GREMLIN Database
Q97YT1 - Toluene-4-monooxygenase system protein A. amino end (TmoA)
UniProt: Q97YT1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 268 (237)
Sequences: 434 (248)
Seq/√Len: 16.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_M174_D4.5801.00
113_E143_E3.6941.00
196_E200_L3.5761.00
88_E138_F3.5210.99
55_Y132_W3.2070.99
55_Y250_V2.9250.98
66_Y142_D2.8860.98
30_V33_E2.8550.98
199_L204_A2.8460.98
115_T185_F2.8210.97
27_P35_L2.7940.97
123_M136_S2.6960.97
239_D242_R2.6510.96
176_W180_A2.6280.96
115_T189_I2.6030.96
132_W194_A2.5340.95
180_A232_A2.5250.95
97_Y221_A2.5020.95
203_F251_L2.4010.94
145_R239_D2.3460.93
183_S187_D2.3150.92
157_N232_A2.2950.92
258_T261_N2.0610.87
55_Y254_F2.0420.86
33_E39_D1.9320.83
145_R242_R1.9160.82
257_V261_N1.8340.79
191_G196_E1.8320.79
127_G133_R1.8130.79
169_K173_V1.7700.77
207_T211_N1.7560.76
67_V168_H1.7170.75
25_W37_P1.6810.73
148_Q212_L1.6030.69
61_V85_V1.6030.69
121_A140_S1.5810.68
209_F240_E1.5780.68
44_P121_A1.5640.67
132_W250_V1.5630.67
88_E91_K1.5630.67
104_F175_G1.4780.63
47_P260_V1.4760.63
134_N138_F1.4690.62
187_D252_K1.4510.61
57_A194_A1.4370.61
141_M144_V1.4180.60
184_F204_A1.4140.59
44_P48_I1.4130.59
63_Y110_P1.4120.59
171_F175_G1.4120.59
179_I186_D1.3990.58
78_F149_L1.3990.58
191_G217_Y1.3930.58
62_T148_Q1.3850.58
38_V73_K1.3850.58
82_E176_W1.3560.56
132_W259_K1.3530.56
243_H247_G1.3500.56
181_A184_F1.3390.55
70_Q145_R1.3340.55
47_P258_T1.3110.53
90_V153_L1.3080.53
70_Q242_R1.3010.53
158_I162_P1.3000.53
36_F232_A1.2830.52
20_A47_P1.2800.52
218_A229_F1.2740.51
184_F205_F1.2710.51
122_R132_W1.2510.50
46_L49_D1.2390.49
57_A186_D1.2330.49
52_T131_E1.2200.48
140_S166_F1.1930.47
70_Q239_D1.1930.47
97_Y125_R1.1860.46
140_S252_K1.1790.46
163_K260_V1.1720.45
63_Y67_V1.1700.45
95_K192_T1.1580.45
151_I162_P1.1580.45
46_L254_F1.1560.44
20_A56_D1.1480.44
195_I254_F1.1430.44
122_R126_F1.1410.44
67_V84_G1.1360.43
118_I187_D1.1230.43
200_L204_A1.0990.41
221_A226_D1.0980.41
106_I147_A1.0940.41
45_N221_A1.0900.41
118_I189_I1.0830.40
26_T83_A1.0750.40
56_D126_F1.0690.40
37_P206_E1.0680.39
106_I256_D1.0620.39
129_A147_A1.0560.39
240_E247_G1.0540.39
86_R113_E1.0480.38
121_A251_L1.0450.38
82_E251_L1.0450.38
166_F170_M1.0370.38
32_E167_A1.0370.38
75_Q212_L1.0320.37
172_W178_P1.0200.37
161_S213_Q1.0170.37
182_R186_D1.0140.36
179_I193_N1.0140.36
105_H213_Q1.0020.36
53_E199_L0.9870.35
168_H204_A0.9850.35
222_N230_S0.9840.35
179_I202_T0.9830.35
63_Y138_F0.9830.35
43_I125_R0.9820.35
240_E244_A0.9790.35
90_V169_K0.9770.35
172_W179_I0.9770.35
106_I232_A0.9750.34
95_K204_A0.9750.34
