GREMLIN Database
Q97YT5 - Uncharacterized protein
UniProt: Q97YT5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (233)
Sequences: 369 (236)
Seq/√Len: 15.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_K267_R7.2581.00
232_S284_Q5.0361.00
80_S122_N4.3371.00
183_V188_V4.2911.00
122_N125_G3.7381.00
70_S73_K3.6631.00
138_K141_A3.2070.99
126_K232_S3.0060.98
68_K72_E2.8050.97
62_A271_G2.7370.97
75_I121_V2.4530.94
94_S113_M2.3710.92
90_A260_V2.3110.91
128_Y212_L2.2610.90
181_Y188_V2.2210.90
71_A119_L2.2050.89
94_S111_Q2.1430.88
222_E226_D2.0750.86
85_G269_I2.0680.86
66_F264_E1.9880.83
191_R251_E1.9180.81
62_A192_M1.8970.80
183_V186_G1.8790.80
216_R228_Y1.8260.78
121_V213_N1.8250.78
139_D143_V1.8150.77
142_L154_I1.7980.77
75_I81_T1.7840.76
188_V191_R1.7570.75
195_E247_K1.7430.74
66_F265_V1.7320.74
249_N262_L1.7030.72
83_G271_G1.6560.70
248_A271_G1.6360.69
110_V146_W1.6180.68
241_G277_Y1.5780.66
226_D229_E1.5630.66
65_K84_E1.5590.65
137_D158_A1.5420.65
197_E247_K1.5150.63
119_L132_P1.5120.63
180_G192_M1.4780.61
189_M259_E1.4540.60
183_V259_E1.4480.59
149_G283_T1.4310.59
140_W177_R1.4200.58
159_M178_L1.4130.58
40_T147_L1.4100.57
49_F52_P1.4000.57
217_F227_L1.3950.57
96_S153_K1.3910.56
140_W223_G1.3790.56
192_M253_G1.3670.55
72_E80_S1.3400.53
242_E275_T1.3170.52
49_F100_W1.3140.52
82_D127_N1.3110.52
78_F265_V1.2970.51
37_L149_G1.2910.51
69_E72_E1.2830.50
149_G218_P1.2810.50
114_E152_K1.2760.50
201_D268_T1.2730.50
96_S99_N1.2710.49
145_G152_K1.2580.49
69_E239_K1.2500.48
201_D204_P1.2460.48
54_Y279_K1.2410.48
190_F250_V1.2360.47
139_D175_G1.2360.47
65_K282_T1.2230.47
36_T48_V1.2210.47
36_T47_I1.2190.47
112_Y152_K1.2170.46
244_W268_T1.1820.44
61_G206_K1.1810.44
149_G220_R1.1720.44
80_S201_D1.1520.43
84_E267_R1.1500.43
236_D281_T1.1440.42
96_S176_L1.1430.42
50_Q201_D1.1400.42
239_K284_Q1.1340.42
92_F260_V1.1290.41
67_T266_E1.1220.41
139_D154_I1.1130.41
114_E136_V1.1090.40
68_K266_E1.1030.40
141_A283_T1.0800.39
138_K150_Y1.0710.38
240_Y276_L1.0630.38
237_E279_K1.0610.38
121_V128_Y1.0590.38
54_Y254_G1.0590.38
248_A276_L1.0550.37
75_I78_F1.0520.37
243_I265_V1.0500.37
129_L271_G1.0450.37
203_L206_K1.0450.37
91_E116_A1.0400.37
89_I272_Y1.0310.36
99_N281_T1.0290.36
255_Y258_D1.0230.36
251_E254_G1.0190.36
53_W144_R1.0020.35
53_W148_D0.9990.35
223_G281_T0.9940.34
118_G131_F0.9920.34
77_G175_G0.9900.34
202_S205_L0.9890.34
82_D132_P0.9790.33
92_F121_V0.9770.33
280_V283_T0.9710.33
94_S119_L0.9700.33
134_M220_R0.9670.33
136_V153_K0.9630.33
73_K232_S0.9610.33
33_S267_R0.9600.33
