GREMLIN Database
Q97YT0 - Toluene-4-monooxygenase system protein A. carboxy end (TmoA)
UniProt: Q97YT0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 310 (278)
Sequences: 191 (100)
Seq/√Len: 6.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_D225_C5.0230.98
52_Y231_Q4.2450.95
211_K230_E4.0680.94
193_C225_C3.8970.93
226_L230_E3.7480.91
252_Q262_K3.6210.89
70_G124_H3.4930.88
193_C221_D3.4390.87
111_W227_W3.0360.79
282_L286_D2.7600.71
129_I171_Y2.6830.69
112_Y289_Y2.6700.69
182_L278_G2.6580.68
211_K226_L2.6410.68
58_F116_F2.6350.68
66_G127_F2.5770.66
154_N161_E2.5540.65
252_Q264_L2.5490.65
144_G168_W2.4990.63
286_D290_A2.4350.61
70_G174_K2.4080.60
289_Y293_Y2.3720.59
121_D159_H2.2540.55
95_G120_L2.2110.53
71_V131_L2.1880.52
44_P82_R2.1700.52
82_R149_E2.1400.51
43_G288_A2.1240.50
122_H126_D2.1010.49
262_K266_D2.0960.49
43_G81_A1.9790.45
268_V272_M1.9450.44
281_G286_D1.8890.42
94_V109_L1.8560.41
252_Q266_D1.8180.40
70_G130_G1.8120.39
266_D271_N1.7670.38
118_L201_A1.7580.38
161_E169_D1.7360.37
173_K177_D1.7180.36
151_K155_E1.7030.36
168_W171_Y1.7020.36
43_G217_M1.6630.34
288_A291_L1.6550.34
58_F108_R1.6380.34
222_S229_F1.6360.34
108_R114_K1.6070.33
264_L267_E1.5740.32
64_L155_E1.5340.30
252_Q263_R1.5210.30
214_K218_Y1.4900.29
26_M54_V1.4840.29
82_R200_P1.4560.28
147_P192_V1.4550.28
26_M138_L1.4460.28
267_E287_G1.4390.28
262_K267_E1.4380.28
44_P290_A1.4200.27
275_T278_G1.4180.27
88_E156_K1.4010.27
47_K107_I1.3910.26
138_L211_K1.3830.26
262_K289_Y1.3770.26
154_N159_H1.3650.26
95_G107_I1.3420.25
87_K121_D1.3340.25
135_R272_M1.3240.24
185_T252_Q1.3150.24
265_L287_G1.3150.24
137_T272_M1.3000.24
210_L288_A1.2980.24
70_G129_I1.2920.24
282_L291_L1.2830.23
264_L269_I1.2790.23
148_D173_K1.2740.23
212_E288_A1.2560.23
205_Y208_I1.2360.22
26_M36_A1.2350.22
154_N165_G1.2210.22
44_P214_K1.2150.22
24_G27_K1.2090.22
24_G28_N1.2090.22
25_L28_N1.2090.22
185_T247_L1.2050.22
51_E55_A1.2050.22
39_M155_E1.1990.21
262_K293_Y1.1970.21
281_G290_A1.1970.21
205_Y291_L1.1950.21
7_L90_M1.1860.21
210_L217_M1.1800.21
123_W159_H1.1780.21
94_V113_W1.1730.21
82_R188_H1.1700.21
197_I230_E1.1590.20
113_W117_E1.1560.20
286_D291_L1.1540.20
161_E165_G1.1530.20
172_I293_Y1.1520.20
153_L168_W1.1480.20
107_I120_L1.1460.20
137_T251_I1.1450.20
117_E273_G1.1430.20
252_Q267_E1.1370.20
192_V212_E1.1340.20
114_K117_E1.1260.20
251_I272_M1.1170.19
96_A103_E1.1070.19
287_G291_L1.1040.19
97_Q262_K1.1030.19
81_A92_E1.1000.19
97_Q264_L1.0970.19
11_K27_K1.0970.19
11_K28_N1.0970.19
11_K25_L1.0970.19
11_K24_G1.0970.19
55_A60_L1.0960.19
82_R133_T1.0950.19
70_G127_F1.0920.19
112_Y293_Y1.0820.19
130_G243_T1.0650.18
39_M168_W1.0610.18
185_T264_L1.0600.18
247_L269_I1.0570.18
185_T271_N1.0480.18
62_V119_E1.0460.18
148_D151_K1.0260.18
197_I211_K1.0250.18
64_L291_L1.0140.17
154_N160_W1.0140.17
119_E225_C1.0100.17
264_L271_N1.0090.17
39_M173_K1.0050.17
275_T284_P1.0020.17
186_A243_T0.9990.17
121_D163_F0.9930.17
10_T28_N0.9890.17
10_T24_G0.9890.17
