GREMLIN Database
Q97YT6 - Uncharacterized protein
UniProt: Q97YT6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 268 (226)
Sequences: 518 (335)
Seq/√Len: 22.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_Y242_R9.0991.00
56_E99_K4.6621.00
207_Q259_K4.4591.00
160_L165_E4.1591.00
99_K102_D4.0521.00
44_P48_L3.2641.00
42_F239_K3.1771.00
51_V98_V2.9911.00
165_E168_R2.9530.99
168_R226_I2.9440.99
105_F188_V2.5250.98
43_D239_K2.4940.98
103_N207_Q2.4310.98
46_K49_D2.3610.97
223_G246_G2.3520.97
38_V246_G2.3420.97
55_L205_L2.3190.97
217_E250_N2.2720.97
91_E113_V2.2600.96
201_D204_E2.2370.96
47_V96_L2.1950.96
42_F240_I2.1670.95
96_L109_P2.1130.95
38_V169_V2.0480.94
172_T222_E2.0430.94
71_T88_K2.0230.93
41_Y60_G1.9940.93
86_E118_P1.9070.91
230_S233_E1.8720.90
115_K118_P1.8590.90
71_T90_M1.8580.90
38_V243_I1.7020.85
160_L163_G1.7000.85
43_D241_N1.6740.85
67_A235_L1.6070.82
191_R204_E1.5870.81
119_L131_L1.5840.81
12_S23_I1.5700.80
170_K224_E1.5590.80
116_D131_L1.5430.79
48_L56_E1.5190.78
126_G258_T1.5090.78
122_G129_K1.5010.77
116_D120_L1.4800.76
89_Y118_P1.4680.76
57_I98_V1.4520.75
243_I246_G1.4480.75
157_G169_V1.4420.74
73_S130_K1.4310.74
174_K222_E1.4230.73
56_E101_N1.4130.73
224_E237_V1.3880.71
12_S24_V1.3830.71
133_Y163_G1.3760.71
58_V104_I1.3720.70
216_G252_S1.3620.70
142_L170_K1.3510.69
52_P128_P1.3100.67
116_D130_K1.2830.65
121_R208_I1.2780.65
255_Q258_T1.2560.63
57_I60_G1.2450.63
144_D215_V1.2410.63
100_Y262_T1.2310.62
132_A220_R1.2290.62
43_D94_I1.2140.61
51_V57_I1.2050.60
31_Y91_E1.1980.60
119_L192_R1.1940.59
51_V54_P1.1800.59
108_F116_D1.1600.57
30_I254_K1.1590.57
211_S256_L1.1360.56
99_K241_N1.1320.55
47_V230_S1.1190.54
73_S115_K1.1090.54
34_E248_Y1.1000.53
87_T123_W1.0960.53
42_F105_F1.0820.52
117_L142_L1.0770.52
46_K239_K1.0710.51
111_M127_Y1.0550.50
21_S50_L1.0470.50
229_G236_E1.0430.49
100_Y247_Y1.0390.49
95_A108_F1.0300.48
48_L167_I1.0300.48
117_L198_D1.0280.48
11_F16_T1.0230.48
34_E250_N1.0220.48
101_N262_T1.0210.48
60_G242_R1.0150.47
73_S141_K1.0140.47
16_T124_L1.0120.47
164_K228_N1.0080.47
219_W243_I1.0070.47
166_I234_E1.0040.47
11_F234_E0.9990.46
43_D46_K0.9980.46
57_I61_E0.9920.46
139_F163_G0.9780.45
13_L126_G0.9600.44
44_P51_V0.9560.43
59_D245_G0.9530.43
44_P188_V0.9520.43
159_A166_I0.9490.43
130_K233_E0.9480.43
89_Y253_F0.9430.42
58_V141_K0.9370.42
29_W88_K0.9310.42
169_V225_V0.9280.41
196_V260_I0.9260.41
169_V228_N0.9260.41
208_I238_L0.9220.41
93_A111_M0.9220.41
