GREMLIN Database
Q97YT2 - Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component, probable (TodA)
UniProt: Q97YT2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 404 (365)
Sequences: 25440 (17798)
Seq/√Len: 931.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_L225_A4.2151.00
35_S80_S4.0251.00
255_N259_E3.2501.00
144_N167_K3.2091.00
169_T202_I3.2061.00
4_E29_R3.1671.00
191_Q195_E2.8911.00
90_E98_V2.8671.00
89_K264_D2.7831.00
202_I221_R2.6911.00
362_Y375_L2.6601.00
167_K200_N2.6401.00
247_Q253_V2.5511.00
17_A105_L2.5181.00
113_R235_S2.4931.00
86_A262_A2.3521.00
101_F104_A2.3371.00
111_R237_N2.3331.00
85_D88_L2.2971.00
103_K264_D2.2631.00
3_C31_I2.2581.00
33_I99_I2.2571.00
111_R239_E2.2071.00
173_V206_S2.1651.00
118_P209_E2.1631.00
209_E216_T2.1101.00
4_E31_I2.0631.00
146_L171_V2.0631.00
31_I76_M2.0371.00
214_I222_K2.0261.00
4_E102_D2.0151.00
5_Y21_L2.0071.00
175_P204_N1.9901.00
216_T222_K1.9841.00
130_D133_D1.9521.00
6_L99_I1.9461.00
6_L33_I1.9121.00
144_N226_D1.9011.00
358_I382_Q1.8961.00
13_A268_A1.8791.00
249_D273_N1.8751.00
205_E219_S1.8651.00
240_L243_R1.8651.00
111_R235_S1.8531.00
357_G386_S1.8371.00
247_Q261_S1.8141.00
105_L302_M1.8141.00
92_I98_V1.8121.00
266_Y301_N1.8081.00
169_T200_N1.7781.00
378_L383_A1.7771.00
129_L133_D1.7651.00
259_E263_R1.7421.00
146_L215_A1.7111.00
29_R74_E1.7091.00
214_I224_E1.6961.00
176_Y187_S1.6851.00
329_E334_D1.6671.00
206_S218_S1.6551.00
298_A302_M1.6471.00
155_V170_V1.6451.00
145_A161_L1.6281.00
184_E332_N1.6251.00
162_I167_K1.6121.00
145_A166_V1.6111.00
128_S131_D1.6081.00
6_L91_A1.5871.00
144_N169_T1.5811.00
202_I205_E1.5801.00
256_E308_A1.5641.00
208_K216_T1.5501.00
103_K266_Y1.5471.00
86_A265_I1.5361.00
90_E100_S1.5351.00
108_T271_I1.5341.00
162_I199_I1.5161.00
329_E337_I1.5131.00
211_Q216_T1.5041.00
83_R92_I1.4991.00
6_L101_F1.4861.00
105_L268_A1.4791.00
184_E188_R1.4761.00
193_Y196_S1.4711.00
20_E300_R1.4531.00
249_D253_V1.4241.00
126_L129_L1.4231.00
10_S34_T1.4171.00
299_A303_A1.4131.00
352_I362_Y1.3871.00
103_K302_M1.3851.00
6_L31_I1.3811.00
7_I18_L1.3671.00
191_Q201_F1.3561.00
205_E218_S1.3541.00
295_G299_A1.3501.00
150_A172_E1.3481.00
172_E203_L1.3411.00
163_T197_K1.3371.00
64_S67_F1.3351.00
124_L138_A1.3301.00
24_I300_R1.3281.00
257_Y301_N1.3221.00
145_A227_M1.3211.00
3_C74_E1.3201.00
171_V223_I1.3201.00
214_I217_T1.3111.00
332_N336_Y1.3111.00
83_R243_R1.2981.00
66_D70_R1.2981.00
176_Y184_E1.2831.00
31_I99_I1.2671.00
191_Q203_L1.2641.00
192_Q195_E1.2631.00
205_E221_R1.2611.00
110_G234_I1.2601.00
5_Y105_L1.2481.00
144_N224_E1.2421.00
82_E92_I1.2331.00
13_A291_A1.2271.00
93_L99_I1.2111.00
129_L132_A1.2101.00
65_D69_K1.2091.00
83_R89_K1.2081.00
208_K218_S1.2081.00
183_D351_V1.2041.00
196_S347_P1.1991.00
259_E264_D1.1971.00
258_L272_A1.1961.00
202_I223_I1.1961.00
143_K226_D1.1831.00
150_A177_I1.1801.00
20_E24_I1.1741.00
67_F71_D1.1731.00
