GREMLIN Database
Q97YT4 - Catechol 2,3-dioxygenase (Metapyrocatechase)
UniProt: Q97YT4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (271)
Sequences: 3383 (2243)
Seq/√Len: 136.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_W28_D4.8521.00
168_K174_K4.6291.00
82_I94_W4.0681.00
162_N165_S3.5611.00
18_K21_D3.2831.00
10_A120_V2.7701.00
72_T119_L2.6021.00
44_L49_D2.5311.00
74_S77_D2.5181.00
83_N87_S2.4411.00
15_L60_S2.4351.00
72_T78_L2.4141.00
77_D148_V2.3521.00
20_D24_W2.3041.00
45_R49_D2.2741.00
82_I86_N2.2271.00
44_L47_W2.1681.00
82_I107_Y2.1611.00
109_F119_L2.1491.00
46_G49_D2.1391.00
34_E37_R2.1241.00
108_K118_K2.1061.00
23_L37_R2.0311.00
81_S119_L1.9691.00
55_L70_W1.9681.00
111_L172_L1.9601.00
227_A254_T1.9471.00
94_W105_K1.9311.00
223_N274_G1.9241.00
23_L34_E1.9201.00
180_V183_I1.8821.00
75_E105_K1.8531.00
258_S272_L1.8331.00
16_T57_V1.8211.00
83_N86_N1.8201.00
75_E79_I1.8161.00
93_G108_K1.7851.00
79_I83_N1.7791.00
40_R59_E1.7781.00
80_D84_I1.7671.00
202_H205_A1.7541.00
226_Y229_D1.7341.00
201_A205_A1.7301.00
15_L64_G1.7181.00
21_D24_W1.6981.00
91_G110_I1.6531.00
287_V290_T1.6401.00
156_I220_V1.5821.00
224_V271_L1.5761.00
41_S45_R1.5711.00
86_N92_L1.5701.00
44_L48_E1.5631.00
11_S69_V1.5611.00
194_W197_V1.5531.00
13_E58_T1.5481.00
280_V285_P1.5351.00
42_V49_D1.5331.00
236_F240_Y1.5321.00
19_I59_E1.5251.00
245_V268_V1.5221.00
67_E118_K1.5111.00
108_K116_I1.5091.00
46_G51_Y1.5071.00
76_K121_W1.4881.00
75_E121_W1.4861.00
13_E67_E1.4721.00
70_W117_G1.4691.00
262_K268_V1.4641.00
249_L258_S1.4301.00
34_E42_V1.4231.00
200_T203_D1.4161.00
110_I116_I1.4131.00
19_I42_V1.4091.00
79_I105_K1.4091.00
167_A195_M1.4011.00
181_N196_A1.3871.00
227_A231_L1.3671.00
199_G202_H1.3621.00
85_V109_F1.3571.00
237_Y261_V1.3551.00
15_L66_K1.3461.00
210_P213_V1.3321.00
42_V46_G1.3301.00
41_S44_L1.3081.00
69_V118_K1.3041.00
17_P63_A1.2941.00
167_A173_L1.2821.00
41_S46_G1.2801.00
42_V47_W1.2761.00
45_R48_E1.2741.00
234_A238_T1.2681.00
41_S49_D1.2521.00
225_D229_D1.2461.00
193_Y196_A1.2421.00
117_G172_L1.2421.00
45_R51_Y1.2311.00
76_K79_I1.2161.00
167_A180_V1.2161.00
47_W51_Y1.2051.00
27_K34_E1.2041.00
23_L44_L1.1981.00
278_N283_W1.1881.00
202_H208_L1.1830.99
68_I156_I1.1800.99
209_D212_G1.1800.99
164_E208_L1.1790.99
284_E287_V1.1750.99
44_L51_Y1.1750.99
109_F117_G1.1710.99
26_F263_E1.1670.99
41_S58_T1.1470.99
145_T148_V1.1470.99
231_L247_G1.1470.99
46_G54_S1.1470.99
247_G254_T1.1400.99
42_V51_Y1.1340.99
79_I82_I1.1330.99
23_L42_V1.1330.99
71_R122_E1.1330.99
42_V45_R1.1240.99
85_V92_L1.1040.99
212_G215_A1.0990.99
111_L117_G1.0870.99
41_S51_Y1.0820.99
23_L27_K1.0780.99
173_L195_M1.0760.99
255_D276_Y1.0670.99
191_I194_W1.0640.99
256_S275_G1.0620.99
25_F261_V1.0490.99
219_H270_E1.0430.99
164_E168_K1.0430.99
84_I88_N1.0420.99
101_M118_K1.0410.99
71_R154_S1.0370.99
160_A163_D1.0330.99
199_G277_L1.0290.99
19_I23_L1.0260.99