39_K244_E0.9200.41
118_P195_A0.9200.41
86_E113_V0.9180.41
134_I178_S0.9160.41
194_P221_G0.9130.40
26_P48_L0.9120.40
114_D119_L0.9110.40
42_F236_E0.9100.40
31_Y157_G0.9100.40
126_G194_P0.9080.40
89_Y129_K0.8970.39
197_Q260_I0.8880.39
176_K220_R0.8680.38
120_L241_N0.8660.37
91_E128_P0.8630.37
89_Y240_I0.8600.37
59_D99_K0.8540.37
121_R221_G0.8540.37
158_Y165_E0.8470.36
106_T246_G0.8450.36
68_K90_M0.8440.36
102_D261_L0.8430.36
88_K119_L0.8420.36
180_Y215_V0.8350.35
25_P77_W0.8330.35
36_I136_I0.8310.35
160_L234_E0.8300.35
58_V217_E0.8300.35
113_V130_K0.8280.35
45_V99_K0.8280.35
113_V116_D0.8240.35
126_G196_V0.8230.35
133_Y160_L0.8220.35
22_Q123_W0.8150.34
61_E181_P0.8140.34
98_V189_Q0.8130.34
223_G243_I0.8090.34
227_L252_S0.8050.34
71_T261_L0.8050.34
220_R245_G0.8040.34
52_P89_Y0.8010.33
66_I247_Y0.8010.33
131_L180_Y0.7990.33
222_E233_E0.7980.33
167_I225_V0.7970.33
230_S234_E0.7950.33
35_M70_F0.7940.33
36_I138_E0.7940.33
113_V119_L0.7890.33
45_V48_L0.7880.33
111_M115_K0.7840.32
36_I133_Y0.7770.32
109_P188_V0.7740.32
114_D128_P0.7720.32
214_R252_S0.7690.31
162_N190_F0.7660.31
86_E125_L0.7660.31
174_K219_W0.7640.31
223_G245_G0.7630.31
132_A209_I0.7580.31
107_Y129_K0.7580.31
115_K127_Y0.7560.31
100_Y109_P0.7560.31
89_Y128_P0.7550.31
113_V118_P0.7500.30
186_P204_E0.7490.30
47_V227_L0.7490.30
110_F130_K0.7450.30
212_D254_K0.7400.30
167_I235_L0.7400.30
99_K104_I0.7390.30
199_G202_V0.7370.30
40_A159_A0.7340.29
134_I191_R0.7340.29
16_T109_P0.7330.29
235_L251_W0.7320.29
41_Y241_N0.7310.29
68_K111_M0.7280.29
51_V109_P0.7230.29
51_V107_Y0.7220.29
226_I229_G0.7210.29
135_S158_Y0.7200.29
116_D247_Y0.7140.28
191_R201_D0.7070.28
41_Y244_E0.7050.28
223_G251_W0.7030.28
27_P118_P0.7020.28
91_E118_P0.7010.28
235_L249_F0.7010.28
197_Q218_V0.6980.27
90_M200_T0.6970.27
107_Y232_N0.6970.27
16_T50_L0.6960.27
125_L258_T0.6950.27
95_A185_G0.6920.27
56_E94_I0.6900.27
60_G246_G0.6890.27
163_G209_I0.6890.27
178_S222_E0.6870.27
176_K218_V0.6840.27
70_F127_Y0.6830.27
190_F203_Y0.6820.27
55_L91_E0.6820.27
168_R228_N0.6800.26
92_A167_I0.6800.26
136_I250_N0.6760.26
42_F214_R0.6760.26
133_Y259_K0.6740.26
214_R259_K0.6720.26
58_V202_V0.6700.26
75_N255_Q0.6690.26
192_R203_Y0.6680.26
86_E121_R0.6670.26
126_G206_G0.6640.26
29_W121_R0.6620.25
187_I208_I0.6580.25
73_S111_M0.6570.25
86_E115_K0.6540.25
118_P196_V0.6520.25
34_E71_T0.6460.25
15_I41_Y0.6450.25
16_T21_S0.6440.25
177_V184_F0.6430.25
195_A203_Y0.6390.24