85_D89_K1.1691.00
258_L298_A1.1691.00
331_R335_E1.1681.00
86_A89_K1.1671.00
3_C103_K1.1671.00
252_I267_A1.1641.00
133_D136_R1.1551.00
63_E67_F1.1531.00
123_A210_I1.1441.00
189_V365_I1.1381.00
350_S364_A1.1381.00
188_R191_Q1.1381.00
192_Q196_S1.1331.00
300_R305_S1.1331.00
211_Q214_I1.1331.00
297_L301_N1.1321.00
323_H370_K1.1281.00
106_I271_I1.1141.00
155_V320_F1.1091.00
257_Y308_A1.1061.00
24_I303_A1.0991.00
60_L63_E1.0881.00
127_R130_D1.0861.00
210_I228_F1.0821.00
148_I228_F1.0821.00
76_M99_I1.0791.00
193_Y197_K1.0791.00
59_M62_F1.0751.00
131_D134_R1.0741.00
93_L97_S1.0731.00
107_S268_A1.0701.00
252_I271_I1.0651.00
8_I106_I1.0641.00
268_A298_A1.0631.00
83_R86_A1.0531.00
331_R351_V1.0531.00
262_A265_I1.0521.00
33_I81_V1.0501.00
85_D90_E1.0481.00
33_I76_M1.0471.00
298_A301_N1.0461.00
112_P115_L1.0441.00
89_K93_L1.0371.00
176_Y191_Q1.0271.00
341_K353_Y1.0271.00
143_K167_K1.0261.00
177_I203_L1.0241.00
352_I375_L1.0141.00
248_V253_V1.0101.00
64_S68_Y1.0081.00
355_K358_I1.0011.00
333_Y336_Y0.9991.00
338_I341_K0.9991.00
88_L98_V0.9971.00
5_Y26_P0.9951.00
195_E200_N0.9941.00
8_I81_V0.9931.00
334_D353_Y0.9921.00
33_I93_L0.9911.00
127_R131_D0.9911.00
254_V267_A0.9891.00
17_A295_G0.9881.00
240_L244_S0.9851.00
80_S94_N0.9801.00
339_R360_K0.9801.00
62_F66_D0.9791.00
21_L299_A0.9761.00
126_L132_A0.9671.00
146_L223_I0.9671.00
257_Y306_R0.9581.00
148_I230_I0.9511.00
254_V272_A0.9471.00
217_T223_I0.9451.00
239_E242_Q0.9421.00
135_I227_M0.9421.00
370_K373_I0.9401.00
260_T267_A0.9401.00
126_L130_D0.9381.00
31_I74_E0.9381.00
17_A268_A0.9381.00
132_A136_R0.9351.00
334_D341_K0.9321.00
142_G166_V0.9311.00
189_V193_Y0.9301.00
57_K133_D0.9231.00
20_E23_Q0.9221.00
324_I365_I0.9221.00
17_A298_A0.9181.00
59_M63_E0.9161.00
158_A170_V0.9151.00
90_E93_L0.9101.00
85_D92_I0.9081.00
116_N120_S0.9071.00
104_A265_I0.9041.00
68_Y71_D0.9031.00
56_E59_M0.9011.00
117_I120_S0.9001.00
182_V326_S0.8991.00
162_I197_K0.8951.00
188_R192_Q0.8901.00
65_D77_L0.8901.00
340_G355_K0.8891.00
155_V194_L0.8881.00
371_E374_A0.8871.00
267_A271_I0.8851.00
20_E296_K0.8841.00
205_E217_T0.8791.00
377_K381_K0.8791.00
8_I108_T0.8781.00
175_P184_E0.8761.00
172_E179_N0.8751.00
259_E266_Y0.8721.00
138_A166_V0.8691.00
7_I14_G0.8661.00
238_V248_V0.8661.00
186_V349_F0.8631.00
61_F64_S0.8621.00
5_Y302_M0.8561.00
259_E301_N0.8561.00
128_S133_D0.8561.00
136_R164_L0.8541.00
266_Y298_A0.8541.00
171_V205_E0.8531.00
113_R116_N0.8521.00
63_E68_Y0.8491.00
266_Y302_M0.8451.00
36_D47_S0.8441.00
182_V316_W0.8441.00
26_P102_D0.8381.00
244_S248_V0.8381.00
185_K351_V0.8351.00
193_Y347_P0.8341.00
105_L298_A0.8331.00
148_I232_V0.8311.00
18_L73_L0.8281.00
124_L227_M0.8271.00
335_E340_G0.8271.00
250_N273_N0.8261.00
144_N166_V0.8261.00
253_V261_S0.8241.00
14_G18_L0.8231.00
127_R133_D0.8231.00
300_R307_E0.8191.00
124_L127_R0.8171.00
125_Y128_S0.8141.00
159_S163_T0.8141.00
147_I154_G0.8131.00