252_G288_W1.0230.99
194_W198_N1.0200.98
9_L153_L1.0190.98
219_H260_Y1.0130.98
221_T272_L1.0130.98
234_A248_P1.0130.98
179_K196_A1.0020.98
199_G203_D0.9960.98
244_I259_L0.9930.98
200_T205_A0.9910.98
80_D144_P0.9910.98
165_S168_K0.9790.98
193_Y197_V0.9660.98
29_I88_N0.9590.98
86_N91_G0.9570.98
69_V120_V0.9550.98
16_T59_E0.9480.98
254_T258_S0.9480.98
90_L109_F0.9480.98
205_A210_P0.9480.98
20_D37_R0.9460.98
235_D239_D0.9440.97
85_V107_Y0.9400.97
67_E108_K0.9390.97
245_V262_K0.9350.97
164_E167_A0.9210.97
181_N195_M0.9180.97
228_D232_K0.9180.97
6_L197_V0.9150.97
77_D80_D0.9140.97
201_A206_V0.9080.97
97_G105_K0.9010.97
41_S47_W0.8950.97
12_V220_V0.8880.96
89_G92_L0.8840.96
178_F197_V0.8830.96
93_G110_I0.8820.96
234_A247_G0.8810.96
43_Y53_Y0.8800.96
210_P214_P0.8780.96
160_A166_L0.8780.96
58_T66_K0.8760.96
95_D106_G0.8720.96
32_L222_F0.8690.96
85_V88_N0.8670.96
183_I287_V0.8570.96
22_T57_V0.8570.96
236_F239_D0.8540.95
254_T275_G0.8500.95
107_Y119_L0.8490.95
202_H207_S0.8450.95
7_S225_D0.8450.95
84_I87_S0.8420.95
94_W107_Y0.8400.95
68_I115_Q0.8380.95
169_T176_L0.8370.95
25_F269_I0.8370.95
193_Y198_N0.8330.95
166_L172_L0.8220.94
65_V68_I0.8160.94
248_P259_L0.8150.94
34_E44_L0.8140.94
14_I115_Q0.8050.94
80_D83_N0.8030.94
202_H206_V0.8030.94
48_E54_S0.8000.94
82_I92_L0.7950.93
181_N201_A0.7930.93
78_L105_K0.7910.93
163_D193_Y0.7910.93
261_V271_L0.7890.93
73_Y77_D0.7840.93
113_S161_Y0.7840.93
250_R255_D0.7810.93
81_S84_I0.7650.92
111_L115_Q0.7620.92
53_Y56_K0.7620.92
224_V229_D0.7620.92
48_E51_Y0.7620.92
29_I240_Y0.7600.92
260_Y270_E0.7580.92
233_A271_L0.7540.91
70_W153_L0.7510.91
218_N268_V0.7380.91
43_Y46_G0.7360.90
223_N228_D0.7350.90
32_L70_W0.7330.90
77_D81_S0.7310.90
43_Y56_K0.7260.90
229_D232_K0.7250.90
152_D272_L0.7240.90
180_V195_M0.7240.90
247_G258_S0.7190.89
231_L234_A0.7180.89
158_I206_V0.7160.89
257_H273_H0.7160.89
163_D208_L0.7130.89
12_V156_I0.7130.89
178_F222_F0.7110.89
106_G118_K0.7100.89
93_G116_I0.7090.89
60_S64_G0.7090.89
84_I177_T0.7080.89
75_E123_M0.7040.88
184_L192_A0.6990.88
140_P143_K0.6990.88
32_L150_A0.6990.88
158_I204_L0.6980.88
163_D206_V0.6980.88
19_I37_R0.6970.88
139_R142_K0.6960.88
30_L269_I0.6950.88
159_F216_R0.6920.88
66_K159_F0.6920.88
205_A209_D0.6920.88
69_V154_S0.6910.87
201_A207_S0.6910.87
155_H202_H0.6910.87
160_A165_S0.6880.87
64_G216_R0.6840.87
10_A71_R0.6810.87
155_H251_H0.6810.87
228_D250_R0.6800.87
203_D208_L0.6800.87
20_D59_E0.6780.87
246_G254_T0.6760.86
202_H209_D0.6710.86
182_E201_A0.6690.86
13_E66_K0.6620.85
199_G205_A0.6610.85
246_G251_H0.6580.85
18_K116_I0.6570.85
95_D108_K0.6550.85
253_I272_L0.6510.84
92_L107_Y0.6500.84
11_S103_V0.6500.84
14_I55_L0.6460.84
78_L82_I0.6450.84
232_K235_D0.6380.83
78_L95_D0.6360.83
41_S48_E0.6320.82
39_D59_E0.6320.82
253_I288_W0.6310.82
65_V217_L0.6310.82
158_I269_I0.6290.82
235_D238_T0.6280.82
203_D212_G0.6260.82