123_W234_E0.6380.24
54_P240_I0.6360.24
31_Y89_Y0.6360.24
185_G242_R0.6330.24
256_L262_T0.6330.24
136_I226_I0.6310.24
98_V107_Y0.6270.24
241_N244_E0.6230.24
70_F108_F0.6210.23
42_F188_V0.6190.23
125_L196_V0.6180.23
40_A128_P0.6170.23
62_G245_G0.6160.23
67_A167_I0.6140.23
177_V220_R0.6110.23
120_L124_L0.6050.23
190_F204_E0.6040.23
256_L260_I0.6040.23
118_P258_T0.6040.23
34_E191_R0.6030.23
12_S53_P0.6030.23
167_I227_L0.6020.22
25_P62_G0.6010.22
113_V121_R0.6000.22
159_A235_L0.6000.22
158_Y241_N0.5970.22
204_E221_G0.5960.22
70_F111_M0.5950.22
171_I221_G0.5940.22
92_A159_A0.5930.22
40_A98_V0.5920.22
88_K115_K0.5920.22
170_K197_Q0.5900.22
61_E244_E0.5900.22
26_P259_K0.5890.22
56_E221_G0.5880.22
196_V258_T0.5870.22
195_A230_S0.5830.22
107_Y128_P0.5790.21
120_L222_E0.5770.21
76_R100_Y0.5770.21
136_I157_G0.5730.21
76_R256_L0.5710.21
47_V119_L0.5710.21
53_P140_H0.5700.21
106_T135_S0.5700.21
191_R221_G0.5640.21
67_A76_R0.5640.21
122_G126_G0.5630.21
12_S131_L0.5620.21
111_M129_K0.5600.21
91_E116_D0.5560.20
42_F235_L0.5550.20
102_D213_F0.5520.20
60_G106_T0.5510.20
91_E114_D0.5480.20
242_R257_G0.5430.20
133_Y158_Y0.5420.20
215_V251_W0.5420.20
23_I117_L0.5420.20
57_I226_I0.5410.20
188_V207_Q0.5410.20
25_P28_P0.5400.20
127_Y189_Q0.5390.20
40_A238_L0.5360.19
216_G250_N0.5350.19
94_I160_L0.5350.19
15_I178_S0.5330.19
42_F62_G0.5330.19
55_L107_Y0.5320.19
13_L132_A0.5310.19
116_D140_H0.5290.19
136_I171_I0.5280.19
35_M227_L0.5270.19
42_F107_Y0.5250.19
91_E129_K0.5240.19
106_T187_I0.5230.19
31_Y255_Q0.5230.19
26_P180_Y0.5220.19
40_A239_K0.5220.19
57_I163_G0.5210.19
62_G109_P0.5200.19
47_V188_V0.5200.19
71_T96_L0.5200.19
27_P109_P0.5180.19
77_W225_V0.5150.19
166_I228_N0.5150.19
171_I191_R0.5150.19
15_I163_G0.5140.19
182_I238_L0.5110.18
33_I68_K0.5110.18
88_K121_R0.5090.18
37_G220_R0.5070.18
68_K134_I0.5070.18
195_A204_E0.5060.18
96_L116_D0.5050.18
76_R241_N0.5040.18
11_F260_I0.5030.18
206_G221_G0.5030.18
15_I244_E0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zboA 4 0.944 100 0.327 Contact Map
4jmdA 4 0.9552 100 0.338 Contact Map
3bh2A 6 0.8881 100 0.354 Contact Map
3bgtA 6 0.8918 100 0.367 Contact Map
3c8wA 6 0.8955 100 0.392 Contact Map
3cmbA 4 0.8881 100 0.405 Contact Map
3c8iA 4 0.3657 2.9 0.973 Contact Map
2qzqA 1 0.5672 2.4 0.974 Contact Map
2ep7A 4 0.3843 2.1 0.975 Contact Map
4aeqA 2 0.153 2 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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