Q97YT5 - SULSO - GREMLIN Contacts

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Q97YT5 - Uncharacterized protein

UniProt:	Q97YT5	Sequences: MVFLSEIGKLETSLMECLFSRLKVKVPMTKNNSDFTLPPTNSGKSQIVFQPPWYYGVTYIGAHVKFTKESAEKVIPGFLSTDGEGWVYIAEFISTSEDNWDYMYQDPDLVQYMEGAIGLKVNFEGKNYLYFPFMWVDKDWALVRGWLDGYPKKIAKIAMTKLHPLLPKYNKPESGLRLGGYVVRGGGVMFRMQVELEGRTDSLPLKSFGPFLNIRRFPSRGEGEVDLYEIVSRVRDESKYGEIWKGKANVELGGYVNDEVSLLEVERTIGGYYYTLYFKVTTTQLISKKIEETISLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	297 (233)
Sequences:	369 (236)
Seq/√Len:	15.4

SULSO - Q97YT5 Q97YT6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
65_K	267_R	7.258	1.00
232_S	284_Q	5.036	1.00
80_S	122_N	4.337	1.00
183_V	188_V	4.291	1.00
122_N	125_G	3.738	1.00
70_S	73_K	3.663	1.00
138_K	141_A	3.207	0.99
126_K	232_S	3.006	0.98
68_K	72_E	2.805	0.97
62_A	271_G	2.737	0.97
75_I	121_V	2.453	0.94
94_S	113_M	2.371	0.92
90_A	260_V	2.311	0.91
128_Y	212_L	2.261	0.90
181_Y	188_V	2.221	0.90
71_A	119_L	2.205	0.89
94_S	111_Q	2.143	0.88
222_E	226_D	2.075	0.86
85_G	269_I	2.068	0.86
66_F	264_E	1.988	0.83
191_R	251_E	1.918	0.81
62_A	192_M	1.897	0.80
183_V	186_G	1.879	0.80
216_R	228_Y	1.826	0.78
121_V	213_N	1.825	0.78
139_D	143_V	1.815	0.77
142_L	154_I	1.798	0.77
75_I	81_T	1.784	0.76
188_V	191_R	1.757	0.75
195_E	247_K	1.743	0.74
66_F	265_V	1.732	0.74
249_N	262_L	1.703	0.72
83_G	271_G	1.656	0.70
248_A	271_G	1.636	0.69
110_V	146_W	1.618	0.68
241_G	277_Y	1.578	0.66
226_D	229_E	1.563	0.66
65_K	84_E	1.559	0.65
137_D	158_A	1.542	0.65
197_E	247_K	1.515	0.63
119_L	132_P	1.512	0.63
180_G	192_M	1.478	0.61
189_M	259_E	1.454	0.60
183_V	259_E	1.448	0.59
149_G	283_T	1.431	0.59
140_W	177_R	1.420	0.58
159_M	178_L	1.413	0.58
40_T	147_L	1.410	0.57
49_F	52_P	1.400	0.57
217_F	227_L	1.395	0.57
96_S	153_K	1.391	0.56
140_W	223_G	1.379	0.56
192_M	253_G	1.367	0.55
72_E	80_S	1.340	0.53
242_E	275_T	1.317	0.52
49_F	100_W	1.314	0.52
82_D	127_N	1.311	0.52
78_F	265_V	1.297	0.51
37_L	149_G	1.291	0.51
69_E	72_E	1.283	0.50
149_G	218_P	1.281	0.50
114_E	152_K	1.276	0.50
201_D	268_T	1.273	0.50
96_S	99_N	1.271	0.49
145_G	152_K	1.258	0.49
69_E	239_K	1.250	0.48
201_D	204_P	1.246	0.48
54_Y	279_K	1.241	0.48
190_F	250_V	1.236	0.47
139_D	175_G	1.236	0.47
65_K	282_T	1.223	0.47
36_T	48_V	1.221	0.47
36_T	47_I	1.219	0.47