259_E262_A0.8111.00
63_E66_D0.8091.00
61_F65_D0.8071.00
154_G172_E0.8071.00
7_I17_A0.8061.00
48_K51_L0.8051.00
244_S262_A0.8041.00
113_R232_V0.8031.00
37_K78_N0.8031.00
83_R87_N0.8021.00
329_E333_Y0.8021.00
68_Y73_L0.8011.00
176_Y188_R0.8011.00
66_D69_K0.8001.00
24_I305_S0.7991.00
189_V192_Q0.7971.00
10_S32_M0.7961.00
127_R135_I0.7891.00
186_V363_L0.7851.00
335_E341_K0.7841.00
76_M97_S0.7831.00
241_A244_S0.7821.00
171_V202_I0.7821.00
26_P30_I0.7811.00
145_A229_L0.7751.00
343_E346_R0.7741.00
190_I324_I0.7731.00
130_D134_R0.7721.00
21_L302_M0.7721.00
78_N95_D0.7721.00
334_D339_R0.7721.00
170_V201_F0.7711.00
208_K220_G0.7711.00
355_K360_K0.7691.00
368_N371_E0.7681.00
331_R341_K0.7661.00
200_N221_R0.7651.00
290_N294_T0.7621.00
4_E100_S0.7611.00
62_F65_D0.7601.00
327_A379_I0.7591.00
127_R132_A0.7581.00
19_K23_Q0.7581.00
174_M179_N0.7551.00
129_L136_R0.7541.00
148_I207_V0.7541.00
357_G385_V0.7531.00
115_L230_I0.7511.00
258_L297_L0.7491.00
3_C29_R0.7481.00
35_S237_N0.7471.00
225_A228_F0.7471.00
183_D363_L0.7401.00
17_A299_A0.7391.00
364_A372_I0.7381.00
316_W326_S0.7361.00
177_I191_Q0.7361.00
6_L104_A0.7351.00
171_V217_T0.7331.00
323_H368_N0.7311.00
236_P251_G0.7291.00
246_M252_I0.7271.00
358_I384_D0.7261.00
177_I187_S0.7261.00
128_S132_A0.7261.00
147_I229_L0.7241.00
246_M261_S0.7231.00
65_D68_Y0.7221.00
313_S379_I0.7211.00
38_Y130_D0.7201.00
359_I375_L0.7201.00
211_Q222_K0.7131.00
169_T225_A0.7111.00
44_P49_D0.7101.00
20_E299_A0.7101.00
21_L30_I0.7081.00
246_M262_A0.7081.00
239_E243_R0.7081.00
333_Y337_I0.7071.00
342_F357_G0.7051.00
352_I359_I0.7051.00
16_N292_E0.7041.00
327_A362_Y0.7041.00
93_L96_G0.7041.00
29_R102_D0.7031.00
78_N94_N0.7031.00
59_M64_S0.7021.00
144_N225_A0.7021.00
268_A295_G0.7011.00
157_V229_L0.6981.00
21_L303_A0.6961.00
62_F67_F0.6951.00
325_E373_I0.6941.00
114_R230_I0.6931.00
147_I158_A0.6921.00
293_Y296_K0.6911.00
307_E310_N0.6901.00
19_K71_D0.6891.00
86_A101_F0.6881.00
61_F68_Y0.6871.00
238_V242_Q0.6861.00
22_L73_L0.6821.00
377_K383_A0.6801.00
296_K300_R0.6791.00
177_I201_F0.6781.00
300_R304_G0.6771.00
330_T333_Y0.6761.00
51_L55_L0.6761.00
153_I231_A0.6761.00
254_V258_L0.6751.00
76_M81_V0.6741.00
258_L301_N0.6741.00
101_F264_D0.6711.00
354_L359_I0.6711.00
158_A199_I0.6691.00
194_L320_F0.6671.00
74_E77_L0.6621.00
370_K374_A0.6621.00
130_D136_R0.6611.00
63_E71_D0.6601.00
82_E94_N0.6581.00
143_K166_V0.6551.00
376_N380_Q0.6531.00
359_I379_I0.6521.00
26_P303_A0.6521.00
112_P116_N0.6511.00
4_E99_I0.6491.00
84_I106_I0.6481.00
317_S370_K0.6481.00
186_V365_I0.6471.00
241_A246_M0.6461.00
133_D137_E0.6441.00
197_K320_F0.6431.00
50_Y133_D0.6431.00
48_K53_G0.6401.00
251_G286_E0.6401.00
118_P121_E0.6381.00
101_F262_A0.6371.00
339_R355_K0.6371.00
297_L309_Y0.6371.00
67_F70_R0.6341.00
194_L201_F0.6311.00
190_I365_I0.6291.00
14_G32_M0.6281.00
114_R120_S0.6231.00
22_L30_I0.6191.00
94_N97_S0.6191.00