184_F222_N0.9650.34
66_Y238_T0.9630.34
77_L228_V0.9610.34
213_Q244_A0.9590.34
203_F238_T0.9570.33
163_K251_L0.9550.33
62_T75_Q0.9500.33
69_N242_R0.9500.33
95_K167_A0.9480.33
143_E206_E0.9410.33
116_A241_A0.9360.32
214_F236_I0.9280.32
71_K93_L0.9280.32
109_V206_E0.9280.32
56_D131_E0.9190.32
25_W29_Y0.9170.31
151_I161_S0.9130.31
47_P92_K0.9110.31
36_F228_V0.9110.31
157_N162_P0.9090.31
111_I172_W0.9070.31
96_T241_A0.9060.31
77_L146_H0.9050.31
91_K138_F0.9040.31
133_R178_P0.9030.31
162_P192_T0.9030.31
109_V176_W0.9010.31
29_Y214_F0.8970.30
122_R240_E0.8970.30
113_E206_E0.8960.30
26_T230_S0.8930.30
109_V210_T0.8850.30
172_W182_R0.8840.30
252_K256_D0.8830.30
140_S189_I0.8830.30
176_W179_I0.8790.30
177_L251_L0.8770.29
143_E221_A0.8770.29
185_F216_A0.8770.29
203_F247_G0.8710.29
123_M242_R0.8680.29
55_Y93_L0.8670.29
184_F191_G0.8670.29
93_L217_Y0.8660.29
144_V199_L0.8570.29
138_F148_Q0.8570.29
47_P174_D0.8560.28
105_H175_G0.8430.28
171_F213_Q0.8400.28
23_L29_Y0.8360.28
184_F256_D0.8360.28
110_P189_I0.8360.28
44_P50_V0.8360.28
104_F191_G0.8350.27
39_D174_D0.8340.27
130_G165_A0.8330.27
118_I123_M0.8270.27
31_K34_E0.8270.27
47_P195_I0.8210.27
86_R234_Q0.8170.27
123_M202_T0.8160.27
71_K106_I0.8130.26
21_N45_N0.8120.26
46_L55_Y0.8100.26
76_R102_F0.8090.26
69_N230_S0.8080.26
191_G247_G0.8040.26
84_G114_Y0.8030.26
47_P50_V0.8030.26
155_H160_A0.8020.26
86_R143_E0.7950.26
149_L236_I0.7930.26
53_E253_A0.7900.25
210_T239_D0.7880.25
63_Y108_A0.7850.25
141_M247_G0.7810.25
53_E255_V0.7780.25
20_A148_Q0.7720.25
73_K242_R0.7710.25
68_K234_Q0.7710.25
57_A142_D0.7700.25
135_L217_Y0.7690.25
140_S170_M0.7630.24
95_K221_A0.7610.24
108_A181_A0.7610.24
59_Y70_Q0.7590.24
199_L256_D0.7590.24
79_S103_C0.7570.24
195_I261_N0.7560.24
21_N226_D0.7510.24
123_M197_F0.7470.24
171_F191_G0.7450.24
250_V254_F0.7410.23
105_H217_Y0.7400.23
152_L201_T0.7400.23
114_Y121_A0.7390.23
93_L199_L0.7390.23
145_R151_I0.7370.23
73_K211_N0.7360.23
90_V138_F0.7340.23
162_P209_F0.7290.23
81_R102_F0.7280.23
146_H210_T0.7250.23
105_H170_M0.7220.23
66_Y138_F0.7210.23
116_A207_T0.7140.22
50_V89_L0.7140.22
95_K259_K0.7130.22
97_Y213_Q0.7130.22
119_A191_G0.7120.22
226_D229_F0.7110.22
144_V153_L0.7100.22
219_A224_T0.7070.22
111_I147_A0.7040.22
175_G256_D0.7020.22
73_K192_T0.7020.22
29_Y37_P0.6960.22
36_F260_V0.6950.21
79_S229_F0.6930.21
36_F84_G0.6930.21
132_W226_D0.6920.21
58_P142_D0.6920.21
65_E106_I0.6910.21
245_Q249_P0.6860.21
76_R80_V0.6840.21
58_P193_N0.6820.21
146_H240_E0.6810.21
132_W222_N0.6760.21
88_E92_K0.6730.21
133_R195_I0.6700.21
82_E259_K0.6690.20
