GREMLIN Database
Q97YS6 - Toluene-4-monooxygenase system protein E. (TmoE)
UniProt: Q97YS6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 376 (306)
Sequences: 420 (254)
Seq/√Len: 14.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
235_K239_E4.9821.00
252_K340_M4.5651.00
152_K201_F3.6630.99
176_F206_H3.5970.99
119_Y195_I3.1850.98
324_P327_K3.1150.98
98_K101_R2.9690.97
249_V341_G2.9620.97
261_E265_A2.9610.97
352_L359_A2.9560.97
95_K103_N2.9270.97
178_I250_L2.8500.97
119_Y315_L2.7280.96
320_F330_I2.7270.96
241_P245_P2.7220.96
195_I259_V2.7080.96
245_P297_I2.5810.94
268_L316_F2.5780.94
248_E343_K2.5440.94
261_E337_W2.3650.91
161_V286_F2.3250.90
109_P184_M2.2880.89
84_P194_S2.2830.89
130_Y205_D2.2070.88
186_L199_F2.1260.85
304_D307_R2.0740.84
337_W340_M2.0690.84
261_E333_W2.0430.83
331_K335_K2.0060.82
178_I254_L1.9900.81
256_T261_E1.9890.81
146_E316_F1.9550.80
208_R304_D1.9250.79
190_A196_A1.9130.79
326_L333_W1.8940.78
70_W86_E1.8920.78
342_F364_R1.8820.77
334_V371_L1.8780.77
184_M203_G1.8750.77
277_L349_R1.8540.76
350_D354_G1.8360.76
121_D337_W1.8210.75
281_H363_I1.8050.74
203_G231_K1.7840.73
248_E252_K1.7540.72
237_F251_E1.7180.71
101_R107_I1.7060.70
112_E361_R1.6950.69
111_F330_I1.6880.69
272_F276_E1.6860.69
325_S328_D1.6650.68
336_D340_M1.6590.68
329_V332_P1.6370.67
192_T210_V1.6310.66
204_M207_L1.6310.66
87_L175_V1.6100.65
142_D212_R1.6090.65
234_R238_E1.6030.65
168_V351_V1.6010.65
92_I100_F1.5920.64
235_K350_D1.5780.64
248_E340_M1.5700.63
125_L149_V1.5640.63
146_E241_P1.5320.61
44_T49_E1.5170.61
131_N233_T1.5100.60
220_L297_I1.5050.60
208_R307_R1.4960.59
181_M254_L1.4830.59
109_P113_R1.4790.59
48_L71_A1.4610.58
325_S350_D1.4540.57
343_K351_V1.4520.57
237_F344_A1.4250.56
211_Q277_L1.3880.54
361_R374_I1.3860.53
119_Y319_A1.3800.53
160_E351_V1.3540.52
140_F144_I1.3420.51
112_E330_I1.3360.51
197_N201_F1.3350.51
71_A85_F1.3340.51
121_D259_V1.3270.50
338_Q368_S1.3130.49
160_E343_K1.3130.49
112_E323_E1.2800.48
127_Y173_R1.2780.48
90_E106_F1.2740.47
104_S184_M1.2680.47
346_E361_R1.2590.46
236_V240_S1.2570.46
260_G319_A1.2530.46
320_F327_K1.2490.46
226_S325_S1.2470.46
111_F114_G1.2470.46
195_I315_L1.2320.45
333_W344_A1.2310.45
231_K362_Q1.2300.45
274_L305_T1.2290.45
165_Y203_G1.2290.45
306_L324_P1.2290.45
359_A363_I1.2260.45
327_K334_V1.2250.45
244_Q251_E1.2210.44
264_V269_A1.2190.44
116_W333_W1.2180.44
141_L347_G1.2160.44
241_P327_K1.2140.44
134_A208_R1.2130.44
330_I336_D1.1690.42
181_M252_K1.1610.41
167_N240_S1.1510.41