10_T27_K0.9890.17
10_T25_L0.9890.17
26_M206_L0.9880.17
122_H159_H0.9830.17
45_A212_E0.9750.17
103_E293_Y0.9750.17
284_P289_Y0.9750.17
224_A289_Y0.9690.16
147_P172_I0.9690.16
82_R97_Q0.9690.16
45_A159_H0.9680.16
54_V201_A0.9650.16
239_R273_G0.9580.16
129_I168_W0.9530.16
6_S24_G0.9500.16
6_S27_K0.9500.16
6_S28_N0.9500.16
6_S25_L0.9500.16
192_V226_L0.9500.16
23_E46_Y0.9480.16
282_L290_A0.9450.16
173_K208_I0.9440.16
164_F228_I0.9430.16
39_M280_A0.9350.16
212_E217_M0.9290.16
121_D200_P0.9260.16
193_C224_A0.9200.15
26_M116_F0.9140.15
152_W236_Y0.9140.15
102_L222_S0.9040.15
277_E286_D0.9040.15
90_M97_Q0.9040.15
245_R248_E0.9030.15
22_S27_K0.8960.15
22_S28_N0.8960.15
22_S25_L0.8960.15
108_R111_W0.8950.15
97_Q293_Y0.8930.15
168_W227_W0.8910.15
136_R184_L0.8900.15
8_G141_S0.8880.15
194_Q229_F0.8830.15
35_F149_E0.8830.15
100_R227_W0.8810.15
55_A186_A0.8810.15
264_L289_Y0.8780.15
128_I131_L0.8730.15
7_L13_E0.8680.15
60_L233_P0.8650.14
278_G286_D0.8600.14
160_W165_G0.8530.14
103_E291_L0.8520.14
130_G135_R0.8500.14
265_L268_V0.8480.14
229_F233_P0.8470.14
115_W200_P0.8470.14
165_G169_D0.8420.14
127_F274_Q0.8320.14
146_T287_G0.8300.14
81_A213_Y0.8250.14
6_S11_K0.8220.14
247_L252_Q0.8220.14
73_M78_P0.8170.14
20_N27_K0.8160.14
20_N28_N0.8160.14
20_N25_L0.8160.14
20_N24_G0.8160.14
191_A218_Y0.8140.14
97_Q263_R0.8140.14
26_M240_R0.8040.13
60_L229_F0.8000.13
111_W183_P0.8000.13
135_R182_L0.7950.13
62_V268_V0.7880.13
159_H162_M0.7880.13
243_T246_V0.7870.13
54_V118_L0.7870.13
187_V249_G0.7840.13
162_M294_R0.7830.13
290_A293_Y0.7820.13
97_Q267_E0.7790.13
16_Q69_T0.7790.13
90_M104_D0.7780.13
217_M288_A0.7730.13
11_K22_S0.7710.13
94_V112_Y0.7700.13
154_N169_D0.7700.13
44_P288_A0.7690.13
59_W193_C0.7650.13
135_R284_P0.7650.13
22_S190_C0.7650.13
135_R278_G0.7620.13
39_M218_Y0.7590.13
97_Q252_Q0.7560.13
147_P155_E0.7530.13
223_P292_L0.7470.13
178_G215_G0.7470.13
134_W183_P0.7460.13
4_E192_V0.7440.12
288_A294_R0.7420.12
135_R268_V0.7410.12
25_L32_T0.7410.12
27_K32_T0.7410.12
24_G32_T0.7410.12
28_N32_T0.7410.12
214_K234_E0.7380.12
170_L174_K0.7320.12
117_E291_L0.7280.12
4_E209_Y0.7240.12
6_S10_T0.7150.12
26_M146_T0.7140.12
105_Y122_H0.7130.12
114_K148_D0.7120.12
267_E271_N0.7120.12
83_I149_E0.7120.12
195_V211_K0.7090.12
82_R262_K0.7030.12
159_H205_Y0.7020.12
11_K20_N0.6980.12
135_R174_K0.6940.12
56_K105_Y0.6860.12
78_P88_E0.6840.12
267_E270_W0.6820.12
67_A214_K0.6810.12
107_I228_I0.6810.12
35_F165_G0.6800.12
61_S108_R0.6740.11
112_Y227_W0.6740.11
55_A74_D0.6720.11
224_A227_W0.6710.11
6_S26_M0.6640.11
63_R243_T0.6640.11
138_L197_I0.6600.11
11_K32_T0.6570.11
10_T22_S0.6480.11
116_F247_L0.6460.11
142_F180_I0.6450.11
263_R289_Y0.6430.11
118_L286_D0.6430.11
15_K167_V0.6430.11
113_W227_W0.6430.11
202_N206_L0.6400.11
151_K205_Y0.6380.11
72_S126_D0.6370.11
82_R293_Y0.6370.11
43_G63_R0.6330.11
63_R66_G0.6320.11
87_K227_W0.6290.11
129_I195_V0.6290.11
133_T138_L0.6250.11
109_L208_I0.6250.11
267_E280_A0.6240.11
103_E284_P0.6240.11
