I	1.660	1.00
202_I	205_Y	1.652	1.00
158_T	193_H	1.652	1.00
187_K	191_T	1.647	1.00
172_R	195_R	1.631	1.00
119_Y	122_Y	1.573	1.00
158_T	179_I	1.549	1.00
8_I	123_V	1.494	1.00
179_I	190_F	1.493	1.00
159_L	168_F	1.482	1.00
178_K	181_K	1.482	1.00
176_S	193_H	1.456	1.00
193_H	200_R	1.450	1.00
181_K	184_N	1.448	1.00
64_F	67_Y	1.419	1.00
69_L	79_I	1.390	1.00
166_G	173_R	1.379	1.00
167_Y	172_R	1.360	0.99
170_F	192_Y	1.349	0.99
174_I	182_L	1.306	0.99
163_Y	206_I	1.303	0.99
192_Y	196_S	1.299	0.99
168_F	194_L	1.283	0.99
43_S	83_F	1.283	0.99
158_T	197_A	1.274	0.99
68_S	174_I	1.256	0.99
177_D	187_K	1.254	0.99
18_W	22_V	1.238	0.99
10_F	116_V	1.208	0.99
22_V	61_N	1.202	0.99
158_T	185_I	1.187	0.99
202_I	206_I	1.180	0.99
180_S	190_F	1.162	0.98
8_I	11_S	1.154	0.98
165_N	174_I	1.150	0.98
151_L	197_A	1.142	0.98
201_I	205_Y	1.138	0.98
199_S	203_K	1.128	0.98
30_L	33_S	1.125	0.98
189_T	192_Y	1.119	0.98
128_E	132_S	1.100	0.98
170_F	188_S	1.089	0.97
188_S	192_Y	1.082	0.97
189_T	194_L	1.080	0.97
154_Y	192_Y	1.074	0.97
82_D	89_N	1.069	0.97
50_K	53_E	1.060	0.97
51_Y	54_L	1.060	0.97
46_V	127_R	1.055	0.97
11_S	139_I	1.054	0.97
46_V	78_K	1.043	0.97
29_T	33_S	1.034	0.97
53_E	57_K	1.031	0.96
113_Y	139_I	1.029	0.96
127_R	136_V	1.024	0.96
170_F	199_S	1.021	0.96
55_I	79_I	1.020	0.96
100_G	104_D	1.012	0.96
183_I	190_F	0.994	0.96
170_F	193_H	0.994	0.96
102_I	116_V	0.991	0.96
51_Y	55_I	0.986	0.95
10_F	127_R	0.985	0.95
117_L	168_F	0.978	0.95
98_V	129_K	0.975	0.95
176_S	187_K	0.975	0.95
167_Y	176_S	0.974	0.95
99_D	119_Y	0.963	0.95
105_G	168_F	0.960	0.95
34_V	168_F	0.958	0.95
160_I	164_K	0.945	0.94
158_T	190_F	0.943	0.94
83_F	92_M	0.941	0.94
125_E	128_E	0.937	0.94
176_S	189_T	0.931	0.94
122_Y	125_E	0.922	0.94
55_I	67_Y	0.920	0.93
186_S	195_R	0.911	0.93
138_F	141_F	0.905	0.93
9_T	113_Y	0.905	0.93
163_Y	168_F	0.904	0.93
189_T	196_S	0.899	0.93
63_S	103_L	0.890	0.92
150_E	204_R	0.885	0.92
75_D	86_R	0.884	0.92
60_R	75_D	0.882	0.92
126_L	187_K	0.882	0.92
45_I	83_F	0.873	0.92
124_N	127_R	0.869	0.91
86_R	184_N	0.863	0.91
170_F	177_D	0.861	0.91
70_V	107_K	0.851	0.90
94_N	175_K	0.851	0.90
74_T	133_K	0.848	0.90
194_L	198_E	0.833	0.90
66_G	69_L	0.831	0.89
118_L	137_E	0.830	0.89
56_N	106_F	0.826	0.89
179_I	183_I	0.820	0.89
177_D	195_R	0.817	0.89
66_G	133_K	0.815	0.88
146_I	169_D	0.814	0.88
168_F	197_A	0.812	0.88
32_F	46_V	0.811	0.88
93_D	97_S	0.810	0.88
197_A	202_I	0.809	0.88
125_E	173_R	0.807	0.88
167_Y	194_L	0.807	0.88
17_C	23_G	0.805	0.88
90_S	93_D	0.805	0.88
187_K	196_S	0.799	0.87
127_R	189_T	0.795	0.87
161_L	174_I	0.792	0.87
137_E	145_D	0.785	0.87
84_R	187_K	0.785	0.87
174_I	190_F	0.778	0.86
185_I	188_S	0.777	0.86
102_I	125_E	0.769	0.85
123_V	140_S	0.768	0.85
60_R	148_E	0.767	0.85
176_S	197_A	0.762	0.85
31_R	45_I	0.762	0.85
141_F	167_Y	0.761	0.85
63_S	152_T	0.760	0.85
189_T	197_A	0.757	0.85
8_I	116_V	0.753	0.84
42_R	45_I	0.751	0.84
99_D	129_K	0.746	0.84
35_D	102_I	0.744	0.83
16_N	45_I	0.742	0.83
149_D	205_Y	0.738	0.83
169_D	199_S	0.735	0.83
17_C	20_N	0.733	0.83
86_R	91_V	0.725	0.82
54_L	144_L	0.723	0.82
170_F	195_R	0.716	0.81
106_F	113_Y	0.715	0.81
21_L	63_S	0.715	0.81
120_E	186_S	0.712	0.81
17_C	112_E	0.710	0.81
196_S	199_S	0.707	0.80
157_K	161_L	0.702	0.80
70_V	74_T	0.693	0.79
58_I	67_Y	0.691	0.79
113_Y	180_S	0.688	0.78
