GREMLIN Database
Q97YT3 - Uncharacterized protein
UniProt: Q97YT3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 139 (128)
Sequences: 2379 (1572)
Seq/√Len: 139.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_K27_E3.6931.00
18_I45_A3.5591.00
35_A60_A2.8341.00
15_D47_K2.8191.00
33_S46_F2.2761.00
75_H127_M2.2421.00
131_K135_K2.1411.00
24_K28_L2.0921.00
35_A46_F2.0231.00
35_A43_L2.0181.00
24_K128_E1.9761.00
43_L46_F1.9141.00
121_A125_Q1.8771.00
106_I134_L1.8761.00
32_V129_I1.8661.00
73_P105_P1.8001.00
15_D22_V1.7351.00
107_I112_V1.7191.00
17_L133_A1.6611.00
37_V115_G1.6461.00
65_W96_R1.6131.00
35_A61_I1.6111.00
9_I44_K1.6011.00
14_A45_A1.4911.00
101_G127_M1.4751.00
62_D96_R1.4711.00
26_K49_M1.4691.00
59_I119_S1.4371.00
21_A133_A1.4321.00
118_V130_A1.4281.00
17_L106_I1.4001.00
33_S56_T1.3551.00
11_D47_K1.3301.00
104_F127_M1.3271.00
22_V47_K1.3191.00
100_F123_A1.2951.00
15_D19_N1.2651.00
46_F57_I1.2571.00
74_T103_G1.2491.00
28_L128_E1.2301.00
58_Q61_I1.2281.00
22_V34_I1.2151.00
17_L116_I1.2141.00
70_F77_W1.2091.00
20_E136_R1.2041.00
21_A116_I1.2011.00
55_L70_F1.1951.00
23_R27_E1.1831.00
75_H101_G1.1791.00
10_S13_L1.1741.00
106_I114_G1.1600.99
25_A129_I1.1580.99
25_A32_V1.1580.99
21_A34_I1.1510.99
127_M131_K1.1130.99
31_N51_G1.1070.99
122_S125_Q1.1020.99
65_W69_S1.0900.99
30_V121_A1.0830.99
8_G39_E1.0760.99
76_E79_N1.0640.99
22_V26_K1.0620.99
91_F95_P1.0620.99
101_G123_A1.0550.99
13_L108_Y1.0520.99
32_V121_A1.0380.99
19_N23_R1.0340.99
51_G111_Q1.0150.99
33_S52_A1.0140.99
21_A118_V1.0090.98
25_A49_M1.0000.98
52_A56_T0.9940.98
11_D15_D0.9890.98
19_N47_K0.9800.98
38_D48_R0.9780.98
108_Y113_I0.9760.98
18_I36_I0.9610.98
62_D98_I0.9590.98
43_L61_I0.9530.98
11_D14_A0.9450.98
55_L69_S0.9410.98
32_V118_V0.9380.98
18_I47_K0.9320.97
40_G48_R0.9300.97
44_K50_D0.9280.97
21_A129_I0.9200.97
24_K132_S0.9160.97
107_I110_E0.9090.97
58_Q62_D0.8950.97
46_F61_I0.8850.97
79_N83_D0.8730.96
104_F131_K0.8700.96
42_E54_I0.8680.96
20_E23_R0.8660.96
132_S135_K0.8640.96
91_F94_I0.8620.96
37_V64_S0.8500.96
78_Y81_L0.8360.95
14_A36_I0.8310.95
125_Q128_E0.8280.95
20_E133_A0.8250.95
32_V120_G0.8200.95
59_I98_I0.7980.94
33_S57_I0.7960.94
67_A74_T0.7940.94
36_I45_A0.7900.94
16_M20_E0.7870.93
22_V49_M0.7810.93
16_M19_N0.7800.93
28_L125_Q0.7790.93
9_I106_I0.7780.93
132_S136_R0.7770.93
77_W81_L0.7760.93
104_F134_L0.7760.93
75_H79_N0.7700.93
62_D94_I0.7650.92
30_V125_Q0.7620.92
68_V115_G0.7620.92
79_N82_K0.7610.92
37_V68_V0.7540.92
53_P56_T0.7470.92
73_P104_F0.7440.91
12_E16_M0.7350.91
116_I134_L0.7310.91
17_L134_L0.7270.90
83_D123_A0.7210.90
115_G134_L0.7170.90
54_I69_S0.7170.90
57_I61_I0.7070.89
43_L57_I0.7040.89
108_Y111_Q0.6990.89
20_E132_S0.6960.88
12_E19_N0.6930.88
14_A44_K0.6860.88
68_V71_G0.6820.87
34_I129_I0.6810.87
116_I133_A0.6800.87
31_N121_A0.6730.87
74_T99_I0.6660.86
71_G112_V0.6640.86
12_E26_K0.6580.85
124_E128_E0.6530.85
23_R26_K0.6520.85
16_M136_R0.6480.85
70_F97_L0.6480.85
13_L16_M0.6470.84
9_I13_L0.6380.84
81_L84_N0.6310.83
78_Y82_K0.6300.83
58_Q94_I0.6110.81
18_I34_I0.6020.80
17_L20_E0.6000.80
103_G130_A0.5990.80
93_K99_I0.5980.80
46_F60_A0.5970.79
89_M92_P0.5960.79
28_L129_I0.5950.79
85_P100_F0.5900.79
55_L59_I0.5850.78
10_S44_K0.5850.78
105_P112_V0.5840.78
90_G93_K0.5770.77
34_I116_I0.5770.77
9_I39_E0.5750.77
104_F130_A0.5640.75
73_P131_K0.5580.75
66_T74_T0.5580.75
18_I32_V0.5540.74
88_A92_P0.5530.74
44_K48_R0.5510.74
53_P123_A0.5480.73
66_T97_L0.5430.73
86_S97_L0.5360.72
81_L99_I0.5350.72
40_G68_V0.5300.71
33_S120_G0.5270.71
88_A97_L0.5260.70
88_A91_F0.5200.70
15_D45_A0.5170.69
28_L121_A0.5140.69
76_E83_D0.5130.68
103_G118_V0.5100.68
52_A96_R0.5100.68
31_N49_M0.5090.68
129_I132_S0.5080.68
70_F94_I0.5080.68
55_L93_K0.5070.68
59_I81_L0.5060.67
21_A32_V0.5050.67
11_D50_D0.5040.67
29_G111_Q0.5020.67
35_A57_I0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nkpA 5 1 100 0.172 Contact Map
2a2lA 5 1 100 0.173 Contact Map
3fpwA 5 0.9568 100 0.194 Contact Map
4clcA 5 0.9928 100 0.225 Contact Map
2ia2A 4 0.9568 82.6 0.888 Contact Map
2o0yA 4 0.9784 77.7 0.894 Contact Map
2o99A 2 0.9209 76.4 0.895 Contact Map
3d3oA 1 0.8921 76.1 0.895 Contact Map
3r4kA 2 0.9568 75.5 0.896 Contact Map
1yspA 1 0.8849 75.4 0.896 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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