37_L92_F0.9600.33
122_N127_N0.9550.32
190_F252_L0.9550.32
81_T121_V0.9540.32
201_D243_I0.9530.32
229_E253_G0.9510.32
174_S186_G0.9470.32
89_I131_F0.9450.32
36_T229_E0.9410.32
214_I259_E0.9400.32
53_W111_Q0.9380.31
268_T271_G0.9360.31
144_R233_R0.9330.31
68_K75_I0.9330.31
111_Q144_R0.9320.31
35_F154_I0.9300.31
238_S279_K0.9240.31
70_S97_E0.9240.31
80_S124_E0.9170.30
66_F71_A0.9170.30
55_Y114_E0.9100.30
130_Y152_K0.9090.30
55_Y280_V0.9090.30
67_T264_E0.9030.30
71_A212_L0.9010.30
124_E287_S0.8940.29
144_R148_D0.8940.29
33_S125_G0.8940.29
116_A134_M0.8800.29
154_I244_W0.8770.29
76_P145_G0.8760.28
67_T117_I0.8750.28
84_E271_G0.8730.28
133_F137_D0.8720.28
39_P65_K0.8690.28
75_I130_Y0.8670.28
182_V189_M0.8650.28
137_D142_L0.8650.28
153_K176_L0.8640.28
122_N266_E0.8620.28
126_K239_K0.8620.28
77_G262_L0.8620.28
130_Y257_N0.8590.28
153_K177_R0.8580.28
233_R283_T0.8540.27
247_K258_D0.8500.27
73_K156_K0.8480.27
153_K227_L0.8470.27
125_G286_I0.8370.27
69_E122_N0.8370.27
148_D283_T0.8320.26
124_E156_K0.8310.26
245_K270_G0.8300.26
50_Q70_S0.8240.26
75_I132_P0.8210.26
54_Y68_K0.8190.26
33_S205_L0.8180.26
138_K148_D0.8160.26
52_P153_K0.8070.25
219_S234_V0.8060.25
266_E270_G0.8010.25
149_G217_F0.7980.25
36_T77_G0.7970.25
181_Y204_P0.7910.25
269_I275_T0.7890.25
146_W217_F0.7890.25
72_E77_G0.7860.24
36_T231_V0.7790.24
231_V245_K0.7760.24
193_Q249_N0.7700.24
81_T84_E0.7680.24
158_A181_Y0.7680.24
196_L258_D0.7610.23
220_R283_T0.7590.23
160_T174_S0.7570.23
79_L230_I0.7570.23
121_V130_Y0.7560.23
145_G149_G0.7560.23
189_M260_V0.7510.23
86_W130_Y0.7490.23
130_Y211_F0.7440.23
94_S286_I0.7430.23
112_Y265_V0.7380.23
53_W96_S0.7330.22
237_E240_Y0.7300.22
62_A119_L0.7270.22
49_F69_E0.7270.22
91_E134_M0.7250.22
178_L188_V0.7230.22
47_I195_E0.7190.22
218_P285_L0.7170.22
66_F86_W0.7160.22
134_M150_Y0.7140.22
112_Y151_P0.7130.22
66_F112_Y0.7120.22
55_Y134_M0.7070.21
192_M250_V0.7060.21
155_A245_K0.7040.21
154_I175_G0.7040.21
122_N224_E0.7040.21
117_I183_V0.7010.21
161_K177_R0.7010.21
210_P229_E0.7000.21
53_W153_K0.7000.21
134_M152_K0.6990.21
199_R245_K0.6990.21
230_I244_W0.6970.21
58_T91_E0.6960.21
141_A220_R0.6910.21
112_Y278_F0.6900.21
59_Y93_I0.6860.21
184_R261_S0.6860.21
65_K147_L0.6810.20
215_R229_E0.6810.20
222_E227_L0.6800.20
111_Q259_E0.6800.20
63_H111_Q0.6790.20
135_W138_K0.6780.20
45_S69_E0.6780.20
121_V132_P0.6760.20
186_G234_V0.6730.20
245_K263_L0.6730.20
248_A287_S0.6730.20
175_G245_K0.6680.20
182_V260_V0.6550.19
96_S111_Q0.6540.19
129_L149_G0.6530.19
150_Y213_N0.6490.19
40_T45_S0.6490.19