112_Y	152_K	1.217	0.46
244_W	268_T	1.182	0.44
61_G	206_K	1.181	0.44
149_G	220_R	1.172	0.44
80_S	201_D	1.152	0.43
84_E	267_R	1.150	0.43
236_D	281_T	1.144	0.42
96_S	176_L	1.143	0.42
50_Q	201_D	1.140	0.42
239_K	284_Q	1.134	0.42
92_F	260_V	1.129	0.41
67_T	266_E	1.122	0.41
139_D	154_I	1.113	0.41
114_E	136_V	1.109	0.40
68_K	266_E	1.103	0.40
141_A	283_T	1.080	0.39
138_K	150_Y	1.071	0.38
240_Y	276_L	1.063	0.38
237_E	279_K	1.061	0.38
121_V	128_Y	1.059	0.38
54_Y	254_G	1.059	0.38
248_A	276_L	1.055	0.37
75_I	78_F	1.052	0.37
243_I	265_V	1.050	0.37
129_L	271_G	1.045	0.37
203_L	206_K	1.045	0.37
91_E	116_A	1.040	0.37
89_I	272_Y	1.031	0.36
99_N	281_T	1.029	0.36
255_Y	258_D	1.023	0.36
251_E	254_G	1.019	0.36
53_W	144_R	1.002	0.35
53_W	148_D	0.999	0.35
223_G	281_T	0.994	0.34
118_G	131_F	0.992	0.34
77_G	175_G	0.990	0.34
202_S	205_L	0.989	0.34
82_D	132_P	0.979	0.33
92_F	121_V	0.977	0.33
280_V	283_T	0.971	0.33
94_S	119_L	0.970	0.33
134_M	220_R	0.967	0.33
136_V	153_K	0.963	0.33
73_K	232_S	0.961	0.33
33_S	267_R	0.960	0.33
37_L	92_F	0.960	0.33
122_N	127_N	0.955	0.32
190_F	252_L	0.955	0.32
81_T	121_V	0.954	0.32
201_D	243_I	0.953	0.32
229_E	253_G	0.951	0.32
174_S	186_G	0.947	0.32
89_I	131_F	0.945	0.32
36_T	229_E	0.941	0.32
214_I	259_E	0.940	0.32
53_W	111_Q	0.938	0.31
268_T	271_G	0.936	0.31
144_R	233_R	0.933	0.31
68_K	75_I	0.933	0.31
111_Q	144_R	0.932	0.31
35_F	154_I	0.930	0.31
238_S	279_K	0.924	0.31
70_S	97_E	0.924	0.31
80_S	124_E	0.917	0.30
66_F	71_A	0.917	0.30
55_Y	114_E	0.910	0.30
130_Y	152_K	0.909	0.30
55_Y	280_V	0.909	0.30
67_T	264_E	0.903	0.30
71_A	212_L	0.901	0.30
124_E	287_S	0.894	0.29
144_R	148_D	0.894	0.29
33_S	125_G	0.894	0.29
116_A	134_M	0.880	0.29
154_I	244_W	0.877	0.29
76_P	145_G	0.876	0.28
67_T	117_I	0.875	0.28
84_E	271_G	0.873	0.28
133_F	137_D	0.872	0.28
39_P	65_K	0.869	0.28
75_I	130_Y	0.867	0.28
182_V	189_M	0.865	0.28
137_D	142_L	0.865	0.28
153_K	176_L	0.864	0.28
122_N	266_E	0.862	0.28
126_K	239_K	0.862	0.28
77_G	262_L	0.862	0.28
130_Y	257_N	0.859	0.28
153_K	177_R	0.858	0.28
233_R	283_T	0.854	0.27
247_K	258_D	0.850	0.27
73_K	156_K	0.848	0.27
153_K	227_L	0.847	0.27
125_G	286_I	0.837	0.27
69_E	122_N	0.837	0.27
148_D	283_T	0.832	0.26
124_E	156_K	0.831	0.26
245_K	270_G	0.830	0.26
50_Q	70_S	0.824	0.26
75_I	132_P	0.821	0.26