139_G243_H0.6650.20
110_P179_I0.6600.20
198_A250_V0.6590.20
106_I217_Y0.6570.20
100_G167_A0.6550.20
239_D247_G0.6540.20
46_L192_T0.6540.20
22_K52_T0.6530.20
161_S164_F0.6510.20
204_A227_F0.6490.20
30_V115_T0.6480.20
79_S168_H0.6480.20
146_H236_I0.6460.20
67_V221_A0.6390.19
95_K215_V0.6370.19
49_D257_V0.6360.19
23_L43_I0.6340.19
91_K251_L0.6310.19
61_V69_N0.6310.19
225_N229_F0.6280.19
95_K216_A0.6280.19
51_W196_E0.6250.19
178_P193_N0.6240.19
73_K243_H0.6240.19
130_G231_S0.6240.19
130_G189_I0.6230.19
63_Y85_V0.6230.19
174_D199_L0.6230.19
131_E250_V0.6230.19
88_E174_D0.6220.19
139_G247_G0.6210.19
51_W148_Q0.6210.19
112_P145_R0.6200.19
130_G140_S0.6190.19
82_E139_G0.6160.19
234_Q245_Q0.6150.19
112_P189_I0.6150.19
237_Q240_E0.6130.18
105_H216_A0.6090.18
47_P225_N0.6030.18
139_G208_G0.6030.18
102_F140_S0.6020.18
53_E251_L0.6020.18
63_Y142_D0.6020.18
94_D225_N0.6000.18
64_R195_I0.5990.18
94_D124_A0.5980.18
211_N240_E0.5970.18
127_G137_T0.5970.18
22_K25_W0.5960.18
60_K143_E0.5960.18
24_E63_Y0.5950.18
127_G255_V0.5900.18
113_E237_Q0.5880.18
155_H158_I0.5860.18
95_K223_K0.5850.17
102_F238_T0.5840.17
183_S211_N0.5830.17
107_T150_Q0.5830.17
33_E125_R0.5810.17
63_Y117_A0.5800.17
115_T180_A0.5790.17
166_F217_Y0.5790.17
190_T249_P0.5790.17
204_A222_N0.5780.17
32_E213_Q0.5740.17
165_A169_K0.5730.17
103_C163_K0.5670.17
200_L217_Y0.5630.17
72_E126_F0.5600.17
72_E78_F0.5590.17
20_A174_D0.5560.17
114_Y141_M0.5530.16
113_E153_L0.5530.16
90_V160_A0.5520.16
98_H196_E0.5450.16
55_Y194_A0.5350.16
68_K184_F0.5340.16
164_F167_A0.5340.16
109_V181_A0.5330.16
119_A235_S0.5330.16
143_E153_L0.5330.16
173_V231_S0.5290.16
127_G135_L0.5290.16
211_N219_A0.5290.16
46_L58_P0.5260.16
68_K138_F0.5240.16
74_D247_G0.5240.16
113_E229_F0.5230.15
34_E230_S0.5220.15
165_A168_H0.5190.15
49_D132_W0.5170.15
131_E212_L0.5160.15
151_I159_Q0.5140.15
101_S217_Y0.5130.15
55_Y203_F0.5120.15
25_W239_D0.5100.15
111_I182_R0.5090.15
122_R191_G0.5080.15
211_N235_S0.5070.15
125_R221_A0.5060.15
86_R95_K0.5060.15
65_E86_R0.5060.15
27_P36_F0.5050.15
34_E169_K0.5040.15
36_F79_S0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2incA 2 0.9552 100 0.208 Contact Map
3ge3A 2 0.9478 100 0.208 Contact Map
2incB 2 0.9888 100 0.219 Contact Map
3u52C 2 0.9776 100 0.221 Contact Map
3ge3B 2 0.9851 100 0.226 Contact Map
1mtyB 2 0.9813 100 0.24 Contact Map
1mhyB 2 0.9776 100 0.243 Contact Map
3u52A 2 0.944 100 0.247 Contact Map
1mtyD 2 0.944 100 0.285 Contact Map
4mudA 2 0.6194 99.4 0.832 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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