70_S126_K0.6490.19
131_F188_V0.6470.19
82_D122_N0.6450.19
34_D81_T0.6450.19
121_V228_Y0.6440.19
49_F125_G0.6440.19
156_K182_V0.6440.19
200_T203_L0.6430.19
219_S224_E0.6430.19
213_N232_S0.6420.19
33_S223_G0.6410.19
129_L208_F0.6390.19
144_R222_E0.6370.19
244_W267_R0.6360.19
148_D220_R0.6340.19
78_F116_A0.6330.19
77_G229_E0.6330.19
55_Y273_Y0.6310.19
188_V250_V0.6300.19
126_K129_L0.6290.18
123_F156_K0.6280.18
156_K186_G0.6220.18
71_A216_R0.6200.18
89_I155_A0.6190.18
157_I196_L0.6180.18
190_F261_S0.6170.18
69_E288_K0.6170.18
137_D253_G0.6120.18
99_N224_E0.6110.18
192_M276_L0.6070.18
117_I132_P0.6060.18
123_F272_Y0.6010.18
189_M264_E0.6010.18
132_P212_L0.5990.17
32_N35_F0.5980.17
97_E180_G0.5970.17
201_D240_Y0.5970.17
91_E255_Y0.5960.17
187_G203_L0.5950.17
114_E150_Y0.5920.17
161_K175_G0.5910.17
227_L285_L0.5910.17
239_K277_Y0.5880.17
156_K201_D0.5870.17
49_F244_W0.5870.17
235_R283_T0.5850.17
80_S246_G0.5800.17
50_Q72_E0.5780.17
144_R160_T0.5780.17
123_F287_S0.5760.17
37_L220_R0.5750.17
38_P145_G0.5740.17
83_G270_G0.5720.17
149_G160_T0.5710.17
83_G131_F0.5700.17
145_G151_P0.5680.16
101_D148_D0.5640.16
58_T255_Y0.5620.16
60_I160_T0.5610.16
246_G268_T0.5580.16
75_I155_A0.5570.16
40_T65_K0.5550.16
174_S185_G0.5550.16
55_Y180_G0.5520.16
98_D280_V0.5510.16
224_E284_Q0.5500.16
225_V236_D0.5480.16
53_W227_L0.5410.16
141_A280_V0.5400.16
45_S260_V0.5400.16
66_F100_W0.5390.16
240_Y279_K0.5370.16
35_F259_E0.5370.16
118_G209_G0.5360.16
52_P139_D0.5360.16
148_D282_T0.5340.15
223_G231_V0.5320.15
212_L232_S0.5320.15
33_S124_E0.5320.15
91_E258_D0.5310.15
86_W240_Y0.5310.15
37_L217_F0.5270.15
203_L249_N0.5270.15
211_F283_T0.5270.15
136_V144_R0.5250.15
51_P141_A0.5250.15
111_Q138_K0.5240.15
48_V176_L0.5230.15
148_D217_F0.5210.15
79_L114_E0.5180.15
153_K285_L0.5180.15
83_G201_D0.5160.15
263_L279_K0.5160.15
83_G86_W0.5150.15
101_D138_K0.5130.15
200_T245_K0.5110.15
238_S245_K0.5090.15
76_P149_G0.5070.15
133_F212_L0.5070.15
143_V266_E0.5040.15
69_E124_E0.5030.15
89_I212_L0.5020.15
77_G266_E0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zboA 4 0.8586 100 0.431 Contact Map
4jmdA 4 0.8721 100 0.434 Contact Map
3bh2A 6 0.8047 100 0.462 Contact Map
3bgtA 6 0.8081 100 0.477 Contact Map
3c8wA 6 0.8215 100 0.501 Contact Map
3cmbA 4 0.8081 100 0.549 Contact Map
2kvoA 1 0.1717 5.2 0.977 Contact Map
4gs5A 1 0.1852 4.1 0.978 Contact Map
2ly8A 1 0.2593 3.6 0.978 Contact Map
1ccwB 2 0.431 3.3 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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