120_E189_M1.1420.40
338_Q364_R1.1400.40
88_G192_T1.1370.40
43_S365_K1.1270.39
168_V278_I1.1190.39
251_E344_A1.1120.39
185_Y189_M1.1110.38
278_I367_H1.1060.38
316_F363_I1.1010.38
146_E327_K1.0950.38
265_A269_A1.0900.37
134_A307_R1.0870.37
233_T269_A1.0860.37
134_A304_D1.0850.37
156_N374_I1.0840.37
148_I177_H1.0840.37
252_K317_K1.0840.37
85_F227_L1.0820.37
256_T282_L1.0740.37
336_D343_K1.0730.37
331_K343_K1.0710.36
214_S225_P1.0670.36
334_V356_Y1.0620.36
265_A337_W1.0620.36
306_L340_M1.0580.36
249_V270_V1.0550.36
155_W331_K1.0500.35
161_V188_T1.0490.35
225_P274_L1.0410.35
325_S331_K1.0380.35
121_D326_L1.0310.34
43_S353_K1.0310.34
256_T312_A1.0300.34
324_P331_K1.0220.34
106_F137_N1.0200.34
132_S299_L1.0040.33
118_D335_K1.0030.33
118_D264_V0.9900.32
226_S278_I0.9880.32
190_A200_I0.9860.32
96_W106_F0.9740.32
261_E336_D0.9730.32
141_L209_R0.9710.31
131_N148_I0.9700.31
117_H194_S0.9670.31
102_D149_V0.9630.31
268_L371_L0.9610.31
309_R360_I0.9560.31
112_E325_S0.9550.31
123_Y134_A0.9520.31
154_D234_R0.9510.31
249_V347_G0.9500.30
268_L351_V0.9440.30
120_E194_S0.9430.30
109_P114_G0.9420.30
128_W197_N0.9410.30
88_G210_V0.9380.30
119_Y157_L0.9370.30
244_Q267_N0.9370.30
249_V269_A0.9340.30
155_W332_P0.9300.30
168_V356_Y0.9160.29
152_K155_W0.9130.29
264_V352_L0.9020.28
110_L372_G0.9010.28
125_L133_M0.8930.28
176_F294_I0.8880.28
174_Y210_V0.8840.27
89_T279_L0.8800.27
154_D216_R0.8760.27
253_M368_S0.8740.27
184_M363_I0.8700.27
370_Y373_G0.8690.27
181_M186_L0.8660.27
127_Y171_P0.8660.27
308_H312_A0.8640.27
305_T312_A0.8580.26
112_E260_G0.8560.26
172_L271_K0.8550.26
47_M145_Y0.8550.26
264_V330_I0.8540.26
169_Y210_V0.8470.26
82_K178_I0.8420.26
207_L264_V0.8390.26
327_K331_K0.8370.25
111_F119_Y0.8320.25
237_F243_F0.8290.25
186_L262_A0.8280.25
367_H371_L0.8280.25
356_Y360_I0.8270.25
206_H286_F0.8260.25
83_G89_T0.8260.25
358_N369_E0.8240.25
105_P230_G0.8240.25
365_K368_S0.8210.25
48_L86_E0.8180.25
47_M50_K0.8150.25
355_E359_A0.8110.24
201_F211_Q0.8110.24
155_W201_F0.8090.24
322_K326_L0.8060.24
111_F351_V0.8060.24
172_L246_T0.8050.24
278_I335_K0.8030.24
335_K342_F0.8030.24
201_F205_D0.8000.24
231_K327_K0.7980.24
126_T215_Q0.7930.24
49_E199_F0.7930.24
160_E306_L0.7920.24
110_L226_S0.7900.24
176_F216_R0.7860.23
265_A315_L0.7780.23
278_I309_R0.7740.23
172_L275_D0.7740.23
242_I316_F0.7700.23
133_M307_R0.7690.23
355_E368_S0.7660.23
109_P243_F0.7660.23
113_R322_K0.7650.23
324_P343_K0.7650.23
104_S177_H0.7650.23
249_V321_S0.7620.22
121_D205_D0.7610.22