53_E	79_I	0.687	0.78
14_H	17_C	0.680	0.78
201_I	204_R	0.678	0.77
83_F	107_K	0.673	0.77
155_E	200_R	0.669	0.76
23_G	193_H	0.669	0.76
29_T	47_V	0.665	0.76
42_R	114_W	0.663	0.76
66_G	122_Y	0.662	0.76
63_S	74_T	0.661	0.76
58_I	121_S	0.657	0.75
116_V	119_Y	0.656	0.75
23_G	202_I	0.655	0.75
16_N	185_I	0.650	0.74
100_G	105_G	0.649	0.74
14_H	114_W	0.648	0.74
143_E	146_I	0.643	0.74
107_K	112_E	0.642	0.74
159_L	198_E	0.641	0.73
45_I	81_F	0.638	0.73
134_G	189_T	0.638	0.73
51_Y	79_I	0.635	0.73
13_E	60_R	0.635	0.73
165_N	190_F	0.630	0.72
129_K	133_K	0.628	0.72
62_N	129_K	0.627	0.72
157_K	160_I	0.626	0.72
32_F	202_I	0.619	0.71
67_Y	70_V	0.615	0.70
13_E	20_N	0.611	0.70
51_Y	66_G	0.609	0.70
64_F	69_L	0.609	0.70
154_Y	198_E	0.608	0.69
92_M	190_F	0.606	0.69
68_S	148_E	0.605	0.69
53_E	173_R	0.605	0.69
124_N	189_T	0.604	0.69
37_E	60_R	0.601	0.69
26_V	32_F	0.597	0.68
55_I	58_I	0.596	0.68
118_L	195_R	0.595	0.68
166_G	169_D	0.595	0.68
150_E	203_K	0.595	0.68
13_E	110_G	0.594	0.68
14_H	112_E	0.592	0.67
53_E	181_K	0.591	0.67
17_C	114_W	0.590	0.67
21_L	139_I	0.589	0.67
10_F	114_W	0.584	0.66
53_E	56_N	0.584	0.66
17_C	91_V	0.583	0.66
8_I	120_E	0.582	0.66
166_G	191_T	0.582	0.66
50_K	113_Y	0.580	0.66
189_T	205_Y	0.575	0.65
39_N	182_L	0.573	0.65
7_E	142_H	0.573	0.65
130_L	134_G	0.571	0.65
161_L	183_I	0.571	0.65
85_K	131_K	0.566	0.64
119_Y	156_L	0.563	0.64
171_P	195_R	0.562	0.63
91_V	95_I	0.562	0.63
138_F	185_I	0.561	0.63
21_L	24_K	0.560	0.63
168_F	176_S	0.559	0.63
113_Y	132_S	0.559	0.63
173_R	204_R	0.559	0.63
51_Y	146_I	0.558	0.63
56_N	206_I	0.558	0.63
161_L	182_L	0.556	0.63
44_L	174_I	0.556	0.63
23_G	111_K	0.554	0.62
172_R	175_K	0.553	0.62
19_T	32_F	0.553	0.62
137_E	199_S	0.551	0.62
137_E	169_D	0.551	0.62
97_S	207_D	0.549	0.62
50_K	109_D	0.547	0.61
196_S	201_I	0.546	0.61
24_K	121_S	0.544	0.61
177_D	181_K	0.542	0.61
18_W	21_L	0.541	0.61
118_L	126_L	0.540	0.60
124_N	168_F	0.539	0.60
68_S	82_D	0.537	0.60
39_N	169_D	0.535	0.60
92_M	102_I	0.535	0.60
75_D	133_K	0.533	0.59
100_G	127_R	0.529	0.59
153_P	163_Y	0.529	0.59
27_V	165_N	0.528	0.59
36_T	184_N	0.528	0.59
159_L	197_A	0.527	0.59
56_N	60_R	0.523	0.58
23_G	107_K	0.522	0.58
60_R	165_N	0.521	0.58
58_I	61_N	0.520	0.58
110_G	132_S	0.520	0.58
167_Y	201_I	0.520	0.58
52_K	207_D	0.518	0.57
100_G	103_L	0.518	0.57
65_I	132_S	0.516	0.57
124_N	128_E	0.515	0.57
83_F	126_L	0.515	0.57
94_N	97_S	0.514	0.57
81_F	186_S	0.513	0.57
75_D	109_D	0.513	0.57
33_S	92_M	0.510	0.56
116_V	200_R	0.510	0.56
105_G	188_S	0.510	0.56
71_S	80_L	0.507	0.56
59_K	125_E	0.506	0.56
45_I	207_D	0.505	0.55
52_K	59_K	0.505	0.55
191_T	196_S	0.505	0.55
175_K	190_F	0.503	0.55
111_K	153_P	0.503	0.55
123_V	157_K	0.502	0.55
89_N	180_S	0.501	0.55
157_K	182_L	0.500	0.55
163_Y	202_I	0.500	0.55
10_F	31_R	0.500	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2o8xA	7	0.2675	97.5	0.849	Contact Map
1ku3A	1	0.2675	97.4	0.853	Contact Map
4wszA	2	0.2895	97.3	0.856	Contact Map
1x3uA	1	0.3465	97	0.861	Contact Map
1ttyA	1	0.3816	97	0.862	Contact Map
1s7oA	3	0.3904	96.9	0.864	Contact Map
1je8A	2	0.2939	96.9	0.864	Contact Map
3hugA	3	0.3509	96.8	0.865	Contact Map
3c57A	2	0.2237	96.8	0.865	Contact Map
2lfwA	1	0.6754	96.8	0.865	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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