Q97YT6 - SULSO - GREMLIN Contacts

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Q97YT6 - Uncharacterized protein

UniProt:	Q97YT6	Sequences: MEEIRPYYNTFSLPITKSGKSQIVPPPPWIYAIEMIGVKAYFDPVKVLDLVPPPLEIVDGEGFVYIAKIFTVSGNRWEMLYEDPEETKYMEAAIALKVKYNDNIFTYFPFMWVDKDLPLLRGWLLGYPKKLAYISISEFHKLLDGYSGPSSGVRMGGYALRNGKEIIRVKITLKEKVSQYPIPFGPIVQFRRFPAVQDGTDVYELGQIISSDFRVGEVWRGEGEVILNGSVNEELEVLKINRIEGGYYFNWSFKQLGTKILTKVPNNY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	268 (226)
Sequences:	518 (335)
Seq/√Len:	22.3

SULSO - Q97YT6 Q97YT5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
41_Y	242_R	9.099	1.00
56_E	99_K	4.662	1.00
207_Q	259_K	4.459	1.00
160_L	165_E	4.159	1.00
99_K	102_D	4.052	1.00
44_P	48_L	3.264	1.00
42_F	239_K	3.177	1.00
51_V	98_V	2.991	1.00
165_E	168_R	2.953	0.99
168_R	226_I	2.944	0.99
105_F	188_V	2.525	0.98
43_D	239_K	2.494	0.98
103_N	207_Q	2.431	0.98
46_K	49_D	2.361	0.97
223_G	246_G	2.352	0.97
38_V	246_G	2.342	0.97
55_L	205_L	2.319	0.97
217_E	250_N	2.272	0.97
91_E	113_V	2.260	0.96
201_D	204_E	2.237	0.96
47_V	96_L	2.195	0.96
42_F	240_I	2.167	0.95
96_L	109_P	2.113	0.95
38_V	169_V	2.048	0.94
172_T	222_E	2.043	0.94
71_T	88_K	2.023	0.93
41_Y	60_G	1.994	0.93
86_E	118_P	1.907	0.91
230_S	233_E	1.872	0.90
115_K	118_P	1.859	0.90
71_T	90_M	1.858	0.90
38_V	243_I	1.702	0.85
160_L	163_G	1.700	0.85
43_D	241_N	1.674	0.85
67_A	235_L	1.607	0.82
191_R	204_E	1.587	0.81
119_L	131_L	1.584	0.81
12_S	23_I	1.570	0.80
170_K	224_E	1.559	0.80
116_D	131_L	1.543	0.79
48_L	56_E	1.519	0.78
126_G	258_T	1.509	0.78
122_G	129_K	1.501	0.77
116_D	120_L	1.480	0.76
89_Y	118_P	1.468	0.76
57_I	98_V	1.452	0.75
243_I	246_G	1.448	0.75
157_G	169_V	1.442	0.74
73_S	130_K	1.431	0.74
174_K	222_E	1.423	0.73
56_E	101_N	1.413	0.73
224_E	237_V	1.388	0.71
12_S	24_V	1.383	0.71
133_Y	163_G	1.376	0.71
58_V	104_I	1.372	0.70
216_G	252_S	1.362	0.70
142_L	170_K	1.351	0.69
52_P	128_P	1.310	0.67
116_D	130_K	1.283	0.65
121_R	208_I	1.278	0.65
255_Q	258_T	1.256	0.63
57_I	60_G	1.245	0.63
144_D	215_V	1.241	0.63
100_Y	262_T	1.231	0.62
132_A	220_R	1.229	0.62
43_D	94_I	1.214	0.61
51_V	57_I	1.205	0.60
31_Y	91_E	1.198	0.60
119_L	192_R	1.194	0.59
51_V	54_P	1.180	0.59
108_F	116_D	1.160	0.57
30_I	254_K	1.159	0.57
211_S	256_L	1.136	0.56
99_K	241_N	1.132	0.55
47_V	230_S	1.119	0.54
73_S	115_K	1.109	0.54
34_E	248_Y	1.100	0.53
87_T	123_W	1.096	0.53
42_F	105_F	1.082	0.52
117_L	142_L	1.077	0.52
46_K	239_K	1.071	0.51
111_M	127_Y	1.055	0.50
21_S	50_L	1.047	0.50
229_G	236_E	1.043	0.49
100_Y	247_Y	1.039	0.49
95_A	108_F	1.030	0.48
48_L	167_I	1.030	0.48
117_L	198_D	1.028	0.48
11_F	16_T	1.023	0.48
34_E	250_N	1.022	0.48
101_N	262_T	1.021	0.48
60_G	242_R	1.015	0.47
73_S	141_K	1.014	0.47
16_T	124_L	1.012	0.47
164_K	228_N	1.008	0.47
219_W	243_I	1.007	0.47
166_I	234_E	1.004	0.47
11_F	234_E	0.999	0.46
43_D	46_K	0.998	0.46
57_I	61_E	0.992	0.46
139_F	163_G	0.978	0.45
13_L	126_G	0.960	0.44
44_P	51_V	0.956	0.43