267_N330_I0.7580.22
282_L363_I0.7540.22
232_E245_P0.7540.22
222_I225_P0.7530.22
247_R344_A0.7520.22
281_H368_S0.7510.22
112_E364_R0.7500.22
317_K321_S0.7490.22
150_N176_F0.7490.22
357_D365_K0.7480.22
219_M341_G0.7480.22
127_Y201_F0.7480.22
108_K243_F0.7450.22
198_V282_L0.7450.22
186_L362_Q0.7400.22
186_L324_P0.7400.22
275_D304_D0.7390.22
237_F247_R0.7390.22
155_W342_F0.7360.21
91_H114_G0.7350.21
268_L312_A0.7330.21
165_Y303_N0.7310.21
185_Y305_T0.7290.21
47_M279_L0.7280.21
110_L152_K0.7280.21
361_R372_G0.7280.21
232_E342_F0.7270.21
94_Q134_A0.7240.21
161_V371_L0.7220.21
87_L178_I0.7200.21
283_T294_I0.7190.21
137_N307_R0.7190.21
170_D213_I0.7180.21
91_H248_E0.7170.21
127_Y131_N0.7150.21
305_T309_R0.7140.21
43_S324_P0.7110.21
104_S293_M0.7090.20
95_K100_F0.7090.20
222_I226_S0.7090.20
141_L293_M0.7080.20
49_E143_K0.7060.20
71_A86_E0.7060.20
280_Q374_I0.7020.20
50_K101_R0.7010.20
287_S351_V0.7010.20
107_I315_L0.6990.20
206_H216_R0.6990.20
268_L303_N0.6980.20
99_H102_D0.6960.20
121_D251_E0.6960.20
287_S295_K0.6950.20
203_G317_K0.6950.20
186_L307_R0.6920.20
161_V278_I0.6910.20
168_V240_S0.6900.20
46_P295_K0.6900.20
203_G296_H0.6890.20
101_R188_T0.6890.20
246_T249_V0.6890.20
112_E290_G0.6880.20
130_Y201_F0.6880.20
158_N190_A0.6860.20
171_P180_Q0.6840.20
286_F291_D0.6800.19
107_I185_Y0.6790.19
352_L356_Y0.6790.19
127_Y180_Q0.6790.19
43_S48_L0.6780.19
43_S354_G0.6770.19
86_E141_L0.6750.19
338_Q354_G0.6740.19
290_G294_I0.6730.19
346_E349_R0.6690.19
42_W72_D0.6690.19
278_I353_K0.6680.19
156_N201_F0.6680.19
244_Q258_D0.6660.19
266_F370_Y0.6630.19
211_Q253_M0.6620.19
338_Q367_H0.6610.19
46_P49_E0.6600.19
176_F198_V0.6570.19
160_E285_P0.6570.19
206_H271_K0.6570.19
212_R301_F0.6570.19
232_E278_I0.6560.19
231_K235_K0.6550.19
316_F330_I0.6550.19
324_P340_M0.6550.19
359_A375_G0.6540.19
259_V337_W0.6520.19
332_P362_Q0.6510.18
226_S369_E0.6500.18
96_W221_D0.6450.18
145_Y301_F0.6450.18
331_K336_D0.6430.18
251_E263_L0.6430.18
128_W204_M0.6410.18
130_Y303_N0.6410.18
193_S203_G0.6380.18
93_T233_T0.6380.18
175_V208_R0.6370.18
98_K178_I0.6360.18
206_H294_I0.6340.18
111_F319_A0.6340.18
167_N368_S0.6300.18
199_F203_G0.6290.18
190_A194_S0.6280.18
335_K339_E0.6270.18
235_K332_P0.6260.18
178_I247_R0.6260.18
232_E358_N0.6240.18
248_E339_E0.6230.18
220_L269_A0.6220.18
268_L294_I0.6220.18
343_K355_E0.6210.17
160_E361_R0.6190.17
119_Y198_V0.6190.17
239_E357_D0.6180.17
334_V346_E0.6170.17
115_E260_G0.6150.17
351_V365_K0.6120.17
321_S362_Q0.6100.17
235_K327_K0.6090.17