330_T363_L0.6191.00
169_T223_I0.6181.00
301_N307_E0.6181.00
81_V91_A0.6151.00
339_R353_Y0.6141.00
176_Y332_N0.6131.00
160_S164_L0.6121.00
217_T221_R0.6111.00
193_Y365_I0.6111.00
68_Y75_V0.6101.00
78_N81_V0.6091.00
126_L133_D0.6091.00
194_L199_I0.6091.00
238_V271_I0.6081.00
16_N20_E0.6061.00
155_V177_I0.6031.00
187_S191_Q0.6021.00
122_N125_Y0.6021.00
21_L26_P0.6011.00
248_V251_G0.6011.00
49_D55_L0.6001.00
132_A135_I0.6001.00
331_R353_Y0.5991.00
114_R125_Y0.5991.00
185_K188_R0.5951.00
120_S230_I0.5951.00
182_V324_I0.5941.00
130_D135_I0.5931.00
251_G273_N0.5911.00
82_E85_D0.5901.00
242_Q248_V0.5901.00
217_T220_G0.5891.00
154_G231_A0.5881.00
375_L379_I0.5871.00
60_L64_S0.5871.00
117_I207_V0.5861.00
362_Y379_I0.5841.00
119_G209_E0.5841.00
260_T265_I0.5821.00
356_G382_Q0.5821.00
327_A376_N0.5801.00
357_G384_D0.5791.00
193_Y322_L0.5791.00
18_L32_M0.5771.00
26_P302_M0.5761.00
122_N126_L0.5761.00
142_G226_D0.5761.00
210_I230_I0.5731.00
354_L357_G0.5721.00
272_A294_T0.5711.00
125_Y131_D0.5701.00
157_V160_S0.5691.00
51_L54_K0.5671.00
3_C6_L0.5671.00
104_A264_D0.5661.00
326_S363_L0.5661.00
207_V215_A0.5651.00
218_S221_R0.5641.00
245_G262_A0.5621.00
244_S265_I0.5601.00
24_I299_A0.5601.00
163_T321_D0.5591.00
3_C76_M0.5591.00
334_D360_K0.5571.00
16_N19_K0.5561.00
161_L166_V0.5551.00
83_R88_L0.5521.00
256_E275_F0.5471.00
115_L120_S0.5461.00
334_D355_K0.5451.00
59_M67_F0.5441.00
122_N138_A0.5441.00
52_K160_S0.5431.00
83_R104_A0.5431.00
34_T75_V0.5431.00
291_A295_G0.5421.00
245_G248_V0.5391.00
16_N295_G0.5391.00
19_K67_F0.5381.00
16_N296_K0.5381.00
88_L93_L0.5381.00
238_V251_G0.5381.00
49_D52_K0.5361.00
145_A168_T0.5361.00
15_Y32_M0.5341.00
173_V179_N0.5341.00
189_V349_F0.5321.00
82_E86_A0.5311.00
14_G107_S0.5311.00
49_D53_G0.5301.00
178_W190_I0.5291.00
224_E227_M0.5291.00
155_V201_F0.5291.00
175_P179_N0.5281.00
159_S197_K0.5271.00
256_E274_I0.5271.00
120_S123_A0.5271.00
126_L131_D0.5231.00
270_D291_A0.5221.00
248_V252_I0.5201.00
252_I260_T0.5131.00
152_F318_D0.5111.00
122_N212_G0.5061.00
81_V86_A0.5061.00
88_L100_S0.5051.00
125_Y129_L0.5041.00
12_I16_N0.5041.00
13_A107_S0.5041.00
5_Y103_K0.5041.00
17_A21_L0.5031.00
310_N380_Q0.5031.00
376_N379_I0.5031.00
50_Y53_G0.5031.00
345_E367_R0.5021.00
112_P125_Y0.5021.00
158_A168_T0.5021.00
72_N75_V0.5011.00
23_Q71_D0.5011.00
346_R367_R0.5011.00
325_E364_A0.5001.00
48_K55_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iwaA 2 0.8762 100 0.239 Contact Map
4fx9A 2 0.9851 100 0.241 Contact Map
3kljA 1 0.9282 100 0.245 Contact Map
3icsA 2 0.995 100 0.246 Contact Map
4eqsA 2 0.9777 100 0.247 Contact Map
3oc4A 2 0.9455 100 0.251 Contact Map
1ojtA 2 0.9455 100 0.252 Contact Map
3cgbA 2 0.9876 100 0.255 Contact Map
1nhpA 2 0.9827 100 0.256 Contact Map
3l8kA 3 0.9455 100 0.256 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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