289_D292_E0.6250.82
18_K59_E0.6230.82
251_H281_P0.6210.81
28_D240_Y0.6210.81
192_A207_S0.6210.81
62_T161_Y0.6200.81
234_A244_I0.6180.81
65_V267_N0.6160.81
167_A193_Y0.6130.80
161_Y165_S0.6130.80
256_S272_L0.6120.80
24_W27_K0.6100.80
74_S121_W0.6070.80
24_W240_Y0.6060.80
234_A259_L0.6060.80
257_H283_W0.6020.79
200_T254_T0.6020.79
26_F57_V0.6000.79
22_T263_E0.5990.79
72_T107_Y0.5980.79
187_G191_I0.5980.79
15_L39_D0.5970.79
110_I114_G0.5920.78
35_V45_R0.5910.78
256_S271_L0.5900.78
85_V90_L0.5890.78
221_T260_Y0.5890.78
44_L57_V0.5880.78
166_L206_V0.5850.77
168_K173_L0.5850.77
29_I112_P0.5840.77
5_L77_D0.5840.77
156_I178_F0.5840.77
16_T113_S0.5820.77
104_G121_W0.5820.77
54_S251_H0.5810.77
201_A251_H0.5800.77
20_D23_L0.5780.77
74_S80_D0.5750.76
253_I276_Y0.5750.76
83_N96_E0.5740.76
69_V157_F0.5710.76
30_L255_D0.5710.76
157_F194_W0.5710.76
253_I256_S0.5700.76
9_L220_V0.5700.76
206_V209_D0.5650.75
9_L156_I0.5640.75
202_H251_H0.5640.75
178_F198_N0.5620.75
29_I242_L0.5610.74
218_N221_T0.5610.74
250_R274_G0.5590.74
210_P215_A0.5580.74
176_L231_L0.5580.74
221_T256_S0.5560.74
169_T264_P0.5550.74
80_D141_M0.5540.73
183_I193_Y0.5530.73
161_Y214_P0.5520.73
38_K43_Y0.5520.73
253_I299_Y0.5520.73
222_F269_I0.5510.73
156_I204_L0.5460.72
115_Q216_R0.5450.72
224_V230_I0.5450.72
36_G52_A0.5410.72
205_A208_L0.5410.72
167_A183_I0.5390.71
192_A197_V0.5390.71
230_I247_G0.5380.71
142_K145_T0.5380.71
249_L254_T0.5380.71
141_M144_P0.5370.71
201_A204_L0.5370.71
254_T272_L0.5360.71
72_T82_I0.5360.71
124_K127_R0.5360.71
97_G107_Y0.5340.71
161_Y166_L0.5330.71
119_L176_L0.5320.70
251_H260_Y0.5320.70
154_S272_L0.5300.70
140_P146_K0.5300.70
230_I271_L0.5290.70
221_T263_E0.5280.70
247_G259_L0.5280.70
33_H139_R0.5260.70
227_A230_I0.5240.69
288_W292_E0.5230.69
93_G96_E0.5220.69
38_K77_D0.5220.69
36_G53_Y0.5220.69
40_R58_T0.5220.69
219_H251_H0.5210.69
258_S275_G0.5180.68
201_A210_P0.5180.68
102_G124_K0.5170.68
12_V68_I0.5150.68
14_I57_V0.5140.68
162_N266_G0.5130.68
161_Y215_A0.5120.68
67_E101_M0.5100.67
70_W203_D0.5100.67
202_H210_P0.5090.67
22_T265_G0.5080.67
9_L65_V0.5080.67
150_A256_S0.5070.67
6_L173_L0.5070.67
78_L121_W0.5060.67
230_I248_P0.5060.67
163_D167_A0.5060.67
38_K41_S0.5050.67
11_S218_N0.5040.66
115_Q153_L0.5040.66
221_T268_V0.5040.66
9_L178_F0.5030.66
209_D213_V0.5010.66
38_K59_E0.5010.66
154_S194_W0.5010.66
140_P145_T0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ghgA 4 0.9493 100 0.4 Contact Map
3b59A 5 0.8866 100 0.406 Contact Map
1f1uA 4 0.9224 100 0.413 Contact Map
3lm4A 4 0.9582 100 0.413 Contact Map
3hpyA 4 0.8716 100 0.47 Contact Map
3vb0A 1 0.8328 100 0.499 Contact Map
2zyqA 2 0.8448 100 0.5 Contact Map
1lgtA 5 0.8358 100 0.502 Contact Map
1kw3B 5 0.8388 100 0.503 Contact Map
1mpyA 3 0.9075 100 0.506 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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