59_D	245_G	0.953	0.43
44_P	188_V	0.952	0.43
159_A	166_I	0.949	0.43
130_K	233_E	0.948	0.43
89_Y	253_F	0.943	0.42
58_V	141_K	0.937	0.42
29_W	88_K	0.931	0.42
169_V	225_V	0.928	0.41
196_V	260_I	0.926	0.41
169_V	228_N	0.926	0.41
208_I	238_L	0.922	0.41
93_A	111_M	0.922	0.41
39_K	244_E	0.920	0.41
118_P	195_A	0.920	0.41
86_E	113_V	0.918	0.41
134_I	178_S	0.916	0.41
194_P	221_G	0.913	0.40
26_P	48_L	0.912	0.40
114_D	119_L	0.911	0.40
42_F	236_E	0.910	0.40
31_Y	157_G	0.910	0.40
126_G	194_P	0.908	0.40
89_Y	129_K	0.897	0.39
197_Q	260_I	0.888	0.39
176_K	220_R	0.868	0.38
120_L	241_N	0.866	0.37
91_E	128_P	0.863	0.37
89_Y	240_I	0.860	0.37
59_D	99_K	0.854	0.37
121_R	221_G	0.854	0.37
158_Y	165_E	0.847	0.36
106_T	246_G	0.845	0.36
68_K	90_M	0.844	0.36
102_D	261_L	0.843	0.36
88_K	119_L	0.842	0.36
180_Y	215_V	0.835	0.35
25_P	77_W	0.833	0.35
36_I	136_I	0.831	0.35
160_L	234_E	0.830	0.35
58_V	217_E	0.830	0.35
113_V	130_K	0.828	0.35
45_V	99_K	0.828	0.35
113_V	116_D	0.824	0.35
126_G	196_V	0.823	0.35
133_Y	160_L	0.822	0.35
22_Q	123_W	0.815	0.34
61_E	181_P	0.814	0.34
98_V	189_Q	0.813	0.34
223_G	243_I	0.809	0.34
227_L	252_S	0.805	0.34
71_T	261_L	0.805	0.34
220_R	245_G	0.804	0.34
52_P	89_Y	0.801	0.33
66_I	247_Y	0.801	0.33
131_L	180_Y	0.799	0.33
222_E	233_E	0.798	0.33
167_I	225_V	0.797	0.33
230_S	234_E	0.795	0.33
35_M	70_F	0.794	0.33
36_I	138_E	0.794	0.33
113_V	119_L	0.789	0.33
45_V	48_L	0.788	0.33
111_M	115_K	0.784	0.32
36_I	133_Y	0.777	0.32
109_P	188_V	0.774	0.32
114_D	128_P	0.772	0.32
214_R	252_S	0.769	0.31
162_N	190_F	0.766	0.31
86_E	125_L	0.766	0.31
174_K	219_W	0.764	0.31
223_G	245_G	0.763	0.31
132_A	209_I	0.758	0.31
107_Y	129_K	0.758	0.31
115_K	127_Y	0.756	0.31
100_Y	109_P	0.756	0.31
89_Y	128_P	0.755	0.31
113_V	118_P	0.750	0.30
186_P	204_E	0.749	0.30
47_V	227_L	0.749	0.30
110_F	130_K	0.745	0.30
212_D	254_K	0.740	0.30
167_I	235_L	0.740	0.30
99_K	104_I	0.739	0.30
199_G	202_V	0.737	0.30
40_A	159_A	0.734	0.29
134_I	191_R	0.734	0.29
16_T	109_P	0.733	0.29
235_L	251_W	0.732	0.29
41_Y	241_N	0.731	0.29
68_K	111_M	0.728	0.29
51_V	109_P	0.723	0.29
51_V	107_Y	0.722	0.29
226_I	229_G	0.721	0.29
135_S	158_Y	0.720	0.29
116_D	247_Y	0.714	0.28
191_R	201_D	0.707	0.28
41_Y	244_E	0.705	0.28
223_G	251_W	0.703	0.28
27_P	118_P	0.702	0.28
91_E	118_P	0.701	0.28
235_L	249_F	0.701	0.28
197_Q	218_V	0.698	0.27
90_M	200_T	0.697	0.27
107_Y	232_N	0.697	0.27
16_T	50_L	0.696	0.27
125_L	258_T	0.695	0.27
95_A	185_G	0.692	0.27
56_E	94_I	0.690	0.27
60_G	246_G	0.689	0.27
163_G	209_I	0.689	0.27
178_S	222_E	0.687	0.27
176_K	218_V	0.684	0.27
70_F	127_Y	0.683	0.27
190_F	203_Y	0.682	0.27
55_L	91_E	0.682	0.27
168_R	228_N	0.680	0.26
92_A	167_I	0.680	0.26
136_I	250_N	0.676	0.26
42_F	214_R	0.676	0.26
133_Y	259_K	0.674	0.26
214_R	259_K	0.672	0.26
58_V	202_V	0.670	0.26
75_N	255_Q	0.669	0.26
192_R	203_Y	0.668	0.26
86_E	121_R	0.667	0.26
126_G	206_G	0.664	0.26
29_W	121_R	0.662	0.25
187_I	208_I	0.658	0.25
73_S	111_M	0.657	0.25
