GREMLIN Database
Q97YS5 - Uncharacterized protein
UniProt: Q97YS5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 153 (127)
Sequences: 545 (354)
Seq/√Len: 31.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_L55_V4.2771.00
41_L52_A3.3161.00
22_Y27_V2.9241.00
90_T94_M2.8991.00
121_K124_L2.7161.00
19_I99_Y2.6761.00
93_L97_E2.6491.00
8_I62_K2.6061.00
21_I55_V2.4770.99
93_L96_E2.4540.99
87_A92_R2.4130.99
121_K126_N2.1340.98
9_L22_Y2.0910.98
40_R77_D2.0800.98
38_F73_E1.9500.97
17_I99_Y1.9260.97
83_N86_Y1.8180.96
121_K129_P1.7610.95
122_V126_N1.7560.95
29_E40_R1.7420.94
36_R71_N1.6540.93
60_K64_M1.6300.92
125_E128_D1.6110.92
57_V61_Y1.5880.91
54_L58_Q1.5720.91
32_I37_I1.5600.90
40_R75_K1.5480.90
41_L59_V1.5440.90
23_D94_M1.5040.88
28_R86_Y1.4860.88
9_L27_V1.4720.87
124_L129_P1.4310.86
113_I117_V1.3850.84
23_D90_T1.3670.83
122_V129_P1.3640.83
8_I66_V1.3340.81
41_L55_V1.3220.81
17_I53_D1.3000.80
26_L41_L1.2820.79
69_D72_V1.2810.79
36_R73_E1.2660.78
47_K86_Y1.2640.78
96_E120_N1.2530.77
27_V54_L1.1900.73
112_K117_V1.1890.73
31_R38_F1.1830.73
38_F75_K1.1760.72
88_T91_G1.1300.69
58_Q61_Y1.1200.69
111_T115_E1.0970.67
8_I69_D1.0850.66
57_V120_N1.0430.63
23_D71_N1.0260.62
43_F51_L1.0150.61
59_V131_E1.0120.61
52_A86_Y1.0080.60
6_V20_N1.0050.60
5_V133_M0.9950.59
81_E86_Y0.9920.59
47_K78_F0.9900.59
21_I27_V0.9840.59
53_D56_A0.9750.58
34_G71_N0.9700.57
91_G123_K0.9700.57
87_A133_M0.9680.57
126_N129_P0.9620.57
21_I41_L0.9620.57
20_N90_T0.9600.57
109_N112_K0.9580.56
127_F130_R0.9450.55
45_A52_A0.9400.55
31_R40_R0.9280.54
90_T93_L0.9210.53
10_R22_Y0.9130.53
96_E125_E0.9090.53
17_I64_M0.9080.52
7_E11_Q0.9040.52
17_I93_L0.8930.51
52_A55_V0.8900.51
42_I84_I0.8780.50
57_V60_K0.8780.50
23_D91_G0.8720.49
41_L45_A0.8720.49
5_V8_I0.8630.49
6_V10_R0.8520.48
42_I86_Y0.8380.47
64_M128_D0.8380.47
62_K66_V0.8360.47
111_T117_V0.8330.46
121_K125_E0.8240.46
26_L52_A0.8140.45
33_E38_F0.8030.44
74_V77_D0.8000.44
87_A91_G0.7970.43
77_D80_E0.7970.43
30_I37_I0.7920.43
113_I118_S0.7840.42
113_I116_L0.7780.42
55_V79_N0.7720.41
22_Y88_T0.7680.41
91_G118_S0.7670.41
63_L133_M0.7650.41
59_V63_L0.7570.40
100_G104_V0.7530.40
52_A76_S0.7510.40
7_E93_L0.7480.40
59_V115_E0.7480.40
11_Q62_K0.7480.40
51_L104_V0.7310.38
4_K10_R0.7160.37
20_N55_V0.7090.37
108_V112_K0.7030.36
54_L79_N0.7020.36
45_A86_Y0.7000.36
43_F104_V0.6970.36
18_P78_F0.6940.35
39_V64_M0.6910.35
125_E129_P0.6910.35
53_D76_S0.6880.35
45_A101_K0.6810.34
37_I72_V0.6800.34
65_K123_K0.6780.34
47_K87_A0.6770.34
84_I104_V0.6730.34
45_A66_V0.6730.34
23_D87_A0.6540.33
59_V76_S0.6540.33
125_E133_M0.6510.32
96_E123_K0.6480.32
32_I106_V0.6420.32
89_E107_L0.6380.31
91_G119_T0.6260.31
36_R72_V0.6240.30
13_Y20_N0.6230.30
47_K77_D0.6190.30
129_P133_M0.6180.30
41_L76_S0.6160.30
41_L72_V0.6160.30
5_V56_A0.6150.30
127_F131_E0.6140.30
9_L115_E0.6120.30
9_L37_I0.6090.29
61_Y89_E0.6030.29
112_K115_E0.6000.29
13_Y27_V0.5970.29
33_E36_R0.5950.28
8_I12_I0.5900.28
6_V106_V0.5890.28
47_K85_G0.5880.28
4_K68_P0.5880.28
5_V63_L0.5860.28
28_R47_K0.5820.28
118_S130_R0.5810.28
119_T126_N0.5800.27
4_K79_N0.5800.27
123_K131_E0.5790.27
17_I128_D0.5780.27
75_K125_E0.5750.27
110_K117_V0.5730.27
36_R83_N0.5710.27
27_V52_A0.5650.27
81_E106_V0.5610.26
66_V69_D0.5610.26
120_N127_F0.5580.26
55_V91_G0.5550.26
110_K113_I0.5490.26
10_R27_V0.5480.25
99_Y130_R0.5400.25
10_R33_E0.5390.25
18_P23_D0.5360.25
51_L101_K0.5330.25
10_R90_T0.5320.24
42_I80_E0.5300.24
114_E117_V0.5290.24
65_K71_N0.5290.24
28_R84_I0.5290.24
109_N113_I0.5270.24
45_A51_L0.5250.24
81_E123_K0.5240.24
22_Y131_E0.5200.24
6_V22_Y0.5150.23
63_L68_P0.5140.23
78_F81_E0.5130.23
40_R132_Y0.5100.23
56_A76_S0.5100.23
107_L123_K0.5080.23
88_T109_N0.5080.23
28_R45_A0.5070.23
51_L124_L0.5030.23
69_D108_V0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lnoA 1 0.6405 99.9 0.607 Contact Map
3cq1A 2 0.6209 99.9 0.616 Contact Map
1uwdA 1 0.6275 99.9 0.616 Contact Map
3ux2A 2 0.7059 99.9 0.645 Contact Map
1xhjA 1 0.5359 76.3 0.935 Contact Map
2m5oA 1 0.5033 73.2 0.936 Contact Map
1vehA 1 0.5033 63.4 0.941 Contact Map
2qyvA 2 0.9542 44.7 0.947 Contact Map
4tmaI 1 0.2549 44.5 0.947 Contact Map
1ycgA 5 0.8235 42 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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