241_P363_I0.6070.17
232_E303_N0.6070.17
327_K343_K0.6050.17
173_R244_Q0.6050.17
162_L314_E0.6040.17
164_L324_P0.6030.17
299_L310_H0.5990.17
83_G160_E0.5980.17
123_Y326_L0.5970.17
83_G155_W0.5940.17
80_Y134_A0.5910.17
215_Q266_F0.5910.17
154_D201_F0.5890.16
157_L282_L0.5890.16
239_E365_K0.5880.16
291_D294_I0.5870.16
243_F333_W0.5850.16
245_P359_A0.5850.16
276_E353_K0.5840.16
87_L100_F0.5810.16
236_V339_E0.5800.16
170_D292_E0.5780.16
139_T343_K0.5780.16
286_F334_V0.5730.16
341_G366_A0.5730.16
162_L261_E0.5730.16
132_S201_F0.5710.16
269_A335_K0.5700.16
320_F332_P0.5700.16
256_T262_A0.5700.16
328_D371_L0.5680.16
154_D337_W0.5660.16
235_K336_D0.5650.16
208_R214_S0.5640.16
135_D203_G0.5640.16
335_K357_D0.5630.16
179_M306_L0.5620.16
145_Y165_Y0.5620.16
139_T277_L0.5620.16
281_H362_Q0.5610.16
353_K361_R0.5610.16
282_L337_W0.5600.16
174_Y326_L0.5580.16
109_P115_E0.5570.16
109_P195_I0.5570.16
364_R368_S0.5550.15
126_T211_Q0.5530.15
250_L281_H0.5530.15
253_M352_L0.5490.15
177_H185_Y0.5480.15
143_K332_P0.5460.15
226_S316_F0.5460.15
157_L269_A0.5450.15
339_E368_S0.5420.15
270_V341_G0.5420.15
328_D368_S0.5400.15
152_K253_M0.5400.15
110_L332_P0.5400.15
185_Y188_T0.5380.15
98_K270_V0.5380.15
296_H303_N0.5380.15
243_F267_N0.5380.15
130_Y225_P0.5370.15
210_V326_L0.5370.15
171_P217_V0.5360.15
152_K156_N0.5360.15
178_I184_M0.5350.15
267_N356_Y0.5340.15
329_V351_V0.5330.15
339_E364_R0.5320.15
100_F232_E0.5280.15
190_A198_V0.5280.15
96_W332_P0.5260.15
236_V348_F0.5250.15
195_I291_D0.5230.15
240_S368_S0.5220.15
126_T212_R0.5200.15
167_N232_E0.5190.14
316_F365_K0.5180.14
107_I162_L0.5160.14
169_Y321_S0.5160.14
338_Q361_R0.5160.14
118_D175_V0.5140.14
273_V367_H0.5100.14
104_S297_I0.5100.14
144_I282_L0.5090.14
240_S372_G0.5080.14
169_Y351_V0.5070.14
121_D311_Q0.5070.14
114_G322_K0.5070.14
174_Y237_F0.5070.14
82_K123_Y0.5070.14
91_H291_D0.5050.14
93_T104_S0.5020.14
119_Y259_V0.5020.14
145_Y199_F0.5010.14
99_H207_L0.5000.14
214_S230_G0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mhyB 2 0.9255 100 0.328 Contact Map
1mtyB 2 0.9309 100 0.331 Contact Map
3u52C 2 0.859 100 0.333 Contact Map
2incB 2 0.8564 100 0.335 Contact Map
3ge3B 2 0.8085 100 0.349 Contact Map
3u52A 2 0.7846 100 0.436 Contact Map
3ge3A 2 0.7793 100 0.438 Contact Map
2incA 2 0.7846 100 0.441 Contact Map
1mtyD 2 0.7926 100 0.469 Contact Map
4mudA 2 0.5532 99.5 0.879 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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