54_Y	68_K	0.819	0.26
33_S	205_L	0.818	0.26
138_K	148_D	0.816	0.26
52_P	153_K	0.807	0.25
219_S	234_V	0.806	0.25
266_E	270_G	0.801	0.25
149_G	217_F	0.798	0.25
36_T	77_G	0.797	0.25
181_Y	204_P	0.791	0.25
269_I	275_T	0.789	0.25
146_W	217_F	0.789	0.25
72_E	77_G	0.786	0.24
36_T	231_V	0.779	0.24
231_V	245_K	0.776	0.24
193_Q	249_N	0.770	0.24
81_T	84_E	0.768	0.24
158_A	181_Y	0.768	0.24
196_L	258_D	0.761	0.23
220_R	283_T	0.759	0.23
160_T	174_S	0.757	0.23
79_L	230_I	0.757	0.23
121_V	130_Y	0.756	0.23
145_G	149_G	0.756	0.23
189_M	260_V	0.751	0.23
86_W	130_Y	0.749	0.23
130_Y	211_F	0.744	0.23
94_S	286_I	0.743	0.23
112_Y	265_V	0.738	0.23
53_W	96_S	0.733	0.22
237_E	240_Y	0.730	0.22
62_A	119_L	0.727	0.22
49_F	69_E	0.727	0.22
91_E	134_M	0.725	0.22
178_L	188_V	0.723	0.22
47_I	195_E	0.719	0.22
218_P	285_L	0.717	0.22
66_F	86_W	0.716	0.22
134_M	150_Y	0.714	0.22
112_Y	151_P	0.713	0.22
66_F	112_Y	0.712	0.22
55_Y	134_M	0.707	0.21
192_M	250_V	0.706	0.21
155_A	245_K	0.704	0.21
154_I	175_G	0.704	0.21
122_N	224_E	0.704	0.21
117_I	183_V	0.701	0.21
161_K	177_R	0.701	0.21
210_P	229_E	0.700	0.21
53_W	153_K	0.700	0.21
134_M	152_K	0.699	0.21
199_R	245_K	0.699	0.21
230_I	244_W	0.697	0.21
58_T	91_E	0.696	0.21
141_A	220_R	0.691	0.21
112_Y	278_F	0.690	0.21
59_Y	93_I	0.686	0.21
184_R	261_S	0.686	0.21
65_K	147_L	0.681	0.20
215_R	229_E	0.681	0.20
222_E	227_L	0.680	0.20
111_Q	259_E	0.680	0.20
63_H	111_Q	0.679	0.20
135_W	138_K	0.678	0.20
45_S	69_E	0.678	0.20
121_V	132_P	0.676	0.20
186_G	234_V	0.673	0.20
245_K	263_L	0.673	0.20
248_A	287_S	0.673	0.20
175_G	245_K	0.668	0.20
182_V	260_V	0.655	0.19
96_S	111_Q	0.654	0.19
129_L	149_G	0.653	0.19
150_Y	213_N	0.649	0.19
40_T	45_S	0.649	0.19
70_S	126_K	0.649	0.19
131_F	188_V	0.647	0.19
82_D	122_N	0.645	0.19
34_D	81_T	0.645	0.19
121_V	228_Y	0.644	0.19
49_F	125_G	0.644	0.19
156_K	182_V	0.644	0.19
200_T	203_L	0.643	0.19
219_S	224_E	0.643	0.19
213_N	232_S	0.642	0.19
33_S	223_G	0.641	0.19
129_L	208_F	0.639	0.19
144_R	222_E	0.637	0.19
244_W	267_R	0.636	0.19
148_D	220_R	0.634	0.19
78_F	116_A	0.633	0.19
77_G	229_E	0.633	0.19
55_Y	273_Y	0.631	0.19
188_V	250_V	0.630	0.19
126_K	129_L	0.629	0.18
123_F	156_K	0.628	0.18
156_K	186_G	0.622	0.18
71_A	216_R	0.620	0.18
89_I	155_A	0.619	0.18
157_I	196_L	0.618	0.18
