GREMLIN Database
Q97YS8 - Toluene-4-monooxygenase system protein C. (TmoC)
UniProt: Q97YS8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 134 (102)
Sequences: 1520 (1074)
Seq/√Len: 106.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_K100_D4.8641.00
72_W85_V2.5201.00
43_Y89_L2.5071.00
93_D104_K2.4491.00
45_A55_E2.4211.00
52_G68_P2.2861.00
13_L40_I2.1621.00
9_K102_F2.0871.00
95_K102_F2.0251.00
7_F95_K1.9421.00
75_N78_T1.8481.00
39_E77_R1.7821.00
44_Y90_F1.7801.00
18_E35_N1.7761.00
35_N38_G1.7741.00
12_T15_D1.7331.00
97_E102_F1.7111.00
62_E77_R1.6301.00
12_T100_D1.6291.00
34_V43_Y1.6251.00
21_A65_I1.6001.00
30_E45_A1.5971.00
59_F76_A1.5721.00
62_E75_N1.5561.00
21_A34_V1.4961.00
29_Y44_Y1.4521.00
31_I42_A1.4431.00
11_L16_I1.4251.00
21_A32_L1.4041.00
13_L99_S1.3941.00
80_E88_S1.3841.00
11_L101_I1.3651.00
53_L69_V1.3000.99
44_Y92_L1.2660.99
51_L69_V1.2430.99
21_A59_F1.2410.99
34_V65_I1.2150.99
64_K73_E1.1920.99
18_E38_G1.1500.98
40_I94_V1.1430.98
48_A89_L1.1290.98
36_I62_E1.1250.98
13_L96_V1.1230.98
52_G69_V1.1120.98
9_K12_T1.1100.98
48_A72_W1.1040.98
60_D66_I1.1030.98
72_W88_S1.0770.98
96_V101_I1.0640.97
50_A72_W1.0540.97
34_V76_A1.0390.97
14_D99_S1.0190.97
48_A85_V0.9980.96
32_L89_L0.9870.96
25_E30_E0.9840.96
16_I40_I0.9500.95
39_E62_E0.9490.95
72_W81_S0.9400.95
17_Y20_E0.9310.94
72_W86_G0.9280.94
16_I22_K0.9240.94
17_Y35_N0.9190.94
41_K91_P0.9190.94
11_L33_V0.9120.94
72_W84_P0.9000.93
81_S88_S0.8960.93
10_L24_V0.8860.93
81_S85_V0.8790.92
81_S84_P0.8790.92
6_E105_V0.8780.92
19_G35_N0.8440.91
36_I59_F0.8400.91
75_N82_I0.8340.90
85_V88_S0.8250.90
31_I103_V0.8240.90
45_A53_L0.8170.89
45_A89_L0.8160.89
12_T99_S0.8070.89
26_V29_Y0.8040.89
11_L15_D0.7980.88
23_L30_E0.7980.88
36_I61_G0.7930.88
46_R51_L0.7760.87
41_K76_A0.7720.87
50_A69_V0.7660.86
98_G102_F0.7650.86
9_K95_K0.7530.85
64_K82_I0.7490.85
60_D73_E0.7430.84
10_L42_A0.7370.84
40_I96_V0.7140.82
33_V94_V0.7110.82
30_E44_Y0.7090.82
92_L104_K0.7050.81
48_A88_S0.6980.81
41_K77_R0.6870.79
10_L14_D0.6860.79
58_S71_L0.6830.79
23_L45_A0.6790.79
43_Y91_P0.6790.79
51_L83_N0.6720.78
71_L85_V0.6690.78
16_I33_V0.6680.78
48_A81_S0.6650.77
46_R53_L0.6610.77
48_A74_Y0.6570.76
52_G85_V0.6540.76
52_G58_S0.6470.75
66_I73_E0.6450.75
58_S66_I0.6440.75
40_I101_I0.6360.74
52_G72_W0.6360.74
73_E82_I0.6240.73
24_V33_V0.6150.72
6_E104_K0.6140.71
42_A103_V0.6140.71
24_V31_I0.6070.71
32_L43_Y0.6040.70
18_E37_K0.6000.70
11_L22_K0.5920.69
74_Y85_V0.5900.68
25_E28_R0.5880.68
8_H94_V0.5820.67
23_L55_E0.5800.67
55_E69_V0.5780.67
73_E83_N0.5680.66
31_I104_K0.5660.65
35_N40_I0.5590.64
95_K98_G0.5590.64
66_I71_L0.5580.64
15_D22_K0.5500.63
68_P71_L0.5490.63
21_A24_V0.5480.63
9_K14_D0.5470.63
72_W76_A0.5430.62
43_Y46_R0.5300.60
19_G77_R0.5300.60
50_A58_S0.5280.60
13_L18_E0.5250.60
44_Y105_V0.5250.60
33_V40_I0.5210.59
8_H26_V0.5210.59
44_Y89_L0.5200.59
29_Y105_V0.5190.59
58_S69_V0.5180.59
31_I88_S0.5180.59
47_C67_C0.5170.58
6_E106_P0.5090.57
6_E37_K0.5040.56
29_Y92_L0.5040.56
17_Y21_A0.5030.56
75_N80_E0.5000.56
21_A76_A0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fqtA 2 0.7985 100 0.359 Contact Map
3dqyA 1 0.7836 100 0.359 Contact Map
3gceA 1 0.7463 100 0.363 Contact Map
2i7fA 1 0.7463 100 0.363 Contact Map
2qpzA 1 0.7612 100 0.367 Contact Map
4aivA 1 0.7836 100 0.367 Contact Map
1vm9A 1 0.7985 100 0.368 Contact Map
2de6D 1 0.7612 100 0.368 Contact Map
3d89A 1 0.8881 100 0.371 Contact Map
2jo6A 1 0.7761 100 0.382 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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