43_G264_L0.6240.11
113_W134_W0.6240.11
60_L194_Q0.6230.11
146_T168_W0.6230.11
70_G285_T0.6220.11
263_R266_D0.6210.11
97_Q170_L0.6190.11
138_L269_I0.6190.11
112_Y220_F0.6180.11
36_A96_A0.6180.11
240_R248_E0.6170.11
52_Y112_Y0.6160.11
7_L182_L0.6140.11
123_W133_T0.6130.11
26_M151_K0.6130.11
172_I181_P0.6120.11
135_R146_T0.6120.11
74_D153_L0.6110.11
191_A239_R0.6110.11
203_G285_T0.6100.11
35_F44_P0.6080.11
284_P287_G0.6070.11
166_R234_E0.6060.10
91_T234_E0.6050.10
48_E232_E0.6030.10
41_E91_T0.6000.10
60_L74_D0.5990.10
119_E221_D0.5980.10
104_D183_P0.5980.10
190_C225_C0.5980.10
130_G136_R0.5960.10
218_Y229_F0.5940.10
74_D88_E0.5940.10
92_E227_W0.5930.10
44_P188_H0.5920.10
151_K291_L0.5910.10
97_Q289_Y0.5860.10
192_V220_F0.5860.10
15_K33_V0.5850.10
137_T249_G0.5840.10
104_D128_I0.5830.10
130_G137_T0.5830.10
15_K31_N0.5820.10
10_T20_N0.5780.10
132_Y277_E0.5780.10
266_D289_Y0.5770.10
217_M226_L0.5770.10
238_G290_A0.5720.10
200_P284_P0.5720.10
131_L271_N0.5710.10
58_F293_Y0.5700.10
218_Y238_G0.5680.10
100_R278_G0.5680.10
97_Q278_G0.5670.10
108_R227_W0.5660.10
31_N101_L0.5650.10
58_F112_Y0.5650.10
130_G175_I0.5650.10
58_F111_W0.5640.10
151_K165_G0.5620.10
171_Y227_W0.5600.10
91_T95_G0.5600.10
82_R290_A0.5580.10
57_G263_R0.5580.10
66_G273_G0.5570.10
41_E234_E0.5570.10
10_T32_T0.5530.10
117_E127_F0.5500.10
40_R107_I0.5490.10
281_G293_Y0.5480.10
58_F224_A0.5480.10
102_L236_Y0.5480.10
281_G288_A0.5470.10
201_A204_K0.5450.10
44_P210_L0.5440.10
46_Y49_A0.5440.10
140_V145_P0.5440.10
6_S22_S0.5410.10
210_L263_R0.5410.10
37_A193_C0.5400.10
6_S20_N0.5390.10
151_K280_A0.5380.10
129_I144_G0.5380.10
92_E171_Y0.5370.10
194_Q242_Y0.5370.10
86_Y140_V0.5360.10
209_Y223_P0.5360.10
159_H176_I0.5350.10
246_V268_V0.5340.10
262_K271_N0.5340.10
267_E291_L0.5340.10
244_Q268_V0.5260.09
116_F149_E0.5250.09
70_G146_T0.5250.09
31_N37_A0.5240.09
195_V208_I0.5240.09
104_D112_Y0.5210.09
227_W273_G0.5200.09
136_R185_T0.5170.09
104_D111_W0.5150.09
85_S220_F0.5140.09
73_M149_E0.5140.09
15_K112_Y0.5130.09
113_W173_K0.5130.09
198_Q221_D0.5120.09
73_M185_T0.5120.09
182_L277_E0.5120.09
269_I276_E0.5120.09
130_G247_L0.5110.09
6_S32_T0.5110.09
144_G281_G0.5100.09
124_H174_K0.5080.09
175_I290_A0.5070.09
57_G95_G0.5070.09
26_M275_T0.5070.09
58_F281_G0.5060.09
185_T262_K0.5050.09
112_Y224_A0.5050.09
70_G197_I0.5040.09
148_D163_F0.5040.09
159_H277_E0.5030.09
93_W160_W0.5030.09
263_R267_E0.5030.09
113_W116_F0.5020.09
35_F270_W0.5020.09
18_L98_L0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u52A 2 0.9032 100 0.353 Contact Map
3ge3A 2 0.9032 100 0.359 Contact Map
2incA 2 0.9032 100 0.359 Contact Map
1mtyD 2 0.9484 100 0.419 Contact Map
1mtyB 2 0.3806 100 0.795 Contact Map
1mhyB 2 0.3806 100 0.796 Contact Map
2incB 2 0.2968 99.9 0.823 Contact Map
3u52C 2 0.3161 99.9 0.837 Contact Map
3ge3B 2 0.2323 99.9 0.84 Contact Map
4mudA 2 0.3355 99.8 0.856 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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