190_F	261_S	0.617	0.18
69_E	288_K	0.617	0.18
137_D	253_G	0.612	0.18
99_N	224_E	0.611	0.18
192_M	276_L	0.607	0.18
117_I	132_P	0.606	0.18
123_F	272_Y	0.601	0.18
189_M	264_E	0.601	0.18
132_P	212_L	0.599	0.17
32_N	35_F	0.598	0.17
97_E	180_G	0.597	0.17
201_D	240_Y	0.597	0.17
91_E	255_Y	0.596	0.17
187_G	203_L	0.595	0.17
114_E	150_Y	0.592	0.17
161_K	175_G	0.591	0.17
227_L	285_L	0.591	0.17
239_K	277_Y	0.588	0.17
156_K	201_D	0.587	0.17
49_F	244_W	0.587	0.17
235_R	283_T	0.585	0.17
80_S	246_G	0.580	0.17
50_Q	72_E	0.578	0.17
144_R	160_T	0.578	0.17
123_F	287_S	0.576	0.17
37_L	220_R	0.575	0.17
38_P	145_G	0.574	0.17
83_G	270_G	0.572	0.17
149_G	160_T	0.571	0.17
83_G	131_F	0.570	0.17
145_G	151_P	0.568	0.16
101_D	148_D	0.564	0.16
58_T	255_Y	0.562	0.16
60_I	160_T	0.561	0.16
246_G	268_T	0.558	0.16
75_I	155_A	0.557	0.16
40_T	65_K	0.555	0.16
174_S	185_G	0.555	0.16
55_Y	180_G	0.552	0.16
98_D	280_V	0.551	0.16
224_E	284_Q	0.550	0.16
225_V	236_D	0.548	0.16
53_W	227_L	0.541	0.16
141_A	280_V	0.540	0.16
45_S	260_V	0.540	0.16
66_F	100_W	0.539	0.16
240_Y	279_K	0.537	0.16
35_F	259_E	0.537	0.16
118_G	209_G	0.536	0.16
52_P	139_D	0.536	0.16
148_D	282_T	0.534	0.15
223_G	231_V	0.532	0.15
212_L	232_S	0.532	0.15
33_S	124_E	0.532	0.15
91_E	258_D	0.531	0.15
86_W	240_Y	0.531	0.15
37_L	217_F	0.527	0.15
203_L	249_N	0.527	0.15
211_F	283_T	0.527	0.15
136_V	144_R	0.525	0.15
51_P	141_A	0.525	0.15
111_Q	138_K	0.524	0.15
48_V	176_L	0.523	0.15
148_D	217_F	0.521	0.15
79_L	114_E	0.518	0.15
153_K	285_L	0.518	0.15
83_G	201_D	0.516	0.15
263_L	279_K	0.516	0.15
83_G	86_W	0.515	0.15
101_D	138_K	0.513	0.15
200_T	245_K	0.511	0.15
238_S	245_K	0.509	0.15
76_P	149_G	0.507	0.15
133_F	212_L	0.507	0.15
143_V	266_E	0.504	0.15
69_E	124_E	0.503	0.15
89_I	212_L	0.502	0.15
77_G	266_E	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4zboA	4	0.8586	100	0.431	Contact Map
4jmdA	4	0.8721	100	0.434	Contact Map
3bh2A	6	0.8047	100	0.462	Contact Map
3bgtA	6	0.8081	100	0.477	Contact Map
3c8wA	6	0.8215	100	0.501	Contact Map
3cmbA	4	0.8081	100	0.549	Contact Map
2kvoA	1	0.1717	5.2	0.977	Contact Map
4gs5A	1	0.1852	4.1	0.978	Contact Map
2ly8A	1	0.2593	3.6	0.978	Contact Map
1ccwB	2	0.431	3.3	0.979	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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