86_E	115_K	0.654	0.25
118_P	196_V	0.652	0.25
34_E	71_T	0.646	0.25
15_I	41_Y	0.645	0.25
16_T	21_S	0.644	0.25
177_V	184_F	0.643	0.25
195_A	203_Y	0.639	0.24
123_W	234_E	0.638	0.24
54_P	240_I	0.636	0.24
31_Y	89_Y	0.636	0.24
185_G	242_R	0.633	0.24
256_L	262_T	0.633	0.24
136_I	226_I	0.631	0.24
98_V	107_Y	0.627	0.24
241_N	244_E	0.623	0.24
70_F	108_F	0.621	0.23
42_F	188_V	0.619	0.23
125_L	196_V	0.618	0.23
40_A	128_P	0.617	0.23
62_G	245_G	0.616	0.23
67_A	167_I	0.614	0.23
177_V	220_R	0.611	0.23
120_L	124_L	0.605	0.23
190_F	204_E	0.604	0.23
256_L	260_I	0.604	0.23
118_P	258_T	0.604	0.23
34_E	191_R	0.603	0.23
12_S	53_P	0.603	0.23
167_I	227_L	0.602	0.22
25_P	62_G	0.601	0.22
113_V	121_R	0.600	0.22
159_A	235_L	0.600	0.22
158_Y	241_N	0.597	0.22
204_E	221_G	0.596	0.22
70_F	111_M	0.595	0.22
171_I	221_G	0.594	0.22
92_A	159_A	0.593	0.22
40_A	98_V	0.592	0.22
88_K	115_K	0.592	0.22
170_K	197_Q	0.590	0.22
61_E	244_E	0.590	0.22
26_P	259_K	0.589	0.22
56_E	221_G	0.588	0.22
196_V	258_T	0.587	0.22
195_A	230_S	0.583	0.22
107_Y	128_P	0.579	0.21
120_L	222_E	0.577	0.21
76_R	100_Y	0.577	0.21
136_I	157_G	0.573	0.21
76_R	256_L	0.571	0.21
47_V	119_L	0.571	0.21
53_P	140_H	0.570	0.21
106_T	135_S	0.570	0.21
191_R	221_G	0.564	0.21
67_A	76_R	0.564	0.21
122_G	126_G	0.563	0.21
12_S	131_L	0.562	0.21
111_M	129_K	0.560	0.21
91_E	116_D	0.556	0.20
42_F	235_L	0.555	0.20
102_D	213_F	0.552	0.20
60_G	106_T	0.551	0.20
91_E	114_D	0.548	0.20
242_R	257_G	0.543	0.20
133_Y	158_Y	0.542	0.20
215_V	251_W	0.542	0.20
23_I	117_L	0.542	0.20
57_I	226_I	0.541	0.20
188_V	207_Q	0.541	0.20
25_P	28_P	0.540	0.20
127_Y	189_Q	0.539	0.20
40_A	238_L	0.536	0.19
216_G	250_N	0.535	0.19
94_I	160_L	0.535	0.19
15_I	178_S	0.533	0.19
42_F	62_G	0.533	0.19
55_L	107_Y	0.532	0.19
13_L	132_A	0.531	0.19
116_D	140_H	0.529	0.19
136_I	171_I	0.528	0.19
35_M	227_L	0.527	0.19
42_F	107_Y	0.525	0.19
91_E	129_K	0.524	0.19
106_T	187_I	0.523	0.19
31_Y	255_Q	0.523	0.19
26_P	180_Y	0.522	0.19
40_A	239_K	0.522	0.19
57_I	163_G	0.521	0.19
62_G	109_P	0.520	0.19
47_V	188_V	0.520	0.19
71_T	96_L	0.520	0.19
27_P	109_P	0.518	0.19
77_W	225_V	0.515	0.19
166_I	228_N	0.515	0.19
171_I	191_R	0.515	0.19
15_I	163_G	0.514	0.19
182_I	238_L	0.511	0.18
33_I	68_K	0.511	0.18
88_K	121_R	0.509	0.18
37_G	220_R	0.507	0.18
68_K	134_I	0.507	0.18
195_A	204_E	0.506	0.18
96_L	116_D	0.505	0.18
76_R	241_N	0.504	0.18
11_F	260_I	0.503	0.18
206_G	221_G	0.503	0.18
15_I	244_E	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4zboA	4	0.944	100	0.327	Contact Map
4jmdA	4	0.9552	100	0.338	Contact Map
3bh2A	6	0.8881	100	0.354	Contact Map
3bgtA	6	0.8918	100	0.367	Contact Map
3c8wA	6	0.8955	100	0.392	Contact Map
3cmbA	4	0.8881	100	0.405	Contact Map
3c8iA	4	0.3657	2.9	0.973	Contact Map
2qzqA	1	0.5672	2.4	0.974	Contact Map
2ep7A	4	0.3843	2.1	0.975	Contact Map
4aeqA	2	0.153	2	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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